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Condition: Stroke
Management: National Institutes of Health (NIH)

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Total 1650 results found since Jan 2013.

NIH ’s vaunted program for solving puzzling medical cases is running out of money
Ten years ago, an athletic 12-year-old from Affton, Missouri, named Mitchell Herndon began to experience muscle weakness that eventually led to him using a wheelchair. After years of visits to specialists failed to diagnose his neurological symptoms, he enrolled in a National Institutes of Health (NIH)-funded program that studies patients with debilitating mystery diseases. Researchers eventually found an explanation for Mitchell’s condition: a mutated gene that causes certain brain cells to produce an overactive protein that leads to neuron damage. Mitchell died 3 years ago at age 19. Since then, 14 more people hav...
Source: Science of Aging Knowledge Environment - June 27, 2022 Category: Geriatrics Source Type: research

CO33 Methodological Challenges and Considerations for Decision Makers When Assessing within-Class Comparative Effectiveness and Cost-Effectiveness: The Case of Non-Vitamin K Antagonist Oral Anticoagulants
The United Kingdom National Institute of Health Care Excellence (NICE) published a draft clinical guideline for consultation on anticoagulation therapy for stroke prevention in individuals with atrial fibrillation in September 2020 that addressed which non-vitamin K antagonist oral anticoagulant (NOAC) therapy (apixaban, dabigatran, rivaroxaban, edoxaban) is most clinically and cost-effective. We aimed to elucidate methodological considerations and challenges involved in evaluating the comparative effectiveness and cost-effectiveness of within-class treatments for the  purpose of decision making by a reimbursement authority.
Source: Value in Health - June 26, 2022 Category: International Medicine & Public Health Authors: A Briggs, A Howarth, S Davies, J Schneider, G Spentzouris, F Mughal, A Fuat, M Fay Source Type: research

Effects of Different Doses of Clopidogrel plus Early Rehabilitation Therapy on Motor Function and Inflammatory Factors in Patients with Ischemic Stroke
Evid Based Complement Alternat Med. 2022 Jun 14;2022:9692382. doi: 10.1155/2022/9692382. eCollection 2022.ABSTRACTThis prospective randomized controlled study was intended to assess the effects of different doses of clopidogrel plus early rehabilitation therapy on motor function and inflammatory factors in patients with ischemic stroke. Between August 2018 and October 2020, 90 cases of ischemic stroke treated in the Second People's Hospital of Yibin were randomized at a ratio of 1 : 1 to receive either oral 50 mg/d clopidogrel plus early rehabilitation therapy (low-dose group) or oral 75 mg/d clopidogrel plus early rehabil...
Source: Evidence-based Complementary and Alternative Medicine - June 24, 2022 Category: Complementary Medicine Authors: Zhuolin Zhao Ying Ma Qin Liu Ling Jiang Huimin Shu Daofeng Chen Jiao Wu Source Type: research

Electrical stimulation of the brain may help people who stutter
When Guillermo Mejias was 7 years old, his parents sent him out to buy bread during a family holiday in southern Spain. Mejias still remembers his growing anxiety as he walked to the bakery, repeating what he would say over and over in his head. But when the moment arrived, he was unable to produce a single word. He recalls returning empty-handed, ashamed, and wondering what to tell his parents. “I was so tense that I had been inadvertently biting my cheeks and tongue and my mouth was bleeding,” he says. Mejias still stutters, but today, as a brain researcher at the Complutense University of Madrid, he investigate...
Source: Science of Aging Knowledge Environment - June 22, 2022 Category: Geriatrics Source Type: research

Circular RNA FUNDC1 for Prediction of Acute Phase Outcome and Long-Term Survival of Acute Ischemic Stroke
This study aimed to explore the potential value of circRNAs for identifying acute neurological deterioration and estimating long-term survival for acute ischemic stroke (AIS). One hundred healthy controls and 200 patients with AIS within 72 h were recruited, 140 of whom were admitted within 24 h after onset. CircRNA levels in peripheral blood were measured by quantitative polymerase chain reaction (qPCR). Compared to the controls, the levels of three circRNAs were significantly increased in three subgroups of patients, including large artery atherosclerosis (LAA) stroke, small artery occlusion (SAO) stroke, and cardioembol...
Source: Atherosclerosis - June 20, 2022 Category: Cardiology Authors: Juan Zu Lei Zuo Lin Zhang Zan Wang Yachen Shi Lihua Gu Zhijun Zhang Source Type: research

NIH launches grant program aimed at closing the funding rate gap between Black and white investigators
After having one idea batted down last year, some National Institutes of Health (NIH) institutes are taking a new tack to bolster the success rate of Black scientists and researchers from other underrepresented groups seeking research grants. A program aiming to diversify the NIH workforce could award up to $20 million a year to neuroscience, drug abuse, and mental health investigators from minority groups. The program will create a new class of NIH’s standard R01 research grant designed to “encourage a more diverse pool of PIs [principal investigators],” said Walter Koroshetz, director of the National Institute...
Source: Science of Aging Knowledge Environment - June 17, 2022 Category: Geriatrics Source Type: research

Revised Use of the Modified National Institutes of Health Stroke Scale for Perioperative Stroke Screening
No abstract available
Source: Journal of Neurosurgical Anesthesiology - June 17, 2022 Category: Anesthesiology Tags: Editorials Source Type: research

Postoperative Screening With the Modified National Institutes of Health Stroke Scale After Noncardiac Surgery: A Pilot Study
Background: Perioperative stroke is associated with high rates of morbidity and mortality, yet there is no validated screening tool. The modified National Institutes of Health Stroke Scale (mNIHSS) is validated for use in nonsurgical strokes but is not well-studied in surgical patients. We evaluated perioperative changes in the mNIHSS score in noncardiac, non-neurological surgery patients, feasibility in the perioperative setting, and the relationship between baseline cognitive screening and change in mNIHSS score. Methods: Patients aged 65 years and above presenting for noncardiac, non-neurological surgery were...
Source: Journal of Neurosurgical Anesthesiology - June 17, 2022 Category: Anesthesiology Tags: Short Reports Source Type: research

Acute Stroke Diagnosis
Am Fam Physician. 2022 Jun 1;105(6):616-624.ABSTRACTStroke accounts for significant morbidity and mortality and is the fifth leading cause of death in the United States, with direct and indirect costs of more than $100 billion annually. Expedient recognition of acute neurologic deficits with appropriate history, physical examination, and glucose testing will help diagnose stroke and rule out mimicking presentations. The National Institutes of Health Stroke Scale should be used to determine stroke severity and to monitor for evolving changes in clinical presentation. Initial neuroimaging is used to differentiate between isc...
Source: American Family Physician - June 15, 2022 Category: Primary Care Authors: Edwin Y Choi Gilberto A Nieves Darrell Edward Jones Source Type: research

Basilar artery occlusion: A review of clinicoradiologic features, treatment selection, and endovascular techniques
Interv Neuroradiol. 2022 Jun 12:15910199221106049. doi: 10.1177/15910199221106049. Online ahead of print.ABSTRACTBasilar artery occlusion (BAO) is an infrequent but often fatal subtype of stroke. Predicting outcomes and selecting patients for endovascular therapy (EVT) remains challenging. Advances in neuroimaging and the development of prognostic scoring systems have augmented clinical decision-making over time. Recent randomized trials, BEST (Basilar Artery Occlusion Endovascular Intervention vs. Standard Medical Treatment), BASICS (Basilar Artery International Cooperation Study), BAOCHE (Basilar Artery Occlusion CHinese...
Source: Interventional Neuroradiology - June 13, 2022 Category: Radiology Authors: Rashid A Ahmed Adam A Dmytriw Aman B Patel Christopher J Stapleton Justin E Vranic James D Rabinov Thabele M Leslie-Mazwi Natalia S Rost Joshua A Hirsch Robert W Regenhardt Source Type: research