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Condition: Hemorrhagic Stroke
Procedure: Carotid Endarterectomy

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Total 185 results found since Jan 2013.

Expression of Vasohibin-1 in Human Carotid Atherosclerotic Plaque.
CONCLUSIONS: The VASH1 expression levels in atheroma reflect both enhanced neovascularization and the inflammatory burden. Therefore, the VASH1 level may be a novel biomarker for evaluating plaque instability in patients with carotid arteriosclerosis and predicting ischemic stroke. PMID: 25843115 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - April 9, 2015 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Contemporary carotid imaging: from degree of stenosis to plaque vulnerability.
Abstract Carotid artery stenosis is a well-established risk factor of ischemic stroke, contributing to up to 10%-20% of strokes or transient ischemic attacks. Many clinical trials over the last 20 years have used measurements of carotid artery stenosis as a means to risk stratify patients. However, with improvements in vascular imaging techniques such as CT angiography and MR angiography, ultrasonography, and PET/CT, it is now possible to risk stratify patients, not just on the degree of carotid artery stenosis but also on how vulnerable the plaque is to rupture, resulting in ischemic stroke. These imaging techniq...
Source: Journal of Neurosurgery - July 31, 2015 Category: Neurosurgery Authors: Brinjikji W, Huston J, Rabinstein AA, Kim GM, Lerman A, Lanzino G Tags: J Neurosurg Source Type: research

Dual Antiplatelet Therapy Prior to Expedited Carotid Surgery Reduces Recurrent Events Prior to Surgery without Significantly Increasing Peri-operative Bleeding Complications.
CONCLUSION: Early introduction of dual antiplatelet therapy was associated with a significant reduction in recurrent neurological events and spontaneous embolization prior to CEA, without incurring a significant increase in major peri-operative bleeding complications. PMID: 26283034 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - August 14, 2015 Category: Surgery Authors: Batchelder A, Hunter J, Cairns V, Sandford R, Munshi A, Naylor AR Tags: Eur J Vasc Endovasc Surg Source Type: research

Safety and efficiency of ultrasound-guided intermediate cervical plexus block for carotid surgery
Conclusions The present work reports our first 50 cases of intermediate CPB using ultrasound guidance. The results underline that this technique is easy to perform, safe and reliable, provided good surgical conditions with continuous intraoperative neurologic monitoring and stable haemodynamics are respected.
Source: Anaesthesia, Critical Care and Pain Medicine - December 6, 2015 Category: Anesthesiology Source Type: research

Carotid stenting and endarterectomy
Stroke, either ischemic or hemorrhagic, remains the second commonest cause of death worldwide in the last decade. Etiologies for ischemic stroke (IS) vary widely. Atherothrombotic occlusion is an essential cause to which carotid artery stenosis (CAS) is a major contributor. Administration of anti-platelet agent to patients with CAS has been shown to reduce incidence of long-term IS. In additional, in patients with symptomatic CAS, clinical trials have demonstrated that carotid endarterectomy (CEA) is superior to medical therapy for prevention of future CAS-related IS.
Source: International Journal of Cardiology - March 28, 2016 Category: Cardiology Authors: Hon-Kan Yip, Pei-Hsun Sung, Chiung-Jen Wu, Cheuk-Man Yu Tags: Review Source Type: research

Vitamin D and Vulnerable Carotid Plaque EXTRACRANIAL VASCULAR
CONCLUSIONS: Low vitamin D levels and plaque thickness predict carotid intraplaque hemorrhage and outperform lumen markers of vulnerable plaque. This research demonstrates a significant link between low vitamin D levels and carotid intraplaque hemorrhage.
Source: American Journal of Neuroradiology - November 14, 2016 Category: Radiology Authors: McNally, J. S., Burton, T. M., Aldred, B. W., Kim, S.- E., McLaughlin, M. S., Eisenmenger, L. B., Stoddard, G. J., Majersik, J. J., Miller, D. V., Treiman, G. S., Parker, D. L. Tags: EXTRACRANIAL VASCULAR Source Type: research

The Role of Neurosonology in the Diagnosis and Management of Patients with Carotid Artery Disease: A Review
ABSTRACT Carotid artery disease (CAD) is a common cause of ischemic stroke with high rates of recurrence. Carotid endarterectomy (CEA) or carotid artery stenting (CAS) are highly recommended for the secondary prevention of symptomatic CAD during the first 14 days following the index event of transient ischemic attack or minor stroke. CEA or CAS may also be offered in selected cases with severe asymptomatic stenosis. Herein, we review the utility of neurosonology in the diagnosis and pre‐/peri‐interventional assessment of CAD patients who undergo carotid revascularization procedures. Carotid ultrasound may provide inval...
Source: Journal of Neuroimaging - January 1, 2018 Category: Radiology Authors: Odysseas Kargiotis, Apostolos Safouris, Georgios Magoufis, Maria Georgala, Andromachi Roussopoulou, Eleftherios Stamboulis, Konstantinos G. Moulakakis, Andreas Lazaris, George Geroulakos, Spyros Vasdekis, Georgios Tsivgoulis Tags: Views and Reviews Source Type: research

Synchronous or Staged Carotid Endarterectomy and Coronary Artery Bypass Grafting? Propensity score matched study.
CONCLUSION: In this experience combined with the data given in literature, our findings suggest a possible superiority of the staged CABG/CEA approach. Large, randomized studies are required to verify our findings and to establish applicable guidelines. PMID: 30311885 [PubMed - in process]
Source: The Heart Surgery Forum - August 17, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Hempe S, Moza A, Goetzenich A, Tewarie L, Bleilevens C, Autschbach R, Schnoering H, Zayat R Tags: Heart Surg Forum Source Type: research

Invited commentary
Since current guidelines based on randomized clinical trials1-6 have established degree of carotid stenosis as the primary surrogate for stroke risk and indication for carotid endarterectomy or stenting, accurate assessment of the degree of carotid stenosis has been the traditional focus of carotid imaging.7 However, the degree of carotid stenosis is an inadequate assessment of stroke risk, and other key factors for determining carotid plaque vulnerability include intraplaque hemorrhage, plaque rupture, and luminal thrombus.
Source: Journal of Vascular Surgery - November 20, 2018 Category: Surgery Authors: Karen J. Ho Tags: From bench to bedside Source Type: research

Association between physical activity and sedentary behaviour on carotid atherosclerotic plaques: an epidemiological and histological study in 90 asymptomatic patients.
CONCLUSION: In this cross-sectional study of asymptomatic patients who underwent endarterectomy (i) higher reported PA, (ii) intensity of PA and (iii) lower reported SB were associated with lower prevalence of intraplaque haemorrhage. This could be a mechanism whereby PA protects against cerebrovascular disease (stroke) and death. PMID: 30842104 [PubMed - as supplied by publisher]
Source: British Journal of Sports Medicine - March 5, 2019 Category: Sports Medicine Authors: Mury P, Mura M, Della-Schiava N, Chanon S, Vieille-Marchiset A, Nicaise V, Chirico EN, Collet-Benzaquen D, Lermusiaux P, Connes P, Millon A, Pialoux V Tags: Br J Sports Med Source Type: research

Magnetic Resonance Imaging Identified Brain Ischaemia in Symptomatic Patients Undergoing Carotid Endarterectomy Is Related to Histologically Apparent Intraplaque Haemorrhage.
CONCLUSION: Symptomatic patients with ipsilateral carotid stenosis and silent brain ischaemia on pre-operative MR-DWI, more often showed pathological evidence of IPH compared with those without ischaemic lesions. This identifies carotid IPH as a marker for patients at risk of silent brain ischaemia and possibly for future stroke and other arterial disease complications. Such patients may be more likely to benefit from CEA than those without evidence of ipsilateral carotid IPH. PMID: 31631008 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - October 16, 2019 Category: Surgery Authors: Rots ML, Timmerman N, de Kleijn DPV, Pasterkamp G, Brown MM, Bonati LH, de Borst GJ Tags: Eur J Vasc Endovasc Surg Source Type: research

Start of Antiplatelet Therapy Increases the Prevalence of Intraplaque Hemorrhage in Patients With Advanced Carotid Artery Lesions: A Longitudinal MR Imaging Study
Introduction: Intraplaque hemorrhage (IPH) is an important feature of plaque vulnerability. Patients with a history of transient ischemic attack or stroke are treated with platelet aggregation inhibitors to prevent secondary myocardial infarction or ischemic stroke. Although antiplatelet medication is effective in reduction of clot formation, it also has adverse effects. It has therefore been hypothesized that platelet aggregation inhibitors could also initiate the onset or progression of IPH. A histopathological study on 154 carotid endarterectomy plaques found that preoperative antiplatelet therapy was associated with an...
Source: European Journal of Vascular and Endovascular Surgery - November 30, 2019 Category: Surgery Authors: Genevi ève Crombag, Madieke Liem, Eline Koornstra, Floris Schreuder, Dianne Nolen-van Dam, Carlo Lucci, Rob van der Geest, Mat Daemen, Anton van der Steen, Jeroen Hendrikse, Werner Mess, Aad van der Lugt, Joachim Wildberger, Robert van Oostenbrugge, Paul Source Type: research

Innovative Multiparametric Characterization of Carotid Plaque Vulnerability by Ultrasound
ConclusionUltrafast ultrasound imaging is an innovative, easily accessible technique that provides imaging modalities on top of the conventional B-mode. Ultrafast ultrasound biomarkers such as plaque stiffness heterogeneity, WSS and intraplaque micro-flows could help to define the vulnerability of the carotid plaque in order to stratify patients that could benefit most from endarterectomy or intensive medical therapy.
Source: Frontiers in Physiology - March 2, 2020 Category: Physiology Source Type: research

Protamine sulfate use during tibial bypass does not appear to increase thrombotic events or affect short-term graft patency.
CONCLUSIONS: Heparin reversal with protamine sulfate after tibial or peroneal bypass grafting is not associated with higher cardiovascular morbidity, bypass thrombosis, amputation, or mortality. Additionally, there was no statistically significant difference in post-operative bleeding or thrombosis complications for patients who did not receive protamine, although the findings are suggestive of a potential difference in a more adequately powered study. Our results suggest that protamine sulfate is safe for intraoperative use without increased risk of thrombotic complications or early tibial bypass graft failure. PMID:...
Source: Vascular - May 10, 2020 Category: Surgery Authors: Phair J, Futchko J, Trestman EB, Carnevale M, Friedmann P, Shukla H, Garg K, Koleilat I Tags: Vascular Source Type: research

Relevance of Infarct Size, Timing of Surgery, and Peri-operative Management for Non-ischaemic Cerebral Complications After Carotid Endarterectomy
CONCLUSION: Infarct size and unintended high peri-operative blood pressure may increase the risk of non-ischaemic complications at CEA independently of whether performed early or delayed.PMID:34872814 | DOI:10.1016/j.ejvs.2021.09.044
Source: PubMed: Eur J Vasc Endovasc ... - December 7, 2021 Category: Surgery Authors: Stephan Hause Robert Sch önefuß Anne Assmann Jens Neumann Frank Meyer Joerg Tautenhahn Stefanie Schreiber Hans-Jochen Heinze Zuhir Halloul Michael Goertler Source Type: research