Improvement in overactive bladder symptoms in patients using functional electrical stimulation of the common peroneal nerve for walking.

CONCLUSION: The results of this exploratory study suggest that functional electrical stimulation use does improve overactive bladder symptoms in people with multiple sclerosis. Further exploration is needed to study this association and explore whether the mechanism is similar to that of percutaneous tibial nerve stimulation, a recognized treatment for the overactive bladder. PMID: 29909652 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - Category: Rehabilitation Authors: Tags: Clin Rehabil Source Type: research

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ConclusionsThis study showed that natalizumab dominated fingolimod with lower costs and higher QALYs in patients with high-activity RRMS. These results are consistent with previous published international literature.
Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research
ConclusionTreatment with fampridine-MR was well-tolerated but did not produce clinical benefit in terms of upper limb function, vision or fatigue, nor was there any measurable effect on objective electrophysiological parameters.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Conclusion: This study confirm that EMA are common in all MS phenotypes, even at the earliest stages. VOG can be useful to detect demyelinating process at preclinical stage by highlighting subclinical EMA even in absence of characteristic lesions visible on MRI.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionsThese findings suggest that MXYF inhibits autophagy after OGD/R-induced PC12 cell injury through the AMPK-mTOR pathway. Thus, MXYF might have therapeutic potential in treating ischemic stroke.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
This study aims to observe the role of target miRNA(miR-652) of NOX2 in ischemic stroke. A rat cerebral ischemia/reperfusion (CI/R) injury model and an SH-SY5Y cell hypoxia/reoxygenation(H/R) model were used to simulate ischemic stroke, and corresponding gene expression, biochemical indicators and pathophysiological indicators were measured to observe the role of miR-652. NOX2 significantly increased in brain tissues subjected to I/R or in SH-SY5Y cells subjected to H/R, while the expression level of miR-652(potential target of NOX2) significantly decreased in both brain tissues and plasma. Overexpression of miR-652 signif...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
The buildup of plaques within blood vessel walls is the underlying cause of strokes and heart attacks. These plaques contain many dead or dying cells that are not flushed out by the immune system fast enough. Now, researchers from Stanford are re...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiac Surgery Cardiology Materials Medicine Nanomedicine Vascular Surgery Source Type: blogs
Conditions:   Multiple Sclerosis;   Fatigue;   Chronic Conditions, Multiple Intervention:   Other: More Stamina Sponsors:   Hospital Italiano de Buenos Aires;   University of Oulu;   University of Seville Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cerebral Palsy Interventions:   Other: Autologous umbilical cord blood transfusion;   Other: placebo Sponsor:   Sheba Medical Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, a novel biosynthesized cellulose (BC)-based drug releasing duraplasty was developed and studied. The BC duraplasty fabrication process allowed readily incorporation of growth factors (GFs) in a sterile manner and control of physical and mechanical properties of the resulting duraplasty. Our results showed that BC duraplasty containing the highest amount of dry cellulose presented swelling ratio of 496 ± 27%, Young's modulus of 0.37 ± 0.02 MPa, ultimate tensile strength of 0.96 ± 0.02 MPa, while releasing GFs for over 10 days. In addition, neur...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 28 January 2020Source: Neuroscience LettersAuthor(s): Andrea S. Heimann, AC Giardini, MB Sant’Anna, Nilton B. Dos Santos, Mayara C.F. Gewehr, Carolina D. Munhoz, Leandro M. Castro, Gisele Picolo, Ricardo A. Remer, Emer S. FerroAbstractPrevious studies suggested the pharmacological potential of rat hemopressin (PVNFKFLSH) and its shorter synthetic peptide NFKF, to protect from pilocarpine-induced seizures in mice. Orally administered NFKF was shown to be hundred times more potent than cannabidiol in delaying the first seizure induced by pilocarpine in mice. Here, using an experimenta...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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