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Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke
AbstractEarly reperfusion is increasingly prioritized in ischemic stroke care, but outcomes remain suboptimal. Therefore, there is an urgent need to find neuroprotective approaches that can be combined with reperfusion to maximize efficacy. Here, the neuroprotective mechanisms behind therapeutic hypothermia were evaluated in a monkey model of ischemic stroke. Focal ischemia was induced in adult rhesus monkeys by placing autologous clots in the middle cerebral artery. Monkeys were treated with tissue plasminogen activator (t-PA) alone or t-PA plus selective intra-arterial cooling (SI-AC). Serial MRI scans and functional def...
Source: Neurotherapeutics - July 23, 2020 Category: Neurology Source Type: research

Comparison of three haemodynamic monitoring methods in comatose post cardiac arrest patients.
CONCLUSION: We found low bias, but relatively wide limits of agreement in SV with PiCCO, FloTrac/Vigileo and TTE during TTM treatment. The methods are not interchangeable. Precision was not improved by transpulmonary thermodilution calibration during hypothermia. PMID: 29544369 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - March 20, 2018 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

The Medical Emergency Of Otto Warmbier
All that the doctors who treated Cincinnati, Ohio resident Otto Warmbier knew is what they had seen or maybe read in the news. They knew he had just been released on June 13 from imprisonment in North Korea where he had been held by for more than 17 months. He had been sentenced in March 2016 to 15 years of hard labor for allegedly removing a propaganda poster from a wall at a Pyongyang hotel where he had been staying. The University of Virginia honors student had been visiting the authoritarian state during a five-day trip with a group called Young Pioneer Tours, which is a group out of China – an important note. Ot...
Source: Healthy Living - The Huffington Post - June 22, 2017 Category: Consumer Health News Source Type: news

Intraoperative mild hypothermia for postoperative neurological deficits in people with intracranial aneurysm.
CONCLUSIONS: It remains possible that intraoperative mild hypothermia could prevent death or dependency in activities of daily living in people with good grade aneurysmal subarachnoid haemorrhage. However, the confidence intervals around this estimate include the possibility of both benefit and harm. There was insufficient information to draw any conclusions about the effects of intraoperative mild hypothermia in people with poor grade aneurysmal subarachnoid haemorrhage or without subarachnoid haemorrhage. We did not identify any reliable evidence to support the routine use of intraoperative mild hypothermia. A high-quali...
Source: Cochrane Database of Systematic Reviews - March 21, 2016 Category: Journals (General) Authors: Li LR, You C, Chaudhary B Tags: Cochrane Database Syst Rev Source Type: research

Between Extremes: Health Effects of Heat and Cold
Nate Seltenrich covers science and the environment from Petaluma, CA. His work has appeared in High Country News, Sierra, Yale Environment 360, Earth Island Journal, and other regional and national publications. Background image: © Roy Scott About This Article open Citation: Seltenrich N. 2015. Between extremes: health effects of heat and cold. Environ Health Perspect 123:A275–A279; http://dx.doi.org/10.1289/ehp.123-A275 Published: 1 November 2015 PDF Version (2.4 MB) Although heat waves and cold snaps pose major health risks and grab headlines when they occur, recent studies have uncovered a more complex and...
Source: EHP Research - November 2, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News November 2015 Source Type: research

Therapeutic hypothermia for acute brain injuries
Therapeutic hypothermia, recently termed target temperature management (TTM), is the cornerstone of neuroprotective strategy. Dating to the pioneer works of Fay, nearly 75 years of basic and clinical evidence support its therapeutic value. Although hypothermia decreases the metabolic rate to restore the supply and demand of O2, it has other tissue-specific effects, such as decreasing excitotoxicity, limiting inflammation, preventing ATP depletion, reducing free radical production and also intracellular calcium overload to avoid apoptosis. Currently, mild hypothermia (33°C) has become a standard in post-resuscitative care...
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - June 5, 2015 Category: Emergency Medicine Authors: Max AndresenJose GazmuriArnaldo MarínTomas RegueiraMaximiliano Rovegno Source Type: research

Increased Brain Perfusion Persists over the First Month of Life in Term Asphyxiated Newborns Treated with Hypothermia: Does it Reflect Activated Angiogenesis?
Abstract Many asphyxiated newborns still develop brain injury despite hypothermia therapy. The development of brain injury in these newborns has been related partly to brain perfusion abnormalities. The purposes of this study were to assess brain hyperperfusion over the first month of life in term asphyxiated newborns and to search for some histopathological clues indicating whether this hyperperfusion may be related to activated angiogenesis following asphyxia. In this prospective cohort study, regional cerebral blood flow was measured in term asphyxiated newborns treated with hypothermia around day 10 of life an...
Source: Translational Stroke Research - January 27, 2015 Category: Neurology Source Type: research

Variables Associated with Effects on Morbidity in Older Adults Following Disasters
Conclusion Older adults are at a known risk for increased morbidity during and shortly after disasters and catastrophic events, especially in the presence of multiple co-morbidities such as hypertension, diabetes, stroke, and heart disease. Other factors, such as the need for prescription medications, low social support, visual and hearing impairment, impaired mobility, and poor economic status, have also been associated with an increased risk of negative health outcomes. The utilization of existing databases of older adults’ vulnerabilities and the measurement of the prevalence of these risk factors in the community may...
Source: PLOS Currents Disasters - December 5, 2014 Category: Global & Universal Authors: jenkins at jhmi.edu Source Type: research

Accidental hypothermia and local cold injury: physiological and epidemiological studies on risk
ConclusionsHypothermia and cold injury continue to cause injury and hospitalisation in the northern region of Sweden. Assessment and management is not standardised across hospitals. With the identification of groups at high risk for fatal hypothermia, it should be possible to reduce the incidence, particularly for highest risk subjects: rural, living alone, alcohol imbibing, and psychiatric diagnosis‐carrying citizens. Long‐term cold‐weather training may affect hand‐rewarming patterns after a cold provocation, and a warmer baseline hand temperature with faster rewarming after a cold provocation may be associated wi...
Source: Acta Anaesthesiologica Scandinavica - January 7, 2013 Category: Anesthesiology Authors: HELGE BRÄNDSTRÖM Tags: PhD Abstract Source Type: research