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Specialty: Neuroscience
Condition: Epilepsy

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Total 161 results found since Jan 2013.

Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Neurochem Res. 2023 Jul 26. doi: 10.1007/s11064-023-03983-z. Online ahead of print.ABSTRACTHot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae), are one of the most used vegetables and spices worldwide. Capsaicin (8-methyl N-vanillyl-6-noneamide) is the main pungent principle of hot green and red peppers. By acting on the capsaicin receptor or transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1), capsaicin selectively stimulates and in high doses defunctionalizes capsaicin-sensitive chemonociceptors with C and Aδ afferent fibers. This channe...
Source: Neurochemical Research - July 26, 2023 Category: Neuroscience Authors: Omar M E Abdel-Salam Gyula M ózsik Source Type: research

BCI-activated electrical stimulation in children with perinatal stroke and hemiparesis: A pilot study
ConclusionBrain computer interface-FES was well -tolerated and feasible in children with hemiparesis. This paves the way for clinical trials to optimize approaches and test efficacy.
Source: Frontiers in Human Neuroscience - March 17, 2023 Category: Neuroscience Source Type: research

Neuroprotective Roles of Apelin-13 in Neurological Diseases
This study summarizes the pathophysiological roles of apelin-13 in the development and progression of neurological related diseases.PMID:36745269 | DOI:10.1007/s11064-023-03869-0
Source: Neurochemical Research - February 6, 2023 Category: Neuroscience Authors: Yang Zhang Weiwei Jiang Wenjie Sun Weiming Guo Beibei Xia Xiangru Shen Mingyuan Fu Teng Wan Mei Yuan Source Type: research

Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex, and Parkinson's disease ‐related changes
Transfer RNA fragments (tRFs) are important regulatory small RNAs with diverse functions. We studied age, sex, and Parkinson's disease (PD) effects on the distributions of tRFs in the cerebrospinal fluid (CSF) and blood, in NIH and PPMI datasets. We discovered that CSF tRFs were more variable in length and cleavage subtypes, negatively correlated with age and showed more pronounced differences between males and females than blood tRFs. Both CSF and blood tRFs differentiated PD patients from controls, based on distinct subsets of tRFs, both highly enriched with mitochondrial Cholino-tRFs. Our findings point at tRFs as a pro...
Source: Journal of Neurochemistry - November 23, 2022 Category: Neuroscience Authors: Iddo Paldor, Nimrod Madrer, Shani Vaknine Treidel, Dana Shulman, David S. Greenberg, Hermona Soreq Tags: ORIGINAL ARTICLE Source Type: research

Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex and Parkinson's disease ‐related changes
AbstractTransfer RNA fragments (tRFs) have recently been shown to be an important family of small regulatory RNAs with diverse functions. Recent reports have revealed modified tRF blood levels in a number of nervous system conditions including epilepsy, ischemic stroke and neurodegenerative diseases, but little is known about tRF levels in the cerebrospinal fluid (CSF). To address this issue, we studied age, sex and Parkinson's disease (PD) effects on the distributions of tRFs in the CSF and blood data of healthy controls and PD patients from the NIH and the Parkinson's Progression Markers Initiative (PPMI) small RNA-seq d...
Source: Journal of Neurochemistry - November 11, 2022 Category: Neuroscience Authors: Iddo Paldor, Nimrod Madrer, Shani Vaknine Treidel, Dana Shulman, David S. Greenberg, Hermona Soreq Tags: ORIGINAL ARTICLE Source Type: research

Isolated ictal apnea in neonatal age: Clinical features and treatment options. A systematic review
CONCLUSIONS: Not homogeneous data and paucity of isolated IA currently reported in literature limits agreement about definition, management and treatment of entity, however an ever-growing attention is needed, and EEG/aEEG, despite their possible controversies in the diagnosis, should be performed to investigate unexplained forms of apnea.PMID:36174277 | DOI:10.1016/j.autneu.2022.103034
Source: Autonomic Neuroscience - September 29, 2022 Category: Neuroscience Authors: Raffaele Falsaperla Maria Chiara Consentino Giovanna Vitaliti Silvia Marino Martino Ruggieri Source Type: research

Anti-NMDAR encephalitis presenting as stroke-like episodes in children: A case series from a tertiary care referral centre from Southern India
Conclusion: Anti-NMDA receptor encephalitis which is a potentially treatable disease should be considered in the differential diagnosis when a child presents with hemiparesis/stroke-like episode.
Source: Journal of Pediatric Neurosciences - June 3, 2022 Category: Neuroscience Authors: Vykuntaraju K Gowda Sukanya Vignesh Balamurugan Natarajan Sanjay K Shivappa Source Type: research

Epilepsia Partialis Continua a Clinical Feature of a Missense Variant in the ADCK3 Gene and Poor Response to Therapy
ConclusionsA novel homozygous missense variant [NM_020247.5: c.814G>T; (p.Gly272Cys)] was identified within theADCK3 gene, which is the first mutation in this gene in the Iranian population. Bioinformatics analysis showed this variant is damaging. Based on our patient, clinicians should consider genetic testing earlier to instant diagnosis and satisfactory treatment based on exact etiology to prevent further neurologic sequelae.
Source: Journal of Molecular Neuroscience - March 11, 2022 Category: Neuroscience Source Type: research

Ying Yang 1 engagement in brain pathology
AbstractHerein, we discuss data concerning the involvement of transcription factor Yin Yang 1 (YY1) in the development of brain diseases, highlighting mechanisms of its pathological actions. YY1 plays an important role in the developmental and adult pathology of the nervous system. YY1 is essential for neurulation as well as maintenance and differentiation of neuronal progenitor cells and oligodendrocytes regulating both neural and glial tissues of the brain. Lack of a YY1 gene causes many developmental abnormalities and anatomical malformations of the central nervous system (CNS). Once dysregulated, YY1 exerts multiple ne...
Source: Journal of Neurochemistry - February 24, 2022 Category: Neuroscience Authors: Sylwia Pabian ‐Jewuła, Aneta Bragiel‐Pieczonka, Marcin Rylski Tags: SYSTEMATIC REVIEW Source Type: research

Understanding Language Reorganization With Neuroimaging: How Language Adapts to Different Focal Lesions and Insights Into Clinical Applications
When the language-dominant hemisphere is damaged by a focal lesion, the brain may reorganize the language network through functional and structural changes known as adaptive plasticity. Adaptive plasticity is documented for triggers including ischemic, tumoral, and epileptic focal lesions, with effects in clinical practice. Many questions remain regarding language plasticity. Different lesions may induce different patterns of reorganization depending on pathologic features, location in the brain, and timing of onset. Neuroimaging provides insights into language plasticity due to its non-invasiveness, ability to image the w...
Source: Frontiers in Human Neuroscience - February 18, 2022 Category: Neuroscience Source Type: research