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Condition: Hemorrhagic Stroke
Nutrition: Calcium
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Total 115 results found since Jan 2013.
Molecular pathophysiological mechanisms of ischemia/reperfusion injuries after recanalization therapy for acute ischemic stroke
J Integr Neurosci. 2021 Sep 30;20(3):727-744. doi: 10.31083/j.jin2003078.ABSTRACTWith the larger variety of methods employed, recanalization therapy is increasingly used to treat acute ischemic stroke resulting in about one-third of patients undergoing early neurological deterioration, in which ischemia/reperfusion injuries are the main cause, leading to increases in the infarcted area, the no-reflow phenomenon, or hemorrhagic transformation. Efficient prevention or treatment of these injuries depends on extensive knowledge of the involved mechanisms. These pathways have dual, damaging, and neuroprotective effects, dependi...
Source: Journal of Integrative Neuroscience - October 14, 2021 Category: Neuroscience Authors: Anamaria Jurcau Ioana Adriana Ardelean Source Type: research
Biomarkers in the Prediction of Hemorrhagic Transformation in Acute Stroke: A Systematic Review and Meta-Analysis
Conclusion: Of the 5 biomarkers, there was enough evidence that MMP-9 has higher diagnostic accuracy for predicting the risk of HT before thrombolysis. MMP-9, ferritin, and NLR also predicted poor short-term outcomes.Cerebrovasc Dis
Source: Cerebrovascular Diseases - September 22, 2021 Category: Neurology Source Type: research
Y-2 reduces oxidative stress and inflammation and improves neurological function of collagenase-induced intracerebral hemorrhage rats
In conclusion, Y-2 sublingual tablets might be a promising therapeutic agent for the treatment of ICH.PMID:34536364 | DOI:10.1016/j.ejphar.2021.174507
Source: European Journal of Pharmacology - September 18, 2021 Category: Drugs & Pharmacology Authors: Yao Hua Limei Zhou Weidong Yang Wenji An Xiaolin Kou Jian Ren Hailang Su Rong Chen Zhengping Zhang Jianjun Zou Zhihong Zhao Source Type: research
The Current Role of Clevidipine in the Management of Hypertension
AbstractAcute hypertension, which may damage blood vessels, causes irreversible organ damage to the vasculature, central nervous system, kidney, and heart. Clevidipine, the first third-generation calcium channel antagonist approved by the Food and Drug Administration (FDA) in the past 20 years, is an ultra-short-acting calcium channel blocker that inhibits L-type calcium channels with high clearance and low distribution, can be rapidly metabolized into the corresponding inactive acid, and is rapidly hydrolyzed into inactive metabolites by esterase in arterial blood. Clevidipine is the same as nicardipine in that the main p...
Source: American Journal of Cardiovascular Drugs - September 2, 2021 Category: Cardiology Source Type: research
Preconditioning Exercise in Rats Attenuates Early Brain Injury Resulting from Subarachnoid Hemorrhage by Reducing Oxidative Stress, Inflammation, and Neuronal Apoptosis
AbstractSubarachnoid hemorrhage (SAH) is a catastrophic form of stroke responsible for significant morbidity and mortality. Oxidative stress, inflammation, and neuronal apoptosis are important in the pathogenesis of early brain injury (EBI) following SAH. Preconditioning exercise confers neuroprotective effects, mitigating EBI; however, the basis for such protection is unknown. We investigated the effects of preconditioning exercise on brain damage and sensorimotor function after SAH. Male rats were assigned to either a sham-operated (Sham) group, exercise (Ex) group, or no-exercise (No-Ex) group. After a 3-week exercise p...
Source: Molecular Neurobiology - August 9, 2021 Category: Neurology Source Type: research
Advances in the Development of Biomarkers for Poststroke Epilepsy
Biomed Res Int. 2021 Apr 17;2021:5567046. doi: 10.1155/2021/5567046. eCollection 2021.ABSTRACTStroke is the main cause of acquired epilepsy in elderly people. Poststroke epilepsy (PSE) not only affects functional recovery after stroke but also brings considerable social consequences. While some factors such as cortical involvement, hemorrhagic transformation, and stroke severity are associated with increased seizure risk, so far that remains controversial. In recent years, there are an increasing number of studies on potential biomarkers of PSE as tools for diagnosing and predicting epileptic seizures. Biomarkers such as i...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Mengke Liang Liren Zhang Zhi Geng Source Type: research
Synergistic Network Pharmacology for Traditional Chinese Medicine Liangxue Tongyu Formula in Acute Intracerebral Hemorrhagic Stroke
CONCLUSION: The LXTYF attenuates AICH partially by antioxidation, anti-inflammatory, and antiapoptosis and lowers blood pressure roles through regulating the targets involved MAPK, calcium, apoptosis, and TNF signaling pathway, which provide notable clues for further experimental validation.PMID:33727915 | PMC:PMC7936909 | DOI:10.1155/2021/8874296
Source: Neural Plasticity - March 17, 2021 Category: Neurology Authors: Yang Chen Ju Dong Dongqing Yang Qin Qian Pengcheng Wang Xiaojuan Yang Wei Li Guochun Li Xu Shen Fushun Wang Source Type: research
Calcium/Calmodulin –Dependent Protein Kinase II in Cerebrovascular Diseases
AbstractCerebrovascular disease is the most common life-threatening and debilitating condition that often leads to stroke. The multifunctional calcium/calmodulin-dependent protein kinase II (CaMKII) is a key Ca2+ sensor and an important signaling protein in a variety of biological systems within the brain, heart, and vasculature. In the brain, past stroke-related studies have been mainly focused on the role of CaMKII in ischemic stroke in neurons and established CaMKII as a major mediator of neuronal cell death induced by glutamate excitotoxicity and oxidative stress following ischemic stroke. However, with growing underst...
Source: Translational Stroke Research - March 13, 2021 Category: Neurology Source Type: research
Can brain natriuretic peptide, S100b, and interleukin-6 prognosticate the neurological consequences in Egyptian patients presented with supratentorial intracerebral hemorrhage?
Conclusion: Pro-BNP, IL-6, and S100b are greatly associated with the presence of IVH that, in turn, correlated well with poor clinical outcome measures.
PMID: 33408945 [PubMed]
Source: Surgical Neurology International - January 9, 2021 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Hypertension Among Hemorrhagic Stroke Patients in Northeast China: A Population-Based Study 2017-2019.
CONCLUSIONS The high prevalence of uncontrolled hypertension and high rates of blood pressure at stages 2 and 3 in patients with prior hemorrhagic stroke indicated a considerable stroke burden in northeast China. Therefore, effective and long-time management of hypertension in stroke survivors should be a priority.
PMID: 33376232 [PubMed - in process]
Source: Medical Science Monitor - January 1, 2021 Category: Research Tags: Med Sci Monit Source Type: research
