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Condition: Multiple Sclerosis

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Total 1656 results found since Jan 2013.

Acetyl-L-carnitine and Amyotrophic Lateral Sclerosis: current evidence and potential use
CONCLUSION: This narrative review aims to update the existing literature on ALCAR molecular profile, tolerability, and translational clinical potential use in neurodegeneration, focusing on ALS.PMID:36998125 | DOI:10.2174/1871527322666230330083757
Source: CNS and Neurological Disorders Drug Targets - March 31, 2023 Category: Drugs & Pharmacology Authors: Fabiola De Marchi Sakthipriyan Venkatesan Massimo Saraceno Letizia Mazzini Elena Grossini Source Type: research

LMP2 deficiency causes abnormal metabolism, oxidative stress, neuroinflammation, myelin loss and neurobehavioral dysfunctions
Substantial evidence suggests that immunoproteasome is implicated in the various neurological diseases such as stroke, multiple sclerosis and neurodegenerative diseases. However, whether the immunoproteasome i...
Source: Journal of Translational Medicine - March 28, 2023 Category: Research Authors: Xingyong Chen, Yanguang Mao, Yueting Guo, Dongyun Xiao, Zejing Lin, Yiyi Huang, Ying Chun Liu, Xu Zhang and Yinzhou Wang Tags: Research Source Type: research

Relationship between motor performance and cortical activity of older neurological disorder patients with dyskinesia using fNIRS: A systematic review
Conclusion: Most of the reviewed studies reported poor motor performance and increased cortical activation of PD, stroke and multiple sclerosis older patients. The external motor performance such as step speed were analyzed only. The design and results were not comprehensive and profound. More than 5 weeks walking training or physiotherapy can contribute to motor function promotion as well as cortices activation of PD and stroke patients. Thus, further study is needed for more statistical analysis on the relationship between motor performance and activation of the motor-related cortex. More different type and program spor...
Source: Frontiers in Physiology - March 27, 2023 Category: Physiology Source Type: research

Evaluation of benzoylacetonitriles as novel anti-neuroinflammatory agents
AbstractInflammation in the central nervous system is associated with numerous neurological disorders, including multiple sclerosis, Parkinson ’s disease, Alzheimer’s disease, and ischemic stroke. Enhanced inflammatory events either drive these disorders directly or are consequences of disease processes. As such, the identification of novel classes of anti-neuroinflammatory agents may help address current treatment shortcomings. In thi s report, we describe the immunomodulatory activity of a series of benzoylacetonitriles in both BV2 and primary microglial cells. Molecules were evaluated for ability to suppress LPS-ind...
Source: Medicinal Chemistry Research - March 23, 2023 Category: Chemistry Source Type: research

Sensors, Vol. 23, Pages 3396: Mobile App Interventions for Parkinson & rsquo;s Disease, Multiple Sclerosis and Stroke: A Systematic Literature Review
Sensors, Vol. 23, Pages 3396: Mobile App Interventions for Parkinson’s Disease, Multiple Sclerosis and Stroke: A Systematic Literature Review Sensors doi: 10.3390/s23073396 Authors: Andreas Triantafyllidis Sofia Segkouli Stelios Zygouris Christina Michailidou Konstantinos Avgerinakis Evangelia Fappa Sophia Vassiliades Anastasia Bougea Nikos Papagiannakis Ioannis Katakis Evangelos Mathioudis Alexandru Sorici Lidia Bajenaru Valentina Tageo Francesco Camonita Christoniki Magga-Nteve Stefanos Vrochidis Ludovico Pedullà Giampaolo Brichetto Panagiotis Tsakanikas Konstantinos...
Source: Sensors - March 23, 2023 Category: Biotechnology Authors: Andreas Triantafyllidis Sofia Segkouli Stelios Zygouris Christina Michailidou Konstantinos Avgerinakis Evangelia Fappa Sophia Vassiliades Anastasia Bougea Nikos Papagiannakis Ioannis Katakis Evangelos Mathioudis Alexandru Sorici Lidia Bajenaru Valentina T Tags: Review Source Type: research

Effect of backward and forward walking on lower limb strength, balance, and gait in multiple sclerosis: a randomized feasibility trial - DelMastro HM, Ruiz JA, Simaitis LB, Gromisch ES, Neto LO, Cohen ET, Wong E, Krug RJ, Lo AC.
We examined the feasibility of a BW intervention...
Source: SafetyLit - March 20, 2023 Category: International Medicine & Public Health Tags: Egress, Escape, Evacuation, Crowds Source Type: news

The role of the blood-brain barrier during neurological disease and infection
Biochem Soc Trans. 2023 Mar 17:BST20220830. doi: 10.1042/BST20220830. Online ahead of print.ABSTRACTA healthy brain is protected by the blood-brain barrier (BBB), which is formed by the endothelial cells that line brain capillaries. The BBB plays an extremely important role in supporting normal neuronal function by maintaining the homeostasis of the brain microenvironment and restricting pathogen and toxin entry to the brain. Dysfunction of this highly complex and regulated structure can be life threatening. BBB dysfunction is implicated in many neurological diseases such as stroke, Alzheimer's disease, multiple sclerosis,...
Source: Biochemical Society Transactions - March 17, 2023 Category: Biochemistry Authors: Adjanie Patabendige Damir Janigro Source Type: research

The role of IL-23/IL-17 axis in ischemic stroke from the perspective of gut-brain axis
Neuropharmacology. 2023 Mar 14:109505. doi: 10.1016/j.neuropharm.2023.109505. Online ahead of print.ABSTRACTBidirectional communication between central nervous system (CNS) and intestine is mediated by nerve, endocrine, immune and other pathways in gut-brain axis. Many diseases of CNS disturb the homeostasis of intestine and gut microbiota. Similarly, the dysbiosis of intestinal and gut microbiota also promotes the progression and deterioration of CNS diseases. IL-23/IL-17 axis is an important inflammatory axis which is widely involved in CNS diseases such as experimental autoimmune encephalomyelitis (EAE), multiple sclero...
Source: Neuropharmacology - March 16, 2023 Category: Drugs & Pharmacology Authors: Yang Jiang Yajie Dai Zhenquan Liu Yan Liao Shuyong Sun Xianghe Kong Jingjing Hu Yibo Tang Source Type: research

Regulatory T cells promote functional recovery after spinal cord injury by alleviating microglia inflammation via STAT3 inhibition
CONCLUSION: Our results suggest that Tregs promote functional recovery after SCI by alleviating microglia inflammatory reaction via STAT3.PMID:36914969 | DOI:10.1111/cns.14161
Source: CNS Neuroscience and Therapeutics - March 14, 2023 Category: Neuroscience Authors: Rui Liu Ying Li Ziyue Wang Peng Chen Yi Xie Wensheng Qu Minghuan Wang Zhiyuan Yu Xiang Luo Source Type: research