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Condition: Pulmonary Thromboembolism

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Health care costs for prostate cancer patients receiving androgen deprivation therapy: treatment and adverse events.
CONCLUSIONS: The economic burden of adverse events is relevant to programs and policies from clinic to government, and that burden merits consideration in the risks and benefits of adt. PMID: 24940106 [PubMed]
Source: Current Oncology - November 19, 2014 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Post-traumatic thrombo-embolic complications in polytrauma patients
Conclusion TE complications were associated with longer ICU and hospital stay as well as a higher mortality. Overall, age and repeated operations were the most important risk factors for the development of TE events.
Source: International Orthopaedics - February 18, 2015 Category: Orthopaedics Source Type: research

Inpatient complications in patients with giant cell arteritis: decreased mortality and increased risk of thromboembolism, delirium and adrenal insufficiency
Conclusion: Hospitalized GCA patients have lower mortality compared with the general inpatient population but greater risk of venous thromboembolism, delirium and adrenal insufficiency.
Source: Rheumatology - July 14, 2015 Category: Rheumatology Authors: Unizony, S., Menendez, M. E., Rastalsky, N., Stone, J. H. Tags: Vasculitis CLINICAL SCIENCE Source Type: research

Antiphospholipid Antibodies and Recurrent Thrombotic Events: Persistence and Portfolio
Conclusions: Rates of TOE/death were not influenced by aPL results at baseline or follow-up. Persistent anti-β2GPI alone, and with persistent second aPL, was independently associated with decreased time to TOE/death. Persistent aPL, an aPL portfolio and newer aPL in ischemic stroke patients are not helpful in predicting an increased rate of recurrent TOEs.Cerebrovasc Dis 2015;40:293-300
Source: Cerebrovascular Diseases - October 30, 2015 Category: Neurology Source Type: research

Reduced Anticoagulant Effect of Dabigatran in a Patient Receiving Concomitant Phenytoin
We describe the first case report, to our knowledge, documenting a drug interaction between phenytoin and dabigatran by using laboratory measurements of dabigatran serum concentrations. A 45‐year‐old African‐American man was admitted to the inpatient cardiology service following defibrillations from his implantable cardioverter defibrillator. The patient was evaluated and received appropriate antitachycardia pacing for atrial tachyarrhythmias for an episode of ventricular tachycardia (VT), and antiarrhythmic therapy with sotalol was initiated to reduce both his AF and VT burden. On review of the patient's medications...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 5, 2016 Category: Drugs & Pharmacology Authors: Barbara S. Wiggins, Amanda Northup, Dominic Johnson, Jeffrey Senfield Tags: Case Report Source Type: research

Mortality and Vascular Events Among Elderly Patients with Chronic Myeloid Leukemia (CML): A Retrospective Analysis of Linked Seer-Medicare Data
Conclusions Elderly CML patients had higher mortality and higher rates of MI, stroke, PE and PAD than non-cancer patients. Event rates were not elevated among TKI-treated (primary imatinib) patients, suggesting that VE risk in these CML patients was driven primarily by underlying factors associated with CML. Teaser TKI treatment of CML may be associated with vascular events (VE). We examined event rates and mortality among elderly CML and non-cancer patients using linked cancer registry and Medicare claims data, 2003-2010. CML patients had higher mortality and VE rates. Rates were not elevated among TKI (primarily imatinib...
Source: Clinical Lymphoma Myeloma and Leukemia - February 7, 2016 Category: Cancer & Oncology Source Type: research

Mortality and Vascular Events Among Elderly Patients With Chronic Myeloid Leukemia: A Retrospective Analysis of Linked SEER-Medicare Data
Conclusion Elderly patients with CML had greater mortality and greater rates of MI, stroke, PE, and PAD than did noncancer patients. The event rates were not elevated among the TKI-treated (primary imatinib) patients, suggesting that the VE risk in these patients with CML was driven primarily by the underlying factors associated with CML. Micro-Abstract Tyrosine-kinase inhibitor (TKI) treatment of chronic myeloid leukemia (CML) can be associated with vascular events (VEs). We examined the event rates and mortality among elderly patients with and without CML using linked cancer registry and Medicare claims data from 2003 t...
Source: Clinical Lymphoma Myeloma and Leukemia - March 21, 2016 Category: Cancer & Oncology Source Type: research

Is Dabigatran As Effective As Warfarin on Cardiac Thrombus in a Patient With Atrial Fibrillation? A Challenging Question
Atrial fibrillation (AF) is an important risk factor for cardioembolic stroke. Warfarin is an effective treatment in reducing the risk of cardioembolic stroke in patients with AF. New anticoagulants have been widely using for stroke prophylaxis in patients with nonvalvular AF. Previous studies have suggested that thrombolytic therapy is effective treatment choice in patients with pulmonary embolisms. Warfarin therapy is also effective on prevention or treatment of cardiac thrombus in patients with AF. However, there are no evidence-based data on treatment of cardiac thrombus with new oral anticoagulants in patients with AF...
Source: American Journal of Therapeutics - May 1, 2016 Category: Drugs & Pharmacology Tags: Case Reports Source Type: research

Pre-treatment clinical assessment in head and neck cancer: United Kingdom National Multidisciplinary Guidelines.
Authors: Robson A, Sturman J, Williamson P, Conboy P, Penney S, Wood H Abstract This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. This paper provides recommendations on the pre-treatment clinical assessment of patients presenting with head and neck cancer. Recommendations • Comorbidity data should be collected as it is important in the analysis of survival, quality of life and functional outcomes after treatment as well as for comparing results of different treatment regimens and different centres. (R) • Patients with hypertens...
Source: Journal of Laryngology and Otology - November 15, 2016 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Is ankylosing spondylitis a risk factor for cardiovascular disease, and how do these risks compare with those in rheumatoid arthritis?
Conclusions Prevalent patients with AS are at a 30%–50% increased risk of incident CV events. When compared with patients with RA, this level of increase was similar for stroke, but only half as high for ACS and thrombotic events.
Source: Annals of the Rheumatic Diseases - January 9, 2017 Category: Rheumatology Authors: Eriksson, J. K., Jacobsson, L., Bengtsson, K., Askling, J. Tags: Immunology (including allergy), Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Clinical and epidemiological research Source Type: research

Study design of GENERAL (general practitioners and embolism prevention in NVAF patients treated with rivaroxaban: Real-life evidence): A multicenter prospective cohort study in primary care physicians to investigate the effectiveness and safety of rivaroxaban in Japanese patients with NVAF
Conclusion This study will provide important information regarding the effectiveness and safety of rivaroxaban treatment in Japanese patients with NVAF among general practitioners.
Source: Journal of Arrhythmia - March 8, 2017 Category: Cardiology Source Type: research

What are the barriers for use of pharmacological prophylaxis (PP) to prevent deep vein thrombosis (DVT) in spontaneous intracranial bleeding (sICH)? (P2.253)
Conclusions:Following this QI project, we started a new pilot study where DVT prophylaxis advisor was included in all stroke admission orders. The pilot project was successful and DVT prophylaxis advisor is now included permanently to all stroke admission orders including the intracranial hemorrhage. We hope this will ensure patients are started on prophylactic anticoagulation per guidelines.Disclosure: Dr. Jayaraman has nothing to disclose. Dr. Sapnar has nothing to disclose. Dr. Joe has nothing to disclose. Dr. Edara has nothing to disclose. Dr. Yaddanapudi has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Jayaraman, D. K., Sapnar, S., Joe, J., Edara, A., Yaddanapudi, S. Tags: Intracerebral Hemorrhage Source Type: research

For post-menopausal women, vaginal estrogens do not raise risk of cancer, other diseases
This study, the first to examine potential adverse health effects in users of vaginal estrogen compared with non-users, suggests that vaginal estrogen therapy is a safe treatment for genitourinary symptoms such as burning, discomfort, and pain during intercourse associated with menopause.AUTHORSThe paper ’s authors are Dr. Carolyn Crandall of UCLA; Kathleen Hovey of the State University of New York at Buffalo; Christopher Andrews of the University of Michigan; Dr. Rowan Chlebowski of City of Hope; Marcia Stefanick of Stanford University; Dr. Dorothy Lane of the State University of New York at Ston y Brook; Dr. Jan Shifre...
Source: UCLA Newsroom: Health Sciences - August 16, 2017 Category: Universities & Medical Training Source Type: news

Left atrial appendage closure for primary primary prevention during percutaneous closure of septal defects in patients with large atria but no atrial fibrillation.
CONCLUSIONS: Concomitant closure of ASD or PFO in the presence of enlarged atria and LAA for primary primary prevention appears feasible and safe but has yet to prove its justification. PMID: 28840592 [PubMed - as supplied by publisher]
Source: Cardiology Journal - August 25, 2017 Category: Cardiology Authors: Kuwata S, Vierecke J, Gloekler S, Maisano F, Meier B, Nietlispach F Tags: Cardiol J Source Type: research

Catheter-directed interventions compared with systemic thrombolysis achieve improved ventricular function recovery at a potentially lower complication rate for acute pulmonary embolism
Conclusions CDIs provide improved recovery of right ventricular function compared with ST. Major bleeding and stroke complications may be lower, but larger studies are needed to validate this. CDIs are complementary to ST, and their use should be individualized on the basis of the patients' clinical presentation, risk profile, and local resources.
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - April 1, 2018 Category: Surgery Source Type: research