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P78 How far is too far in stroke thrombectomy? From XL to XS vessel occlusions with radially adjustable stent-retrievers - Tigertriever XL and Tigertriever 13
ConclusionMechanical thrombectomy for both primary or secondary DMVO seems feasible and as safe as for LVO. Our initial experience using the Tigertriever13 is of special interest as it shows we can potentially significantly expand AIS population that can benefit from mechanical thrombectomy treatment.ReferencesGuenego A, Mine B, Bonnet T, et al. Thrombectomy for distal medium vessel occlusion with a new generation of stentretriever (tigertriever 13). Interv Neuroradiol 2021: 15910199211039926. 2021/09/14. DOI: 10.1177/15910199211039926. Do you have any conflict of interest to declare?: YesConflict of Interest StatementCons...
Source: Journal of NeuroInterventional Surgery - August 29, 2022 Category: Neurosurgery Authors: Guenego, A., Lubicz, B. Tags: 14th Congress of the European Society of Minimally Invasive Neurological Therapy 2022 Meeting Abstracts Source Type: research

P79 Multicenter assessment of the Tigertriever 13 for thrombectomy in primary medium vessels occlusions
ConclusionMechanical thrombectomy using the Tigertriever 13 appears to be safe and effective for MeVO among different centers and physicians, as a first-line device or as a recue-therapy after an other approach failure.ReferencesGuenego A, Mine B, Bonnet T, et al. Thrombectomy for distal medium vessel occlusion with a new generation of stentretriever (tigertriever 13). Interv Neuroradiol 2021: 15910199211039926. 2021/09/14. DOI: 10.1177/15910199211039926. Do you have any conflict of interest to declare?: YesConflict of Interest StatementConsultancy for Rapid Medical (travel grant only)
Source: Journal of NeuroInterventional Surgery - August 29, 2022 Category: Neurosurgery Authors: Guenego, A., Lubicz, B., Dmytriw, A., Regenhardt, R., Diestro, J., Jabbour, P., Siegler, J., Gonzalez, N., Levitt, M., Tancredi, I., Rouchaud, A., Fiehler, J., Kan, P., Berge, J., Nedelcu, S., Ota, T., Yeo, L., Sheth, S., Collin, T., Renieri, L., Mowla, A Tags: 14th Congress of the European Society of Minimally Invasive Neurological Therapy 2022 Meeting Abstracts Source Type: research

LB003 Multicenter assessment of the tigertriever 13 for thrombectomy in primary medium vessels occlusions
ConclusionMechanical thrombectomy using the Tigertriever13 appears to be safe and effective for MeVO among different centers and physicians, as a first-line device or as a recue-therapy after an other approach failure.Disclosures A. guenego: 6; C; Travel Grant to PAIRS in Dubai by Rapid Medical. B. lubicz: None. A. Dmytriw: None. R. Regenhardt: None. J. diestro: None. V. pereira: None. P. jabbour: None. J. siegler: None. N. gonzalez: None. M. Levitt: None. I. Tancredi: None. A. Rouchaud: None. J. Fiehler: None. T. Faizy: None. P. Kan: None. X. barreau: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2022 Category: Neurosurgery Authors: Guenego, A., Lubicz, B., Dmytriw, A., Regenhardt, R., Diestro, J., Pereira, V., Jabbour, P., Siegler, J., Gonzalez, N., Levitt, M., Tancredi, I., Rouchaud, A., Fiehler, J., Faizy, T., Kan, P., Barreau, X. Tags: SNIS 19th annual meeting late-breaking oral abstracts Source Type: research

Sex Differences in Sex Hormone Profiles and Prediction of Consciousness Recovery After Severe Traumatic Brain Injury
Conclusion: These findings indicate that TBI differentially affects the levels of sex-steroid hormones in men and women patients. Plasma levels of testosterone could be a good candidate blood marker to predict recovery from unconsciousness after sTBI for male patients. Introduction Traumatic brain injury (TBI) is a major cause of death and disability worldwide and is increasing in incidence (1). Patients with acute severe TBI (sTBI) often develop severe disorders of consciousness, i.e., coma, minimally conscious state or vegetative state. Although many patients may regain consciousness during the 1-month post-TBI p...
Source: Frontiers in Endocrinology - April 25, 2019 Category: Endocrinology Source Type: research

Associations of Anemia With Outcomes in Patients With Spontaneous Intracerebral Hemorrhage: A Meta-Analysis
Conclusions: Anemia on admission was associated with higher mortality and an increased risk of poor outcome in patients with ICH. However, the results were limited by the high heterogeneity of included studies. Prospective, multi-center or population-based, large sample cohort studies are needed in the future. Introduction Intracerebral hemorrhage (ICH) is the second most common cause of stroke and a highly lethal disease (1), which still lacks effective therapeutic interventions (2, 3). Although age, baseline ICH volume and neurological status on admission are well-known predictors of outcome of ICH (4), none of t...
Source: Frontiers in Neurology - April 24, 2019 Category: Neurology Source Type: research

A Novel Homozygous Non-sense Mutation in the Catalytic Domain of MTHFR Causes Severe 5,10-Methylenetetrahydrofolate Reductase Deficiency
Conclusion: We identified a novel non-sense mutation in MTHFR gene in a single Egyptian family with severe MTHFR deficiency. The present investigation is clinically important, as it adds to the growing list of MTHFR mutations, which might help in genetic counseling of families of affected children and proper genotype-phenotype correlation. Background Severe 5,10-Methylenetetrahydrofolate reductase (MTHFR; OMIM 236250) deficiency is a rare inborn error of metabolism and inherited in an autosomal recessive fashion. It is a very common disorder of folate metabolism and is clinically characterized with low plasma methion...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Frequency of Hemorrhage on Follow Up Imaging in Stroke Patients Treated With rt-PA Depending on Clinical Course
Conclusions: Frequency of hemorrhagic transformation in Routine follow-up brain imaging and consecutive changes in therapeutic management were different depending on clinical course measured by NHISS score. Introduction Brain imaging 24–36 h after systemic thrombolysis for acute ischemic stroke is recommended in American Stroke Association and European Stroke Organization guidelines (1, 2). Brain imaging is performed to detect secondary bleeding or hemorrhagic transformation in order to adapt medical stroke prevention if necessary. Guideline recommendations are based on the results of the first study on rt-PA...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Platelet Count Predicts Adverse Clinical Outcomes After Ischemic Stroke or TIA: Subgroup Analysis of CNSR II
Conclusion: In ischemic stroke or TIA patients with platelet count within normal range, platelet count may be a qualified predictor for long-term recurrent stroke, mortality, and poor functional outcome. Introduction Platelets exert a critical role in the pathogenesis of atherosclerotic complications of cardio-cerebrovascular disease, contributing to thrombus formation, and embolism (1, 2). Previous literature reported that platelets of various size and density are produced by megakaryocytes of different size and stages of maturation in different clinical conditions, suggesting various platelet patterns in differen...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and n...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

E-027 Matricidal cavernous aneurysms: a multicenter case series
Conclusion Matricidal aneurysms require careful consideration and planning. The restricted anatomy of the cavernous sinus can make successful execution of endovascular interventions difficult. Direct elastic compression of the parent artery does not respond to angioplasty and stenting the way that atherosclerotic stenosis does. Because of this, planning for possible parent vessel sacrifice is important. Abstract E-027 Table 1 Intended Treatments and Outcomes n Intended Treatment Failed Treatment (rate) All Patients 37 10 (27%) Flow Diversion 18 5 (28%) Parent Vessel Sacrifice 11 With Bypass 4 2 (50%) Without Bypass 7 0 ...
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Roberts, M., Nickele, C., Welch, B., Ban, V., Ringer, A., Kim, L., Levitt, M., Lanzino, G., Kan, P., Shallwani, H., Siddiqui, A., Elijovich, L., Arthur, A. Tags: Electronic Poster Abstracts Source Type: research

The Temporospatial Role of Microcirculatory Dysfunction in the Prediction of Ischemia or Infarction in Patients with Aneurysmal Subarachnoid Hemorrhages (P2.281)
Conclusions:This ongoing study suggests that patients with low mean minimal pulsatility index had poor functional outcomes relative to patients that had higher mean pulsatility index.Study Supported by: This work was supported in part by a grant from the McKnight Brain Research Foundation, Brain and Spinal Cord Injury Research Trust Fund, a grant from NIH National Institute of Neurological Disorders and Stroke, a Medical Student Anesthesia Research Fellowship awarded by the Foundation for Anesthesiology Education and Research, a grant from the Medical Student Research Program at the University of Florida, and the Departmen...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zamora, A., Gupta, A., Leclerc, J., Vasilopoulos, T., Dore, S. Tags: Subarachnoid Hemorrhage, Intracranial Aneurysm, and Other Cerebrovascular Malformations Source Type: research

No association of moon phase with stroke occurrence (P4.309)
Conclusions:In this decade-long nationwide study including a total of 46 million person years of follow-up, we found no association between moon phases and occurrence or in-hospital mortality rates of the three major stroke subtypes (IS, ICH and SAH).Study Supported by: VTR-funding of the hospital district of Southwestern Finland and grant funding of the Finnish Cardiac SocietyDisclosure: Dr. Ruuskanen has received personal compensation for activities with Merck, Biogen, and UCB Pharma. Dr. Siplia has received personal compensation from Orion Corporation, Abbvie, Lundbeck, Merck Serono, and Sanquin. Dr. Rautava has nothing...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ruuskanen, J., Sipila, J., Rautava, P., Kyto, V. Tags: Neuroepidemiology: Cerebrovascular Disease II Source Type: research

COLADAS: Caribbean Origin Latin Americans Disparities in Acute Stroke (S4.002)
Conclusions: Our study reveals intrinsic sex differences that may imply under treatment. Understanding the reasons underlying these "sex-gaps" is critical. Study Supported By: Award Number Grants 5S21MD000242 and 5S21MD000138, from the National Center for Minority Health and Health Disparities, National Institutes of Health (NCMHD-NIH).Disclosure: Dr. Teron Molina has nothing to disclose. Dr. Rodríguez Centeno has nothing to disclose. Dr. Santiago has nothing to disclose. Dr. López Valentín has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Teron Molina, I., Rodriguez Centeno, A., Santiago, F., Lopez Valentin, M. Tags: Health Disparities and Sex Differences in Stroke Source Type: research

COLADAS: Caribbean Origin Latin Americans Disparities in Acute Stroke (I5.006)
Conclusions: Our study reveals intrinsic sex differences that may imply under treatment. Understanding the reasons underlying these "sex-gaps" is critical. Study Supported By: Award Number Grants 5S21MD000242 and 5S21MD000138, from the National Center for Minority Health and Health Disparities, National Institutes of Health (NCMHD-NIH).Disclosure: Dr. Teron Molina has nothing to disclose. Dr. Rodríguez Centeno has nothing to disclose. Dr. Santiago has nothing to disclose. Dr. López Valentín has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Teron Molina, I., Rodriguez Centeno, A., Santiago, F., Lopez Valentin, M. Tags: Sex-related Factors in Neurological Disease Data Blitz Presentations Source Type: research