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Effects of Transcutaneous Electrical Nerve Stimulation at Two Frequencies on Urinary Incontinence in Poststroke Patients: A Randomized Controlled Trial
The objective of this study was to compare the effects of two frequencies of transcutaneous electrical nerve stimulation (TENS) on urinary incontinence caused by stroke. Methods: Eighty-one patients with poststroke urinary incontinence were recruited and randomized into the following three groups with a 1:1 ratio: a 20-Hz TENS group, a 75-Hz TENS group, and a no-treatment control group (n = 27 per group). TENS currents were biphasic square waves with pulse durations of 150 μsecs and pulse frequencies of 20 Hz or 75 Hz and were applied for 30 mins once per day for 90 days. The positive electrodes were placed in the region...
Source: American Journal of Physical Medicine and Rehabilitation - February 24, 2016 Category: Rehabilitation Tags: Original Research Article Source Type: research

Nocturia indicates a poor health status and increases mortality in male patients with type 2 diabetes mellitus
Conclusions The presence of nocturia was associated with erectile dysfunction, systemic vascular events, higher mortality, and indicated poor health in male with type 2 diabetic mellitus.
Source: International Urology and Nephrology - May 6, 2016 Category: Urology & Nephrology Source Type: research

Cardiovascular Safety of the β3 -Adrenoceptor Agonist Mirabegron and the Antimuscarinic Agent Solifenacin in the SYNERGY Trial.
Abstract There have been concerns that treatment of overactive bladder with β3 -adrenoceptor agonists may potentially have detrimental cardiovascular (CV) side effects. We evaluated the CV safety of mirabegron, a β3 -adrenoceptor agonist, alone and in combination therapy with the antimuscarinic agent solifenacin. The SYNERGY trial was a multinational, multicenter, randomized, double-blind, parallel-group, placebo and active-controlled phase 3 trial. Patients were randomized to receive solifenacin 5 mg + mirabegron 50 mg (combination 5 + 50 mg), solifenacin 5 mg + mirabegron 25 mg (combination 5 + 2...
Source: The Journal of Clinical Pharmacology - April 12, 2018 Category: Drugs & Pharmacology Authors: White WB, Chapple C, Gratzke C, Herschorn S, Robinson D, Frankel J, Ridder A, Stoelzel M, Paireddy A, van Maanen R, Weber MA Tags: J Clin Pharmacol Source Type: research

Improvement in overactive bladder symptoms in patients using functional electrical stimulation of the common peroneal nerve for walking.
CONCLUSION: The results of this exploratory study suggest that functional electrical stimulation use does improve overactive bladder symptoms in people with multiple sclerosis. Further exploration is needed to study this association and explore whether the mechanism is similar to that of percutaneous tibial nerve stimulation, a recognized treatment for the overactive bladder. PMID: 29909652 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - June 1, 2018 Category: Rehabilitation Authors: Hare N, Georgopoulos P, Philips KE, Johnson JE, Seary C, Panicker JN, Stevenson VL Tags: Clin Rehabil Source Type: research

Interest of transcranial stimulation in pelvic and perineal disorders.
CONCLUSION: Data from the literature suggest that transcranial stimulation is a noninvasive treatment that may have a role in the management of pelvic and perineal disorders. Its promising field of action would require prospective and randomized studies on a larger scale. PMID: 31036483 [PubMed - as supplied by publisher]
Source: Progres en Urologie - May 2, 2019 Category: Urology & Nephrology Tags: Prog Urol Source Type: research

Noninvasive spinal neuromodulation to map and augment lower urinary tract function in rhesus macaques.
Abstract Dysfunction of the lower urinary tract (LUT) is prevalent in neurological disorders, including multiple sclerosis, stroke, spinal cord injury and neurodegenerative conditions. Common symptoms include urgency, incontinence, and urinary retention. Recent advances in neuromodulation have resulted in improved treatments for overactive bladder symptoms of urgency, frequency, and nocturia. However, there are presently no treatments available for the induction of voiding to overcome urinary retention. We demonstrate that transcutaneous spinal cord stimulation (TSCS), a non-invasive intervention, applied over the...
Source: Experimental Neurology - August 6, 2019 Category: Neurology Authors: Havton LA, Christe KL, Edgerton VR, Gad PN Tags: Exp Neurol Source Type: research

New clinical trial examines a potential noninvasive solution for overactive bladders
(University of Southern California - Health Sciences) Keck Medicine of USC urologists are launching a clinical trial to evaluate the effectiveness of spinal cord stimulation in patients with an overactive bladder due to neurological conditions, such as a spinal cord injury or stroke, and idiopathic (unknown) causes.
Source: EurekAlert! - Medicine and Health - March 10, 2020 Category: International Medicine & Public Health Source Type: news

Effects of tibial and parasacral nerve electrostimulation techniques on women with poststroke overactive bladder: study protocol for a randomized controlled trial
Neurogenic bladder (NB) can affect people after stroke episodes. NB features changes in the normal voiding pattern at the bladder filling and emptying phases. Overactive NB is characterized by urgency symptoms...
Source: Trials - November 19, 2020 Category: General Medicine Authors: Thais Alves Candido, Bruna Miranda Ribeiro, Cristiane Rodrigues Cardoso de Ara újo, Rogério de Melo Costa Pinto, Ana Paula Magalhães Resende and Vanessa Santos Pereira-Baldon Tags: Study protocol Source Type: research

Pharmacist ’s knowledge regarding the management of overactive bladder in elderly women
Anticholinergic drugs used to treat overactive bladder (OAB), have common side effects, including constipation, dry eyes and dry mouth. They can also cause central nervous system effects such as confusion and reduction in cognitive function [1]. Polypharmacy and an increase in blood brain barrier permeability increase these effects [2] which, are more likely in the elderly [3] as aging, as well as trauma, multiple sclerosis, hypertension, stroke and diabetes [4], leads to increased blood brain barrier permeability.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - January 16, 2021 Category: OBGYN Authors: George Araklitis, Angie Rantell, Georgina Baines, Richard Flint, Dudley Robinson, Linda Cardozo Tags: Full length article Source Type: research

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