Molecular mechanisms of mechanical load-induced osteoarthritis
ConclusionThis review highlights the molecular mechanisms of mechanical loading in inducing chondrocyte apoptosis and extracellular matrix degradation. These mechanisms provide potential targets for osteoarthritis prevention and treatment. (Source: International Orthopaedics)
Source: International Orthopaedics - January 18, 2021 Category: Orthopaedics Source Type: research

Mobilization versus displacement on lateral stress radiographs for determining operative fixation of minimally displaced lateral compression type I (LC1) pelvic ring injuries
ConclusionUnder the mobilization protocol, unstable LC1 injuries were less likely to mobilize and the time to surgery was increased. (Source: International Orthopaedics)
Source: International Orthopaedics - January 16, 2021 Category: Orthopaedics Source Type: research

Gait analysis in the elderly patients with lumbar spinal stenosis
This study aims to analyze the gait characteristics of the elderly patients with lumbar spinal stenosis by an intelligent device for energy expenditure and activity (IDEEA) to assist clinical work.MethodsA total of 98 subjects were included in this study from January 2017 to December 2018. A total of 49 elderly outpatients with symptomatic lumbar spinal stenosis in unilateral lower extremity were included as the experimental group, and another 49 healthy subjects matched with gender, age, and body mass index (BMI) were analyzed as the control group. The gait data of the subjects (including single support, double support, S...
Source: International Orthopaedics - January 16, 2021 Category: Orthopaedics Source Type: research

Humeral amputation following total elbow arthroplasty
ConclusionThe results of this study highlight a low incidence of amputation after TEA. Most amputations were the direct result of TEA complications, with infection being the most common cause of amputation. Outcomes after amputation are concerning, with poor overall survival and few patients being fit for a prosthesis. (Source: International Orthopaedics)
Source: International Orthopaedics - January 15, 2021 Category: Orthopaedics Source Type: research

Total knee arthroplasty improves the quality-adjusted life years in patients who exceeded their estimated life expectancy
This study aimed to evaluate the functional outcome, rates of complication and mortality, and quality-adjusted life years (QALY) in patients who exceeded their estimated life expectancy.MethodsNinety-seven TKA implanted in 86 patients who exceeded their estimated life expectancy at the time of TKA were prospectively included in our institutional joint registry and retrospectively analyzed. At latest follow-up, the functional outcome with the Knee Society Score (KSS), rates of complication and mortality, and QALY with utility value of EuroQol-5D score were evaluated.ResultsAt a mean follow-up of three  ±&thins...
Source: International Orthopaedics - January 15, 2021 Category: Orthopaedics Source Type: research

Long-term results of subtalar arthroereisis for the treatment of symptomatic flexible flatfoot in children: an average fifteen  year follow-up study
ConclusionSTA with a bioabsorbable implant showed satisfactory long-term results. Based on the data subgroup analysis, nine to 11.5 years for female and nine to 13.5 years for male appeared to be the most appropriate age for surgery. (Source: International Orthopaedics)
Source: International Orthopaedics - January 14, 2021 Category: Orthopaedics Source Type: research

Tibiotalocalcaneal arthrodesis with a retrograde intramedullary nail: a prospective cohort study at a minimum five  year follow-up
AbstractPurposeTo evaluate prospectively the functional outcomes of tibiotalocalcaneal (TTC) arthrodesis with a contemporary retrograde intramedullary nail after a minimum follow-up of five  years.MethodsSixty-one patients with a mean age of 51.3 (range, 18 –79) years were included in the study. Functional outcome was assessed using the American Orthopaedic Foot and Ankle Society Ankle Hindfoot score (AOFAS), Short-Form 12-item Health Survey (SF12), and visual analog scales (VAS) for both pain and patient satisfaction. Radiographic evaluation was als o assessed.ResultsThe mean post-operative follow-up was 6.8 (r...
Source: International Orthopaedics - January 14, 2021 Category: Orthopaedics Source Type: research

Epidemiology and clinical outcomes of spinal cord injuries at a level II trauma centre in Nigeria: a longitudinal five  year study
ConclusionsMotor vehicular crash and fall-related traumatic SCI affected mostly males and the working age group with complete tetraplegia as the predominating clinical pattern. There is a need for strategic interventions to reduce MVA and improve pre-hospital care and health policies to ensure early definitive care. (Source: International Orthopaedics)
Source: International Orthopaedics - January 14, 2021 Category: Orthopaedics Source Type: research

Radiographic analysis of the proximal femoral anatomy in the Croatian population
ConclusionOur results support the observation on high diversity in the morphology of the proximal femur and the specificity of the proximal femoral anatomy of the Croatian population. (Source: International Orthopaedics)
Source: International Orthopaedics - January 13, 2021 Category: Orthopaedics Source Type: research

V-Y turndown flap augmentation for acute quadriceps rupture after total knee arthroplasty: a prospective matched cohort study
ConclusionThe quadriceps V-Y turndown is an effective and safe procedure for quadriceps ruptures in the setting of TKA. Although the functional outcomes were lower than in TKA patients with no quadriceps rupture, the quality of life and satisfaction were successful in the TKA patients with quadriceps rupture. (Source: International Orthopaedics)
Source: International Orthopaedics - January 13, 2021 Category: Orthopaedics Source Type: research

Prospective randomized study of the vitamin C effect on pain and complex pain regional syndrome after total knee arthroplasty
AbstractPurposeComplex regional pain syndrome (CRPS) type I, formerly known as reflex sympathetic dystrophy (RSD) or algodystrophy, is a condition with chronic pain condition following a trauma or surgery. The physiopathology of this syndrome remained incompletely known. Due to the lack of effective curative treatment, prevention of this complication is important. Therefore, we evaluated the efficacy of vitamin C in preventing this complication.Material and methodsBetween January 2018 and July 2019, we conducted a prospective randomized study on the efficiency of vitamin C (one group with and one without vitamin C) on prev...
Source: International Orthopaedics - January 12, 2021 Category: Orthopaedics Source Type: research

Serum cartilage oligomeric matrix protein as a biomarker for predicting development and progression of knee osteoarthritis
ConclusionThe study demonstrates that sCOMP is significantly higher in patients with knee OA than in those without the disease. Values of sCOMP were also found to increase with severity of knee OA, indicating the possibility of its use as a marker of diagnosis and severity. (Source: International Orthopaedics)
Source: International Orthopaedics - January 12, 2021 Category: Orthopaedics Source Type: research

Assessment of safety and efficacy of intra-articular injection of stromal vascular fraction for the treatment of knee osteoarthritis —a systematic review
ConclusionIntra-articular injection of SVF is a safe and effective technique for the management of knee OA. However, comparative Level I studies are needed to support the use of adjuvants with SVF and also to compare the use of SVF (with or without adjuvants) with ADMSCs, PRP, and bone marrow concentrate. (Source: International Orthopaedics)
Source: International Orthopaedics - January 12, 2021 Category: Orthopaedics Source Type: research

Letter to editor “Risk factors for aseptic loosening in complex revision total knee arthroplasty using rotating hinge implants”
(Source: International Orthopaedics)
Source: International Orthopaedics - January 11, 2021 Category: Orthopaedics Source Type: research

Pulmonary metastasis of giant cell tumour: a retrospective study of three hundred and ten cases
ConclusionsGiant cell tumour patients with soft tissue mass and overall local recurrence are prone to develop pulmonary metastasis. Although giant cell tumour is a benign tumor, more attention should be paid to the problem of pulmonary metastatic lesions, and chest CT scan should be recommended during follow-up. (Source: International Orthopaedics)
Source: International Orthopaedics - January 11, 2021 Category: Orthopaedics Source Type: research

Clinical study on minimally invasive treatment of femoral head necrosis with two different bone graft materials
ConclusionBioceramics and autologous iliac bone minimally invasive treatment of early and medium-term femoral head necrosis exhibited satisfactory clinical efficacy in the short and medium-term. The bioceramics graft materials have the advantages of reducing trauma, bleeding, operation time, and quick recovery of post-operative functions. (Source: International Orthopaedics)
Source: International Orthopaedics - January 11, 2021 Category: Orthopaedics Source Type: research

Bernese peri-acetabular osteotomy performed with navigation and patient-specific templates is a reproducible and safe procedure
ConclusionsOur study indicates that PAO performed with EMN and PST seems to be a safe and reproducible procedure with a short learning curve. Additionally, navigated reorientation of the acetabular fragment is significantly more accurate than the fluoroscopic technique. (Source: International Orthopaedics)
Source: International Orthopaedics - January 11, 2021 Category: Orthopaedics Source Type: research

Surgical strategy for non-continuous thoracic spinal stenosis: one- or two-stage surgery?
ConclusionDifferent surgical procedures are suitable for different types of NTSS. For patients with NTSS mainly caused by posterior compression, PD via laminectomy in one-stage with two incisions can achieve satisfying clinical outcomes. Staged surgery, including CD and PD procedures, is recommended for patients with NTSS mainly caused by anterior compression. (Source: International Orthopaedics)
Source: International Orthopaedics - January 11, 2021 Category: Orthopaedics Source Type: research

Short stem total hip arthroplasty with the direct anterior approach demonstrates suboptimal fixation
ConclusionPatients presenting radiological alterations at five years had an increased risk of revision for aseptic stem loosening and also inferior clinical results. Our study warrants further continued scrutiny of mid- and long-term survivorship of the AMIStem-H ®, with radiological results at five years indicating suboptimal fixation of the stem in younger and active patients. (Source: International Orthopaedics)
Source: International Orthopaedics - January 11, 2021 Category: Orthopaedics Source Type: research

Answer to Letter to the Editor of Chen concerning “A randomized controlled trial: comparing extracorporeal shock wave therapy versus local corticosteroid injection for the treatment of carpal tunnel syndrome”
(Source: International Orthopaedics)
Source: International Orthopaedics - January 11, 2021 Category: Orthopaedics Source Type: research

Comment on “Risk factors for aseptic loosening in complex revision total knee arthroplasty using rotating hinge implants”
(Source: International Orthopaedics)
Source: International Orthopaedics - January 11, 2021 Category: Orthopaedics Source Type: research

Post-operative deep vein thrombosis in patients over sixty years of age diagnosed with closed distal femur fractures undergoing open reduction internal fixation
ConclusionOur findings indicate a strong association between venous thrombosis at admission, the longer operation duration, and considerable intra-operative blood loss with high risk of post-operative DVTs in patients over age 60 years with closed DFFs. Preventive approaches for postoperative DVTs should seek to shorten operation duration and reduce intra-operative blood loss. (Source: International Orthopaedics)
Source: International Orthopaedics - January 9, 2021 Category: Orthopaedics Source Type: research

Does healing of both greater and lesser tuberosities improve functional outcome after reverse shoulder arthroplasty for fracture? A retrospective study of twenty-eight cases with a computed tomography scan at a minimum of one-year follow-up
ConclusionGT and LT healing was associated with better functional results and active motion. Anatomical reduction and consolidation of both tuberosities is beneficial with a cumulative effect for functional recovery. (Source: International Orthopaedics)
Source: International Orthopaedics - January 9, 2021 Category: Orthopaedics Source Type: research

The blister occurring in severe tibial plateau fractures (Schatzker V –VI) decreases the risk of acute compartment syndrome
AbstractBackgroundSevere tibial plateau fractures may result in acute compartment syndrome (ACS) of the leg, which is always considered to be an orthopaedic emergency. Blistering is not an uncommon sign and may be related to decreased compartment pressure. No experiments on the risk of ACS based on the presence of blisters after tibial plateau fractures have been conducted, and controversies about the high rate of ACS in patients with tibial plateau fractures still exist.Questions/purposesThis research retrospectively followed the bicondylar tibial plateau fractures treated with locking plates and verified if the risk of A...
Source: International Orthopaedics - January 8, 2021 Category: Orthopaedics Source Type: research

Effectiveness of ankle arthroscopic debridement in acute, subacute ankle- bimalleolar, and trimalleolar fractures
ConclusionThrough minimally invasive visualization of intra-articular structures, ankle arthroscopy can offer an essential option for selected patients both in acute and in sequelae after an ankle fracture. More studies are needed to understand the real effectiveness of the procedure, especially in acute at the same time of osteosynthesis. (Source: International Orthopaedics)
Source: International Orthopaedics - January 8, 2021 Category: Orthopaedics Source Type: research

A new computed tomography scoring system to assess osteochondral allograft transplantation for the knee: inter-observer and intra-observer agreement
AbstractAim of the studyTo describe a new semiquantitative computed tomography (CT) scoring system for multi-feature analysis of cartilage defect repair by osteochondral allografts for the knee and to assess its intra-observer and inter-observer variability.MethodA semiquantitative assessment CT osteochondral allograft (ACTOCA) scoring system was designed based on fresh osteochondral allograft transplantations for the knee. The system includes five CT features: density relative to host bone, integration at the host-graft junction, surface percentage with a discernible cleft at the host-graft junction, cystic changes, and i...
Source: International Orthopaedics - January 8, 2021 Category: Orthopaedics Source Type: research

Letter to the editor
(Source: International Orthopaedics)
Source: International Orthopaedics - January 8, 2021 Category: Orthopaedics Source Type: research

Comment on article by Milenkovic et al.: lateral tibial plateau fractures —functional outcomes and complications after open reduction and internal fixation
(Source: International Orthopaedics)
Source: International Orthopaedics - January 8, 2021 Category: Orthopaedics Source Type: research

Letter to the editor: “Efficacy of platelet-rich plasma injections in patients with adhesive capsulitis of the shoulder”
(Source: International Orthopaedics)
Source: International Orthopaedics - January 8, 2021 Category: Orthopaedics Source Type: research

Pre-operative bone mineral density is a predictive factor for excellent early patient-reported outcome measures in cementless total hip arthroplasty using a proximally fixed anatomic stem. A prospective study at two year minimum follow-up: several questions
(Source: International Orthopaedics)
Source: International Orthopaedics - January 7, 2021 Category: Orthopaedics Source Type: research

Pre-operative predictors of lower extremity swelling following total knee arthroplasty in patients with venous insufficiency and osteoarthritis
ConclusionGSV diameter of>  5.38 mm and GSV reflux duration>  1.23 s had the best predictive value for lower extremity oedema following TKA. (Source: International Orthopaedics)
Source: International Orthopaedics - January 7, 2021 Category: Orthopaedics Source Type: research

Determinants of regeneration and strength of hamstrings after anterior cruciate ligament reconstruction —fate of hamstring tendon
AbstractBackground and aimArthroscopic reconstruction of anterior cruciate ligament (ACL) surgical procedure using hamstring autograft is the  most common surgery performed in the arena of sports medicine and arthroscopy. Most studies in literature are ambiguous regarding the fate of hamstrings based on function, regenerative potential, and cross-sectional area (CSA). The aim of this research study is analysis of the fate of hamstring te ndons (both semitendinosus and gracilis) during the time course for determinants of regeneration and strength.MethodsFifty patients who were operated for unilateral isolated ACL recon...
Source: International Orthopaedics - January 6, 2021 Category: Orthopaedics Source Type: research

Intra-articular gold induced cytokine (GOLDIC ®) injection therapy in patients with osteoarthritis of knee joint: a clinical study
AbstractPurposeTo evaluate the safety and efficacy of a novel technique of preconditioning autologous blood with gold particles (GOLDIC ®) and injection in patients with moderate to severe knee osteoarthritis (KOA).MethodsDuring this phase 2a, proof-of-concept (PoC) open label study, 83 consecutive patients that 64 patients met inclusion criteria (mean age: 64.8 years; 89 knees) with radiographically proven KOA, received four ultrasound guided intra-articular knee injections of GOLDIC ® at three to six day intervals. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Knee injury and Osteoart...
Source: International Orthopaedics - January 6, 2021 Category: Orthopaedics Source Type: research

Poor outcomes of primary total knee arthroplasty in patients with Parkinson ’s disease
AbstractPurposeThe purpose of this study was to compare the functional outcomes, activity levels, mortalities, implant survival rates, and complications of total knee arthroplasty (TKA) of patients with Parkinson ’s disease (PD) with those of patients in a control group over a minimum ten year follow-up period.MethodsFrom January 2007 to December 2009, 46 TKAs were performed in 29 patients with PD (PD group). Fifty-eight matched patients without PD were used as the control group in a two-to-one ratio using propensity scoring matching. The functional outcomes, activity levels, mortalities, implant survival rates,...
Source: International Orthopaedics - January 6, 2021 Category: Orthopaedics Source Type: research

Joint classification from the viewpoint of Avicenna and modern medicine
ConclusionAvicenna established preservation of health and treatment of diseases based on anatomy. Therefore, Avicenna ’s functional approach to the division of joints is important both in terms of the history of medicine according to Avicenna’s description a thousand years ago and in terms of content and structure do not differ compared to today’s Classification in medicine and it’s interesting. (Source: International Orthopaedics)
Source: International Orthopaedics - January 5, 2021 Category: Orthopaedics Source Type: research

Impact of orthogeriatric management on the average length of stay of patients aged over seventy five years admitted to hospital after hip fractures
DiscussionOrthogeriatric unit treatment reduced the median length of stay by one day, in line with most previous studies. According to Pablos-Hernandez et al., multifaceted orthogeriatric treatment is most effective. In our study, only 38% of the patients received surgical treatment within 48 hours, where early surgery is key for reducing the length of hospital stay. The intrahospital mortality rate was 2.6%, which is comparable to literature data. The discharge rate did not differ by orthogeriatric treatment status, which is also consistent with previous findings (e.g. Gregersen et al.). Lastly, the mortality rate after s...
Source: International Orthopaedics - January 4, 2021 Category: Orthopaedics Source Type: research

Treatment of knee osteoarthritis by intra-articular injection of concentrated autologous adipose tissue: a twenty four  month follow-up study
ConclusionsIn patients with knee OA, a single intra-articular injection of autologous adipose tissue reduced knee pain, stiffness, improved knee function and quality of life without severe complications. (Source: International Orthopaedics)
Source: International Orthopaedics - January 4, 2021 Category: Orthopaedics Source Type: research

Reduction of spondylolisthesis and sagittal balance correction by anterior lumbar interbody fusion (ALIF)
ConclusionsALIF offers a good reduction of the slipped vertebra providing good conditions for fusion and is an efficient surgical technique to recreate the sagittal spine balance. (Source: International Orthopaedics)
Source: International Orthopaedics - January 4, 2021 Category: Orthopaedics Source Type: research

Understanding the difference between symptoms of focal cartilage defects and osteoarthritis of the knee: a matched cohort analysis
ConclusionWhen compared to patients with focal cartilage defects, adults with knee osteoarthritis scheduled for knee arthroplasty have a more severe presentation of symptoms, particularly medial-sided pain, swelling of the knee, pain associated with straightening the knee, standing upright, and rising from sitting. (Source: International Orthopaedics)
Source: International Orthopaedics - January 4, 2021 Category: Orthopaedics Source Type: research

The Dark Age of medieval surgery in France in the first part of Middle Age (500 –1000): royal touch, wound suckers, bizarre medieval surgery, monk surgeons, Saint Healers, but foundation of the oldest worldwide still-operating hospital
ConclusionThis account of surgery before it became scientific is based on a chronology that runs from the Clovis baptism to the reign of Charlemagne; much of the medicine in this period was based on ancient doctrines; indeed, much of the development of medicine in the period called as “Dark Age” was due to the slow and difficult business of recovering and trying to understand ancient medicine (Source: International Orthopaedics)
Source: International Orthopaedics - January 4, 2021 Category: Orthopaedics Source Type: research

Acknowledgement for our reviewers
(Source: International Orthopaedics)
Source: International Orthopaedics - January 4, 2021 Category: Orthopaedics Source Type: research

C-reactive protein and tumour diagnosis predict survival in patients treated surgically for long bone metastases
ConclusionOur prognostic score based on only two simple variables (C-reactive protein and primary tumour diagnosis) was able to predict the 12-month survival of patients treated surgically for long bone metastases and could be helpful in choosing the best treatment for these patients. (Source: International Orthopaedics)
Source: International Orthopaedics - January 4, 2021 Category: Orthopaedics Source Type: research

Comment on Sigmund et al. “Inferior performance of established and novel serum inflammatory markers in diagnosing periprosthetic joint infections”
(Source: International Orthopaedics)
Source: International Orthopaedics - January 4, 2021 Category: Orthopaedics Source Type: research

Why compromise the patella? Five-year follow-up results of medial patellofemoral ligament reconstruction with soft tissue patellar fixation
ConclusionMPFL reconstruction with soft tissue patellar fixation leads to significant improvement of knee function and low midterm redislocation rate. Patients with high-grade trochlear dysplasia should be considered for additional osseous correction. (Source: International Orthopaedics)
Source: International Orthopaedics - January 2, 2021 Category: Orthopaedics Source Type: research

Effect of the defect localization and size on the success of third-generation autologous chondrocyte implantation in the knee joint
ConclusionThird-generation autologous chondrocyte implantation in ACI-treated femoral cartilage defects leads to a superior clinical outcome in a follow-up of three  years compared with patellar defects. No significant influence of the defect size was found in either femoral or patellar cartilage defects. (Source: International Orthopaedics)
Source: International Orthopaedics - December 6, 2020 Category: Orthopaedics Source Type: research

Variables affecting patellar height in patients undergoing primary total knee replacement
AbstractBackgroundAlteration of patellar height is commonly encountered in total knee arthroplasty (TKA), and failure to address patella baja can result in suboptimal functional outcomes. It may therefore be prudent to evaluate pre-operative patellar height (PPH) and to seek risk factors for patella baja.MethodsTwo hundred eighty-five patients who underwent TKA were included. Patient ’s age, gender, body mass index (BMI), and history of prior arthroscopy were recorded. PPH was measured using plateau-patella angle (PPA) as well as the Blackburn-Peel (BP), Caton-Deschamps (CD), and Insall-Salvati (IS) ratios.ResultsThe...
Source: International Orthopaedics - December 4, 2020 Category: Orthopaedics Source Type: research

Metasul vs Cerasul bearings: a prospective, randomized study at a mean eighteen years
ConclusionAt 18  years, Cerasul demonstrated higher survivorship than Metasul considering aseptic loosening as an end point. However, Cerasul liners had high rate of fracture because of its sandwich design (thin ceramic liner into polyethylene). These implants are no more available on the market. (Source: International Orthopaedics)
Source: International Orthopaedics - November 20, 2020 Category: Orthopaedics Source Type: research

Comment on the article —“Acetabular cup migration after primary cementless total hip arthroplasty in rheumatoid arthritis and its influencing factors: a comparative study with osteoarthritic hip”
(Source: International Orthopaedics)
Source: International Orthopaedics - November 20, 2020 Category: Orthopaedics Source Type: research

Comment on “The role of ulnar nerve subcutaneous anterior transposition during open reduction and internal fixation of distal humerus fractures: a retrospective cohort study”
(Source: International Orthopaedics)
Source: International Orthopaedics - November 20, 2020 Category: Orthopaedics Source Type: research

The V-shaped subscapularis tenotomy for anatomic total shoulder arthroplasty
ConclusionVT during TSA appears to provide healing rates at least equal to those reported for TT, and not dissimilar from those of lesser tuberosity osteotomy. Clinical outcomes are comparable to reported results in the literature for alternative techniques, and not different from those observed here in a comparison cohort with TSA performed without violating the subscapularis tendon.VT therefore potentially offers a more effective and secure tendon repair than a traditional TT, with at least comparable clinical outcomes. (Source: International Orthopaedics)
Source: International Orthopaedics - November 19, 2020 Category: Orthopaedics Source Type: research