• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Cilostazol for intermittent claudication.
CONCLUSIONS: Cilostazol has been shown to be of benefit in improving walking distance in people with intermittent claudication secondary to PAD. Although there is an increase in adverse side effects, they are generally mild and treatable. There is currently insufficient data on whether taking cilostazol results in a reduction of all-cause mortality and cardiovascular events or an improvement in quality of life. Future research into the effect of cilostazol on intermittent claudication should carefully consider comparability, sample size and homogeneity when designing a study. PMID: 25358850 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - November 5, 2014 Category: Journals (General) Authors: Bedenis R, Stewart M, Cleanthis M, Robless P, Mikhailidis DP, Stansby G Tags: Cochrane Database Syst Rev Source Type: research

Statin therapy and long-term adverse limb outcomes in patients with peripheral artery disease: insights from the REACH registry
Conclusion Among patients with PAD in the REACH registry, statin use was associated with an ~18% lower rate of adverse limb outcomes, including worsening symptoms, peripheral revascularization, and ischaemic amputations. These findings suggest that statin therapy not only reduces the risk of adverse cardiovascular events, but also favourably affects limb prognosis in patients with PAD.
Source: European Heart Journal - November 1, 2014 Category: Cardiology Authors: Kumbhani, D. J., Steg, P. G., Cannon, C. P., Eagle, K. A., Smith, S. C., Goto, S., Ohman, E. M., Elbez, Y., Sritara, P., Baumgartner, I., Banerjee, S., Creager, M. A., Bhatt, D. L., on Behalf of the REACH Registry Investigators Tags: Vascular medicine Source Type: research

Socioeconomic Position and Incidence of Ischemic Stroke in Denmark 2003-2012. A Nationwide Hospital-Based Study Stroke
Conclusions In Denmark, there is a strong relation between low socioeconomic position and risk for hospitalization for stroke. Lifestyle, as indicated by smoking, obesity, and alcohol consumption, and diabetes appears to increase the risk for stroke in people with lower socioeconomic position.
Source: JAHA:Journal of the American Heart Association - July 16, 2014 Category: Cardiology Authors: Andersen, K. K., Steding-Jessen, M., Dalton, S. O., Olsen, T. S. Tags: Stroke Source Type: research

Herpes zoster as a risk factor for stroke and TIA: A retrospective cohort study in the UK
Conclusion: HZ is an independent risk factor for vascular disease in the UK population, particularly for stroke, TIA, and MI in subjects affected before the age of 40 years. In older subjects, better ascertainment of vascular risk factors and earlier intervention may explain the reduction in risk of stroke after HZ infection.
Source: Neurology - July 7, 2014 Category: Neurology Authors: Breuer, J., Pacou, M., Gautier, A., Brown, M. M. Tags: CORRECTED AND REPUBLISHED ARTICLES Source Type: research

Abstract 312: Anatomic Runoff Score Predicts Cardiovascular Outcomes in Patients with Lower Extremity Peripheral Artery Disease Session Title: Poster Session III
Conclusions: After adjustment for clinical factors, the LE-PAD anatomic runoff score, age and indication for procedure were the most significant predictors of future cardiovascular morbidity and mortality in a broadly-representative patient population undergoing revascularization for symptomatic PAD. The use of a clinically useful anatomic scoring system, if validated, may assist clinicians in risk-stratifying patients during the course of clinical decision-making.
Source: Circulation: Cardiovascular Quality and Outcomes - June 2, 2014 Category: Cardiology Authors: Jones, W. S., Patel, M. R., Tsai, T. T., Go, A. S., Gupta, R., Hedayati, N., Ho, P. M., Jazaeri, O., Rogers, R. K., Shetterly, S. M., Wagner, N. M., Magid, D. J. Tags: Session Title: Poster Session III Source Type: research

Screening for peripheral arterial disease.
CONCLUSIONS: Unfortunately, no randomised controlled trial data are available regarding screening for PAD. Therefore, we are unable to determine the effects of screening for PAD in order to guide decision making by healthcare providers and planners. High quality randomised controlled trials evaluating the effectiveness of screening for PAD in asymptomatic and undiagnosed individuals in terms of reduction of all-cause mortality, cardiovascular events (for example myocardial infarction and stroke), morbidity from PAD (intermittent claudication, amputation, reduced walking distance) and improvement in quality of life are need...
Source: Cochrane Database of Systematic Reviews - April 7, 2014 Category: Journals (General) Authors: Andras A, Ferket B Tags: Cochrane Database Syst Rev Source Type: research

Ramipril improves walking times and quality of life in patients with stable intermittent claudication
Commentary on: Ahimastos AA, Walker PJ, Askew C, et al.. Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. JAMA 2013;309:453–60. Context Intermittent claudication (IC) is a common condition that may be associated with significant disability and reduction in quality of life. Pharmacological options for the treatment of the symptoms of this condition are very limited. Naftidrofuryl oxalate is recommended in the National Institute for Health and Care Excellence (NICE) guidelines,1 and while this has been sho...
Source: Evidence-Based Medicine - January 22, 2014 Category: Internal Medicine Authors: Brittenden, J. Tags: Health policy, Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Stroke, Hypertension, Health service research Therapeutics Source Type: research

Prognostic Effect of High-Sensitive Troponin T Assessment in Elderly Patients With Chronic Heart Failure: Results From the CORONA Trial Original Articles
Conclusions— Elevated hs-cTnT levels provide strong and independent prognostic information in older patients with chronic ischemic HF. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00206310.
Source: Circulation: Heart Failure - January 21, 2014 Category: Cardiology Authors: Gravning, J., Askevold, E. T., Nymo, S. H., Ueland, T., Wikstrand, J., McMurray, J. J. V., Aukrust, P., Gullestad, L., Kjekshus, J., on behalf of the CORONA Study Group Tags: Congestive Original Articles Source Type: research

Herpes zoster as a risk factor for stroke and TIA: A retrospective cohort study in the UK
Conclusion: HZ is an independent risk factor for vascular disease in the UK population, particularly for stroke, TIA, and MI in subjects affected before the age of 40 years. In older subjects, better ascertainment of vascular risk factors and earlier intervention may explain the reduction in risk of stroke after the occurrence of HZ.
Source: Neurology - January 20, 2014 Category: Neurology Authors: Breuer, J., Pacou, M., Gauthier, A., Brown, M. M. Tags: Stroke in young adults, Viral infections, All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Study may bust myth of 'fat and fit' healthy obesity
Conclusion This meta-analysis provides further evidence about the known risk factors for cardiovascular disease and mortality. What this study adds is the indication that people who are metabolically unhealthy regardless of their weight are at increased risk. However, interestingly, no increase in risk was seen for the category of people who are metabolically healthy though overweight. A strength of this meta-analysis is the large sample size. However, the results should be interpreted with caution as: The studies did not use the same criteria for assessing metabolic status. The studies did not use the same criteri...
Source: NHS News Feed - December 4, 2013 Category: Consumer Health News Tags: Food/diet Lifestyle/exercise Obesity Source Type: news

Secondhand smoke exposure and intermittent claudication: a Scotland-wide study of 4231 non-smokers
Conclusions As with coronary heart disease and stroke, SHS exposure was independently associated with IC. Our findings add to the published evidence in support of protecting the general public from SHS exposure.
Source: Heart - August 15, 2013 Category: Cardiology Authors: Lu, L., Mackay, D. F., Pell, J. P. Tags: Health policy, Drugs: cardiovascular system, Epidemiology, Tobacco use Peripheral vascular disease Source Type: research

Neuraxial anaesthesia for lower-limb revascularization.
CONCLUSIONS: Available evidence from included trials that compared neuraxial anaesthesia with general anaesthesia was insufficient to rule out clinically important differences for most clinical outcomes. Neuraxial anaesthesia may reduce pneumonia. No conclusions can be drawn with regard to mortality, myocardial infarction and rate of lower-limb amputation, or less common outcomes. PMID: 23897485 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - August 3, 2013 Category: Journals (General) Authors: Barbosa FT, Jucá MJ, Castro AA, Cavalcante JC Tags: Cochrane Database Syst Rev Source Type: research

Low levels of a natural IgM antibody are associated with vein graft stenosis and failure
Conclusions: A naturally occurring IgM antibody directed against the proinflammatory epitope PC may be protective against vein graft stenosis and failure, through anti-inflammatory mechanisms. Measurement of this antibody may be a useful prognostic indicator, although larger studies of more diverse populations will be needed to confirm these results. The biological actions of anti-PC IgM suggest it may be useful in developing immunotherapies to improve bypass longevity.
Source: Journal of Vascular Surgery - July 15, 2013 Category: Surgery Authors: Michael Sobel, Katherine I. Moreno, Mayumi Yagi, Ted R. Kohler, Gale L. Tang, Alexander W. Clowes, Xiao-Hua A. Zhou, Evercita Eugenio Tags: Clinical research studies Source Type: research

Risk factor burden predicts long‐term mortality after cerebral infarction
ConclusionIncreasing number of traditional risk factors is associated with long‐term mortality in patients with cerebral infarction, irrespective of age. Careful long‐term follow‐up is important, especially among patients with several risk factors.
Source: Acta Neurologica Scandinavica - June 27, 2013 Category: Neurology Authors: G. Gjerde, H. Naess Tags: Original Article Source Type: research

Insulin Resistance, Small LDL Particles, and Risk for Atherosclerotic Disease.
Abstract There is a global epidemic of obesity, metabolic syndrome, and diabetes mellitus. Insulin resistance (IR) is etiologic for both metabolic syndrome and diabetes mellitus. IR induces a broad range of toxic systemic effects, including dyslipidemia, hypertension, hyperglycemia, increased production of advanced glycosylation end products, increased inflammatory tone, as well as a prothrombotic and pro-oxidative state. Patients with IR are highly vulnerable to the development of accelerated atherosclerosis as well its clinical sequelae, including coronary artery disease and myocardial infarction, carotid artery...
Source: Current Vascular Pharmacology - April 25, 2013 Category: Drugs & Pharmacology Authors: Toth PP Tags: Curr Vasc Pharmacol Source Type: research

Pages: 1  2  3  4  5  6  7