Filtered By:
Specialty: Neuroscience
Condition: Subarachnoid Hemorrhage

This page shows you your search results in order of date.

Order by Relevance | Date

Total 56 results found since Jan 2013.

Functional effects of haemoglobin can be rescued by haptoglobin in an in vitro model of subarachnoid haemorrhage
Subarachnoid haemorrhage causes significant cognitive and functional disability in survivors, and one contributing factor is exposure of neurons to haemoglobin causing cell loss and dysfunction. In this in vitro subarachnoid haemorrhage model, haemolysate application to cultured neurons impairs cytoskeletal integrity. Furthermore, amplitude of AMPA receptor-mediated synaptic currents is reduced by haemolysate, driven by reduction in GluA1 expression. These deficits can be prevented with application of exogenous haptoglobin without off-target effects. These results provide new insight into neuronal dysfunction in haemorrhag...
Source: Journal of Neurochemistry - September 14, 2023 Category: Neuroscience Authors: Hannah Warming, Katrin Deinhardt, Patrick Garland, John More, Diederik Bulters, Ian Galea, Mariana Vargas ‐Caballero Tags: ORIGINAL ARTICLE Source Type: research

Connection between oxidative stress and subcellular organelle in subarachnoid hemorrhage: Novel mechanisms and therapeutic implications
CNS Neurosci Ther. 2023 Jul 5. doi: 10.1111/cns.14348. Online ahead of print.ABSTRACTSpontaneous subarachnoid hemorrhage (SAH) is one of the most devastating forms of stroke, with limited treatment modalities and poor patient outcomes. Previous studies have proposed multiple prognostic factors; however, relative research on treatment has not yet yielded favorable clinical outcomes. Moreover, recent studies have suggested that early brain injury (EBI) occurring within 72 h after SAH may contribute to its poor clinical outcomes. Oxidative stress is recognized as one of the main mechanisms of EBI, which causes damage to vario...
Source: CNS Neuroscience and Therapeutics - July 6, 2023 Category: Neuroscience Authors: Jiahao Zhang Zeyu Zhang Xiaoyu Wang Yibo Liu Qian Yu Kaikai Wang Yuanjian Fang Cameron Lenahan Maohua Chen Sheng Chen Source Type: research

Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke
AbstractPurpose of ReviewThis review aims to provide an overview of neuroinflammation in ischemic and hemorrhagic stroke, including recent findings on the mechanisms and cellular players involved in the inflammatory response to brain injury.Recent FindingsNeuroinflammation is a crucial process following acute ischemic stroke (AIS) and hemorrhagic stroke (HS). In AIS, neuroinflammation is initiated within minutes of the ischemia onset and continues for several days. In HS, neuroinflammation is initiated by blood byproducts in the subarachnoid space and/or brain parenchyma. In both cases, neuroinflammation is characterized b...
Source: Current Neurology and Neuroscience Reports - July 3, 2023 Category: Neuroscience Source Type: research

Toll ‐like receptor 4‐mediated microglial inflammation exacerbates early white matter injury following experimental subarachnoid hemorrhage
In conclusion, microglial inflammation has dual effects on early WMI after experimental SAH. Future explorations on more clinically relevant methods for modulating neuroinflammation are warranted to combat stroke with both WMI and gray matter destruction.
Source: Journal of Neurochemistry - June 13, 2023 Category: Neuroscience Authors: Jianhua Peng, Yuke Xie, Jinwei Pang, Yue Wu, Jian Zhou, Long Gu, Kecheng Guo, Lifang Zhang, Bingqing Xie, Shigang Yin, Xiaochuan Sun, Ligang Chen, Yong Jiang Tags: ORIGINAL ARTICLE Source Type: research

Targeting Non-Coding RNA for CNS Injuries: Regulation of Blood-Brain Barrier Functions
Neurochem Res. 2023 Feb 14. doi: 10.1007/s11064-023-03892-1. Online ahead of print.ABSTRACTCentral nervous system (CNS) injuries are the most common cause of death and disability around the world. The blood-brain barrier (BBB) is located at the interface between the CNS and the surrounding environment, which protects the CNS from exogenous molecules, harmful agents or microorganisms in the blood. The disruption of BBB is a common feature of CNS injuries and participates in the pathological processes of secondary brain damage. Recently, a growing number of studies have indicated that non-coding RNAs (ncRNAs) play an importa...
Source: Neurochemical Research - February 14, 2023 Category: Neuroscience Authors: Li Zhang Wanshan Bai Lean Sun Yixing Lin Mi Tian Source Type: research

Predictors of Time to Aneurysm Repair and Mortality in Aneurysmal Subarachnoid Hemorrhage
CONCLUSION: Our results indicate that treatment at a CSC was associated with a lower risk of in-hospital mortality. Time to aneurysm repair did not influence mortality and did not explain the mortality benefit observed in CSCs. Research is needed to explore interdisciplinary hospital factors including nursing and nurse-sensitive interventions that may explain the relationship between CSCs and mortality outcomes.
Source: Journal of Neuroscience Nursing - September 10, 2022 Category: Neuroscience Tags: Articles Source Type: research

A Scoping Review of the Incidence, Predictors, and Outcomes of Delirium Among Critically Ill Stroke Patients
CONCLUSIONS: Current findings are limited by heterogenous populations, assessments, and measurement parameters. Detection and management of delirium among critically ill stroke patients requires an approach with specific considerations to the complexities of acute neurological injury and concomitant critical illness.
Source: Journal of Neuroscience Nursing - May 13, 2022 Category: Neuroscience Tags: Articles Source Type: research

The blood –brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments
AbstractThe response of the blood –brain barrier (BBB) following a stroke, including subarachnoid hemorrhage (SAH), has been studied extensively. The main components of this reaction are endothelial cells, pericytes, and astrocytes that affect microglia, neurons, and vascular smooth muscle cells. SAH induces alterations in individ ual BBB cells, leading to brain homeostasis disruption. Recent experiments have uncovered many pathophysiological cascades affecting the BBB following SAH. Targeting some of these pathways is important for restoring brain function following SAH. BBB injury occurs immediately after SAH and has l...
Source: Fluids and Barriers of the CNS - April 11, 2022 Category: Neuroscience Source Type: research

Blood Pressure in Acute Stroke and Secondary Stroke Prevention
This article reviews current guidelines for early management of blood pressure (BP) and highlights the findings of recent investigative works.Recent FindingsIntensive blood pressure reduction after receiving alteplase has not been shown to improve outcomes. Patients with large vessel occlusions may benefit from lower blood pressure targets post-intervention. Retrospective analyses of large intracerebral hemorrhage trials suggest that specific subgroups of patients may disproportionately benefit from or be harmed by intensive BP reduction. Robust data for management of blood pressure in subarachnoid hemorrhage patients is l...
Source: Current Neurology and Neuroscience Reports - March 25, 2022 Category: Neuroscience Source Type: research

Dysphagia screening and pneumonia after subarachnoid hemorrhage: Findings from the Chinese stroke center alliance
CONCLUSION: More than a quarter of patients with SAH did not have documented DS, while one-fifth developed pneumonia. DS performance was associated with a lower risk of pneumonia. Randomized controlled trials may be needed to determine the effectiveness of DS.PMID:35233938 | DOI:10.1111/cns.13822
Source: CNS Neuroscience and Therapeutics - March 2, 2022 Category: Neuroscience Authors: Mei-Ru Wu Yi-Tong Chen Zi-Xiao Li Hong-Qiu Gu Kai-Xuan Yang Yun-Yun Xiong Yong-Jun Wang Chun-Juan Wang Source Type: research

Differential Diagnosis of Akinetic Mutism and Disorder of Consciousness Using Diffusion Tensor Tractography: A Case Report
This paper presents a case in whom a differential diagnosis of akinetic mutism with a disorder of consciousness was made using diffusion tensor tractography (DTT). A 69-year-old female patient was diagnosed with subarachnoid hemorrhage, intraventricular hemorrhage, and intracerebral hemorrhage produced by the subarachnoid hemorrhage. She exhibited impaired consciousness with a Coma Recovery Scale-Revised score of 13 until 1 month after onset. Her impaired consciousness recovered slowly to a normal state according to the Coma Recovery Scale-Revised (23 points: full score) at 7 weeks after onset. On the other hand, she exhib...
Source: Frontiers in Human Neuroscience - February 25, 2022 Category: Neuroscience Source Type: research

Issue Information
Front cover:Restoring the cerebral blood flow and minimizing the loss of neurons are the two main aims in acute stroke therapy, in order to preserve energy supply to the neurons and other cells in the brain. The brain ’s energy homeostasis is therefore an important target in stroke therapy. The various articles in this special issue “Stroke and Energy Metabolism” pinpoint the hotspots of energy metabolism changes following stroke, including disturbed cerebral blood circulation, mitochondrial dysfunction, pr ogrammed neuronal cell death, and cell-cell communications for brain metabolism, to provide insights and toe-ho...
Source: Journal of Neurochemistry - December 29, 2021 Category: Neuroscience Tags: Issue Information Source Type: research

Anisocoria Correlates With Injury Severity and Outcomes After Blunt Traumatic Brain Injury
CONCLUSION: Anisocoria correlates with injury severity and with patient outcomes after blunt TBI. Anisocoria after light stimulation seems to be a stronger predictor than does anisocoria in ambient light. These findings represent continued efforts to understand pupillary changes in the setting of TBI.
Source: Journal of Neuroscience Nursing - November 17, 2021 Category: Neuroscience Tags: Articles Source Type: research

Cerebrovascular Complications of Anemia
AbstractPurpose of the ReviewAnemia has been called the fifth cardiovascular risk factor. It is one of the most prevalent pathologies worldwide. In this article, we aimed to perform a narrative review of the main cerebrovascular complications of anemia and its influence on stroke prognosis.Recent FindingsBoth hypoproliferative anemia (thalassemia, iron deficiency anemia, etc.) and hyperproliferative anemia (sickle cell disease, paroxysmal nocturnal hemoglobinuria, hereditary spherocytosis, etc.) are associated to cerebrovascular disease ranging from transient ischemic attack to ischemic stroke and hemorrhagic stroke with b...
Source: Current Neurology and Neuroscience Reports - September 3, 2021 Category: Neuroscience Source Type: research