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Variability of postural orthostatic tachycardia in patients with myalgic encephalomyelitis and orthostatic intolerance
In conclusion, in ME patients with orthostatic intolerance, the exaggerated activation of the sympathetic nervous system while standing appears to switch to the impaired sympathetic activation after the system is loaded with the additional accentuated stimuli associated with the preload reduction.
Source: Heart and Vessels - September 15, 2015 Category: Cardiology Source Type: research

Cardiac dysfunction and orthostatic intolerance in patients with myalgic encephalomyelitis and a small left ventricle
In conclusion, a small LV size with a low cardiac output was common in ME patients, in whom OI was extremely common. Cardiac dysfunction with a small heart appears to be related to the symptoms of ME.
Source: Heart and Vessels - July 1, 2015 Category: Cardiology Source Type: research

Hacking The Nervous System
(Photo: © Job Boot) One nerve connects your vital organs, sensing and shaping your health. If we learn to control it, the future of medicine will be electric.When Maria Vrind, a former gymnast from Volendam in the Netherlands, found that the only way she could put her socks on in the morning was to lie on her back with her feet in the air, she had to accept that things had reached a crisis point. “I had become so stiff I couldn’t stand up,” she says. “It was a great shock because I’m such an active person.”It was 1993. Vrind was in her late 40s and working two jobs, athletics coach and a carer for disabled ...
Source: Healthy Living - The Huffington Post - May 30, 2015 Category: Consumer Health News Source Type: news

Sonic Hedgehog Signaling Mediates Resveratrol to Increase Proliferation of Neural Stem Cells After Oxygen-Glucose Deprivation/Reoxygenation Injury in Vitro
Conclusion: Shh signaling mediates resveratrol to increase NSCs proliferation after OGD/R injury in vitro.Cell Physiol Biochem 2015;35:2019-2032
Source: Cellular Physiology and Biochemistry - April 8, 2015 Category: Cytology Source Type: research

The Toll-like Receptor Radical Cycle pathway: a new drug target in immune-related chronic fatigue.
Abstract In this review we discuss that peripheral and central activation of the Toll-like receptor 2/4 (TLR2/4) Radical Cycle may underpin the pathophysiology of immune-related chronic fatigue secondary to other medical diseases and conditions. The TLR Radical Cycle plays a role in illnesses and conditions that are disproportionately commonly comorbid with secondary chronic fatigue, including a) neuroinflammatory disorders, e.g. Parkinson's disease, stroke, depression, psychological stressors, and b) systemic disorders, e.g. (auto)immune disorders, chronic obstructive pulmonary disease, ankylosing spondylitis, ch...
Source: CNS and Neurological Disorders Drug Targets - March 17, 2015 Category: Drugs & Pharmacology Authors: Lucas K, Morris G, Anderson G, Maes M Tags: CNS Neurol Disord Drug Targets Source Type: research

The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases
Abstract Many patients with systemic immune-inflammatory and neuro-inflammatory disorders, including depression, rheumatoid arthritis, systemic lupus erythematosus, Sjögren’s disease, cancer, cardiovascular disorder, Parkinson’s disease, multiple sclerosis, stroke, and chronic fatigue syndrome/myalgic encephalomyelitis, endure pathological levels of fatigue. The aim of this narrative review is to delineate the wide array of pathways that may underpin the incapacitating fatigue occurring in systemic and neuro-inflammatory disorders. A wide array of immune, inflammatory, oxidative and nitrosative stress (O&...
Source: Molecular Neurobiology - January 20, 2015 Category: Neurology Source Type: research

Orthostatic responses in adolescent chronic fatigue syndrome: contributions from expectancies as well as gravity
Conclusions: These results suggest that in CFS patients expectancies towards orthostatic challenge might be additional determinants of autonomic cardiovascular modulation along with the gravitational stimulus per se.
Source: BioPsychoSocial Medicine - September 15, 2014 Category: Psychiatry & Psychology Authors: Vegard WyllerEven FagermoenDag SulheimAnette WingerEva SkovlundJerome Saul Source Type: research

Joint hypermobility and autonomic hyperactivity: relevance to neurodevelopmental disorders
Conclusion We demonstrate for the first time that rates of hypermobility and symptoms of autonomic dysfunction are particularly high in adults with neurodevelopmental diagnoses. It is likely that the importance of hypermobility and autonomic dysfunction to the generation and maintenance of psychopathology in neurodevelopmental disorders is poorly appreciated. Work underway(autonomic testing, fMRI) will test the hypothesis that autonomic reactivity and interoceptive sensitivity predispose to the expression of psychiatric symptoms, particularly anxiety. It is further hypothesized that inefficient neural co-ordination of effe...
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 9, 2014 Category: Neurosurgery Authors: Eccles, J., Iodice, V., Dowell, N., Owens, A., Hughes, L., Skipper, S., Lycette, Y., Humphries, K., Harrison, N., Mathias, C., Critchley, H. Tags: Neurogastroenterology, Genetics, Movement disorders (other than Parkinsons), Muscle disease, Neuromuscular disease, Stroke, Anxiety disorders (including OCD and PTSD), Child and adolescent psychiatry, Mood disorders (including depression), Fibromyalgia, M Source Type: research

The use of stimulant medications for non-core aspects of ADHD and in other disorders.
Abstract Psychostimulants play a central role in the management of ADHD. Here we review the evidence pertaining to the use of methylphenidate, dexamphetamine and related amphetamine salts, the prodrug lisdexamfetamine and modafinil for the management of comorbid ADHD and non-ADHD indications. There is a growing consensus that stimulant medications are helpful at improving the emotional dysregulation and lability, and oppositional and conduct symptoms that are often associated with ADHD. There is some evidence that psychostimulants may improve outcomes in those with treatment resistant depression, reduce negative s...
Source: Neuropharmacology - June 18, 2014 Category: Drugs & Pharmacology Authors: Sinita E, Coghill D Tags: Neuropharmacology Source Type: research

Macular dystrophy associated with the mitochondrial DNA A3243G mutation: pericentral pigment deposits or atrophy? Report of two cases and review of the literature
Conclusion: Observation of RPE abnormalities in the context of suggestive systemic findings should prompt mtDNA testing.
Source: BMC Ophthalmology - Latest articles - June 6, 2014 Category: Opthalmology Authors: Alejandra DaruichAlexandre MatetFrançois-Xavier Borruat Source Type: research

Ceruloplasmin dysfunction: a key factor in the pathophysiology of atrial fibrillation?
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - November 5, 2013 Category: Internal Medicine Authors: Jamie Y Jeremy, Nilima Shukla Tags: Editorial Comment Source Type: research

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