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Integrity of The Hand Fibers of The Corticospinal Tract Shown by Diffusion Tensor Imaging Predicts Hand Function Recovery After Hemorrhagic Stroke
Hemorrhagic stroke often results in motor dysfunction. One of the treatment goals for stroke is the recovery of motor function, especially the hand function, which is critical for daily life.1 It has been suggested that damage to neural pathways is a critical factor for the prognosis of stroke.2,3 The corticospinal tract (CST) is an important neural pathway through which the cerebral cortex controls limb movement. In patients with hemorrhagic stroke, lesions to the CST are the primary reason of motor dysfunction.
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2020 Category: Neurology Authors: Zhigang Gong, Rongjun Zhang, Wenbin Jiang, Zhihui Fu Source Type: research

Triage of Patients with Intracerebral Hemorrhage to Comprehensive Versus Primary Stroke Centers
The management of patients admitted with intracerebral hemorrhage (ICH) mostly occurs in an ICU. While guidelines recommend initial treatment of these patients in a neurocritical care or stroke unit, there is limited data on which patients would benefit most from transfer to a comprehensive stroke center where on-site neurosurgical coverage is available 24/7. As neurocritical units become more common in primary stroke centers, it is important to determine which patients are most likely to require neurosurgical intervention and transfer to comprehensive stroke centers.
Source: Journal of Stroke and Cerebrovascular Diseases - March 14, 2021 Category: Neurology Authors: Nikhil M. Patel, Quincy K. Tran, Paul Capobianco, Timothy Traynor, Michael J. Armahizer, Melissa Motta, Gunjan Y. Parikh, Neeraj Badjatia, Wan-Tsu Chang, Nicholas A. Morris Source Type: research

Factors Linked to Chronic Kidney Disease Among Stroke Survivors in Ghana
Stroke and chronic kidney disease (CKD) are major health problems across several regions of the globe. The Global Burden of Disease (GBD) collaborators have estimated the global lifetime risk of stroke for adults 25 years or older at 24.9% in 2016.1 An estimated 11-13% of the population worldwide has kidney disease.2 Both stroke and renal disease share traditional vascular risk factors such as hypertension, diabetes, obesity, dyslipidemia and obesity.3 Among ischemic stroke patients, 20% to 35% have CKD4,5 while 20 to 46% of patients with acute intracerebral hemorrhage have CKD.
Source: Journal of Stroke and Cerebrovascular Diseases - March 8, 2021 Category: Neurology Authors: Fred Stephen Sarfo, Martin Agyei, Isaac Ogyefo, Priscilla Abrafi Opare-Addo, Bruce Ovbiagele Source Type: research

Do all gliflozins reduce stroke in patients with type 2 diabetes mellitus and impaired renal function?
We have read with great interest a study of meta-analysis1 recently published in Journal of Stroke and Cerebrovascular Diseases. In that study1 Barkas and colleagues drew their main conclusion that sodium-glucose transporter 2 (SGLT2) inhibitors reduce the risk of total stroke in patients with type 2 diabetes mellitus (T2DM) and impaired renal function (IRF), which was based on the result of meta-analysis on the outcome of total stroke (including ischemic and hemorrhagic stroke) in the subgroup of patients with T2DM and IRF (Fig.
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2021 Category: Neurology Authors: Li-Min Zhao, Liang-Liang Ding, Ze-Lin Zhan, Mei Qiu Tags: Letter to the Editor Source Type: research

Moyamoya Disease and Syndrome: A National Inpatient Study of Ischemic Stroke Predictors
Ischemic stroke and hemorrhagic stroke are the most common sequelae of the Moyamoya variants [Moyamoya disease (MMD) and syndrome (MMS)]. We sought to determine the rates of stroke subtypes and the predictive factors of arterial ischemic stroke (AIS) utilizing a large data sample of MMD and MMS patients in the US.
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2021 Category: Neurology Authors: Santiago R. Unda, Aldana M. Antoniazzi, Raphael Miller, Daniel Klyde, Kainaat Javed, Rose Fluss, Ryan Holland, Rafael de la Garza Ramos, Neil Haranhalli, David J. Altschul Source Type: research

Letter to the editor regarding ‘prediction of intracerebral hemorrhage after endovascular treatment of acute ischemic stroke: Combining quantitative parameters on dual-energy CT with clinical related factors’
This study recruited 72 acute ischemic stroke patients treated with endovascular treatment, forty of whom developed intracerebral hemorrhage (ICH). According to the results of receiver operating characteristic curve and multivariate logistic regression analysis, the authors have found that hyperdensity areas (HDA) volumes, alberta stroke program early CT score (ASPECTS), National Institutes of Health Stroke Scale (NIHSS) score and some other parameters may be related to and be able to predict ICH after endovascular treatment.
Source: Journal of Stroke and Cerebrovascular Diseases - September 22, 2021 Category: Neurology Authors: Meidi Peng, Yachi Gong, Yupei Chen, Wenxuan Zhao Tags: Letter to the Editor Source Type: research

Stroke Associated with COVID-19 Vaccines
Development of safe and effective vaccines against coronavirus disease 2019 (COVID-19) remains the cornerstone of controlling this pandemic. However, there are increasing reports of various types of stroke including ischemic stroke, and hemorrhagic stroke, as well ascerebral venous sinus thrombosis (CVST) after COVID-19 vaccination. This paper aims to review reports of stroke associated with COVID-19 vaccines and provide a coherent clinical picture of this condition. Most of such patients are women under 60 years of age and who had received ChAdOx1 nCoV-19 vaccine.
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2022 Category: Neurology Authors: Maryam Kakovan, Samaneh Ghorbani Shirkouhi, Mojtaba Zarei, Sasan Andalib Tags: Review Article Source Type: research

Relationship between Alcohol Intake and Stroke Severity in Japanese Patients: a Sex- and Subtype-Stratified Analysis
Stroke is a severe disease that causes disability in many patients, warranting the urgent development of treatment options.1-4 Previous studies have reported that the risk of hemorrhagic stroke (HS) linearly increases with increasing alcohol intake.5-12 Furthermore, moderate alcohol intake has been shown to lower the risk of ischemic stroke (IS), and a J-curve association has been observed between alcohol consumption and morbidity rate of IS.7-14 These reports were similar in that they considered alcohol intake as a risk factor for stroke development.
Source: Journal of Stroke and Cerebrovascular Diseases - April 26, 2022 Category: Neurology Authors: Hiroyuki Shiotsuki, Yasuaki Saijo, Yoichi Ogushi, Shotai Kobayashi Source Type: research

Machine learning based reanalysis of clinical scores for distinguishing between ischemic and hemorrhagic stroke in low resource setting
Identifying ischemic or hemorrhagic strokes clinically may help in situations where neuroimaging is unavailable to provide primary-care prior to referring to stroke-ready facility. Stroke classification-based solely on clinical scores faces two unresolved issues. One pertains to overestimation of score performance, while other is biased performance due to class-imbalance inherent in stroke datasets. After correcting the issues using Machine Learning theory, we quantitatively compared existing scores to study the capabilities of clinical attributes for stroke classification.
Source: Journal of Stroke and Cerebrovascular Diseases - August 1, 2022 Category: Neurology Authors: Aman Bhardwaj, MV Padma Srivastava, Pulikottil Vinny Wilson, Amit Mehndiratta, Venugopalan Y Vishnu, Rahul Garg Source Type: research

Outcomes in patients with ischaemic stroke undergoing endovascular thrombectomy: Impact of atrial fibrillation
Endovascular thrombectomy (EVT) is associated with good clinical outcomes in ischaemic stroke, but the risk of intracerebral haemorrhage (ICH) and mortality remains common following ischaemic stroke. The effect of concomitant atrial fibrillation (AF) on clinical outcomes following acute ischaemic stroke in patients receiving EVT remains unclear. The aim is to investigate associations between AF and intracerebral haemorrhage and all-cause mortality at 90 days in patients with ischaemic stroke undergoing EVT.
Source: Journal of Stroke and Cerebrovascular Diseases - December 3, 2022 Category: Neurology Authors: Muath Alobaida, Stephanie L. Harrison, Deirdre A. Lane, Paula Underhill, Andrew Hill, Gregory Y.H. Lip Source Type: research

Original Article: Increased Stroke Severity and Mortality in Patients with SARS-CoV-2 Infection: An Analysis from the N3C Database
Studies from early in the COVID-19 pandemic showed that patients with ischemic stroke and concurrent SARS-CoV-2 infection had increased stroke severity. We aimed to test the hypothesis that this association persisted throughout the first year of the pandemic and that a similar increase in stroke severity was present in patients with hemorrhagic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 10, 2023 Category: Neurology Authors: Jackson A Narrett, Indika Mallawaarachchi, Chad M. Aldridge, Ethan D Assefa, Arti Patel, Johanna J Loomba, Sarah Ratcliffe, Ofer Sadan, Teshamae Monteith, Bradford B Worrall, Donald E Brown, Karen C Johnston, Andrew M Southerland, N3C consortium Source Type: research

Increased stroke severity and mortality in patients with SARS-CoV-2 infection: An analysis from the N3C database
Studies from early in the COVID-19 pandemic showed that patients with ischemic stroke and concurrent SARS-CoV-2 infection had increased stroke severity. We aimed to test the hypothesis that this association persisted throughout the first year of the pandemic and that a similar increase in stroke severity was present in patients with hemorrhagic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 10, 2023 Category: Neurology Authors: Jackson A Narrett, Indika Mallawaarachchi, Chad M. Aldridge, Ethan D Assefa, Arti Patel, Johanna J Loomba, Sarah Ratcliffe, Ofer Sadan, Teshamae Monteith, Bradford B Worrall, Donald E Brown, Karen C Johnston, Andrew M Southerland, N3C consortium Source Type: research

Hospital Discharge and Readmissions Before and During the COVID-19 Pandemic for California Acute Stroke Inpatients
Stroke is a leading cause of death and disability in the United States, with approximately 795,000 new strokes occurring annually, including acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH).1 The Coronavirus Disease 2019 (COVID-19) pandemic has impacted all levels of care for stroke patients, such as delays in initial presentation, reduction in acute therapies, limitations of in-patient resources, delays or lack of initiation of secondary stroke prevention therapy, and limitations in rehabilitation services after hospital discharge.
Source: Journal of Stroke and Cerebrovascular Diseases - June 23, 2023 Category: Neurology Authors: George P. Albert, Daryl C. McHugh, Debra E. Roberts, Adam G. Kelly, Remi Okwechime, Robert G. Holloway, Benjamin P. George Source Type: research

Diversity of Stroke Presentation in CADASIL: Study from Patients Harboring the Predominant NOTCH3 Mutation R544C
This study investigated the clinical stroke presentation and cranial magnetic resonance imaging (MRI) findings in a group of patients with CADASIL. We reviewed the clinical stroke presentation and brain MRI findings in 73 consecutive Korean patients aged>18 years diagnosed with CADASIL between May 2004 and April 2009. Brain MRI images were also scored for lacunar infarction and cerebral microbleeds. Intracranial atherosclerosis (ICAS) was assessed by magnetic resonance angiography. Disability was measured with the modified Rankin scale (mRS) and classified as good (mRS score 0-2) or poor (mRS score 3-5). In this study, 65 ...
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2011 Category: Neurology Authors: Jay Chol Choi, Sook-Keun Song, Jung Seok Lee, Sa-Yoon Kang, Ji-Hoon Kang Tags: Original Articles Source Type: research

Racial and Ethnic Disparities in the Use of Intravenous Recombinant Tissue Plasminogen Activator and Outcomes for Acute Ischemic Stroke
This study investigated possible racial and ethnic disparities in the administration and outcome of recombinant tissue plasminogen activator (rtPA) therapy for acute ischemic stroke in whites, blacks, Hispanics, and Asian/Pacific Islanders. Using the National Inpatient Sample for 2001-2008, we selected patients with a primary diagnosis of acute ischemic stroke who received treatment with rtPA. Patient data were stratified by race (white, black, Hispanic, and Asian/Pacific Islander). We analyzed the association of patient race on rtPA utilization rate, in-hospital morbidity (ie, discharge to long-term facility), intracrania...
Source: Journal of Stroke and Cerebrovascular Diseases - December 12, 2011 Category: Neurology Authors: Deena M. Nasr, Waleed Brinjikji, Harry J. Cloft, Alejandro A. Rabinstein Tags: Original Articles Source Type: research

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