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Condition: Stroke
Management: National Institutes of Health (NIH)

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Total 1650 results found since Jan 2013.

Treatment of progressive ischemic stroke with low ‑dose eptifibatide: A retrospective case‑control study
Exp Ther Med. 2022 Nov 22;25(1):22. doi: 10.3892/etm.2022.11721. eCollection 2023 Jan.ABSTRACTProgressive ischemic stroke (PIS) is a therapeutic challenge in clinical practice. The present retrospective study aimed to investigate the safety and effectiveness of eptifibatide in the treatment of PIS. The present study enrolled patients with PIS admitted to Xiangtan Central Hospital (Xiangtan, China) between March 2020 and March 2021 with National Institutes of Health Stroke Scale (NIHSS) progression scores of ≥2 points during the initial 72 h. Patients were then divided into two groups according to their different anti-pla...
Source: Experimental and Therapeutic Medicine - December 23, 2022 Category: General Medicine Authors: Long Luo Jinsheng Lin Ye Deng Zhigang Li Ying Yuan Wen Zhang Source Type: research

Impact of presenting Stroke Severity and Thrombolysis on Outcomes After Urgent Carotid Interventions
Carotid interventions are increasingly performed in select patients after acute stroke. We aimed to determine the effects of presenting stroke severity (National Institutes of Health Stroke Scale [NIHSS]) and use of systemic thrombolysis (tPA) on clinical and discharge neurologic outcomes (modified Rankin scale [mRS] score) after urgent carotid endarterectomy (uCEA) and urgent carotid artery stenting (uCAS).
Source: Journal of Vascular Surgery - December 21, 2022 Category: Surgery Authors: Aaron Hayson, Jeff Burton, Joseph Allen, W.C. Sternbergh, Daniel Fort, Hernan Bazan Source Type: research

Corrigendum to ‘Self-Reported Race as a Social Determinant of Stroke Risk in Observational Versus Clinical Trial Datasets’
The authors regret omitting the funding support for Dr. Karen C. Johnston's effort on the project, National Center for Advancing Translational Science of the National Institutes of Health Award UL1TR003015/ KL2TR003016. The authors would like to apologize for any inconvenience caused.
Source: Journal of Stroke and Cerebrovascular Diseases - December 19, 2022 Category: Neurology Authors: Alison L. Herman, Kevin N. Sheth, Olajide A. Williams, Karen C. Johnston, Shyam Prabhakaran, Adamde Havenon Tags: Corrigendum Source Type: research

Low NIHSS score large vessel occlusion caused by infective endocarditis treated with thrombectomy
A 24-year-old woman had undergone dental treatment 3 weeks before and had a mild fever for a week. She presented to the emergency department with the chief complaint of weakness in the right upper limb after waking up. She had mild paralysis of the right upper limb (National Institutes of Health Stroke Scale [NIHSS] score 1). Head magnetic resonance imaging (MRI) showed scattered infarcts in the left frontal and parietal lobes and left internal cerebral artery (ICA) occlusion (Fig. 1A, B). Cerebral angiography showed that the left ICA was occluded immediately after its origin (Fig.
Source: Journal of Stroke and Cerebrovascular Diseases - December 17, 2022 Category: Neurology Authors: So Matsukawa, Kohichi Go, Tao Yang, Takahisa Katsuki, Yohei Takenobu, Kenji Hashimoto Tags: Case Report Source Type: research

Role of Inpatient Rehabilitation Facility Quality Measures to Predict Community Discharge After Stroke
Main objective: Examine the association between National Institutes of Health Stroke Scale (NIHSS) scores measured during the acute care stay and inpatient rehabilitation facility (IRF) admission functional status, measured by the IRF-Patient Assessment Instrument (IRF-PAI) self-care and mobility quality measures, to deduce if quality measures can serve as a proxy for stroke severity. The self-care and mobility quality measures are indicators of physical function.Secondary objective: Investigate the predictive power of the NIHSS and IRF-PAI admission physical function quality measures to predict community discharge from IRF after stroke.
Source: Archives of Physical Medicine and Rehabilitation - December 1, 2022 Category: Rehabilitation Authors: Elizabeth Mangone, Eahsan Shahriary, Pamela Bosch Tags: Research Poster 2184386 Source Type: research

Nurse-Led Motor Function Rehabilitation Program for Acute Ischemic Stroke: A Randomized Pilot Study
This article was designed to evaluate the feasibility and effectiveness of implementing a nurse-led motor function rehabilitation program on patients with acute ischemic stroke. Methods From January to October 2018, patients with initial acute ischemic stroke were assigned to one of two groups using a pilot randomized controlled trial design, with one group receiving a nurse-led motor function intervention program developed based on Orem's theory (7 consecutive days, twice daily for 30 minutes, experimental group) and the other receiving usual care (control group). The effectiveness measures included changes in the ...
Source: Journal of Nursing Research - November 28, 2022 Category: Nursing Tags: ORIGINAL ARTICLES Source Type: research

A clinical application study of a stent placement assessment
Discussion: Currently, no prospective controlled data exist regarding the efficacy and safety of carotid stenting in the acute phase. Previously, we had developed an ECASES stent placement system for acute carotid artery occlusion. The present study will evaluate the efficacy and safety of ECASES in a randomized, double-blind prospective study and clarify its guiding significance in acute atherosclerotic carotid artery occlusion surgery.
Source: Medicine - November 25, 2022 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

The acute-to-chronic glycemic ratio correlates with the severity of illness at admission in patients with diabetes experiencing acute ischemic stroke
Front Neurol. 2022 Nov 7;13:938612. doi: 10.3389/fneur.2022.938612. eCollection 2022.ABSTRACTAcute hyperglycemia is a powerful indicator of the severity of acute ischemic stroke (AIS); however, the relationship between these two factors is not very clear in patients with diabetes. We aimed to retrospectively evaluate data from 335 consecutive patients who experienced AIS from November 2015 to November 2016 to investigate whether a comprehensive assessment of blood glucose levels is a more valuable indicator of the severity of AIS or the presence of acute hyperglycemia in patients with diabetes. We collected demographic dat...
Source: Atherosclerosis - November 24, 2022 Category: Cardiology Authors: Chao Liu Xu-Ping Zhu Xiao-Wei Zhu Yan-Min Jiang Guang-Jun Xi Lan Xu Source Type: research

Factors Predicting Misidentification of Acute Ischemic Stroke and Large Vessel Occlusion by Paramedics
The emergence of thrombectomy for large vessel occlusions has increased the importance of accurate prehospital identification and triage of acute ischemic stroke (AIS). Despite available clinical scores, prehospital identification is suboptimal. Our objective was to improve the sensitivity of prehospital AIS identification by combining dispatch information with paramedic impression. We performed a retrospective cohort review of emergency medical services and hospital records of all patients for whom a stroke alert was activated in 1 urban, academic emergency department from January 1, 2018, to December 31, 2019. Using admi...
Source: Critical Pathways in Cardiology - November 24, 2022 Category: Cardiology Tags: Original Study Source Type: research

Sex as a biological variable in determining the metabolic changes influencing acute ischemic stroke outcomes —Where is the data: A systematic review
Women continue to face a greater lifetime morbidity and mortality from stroke and have been shown to respond differently to stroke treatments compared to men. Since 2016, updated National Institutes of Health (NIH) policies require research studies to consider sex as a biological variable. However, the way in which this policy affects study design, analysis, and reporting is variable, with few studies performing and reporting a subgroup analysis based on biological sex. In acute ischemic stroke, the underlying biological explanation for sex-based differences in patient outcomes and response to treatments remains understudi...
Source: Frontiers in Neurology - November 24, 2022 Category: Neurology Source Type: research

Bioinformatic analysis and clinical diagnostic value of hsa_circ_0004099 in acute ischemic stroke
This study investigates the expression and effect of hsa_circ_0004099 in acute ischemic stroke (AIS). We conducted a case-controlled study that included 40 patients with AIS within 24 hours and 40 healthy subjects during the same period as a control group. Differentially expressed circular RNAs (circRNAs) were obtained using GEO2R, and the expression of hsa_circ_0004099 was verified using RT-PCR. Correlation analysis of the National Institutes of Health Stroke Scale (NIHSS) disease severity score and ischemic time with hsa_circ_0004099 expression levels was also performed. The receiver operating characteristic (ROC) curve ...
Source: Cancer Control - November 18, 2022 Category: Cancer & Oncology Authors: Jiqing Zheng Shuiming Luo Yaobin Long Source Type: research

Multicentre registration of wake-up stroke in China (MCRWUSC): a protocol for a prospective, multicentre, registry-based cohort study
This study is approved by the ethics committee of Shanghai Pudong Hospital (Shanghai, China) and rest of all participating centres. The findings will be disseminated through peer-reviewed publications and conference presentations. PROSPERO registration number ChiCTR2100049133.
Source: BMJ Open - November 10, 2022 Category: General Medicine Authors: Zhang, Z., Yang, H., Tu, Z., Nepal, G., Ojha, R., Xi, Y., Qiao, J., Hu, M., Li, C., Lin, F., Zhou, L., Jin, P., Hou, S. Tags: Open access, Neurology Source Type: research

Efficacy and safety of human-derived neural stem cell in patients with ischaemic stroke: study protocol for a randomised controlled trial
Introduction Stroke is the most common cause of neurological disability in adults worldwide. Neural stem cell (NSC) transplantation has shown promising results as a treatment for stroke in animal experiments. The pilot investigation of stem cells in stroke phase 1 and phase 2 trials showed that transplantation of the highest dose (20 million cells) was well tolerated. Preliminary clinical benefits have also been observed. However, the trials were open-label and had a small sample size. Furthermore, human NSCs (hNSCs) were intracerebrally implanted, and some serious adverse events were considered to be related to the surgic...
Source: BMJ Open - November 8, 2022 Category: General Medicine Authors: Xie, C., Wang, K., Peng, J., Jiang, X., Pan, S., Wang, L., Wu, Y., Guan, Y. Tags: Open access, Neurology Source Type: research