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Condition: Obesity
Drug: Metformin

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Total 44 results found since Jan 2013.

Using Artificial Intelligence to Develop a Multivariate Model with a Machine Learning Model to Predict Complications in Mexican Diabetic Patients without Arterial Hypertension (National Nested Case-Control Study): Metformin and Elevated Normal Blood Pressure Are Risk Factors, and Obesity Is Protective
In conclusion, the results we have obtained show that artificial intelligence is a powerful and feasible tool to use for this type of study. However, we suggest that more studies be conducted to verify and elaborate upon our findings.PMID:36846513 | PMC:PMC9949947 | DOI:10.1155/2023/8898958
Source: Cancer Control - February 27, 2023 Category: Cancer & Oncology Authors: Sergio A Zaizar-Fregoso Agustin Lara-Esqueda Carlos M Hern ández-Suarez Josuel Delgado-Enciso Arturo Garcia-Nevares Luis M Canseco-Avila Jose Guzman-Esquivel Iram P Rodriguez-Sanchez Margarita L Martinez-Fierro Gabriel Ceja-Espiritu Hector Ochoa-D íaz-L Source Type: research

People With Diabetes Are More Vulnerable to Heart Disease. How to Reduce the Risk
If you’ve been diagnosed with diabetes, know that you’ve got plenty of company. The American Diabetes Association (ADA) reports that in 2019, the most recent year for which data is available, 37.3 million adults in the U.S.—about 11.3% of the population—had the chronic condition, and that number continues to grow. Type 1 diabetes develops when the body isn’t able to produce insulin, and Type 2 occurs when the body doesn’t use insulin correctly. Type 2 is the most common form of diabetes, and when it’s uncontrolled, a person’s blood sugar can jump to dangerous levels that requ...
Source: TIME: Health - July 20, 2022 Category: Consumer Health News Authors: Elaine K. Howley Tags: Uncategorized Disease freelance healthscienceclimate Source Type: news

Polycystic ovary syndrome: a "risk-enhancing" factor for cardiovascular disease
Fertil Steril. 2022 May;117(5):924-935. doi: 10.1016/j.fertnstert.2022.03.009.ABSTRACTPolycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age and is hallmarked by hyperandrogenism, oligo-ovulation, and polycystic ovarian morphology. Polycystic ovary syndrome, particularly the hyperandrogenism phenotype, is associated with several cardiometabolic abnormalities, including obesity, dyslipidemia, elevated blood pressure, and prediabetes or type 2 diabetes. Many, but not all, studies have suggested that PCOS is associated with increased risk of cardiovascular disease (CVD), includi...
Source: Atherosclerosis - May 5, 2022 Category: Cardiology Authors: Carolyn Guan Salman Zahid Anum S Minhas Pamela Ouyang Arthur Vaught Valerie L Baker Erin D Michos Source Type: research

Sex-disparities in risk factors and atherosclerosis cardiovascular disease in diabetic patients
Conclusion: Among diabetic people, compared to males, females had a higher comorbid burden but received less optimal treatment, which might partly explain their higher prevalence of composite ASCVD and CHD.PMID:33874831 | DOI:10.1080/00325481.2021.1917930
Source: Postgraduate Medicine - April 20, 2021 Category: Internal Medicine Authors: Yue Sun Dong Yan Lijuan Cui Guiping Li Yan Sun Zirui Hao Source Type: research

Blood Flow Restriction Exercise Attenuates the Exercise-Induced Endothelial Progenitor Cell Response in Healthy, Young Men
Conclusion In summary, this is the first study to show that BFR exercise did not augment EPC response to exercise, and in fact blunted the EPC response to low load unilateral KE exercise in young, healthy males. Ethics Statement This study was carried out in accordance with the recommendations of Edinburgh Napier University Research and Ethics Governance Committee. The study was ethically approved by Edinburgh Napier University Research and Ethics Governance Committee. All participants gave written informed consent in accordance with the Declaration of Helsinki. Author Contributions MR, RM, AP, CW, GF-J designed the s...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

The Impact of Metformin Use on the Cardiovascular Effects of DPP ‐4 Inhibitors: an Analysis of Medicare Claims Data 2007‐2015
ConclusionsIncidence rate differences in multiple cardiovascular outcomes appeared more favorable when DPP ‐4i initiation occurred in the presence of metformin, suggesting a possible interaction between DPP‐4i and metformin.This article is protected by copyright. All rights reserved.
Source: Diabetes, Obesity and Metabolism - November 20, 2018 Category: Endocrinology Authors: Matthew J. Crowley, Mugdha Gokhale, Virginia Pate, Til St ürmer, John B. Buse Tags: ORIGINAL ARTICLE Source Type: research

Metformin for the Management of Peri ‐operative Hyperglycemia
Perioperative hyperglycemia is an all too common issue (incidence 20‐40%) associated with significant surgical morbidity and mortality [1]. Often defined as a blood glucose >11.1mmol/L, peri‐operative hyperglycemia increases the risk for developing costly surgical site infections, sepsis, impairs wound healing, promotes endothelial dysfunction, thrombus formation, myocardial ischemia, stroke, neurocognitive dysfunction, prolongs length of hospitalization, and even death [2‐7].
Source: Diabetes, Obesity and Metabolism - November 9, 2017 Category: Endocrinology Authors: Russell Brown, James Paul Tags: LETTER TO THE EDITOR Source Type: research

Oral antidiabetic drugs and dementia risk: Does treatment matter?
As the population ages, dementia grows as a public health problem. The rising life expectancy and the aging of the so-called baby boomer cohort translate to a substantial number of people reaching ages of high risk for age-related conditions like dementia. As a major cause of disability and dependency in elderly people, dementia puts social and economic burden on patients and their families and affects health care systems worldwide. In the absence of a cure, primary prevention will have the largest effect on the reduction of dementia occurrence.1 Thus, public health research should focus on the identification of modifiable...
Source: Neurology - October 30, 2017 Category: Neurology Authors: Fink, A., Haenisch, B. Tags: All Cognitive Disorders/Dementia, All epidemiology EDITORIALS Source Type: research

Impact of metformin on cardiovascular disease: a meta-analysis of randomised trials among people with type 2 diabetes
Conclusions/interpretationThere remains uncertainty about whether metformin reduces risk of cardiovascular disease among patients with type 2 diabetes, for whom it is the recommended first-line drug. Although this is mainly due to absence of evidence, it is unlikely that a definitive placebo-controlled cardiovascular endpoint trial among people with diabetes will be forthcoming. Alternative approaches to reduce the uncertainty include the use of electronic health records in long-term pragmatic evaluations, inclusion of metformin in factorial trials, publication of cardiovascular outcome data from adverse event reporting in...
Source: Diabetologia - August 2, 2017 Category: Endocrinology Source Type: research

Cardiovascular benefits and safety of non-insulin medications used in the treatment of type 2 diabetes mellitus.
Authors: Yandrapalli S, Jolly G, Horblitt A, Sanaani A, Aronow WS Abstract Diabetes mellitus is a growing in exponential proportions. If the current growth trend continues, it may result in every third adult in the United States having diabetes mellitus by 2050, and every 10(th) adult worldwide. Type 2 diabetes mellitus (T2DM) confers a 2- to 3-fold increased risk of cardiovascular (CV) events compared with non-diabetic patients, and CV mortality is responsible for around 80% mortality in this population. Patients with T2DM can have other features of insulin resistance-metabolic syndrome like hypertension, lipid ab...
Source: Postgraduate Medicine - July 29, 2017 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Managing glycaemia in older people with type 2 diabetes: A retrospective, primary care ‐based cohort study, with economic assessment of patient outcomes
ConclusionsWith respect to treatment choice, data from the present study support the notion of prescribing beyond metformin + SU, as alternative regimens have been shown to be associated with reduced outcomes risk and value for money.
Source: Diabetes, Obesity and Metabolism - February 22, 2017 Category: Endocrinology Authors: Jason Gordon, Phil McEwan, Marc Evans, Jorge Puelles, Alan Sinclair Tags: ORIGINAL ARTICLE Source Type: research

Managing glycaemia in older people with type 2 diabetes: a retrospective, primary care based cohort study, with economic assessment of patient outcomes
ConclusionsWith respect to treatment choice, data from this study supports the notion of prescribing beyond M+SU, as alternative regimens have been demonstrated to be associated with reduced outcomes risk and value for money.
Source: Diabetes, Obesity and Metabolism - December 26, 2016 Category: Endocrinology Authors: Jason Gordon, Phil McEwan, Marc Evans, Jorge Puelles, Alan Sinclair Tags: ORIGINAL ARTICLE Source Type: research

Sex differences in outcomes after stroke among patients with low total cholesterol levels: a large hospital-based prospective study
ConclusionsThese findings suggest that patients (both men and women) with atherothrombotic infarction who have low TC levels would not benefit from receiving statin treatment. Therefore, it is crucial to explore the impact of statin treatment on outcomes in Asian patients, especially Chinese patients with atherothrombotic and low TC levels, in order to improve outcomes after stroke and reduce the disease burden.
Source: Biology of Sex Differences - November 23, 2016 Category: Biology Source Type: research