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Symptomatic Carotid Atherosclerotic Disease: Correlations Between Plaque Composition and Ipsilateral Stroke Risk Clinical Sciences
Conclusions— Features of the vulnerable carotid plaque, including plaque thrombus, low fibrous content, macrophage infiltration, and microvessel density, correlate with predicted stroke risk. This study provides a basis for plaque imaging studies focused on stroke risk stratification.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Howard, D. P. J., van Lammeren, G. W., Rothwell, P. M., Redgrave, J. N., Moll, F. L., de Vries, J.-P. P. M., de Kleijn, D. P. V., den Ruijter, H. M., de Borst, G. J., Pasterkamp, G. Tags: Pathophysiology, Carotid Stenosis, Primary and Secondary Stroke Prevention, Carotid endarterectomy Clinical Sciences Source Type: research

Stroke prevention.
Abstract Patients who have had a stroke are at high risk for recurrent stroke, myocardial infarction, and vascular death. Prevention of these events should be initiated promptly after stroke, because many recurrent events occur early, and should be tailored to the precise cause of stroke, which may require specific treatment. Lifestyle advice including abstinence from smoking, regular exercise, Mediterranean-style diet, and reduction of salt intake and alcohol consumption are recommended for all patients with stroke. For most patients with ischemic stroke or TIA, control of risk factors, including lowering blood p...
Source: Presse Medicale - November 1, 2016 Category: Journals (General) Authors: Isabel C, Calvet D, Mas JL Tags: Presse Med Source Type: research

Short telomere length in blood leukocytes contributes to the presence of atherothrombotic stroke and hemorrhagic stroke and risk of post-stroke death
Conclusions—Shorter telomere length may serve as a potential marker for the presence of atherothrombotic and hemorrhagic stroke and for the risk of post-stroke death.
Source: Clinical Science - January 16, 2013 Category: Biomedical Science Authors: W Zhang, Y Chen, Y Wang, P Liu, M Zhang, C Zhang, F B Hu, R Hui Source Type: research

Clinical and Imaging Features Associated with an Increased Risk of Early and Late Stroke in Patients with Symptomatic Carotid Disease.
Abstract OBJECTIVE: The aim of this review was to identify clinical and/or imaging parameters that are associated with an increased (decreased) risk of early/late stroke in patients with symptomatic carotid disease. IN THE FIRST 14 DAYS: Natural history studies suggest that 8-15% of patients with 50-99% stenoses will suffer a stroke within 72 hours of their index symptom. Currently, there are insufficient validated data to identify highest-risk patients for emergency carotid endarterectomy (CEA), but an increased risk of stroke appears to be predicted by (i) an ABCD(2) score of 4-7; (ii) the presence of acute cere...
Source: PubMed: Eur J Vasc Endovasc ... - March 3, 2015 Category: Surgery Authors: Naylor AR, Sillesen H, Schroeder TV Tags: Eur J Vasc Endovasc Surg Source Type: research

Diastolic Blood Pressure is a Risk Factor for Peri-procedural Stroke Following Carotid Endarterectomy in Asymptomatic Patients.
CONCLUSION: In ACST-1, diastolic blood pressure was the only independent risk factor associated with peri-procedural stroke or death. While the underlying mechanisms of the association between lower diastolic blood pressure and peri-procedural risk remain unclear, good pre-operative control of blood pressure may improve procedural outcome of carotid surgery in asymptomatic patients. PMID: 28318997 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - March 15, 2017 Category: Surgery Authors: de Waard DD, de Borst GJ, Bulbulia R, Huibers A, Halliday A, Asymptomatic Carotid Surgery Trial-1 Collaborative Group Tags: Eur J Vasc Endovasc Surg Source Type: research

Identifying asymptomatic patients at high-risk for stroke.
CONCLUSIONS: Results from ongoing large, multi-centre randomised clinical trials comparing carotid endarterectomy and carotid artery stenting with good medical therapy may be consistent with earlier trials, showing a halving of the long-term risk of stroke following successful carotid revascularisation. However, they may well lack sufficient statistical power to identify higher-risk subgroups in whom the absolute gains of treatment are significantly higher. Large contemporary cohort studies are needed to provide further clarity regarding high-risk features associated with increased long-term stroke risk in asymptomatic pat...
Source: The Journal of Cardiovascular Surgery - February 20, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Gaba K, Bulbulia R Tags: J Cardiovasc Surg (Torino) Source Type: research

Carotid Endarterectomy After Intracranial Endovascular Thrombectomy for Acute Ischaemic Stroke in Patients with Carotid Artery Stenosis
CONCLUSION: These results indicate that CEA is safe to perform after previous successful EVT for acute ischaemic stroke. Results were comparable with those undergoing CEA only, despite the EVT+CEA patients having more severe stroke symptoms prior to surgery, and timing was similar.PMID:34887207 | DOI:10.1016/j.ejvs.2021.10.034
Source: PubMed: Eur J Vasc Endovasc ... - December 10, 2021 Category: Surgery Authors: Magnus Jonsson Ellinoora Aro Katarina Bj örses Staffan Holmin Petra Ij äs Nicolas Martinez-Majander Pirkka Vikatmaa Carl-Magnus Wahlgren Maarit Venermo Martin Bj örck Source Type: research

Closing the Loop: A 21-year Audit of Strategies for Preventing Stroke and Death Following Carotid Endarterectomy.
The objective of this review was to identify causes of stroke/death after carotid endarterectomy (CEA) and to develop transferable strategies for preventing stroke/death after CEA, via an overview of a 21-year series of themed research and audit projects. Three preventive strategies were identified: (i) intra-operative transcranial Doppler (TCD) ultrasound and completion angioscopy which virtually abolished intra-operative stroke, primarily through the removal of residual luminal thrombus prior to restoration of flow; (ii) dual antiplatelet therapy with a single 75-mg dose of clopidogrel the night before surgery in additio...
Source: PubMed: Eur J Vasc Endovasc ... - June 13, 2013 Category: Surgery Authors: Naylor AR, Sayers RD, McCarthy MJ, Bown MJ, Nasim A, Dennis MJ, London NJ, Bell PR Tags: Eur J Vasc Endovasc Surg Source Type: research

Closing the Loop: A 21-year Audit of Strategies for Preventing Stroke and Death Following Carotid Endarterectomy
The objective of this review was to identify causes of stroke/death after carotid endarterectomy (CEA) and to develop transferable strategies for preventing stroke/death after CEA, via an overview of a 21-year series of themed research and audit projects. Three preventive strategies were identified: (i) intra-operative transcranial Doppler (TCD) ultrasound and completion angioscopy which virtually abolished intra-operative stroke, primarily through the removal of residual luminal thrombus prior to restoration of flow; (ii) dual antiplatelet therapy with a single 75-mg dose of clopidogrel the night before surgery in additio...
Source: European Journal of Vascular and Endovascular Surgery - June 17, 2013 Category: Surgery Authors: A.R. Naylor, R.D. Sayers, M.J. McCarthy, M.J. Bown, A. Nasim, M.J. Dennis, N.J.M. London, P.R.F. Bell Tags: Carotid Disease Source Type: research

Mechanism of Procedural Stroke Following Carotid Endarterectomy or Carotid Artery Stenting Within the International Carotid Stenting Study (ICSS) Randomised Trial.
CONCLUSION: Although the mechanism of procedural stroke in both CAS and CEA is diverse, haemodynamic disturbance is an important mechanism. Careful attention to blood pressure control could lower the incidence of procedural stroke. PMID: 26160210 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - July 6, 2015 Category: Surgery Authors: Huibers A, Calvet D, Kennedy F, Czuriga-Kovács KR, Featherstone RL, Moll FL, Brown MM, Richards T, de Borst GJ Tags: Eur J Vasc Endovasc Surg Source Type: research

Extracranial carotid plaque hemorrhage predicts ipsilateral stroke recurrence in patients with carotid atherosclerosis - a study based on high-resolution vessel wall imaging MRI
CONCLUSIONS: Carotid intraplaque hemorrhage is strongly associated with recurrent ischemic events and could predict recurrent ipsilateral stroke.PMID:35764942 | DOI:10.1186/s12883-022-02758-3
Source: Atherosclerosis - June 28, 2022 Category: Cardiology Authors: Fengli Che Donghua Mi Anxin Wang Yi Ju Binbin Sui Xiaokun Geng Xihai Zhao Xingquan Zhao Source Type: research

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