Noninvasive spinal neuromodulation to map and augment lower urinary tract function in rhesus macaques.
Noninvasive spinal neuromodulation to map and augment lower urinary tract function in rhesus macaques. Exp Neurol. 2019 Aug 07;:113033 Authors: Havton LA, Christe KL, Edgerton VR, Gad PN Abstract Dysfunction of the lower urinary tract (LUT) is prevalent in neurological disorders, including multiple sclerosis, stroke, spinal cord injury and neurodegenerative conditions. Common symptoms include urgency, incontinence, and urinary retention. Recent advances in neuromodulation have resulted in improved treatments for overactive bladder symptoms of urgency, frequency, and nocturia. However, there are presently no treatments available for the induction of voiding to overcome urinary retention. We demonstrate that transcutaneous spinal cord stimulation (TSCS), a non-invasive intervention, applied over the thoracolumbar spine in neurologically intact rhesus macaques can activate the LUT, including activation of the bladder detrusor muscle, the urethral sphincter and pelvic floor muscles. Urodynamic studies show improved voiding efficiency and decreased post-voiding residual volumes in the bladder, while maintaining coordinated activity in the detrusor and sphincter with physiologic detrusor peak pressure, contraction duration, and urine flow rate remaining unchanged. We conclude that TSCS may represent a novel approach to activate the LUT and enable voiding in select neurological conditions. PMID: 31400304 [PubMed - as supplied by publisher]
Conclusion: Plasma levels of adiponectin are associated with the ASPECTS scores.RESUMO Introdu ção: A Alberta Stroke Early Score (ASPECTS) foi desenvolvida para monitorização de alterações isquêmicas precoces na tomografia computadorizada de crânio, estando associada a desfechos clínicos. A ASPECTS também pode se associar aos biomarcadores periféricos que refletem a resposta fisio patológica do cérebro ao AVC isquêmico. Objetivo: Investigar à associação entre os parâmetros periféricos com a Alber...
Publication date: Available online 31 May 2020Source: Neurología (English Edition)Author(s): F. Castillo-Álvarez, P. Pérez-Matute, J.A. Oteo, M.E. Marzo-Sola
June 1, 2020 -- AstraZeneca’s Brilinta (ticagrelor) has been approved in the US to reduce the risk of a first heart attack or stroke in high-risk patients with coronary artery disease (CAD), the most common type of heart disease. The approval...
The new indication is based on the THEMIS trial, which entered patients with CAD and type 2 diabetes without previous MI or stroke and showed clinical benefit, but also bleeding concerns.FDA Approvals
We report on the feasibility of implementing such standardized assessments into routine clinical care via measures of adherence. We also report on initial analyses of the data within the database that provide insights into the opportunities to track change. This initiative highlights the feasibility of collecting clinical data using a standardized assessment measure across acute and inpatient rehabilitation care settings. Practice-based evidence may inform future research by contributing pilot data and systematic observations that may lead to the development of empirical studies, which can then feed back into clinical practice.
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HIGH blood pressure is often due to a person's lifestyle and dietary habits. This is why what you consume and how you live your life could literally be a case of life or death as the condition is often related to heart attacks or strokes. Fortunately, a few simple tweaks and you will be on your way to lower readings and less health risks.
Findings on neuroimaging suggest that for patients with progressive multiple sclerosis, constraint-induced movement therapy leads to changes in white and gray matter.Medscape Medical News
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