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Interpretable machine learning for predicting 28-day all-cause in-hospital mortality for hypertensive ischemic or hemorrhagic stroke patients in the ICU: a multi-center retrospective cohort study with internal and external cross-validation
ConclusionsThe XGBoost model accurately predicted 28-day all-cause in-hospital mortality among hypertensive ischemic or hemorrhagic stroke patients admitted to the ICU. The SHAP method can provide explicit explanations of personalized risk prediction, which can aid physicians in understanding the model.
Source: Frontiers in Neurology - August 8, 2023 Category: Neurology Source Type: research

Resolution of Cerebral Inflammation Following Subarachnoid Hemorrhage
ConclusionsBy the herein presented molecular and histological data we provide an important indication for an incomplete resolution of inflammation within the brain parenchyma after SAH. Inflammatory resolution and the return to tissue homeostasis represent an important contribution to the disease ’s pathology influencing the impact on brain damage and outcome after SAH. Therefore, we consider a novel complementary or even superior therapeutic approach that should be carefully rethought in the management of cerebral inflammation after SAH. An acceleration of the resolution phase at the cell ular and molecular levels could...
Source: Neurocritical Care - June 22, 2023 Category: Neurology Source Type: research

Alpha-Asarone Ameliorates Neurological Dysfunction of Subarachnoid Hemorrhagic Rats in Both Acute and Recovery Phases via Regulating the CaMKII-Dependent Pathways
AbstractEarly brain injury (EBI) is the leading cause of poor prognosis for patients suffering from subarachnoid hemorrhage (SAH), particularly learning and memory deficits in the repair phase. A recent report has involved calcium/calmodulin-dependent protein kinase II (CaMKII) in the pathophysiological process underlying SAH-induced EBI. Alpha-asarone (ASA), a major compound isolated from the Chinese medicinal herbAcorus tatarinowii Schott, was proven to reduce secondary brain injury by decreasing CaMKII over-phosphorylation in rats ’ model of intracerebral hemorrhage in our previous report. However, the effect of ASA o...
Source: Translational Stroke Research - February 13, 2023 Category: Neurology Source Type: research

Downregulation of mitochondrial calcium uptake family 3 attenuates secondary brain injury after intracerebral hemorrhage in rats
In conclusion, MICU3 is expected to be a molecular marker and a potential therapeutic target for ICH.PMID:36549422 | DOI:10.1016/j.expneurol.2022.114302
Source: Experimental Neurology - December 22, 2022 Category: Neurology Authors: Jiahe Wang Siyuan Yang Haiying Li Haitao Shen Xiaocheng Lu Xiang Li Gang Chen Source Type: research

Cannabidiol's Multifactorial Mechanisms Has Therapeutic Potential for Aneurysmal Subarachnoid Hemorrhage: a Review
Transl Stroke Res. 2022 Sep 15. doi: 10.1007/s12975-022-01080-x. Online ahead of print.ABSTRACTSubarachnoid hemorrhage (SAH) is a major health burden that accounts for approximately 5% of all strokes. The most common cause of a non-traumatic SAH is the rupture of a cerebral aneurysm. The most common symptom associated with SAH is a headache, often described as "the worst headache of my life." Delayed cerebral ischemia (DCI) is a major factor associated with patient mortality following SAH and is often associated with SAH-induced cerebral vasospasm (CV). Cannabidiol (CBD) is emerging as a potential drug for many therapeutic...
Source: Cell Research - September 15, 2022 Category: Cytology Authors: Nicholas Henry Justin F Fraser Joseph Chappell Tamra Langley Jill M Roberts Source Type: research

Cannabidiol ’s Multifactorial Mechanisms Has Therapeutic Potential for Aneurysmal Subarachnoid Hemorrhage: a Review
AbstractSubarachnoid hemorrhage (SAH) is a major health burden that accounts for approximately 5% of all strokes. The most common cause of a non-traumatic SAH is the rupture of a cerebral aneurysm. The most common symptom associated with SAH is a headache, often described as “the worst headache of my life.” Delayed cerebral ischemia (DCI) is a major factor associated with patient mortality following SAH and is often associated with SAH-induced cerebral vasospasm (CV). Cannabidiol (CBD) is emerging as a potential drug for many therapeutic purposes, including epilepsy , anxiety, and pain relief. We aim to review the pote...
Source: Translational Stroke Research - September 15, 2022 Category: Neurology Source Type: research

Related Factors of Cerebral Hemorrhage after Cerebral Infarction and the Effect of Atorvastatin Combined with Intensive Nursing Care
CONCLUSION: Patients with hypertension, large infarction lesions, high NIHSS score at admission, atrial fibrillation, and small artery occlusion cerebral infarction can increase the risk of bleeding transformation in patients with cerebral infarction. For patients with bleeding transformation, atorvastatin calcium tablets combined with early intensive nursing intervention has a certain value for improving the prognosis of patients.PMID:35959354 | PMC:PMC9357761 | DOI:10.1155/2022/9546006
Source: Computational and Mathematical Methods in Medicine - August 12, 2022 Category: Statistics Authors: Qian Yang Yuedong Yang Xiaoting Li Source Type: research

Usability of serum annexin A7 as a biochemical marker of poor outcome and early neurological deterioration after acute primary intracerebral hemorrhage: A prospective cohort study
ConclusionSerum ANXA7 may represent a useful blood-derived biomarker for assessing the severity, END, and prognosis of ICH.
Source: Frontiers in Neurology - August 8, 2022 Category: Neurology Source Type: research

Association between serum calcium levels and first stroke: A community-based nested case-control study
ConclusionsOur results suggested a U-shaped association between serum calcium and first stroke; both low and high serum calcium levels were associated with an increased risk of the first stroke in the Chinese population.
Source: Frontiers in Neurology - August 5, 2022 Category: Neurology Source Type: research

Calcium and magnesium in drinking water and risk of myocardial infarction and stroke - a population-based cohort study
CONCLUSION: Drinking water with a high concentration of calcium and magnesium, particularly magnesium, may lower the risk of stroke in postmenopausal women.PMID:35816459 | DOI:10.1093/ajcn/nqac186
Source: Am J Clin Nutr - July 11, 2022 Category: Nutrition Authors: Emilie Helte Melle S äve-Söderbergh Susanna C Larsson Agneta Åkesson Source Type: research

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