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Condition: Hydrocephalus

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Total 527 results found since Jan 2013.

Intraventricular Hemorrhage: the Role of Blood Components in Secondary Injury and Hydrocephalus
Source: Translational Stroke Research - June 29, 2016 Category: Neurology Source Type: research

E-099 Does Anterior Cerebral Artery Vasospasm after Spontaneous Subarachnoid Hemorrhage Predict Short Term Cognitive Outcome
ConclusionsOur study reaffirms that occurrence of DCI after SAH predicts poor cognitive outcome at 3 months. The fact that cognitive outcomes were not superior in patients treated for CVS suggests that a complex pathophysiology determines outcomes after SAH. Relatively poor cognitive outcome among patients with SAH in locations other than ACA/ACom alludes to involvement of functional neural network apart from frontal lobe based networks that needs further investigation.DisclosuresV. Pandav: None. B. Bohnstedt: None. L. Yearout: None. D. Thompson: None. B. Ray: None.
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Pandav, V., Bohnstedt, B., Yearout, L., Thompson, D., Ray, B. Tags: Electronic poster abstracts Source Type: research

Revisiting secondary normal pressure hydrocephalus: does it exist? A review.
CONCLUSIONS Secondary NPH encompasses a diverse group of clinical manifestations associated with a subset of patients with acquired hydrocephalus. The most common etiologies of sNPH include SAH and traumatic brain injury. Secondary NPH does indeed exist, and should be differentiated from idiopathic NPH based on outcome and on clinical, pathophysiological, and epidemiological characteristics, but should not be considered as a separate entity. PMID: 27581318 [PubMed - in process]
Source: Neurosurgical Focus - August 31, 2016 Category: Neurosurgery Authors: Daou B, Klinge P, Tjoumakaris S, Rosenwasser RH, Jabbour P Tags: Neurosurg Focus Source Type: research

An improved reservoir for the flushing test to diagnose shunt insufficiency.
CONCLUSIONS Shunt obstructions can be assessed using the pumping test. The reservoir construction presented here provides a clear enhancement of that diagnostic test. PMID: 27581310 [PubMed - in process]
Source: Neurosurgical Focus - August 31, 2016 Category: Neurosurgery Authors: Schlosser HG, Crawack HJ, Miethke C, Knitter T, Zeiner A, Sprung C Tags: Neurosurg Focus Source Type: research

Merging Transport Data for Choroid Plexus with Blood-Brain Barrier to Model CNS Homeostasis and Diseases More Effectively.
Abstract Robust modeling of CNS transport integrates molecular fluxes at the microvascular blood-brain barrier and epithelial choroid plexus blood-CSF barrier. Normal activity of solute transporters, channels and aquaporins, in the cerebral endothelium and choroidal epithelium, sets the microenvironment composition for neurons and glia. Conversely, perturbed transport/permeability at the barrier interfaces causes interstitial fluid dyshomeostasis (e.g. edema) arising in neural disorders. Critically-important transependymal solute/water distribution between brain and CSF needs more attention. This treatise encourag...
Source: CNS and Neurological Disorders Drug Targets - September 14, 2016 Category: Drugs & Pharmacology Authors: Johanson C, Johanson N Tags: CNS Neurol Disord Drug Targets Source Type: research

Risk of Shunting After Aneurysmal Subarachnoid Hemorrhage: A Collaborative Study and Initiation of a Consortium Clinical Sciences
Conclusions— Shunt dependency after aSAH is associated with higher morbidity and mortality, and prediction modeling of shunt dependency is feasible with clinically useful yields. It is important to identify and understand the factors that increase risk for shunting and to eliminate or mitigate the reversible factors. The aSAH-PARAS Consortium (Aneurysmal Subarachnoid Hemorrhage Patients’ Risk Assessment for Shunting) has been initiated to pool the collective insights and resources to address key questions in post-aSAH shunt dependency to inform future aSAH treatment guidelines.
Source: Stroke - September 25, 2016 Category: Neurology Authors: Adams, H., Ban, V. S., Leinonen, V., Aoun, S. G., Huttunen, J., Saavalainen, T., Lindgren, A., Frosen, J., Fraunberg, M., Koivisto, T., Hernesniemi, J., Welch, B. G., Jaaskelainen, J. E., Huttunen, T. J. Tags: Epidemiology, Risk Factors, Complications, Quality and Outcomes, Cerebral Aneurysm Clinical Sciences Source Type: research

Hydrocephalus associated with childhood nonaccidental head trauma.
CONCLUSIONS PTV presents early after NAHT, particularly after a DC has been performed. However, the authors found that only a few PTV/NAHT patients developed shunt-dependent hydrocephalus. PMID: 27798981 [PubMed - in process]
Source: Neurosurgical Focus - October 31, 2016 Category: Neurosurgery Authors: Vadivelu S, Rekate HL, Esernio-Jenssen D, Mittler MA, Schneider SJ Tags: Neurosurg Focus Source Type: research

Cerebral vasospasm and delayed cerebral infarctions in 225 patients with non-aneurysmal subarachnoid hemorrhage: the underestimated risk of Fisher 3 blood distribution
Conclusions Patients with NASAH without a Fi3 bleeding pattern had a similar excellent outcome to patients with PM-SAH. Patients with Fi3 had a high risk for early hydrocephalus, CVS, DCI, and an unfavorable outcome, similar to patients with aneurysmal SAH. After multivariate analysis, early hydrocephalus, elderly patients, and Fi3 were identified as negative prognostic factors. Therefore, patients with Fi3 are at risk and need careful clinical observation.
Source: Journal of NeuroInterventional Surgery - November 14, 2016 Category: Neurosurgery Authors: Konczalla, J., Kashefiolasl, S., Brawanski, N., Lescher, S., Senft, C., Platz, J., Seifert, V. Tags: Hemorrhagic stroke Source Type: research

Possible role of transforming growth factor β in tuberculous meningitis.
CONCLUSION: CSF TGF-β levels are elevated in TBM and correlate with infarction and tuberculoma. PMID: 27865204 [PubMed - as supplied by publisher]
Source: Cytokine - November 15, 2016 Category: Molecular Biology Authors: Kalita J, Misra UK, Bhoi SK, Chauhan PS, Sagar B Tags: Cytokine Source Type: research

Cerebral Amyloid Deposition Is Associated with Gait Parameters in the Mayo Clinic Study of Aging
ConclusionPiB‐PET SUVR across ROIs, independent of general measures of AD‐associated neurodegeneration, is associated with poorer performance on multiple gait parameters among cognitively normal women, aged 50 to 69 years. Longitudinal studies are needed to determine whether Aβ predicts gait decline in both women and men.
Source: Journal of the American Geriatrics Society - November 20, 2016 Category: Geriatrics Authors: Alexandra M. V. Wennberg, Rodolfo Savica, Clinton E. Hagen, Rosebud O. Roberts, David S. Knopman, John H. Hollman, Prashanthi Vemuri, Clifford R. Jack, Ronald C. Petersen, Michelle M. Mielke Tags: Clinical Investigations Source Type: research

MRI Characterization in the Acute Phase of Experimental Subarachnoid Hemorrhage
In conclusion, T2 lesion, WMI, and hydrocephalus were the most prevalent MRI characteristics 24 h after experimental SAH. The T2 lesion area matched with fibrinogen/fibrin positive staining in the acute phase of SAH. SAH induced more s evere brain injury in females compared to males in the acute phase of SAH.
Source: Translational Stroke Research - November 27, 2016 Category: Neurology Source Type: research

The learning curve in endoscopic endonasal resection of craniopharyngiomas.
CONCLUSIONS High rates of near- or total resection and visual improvement can be achieved using an endoscopic endonasal approach for craniopharyngiomas. However, the authors did find evidence for a learning curve. After 20 cases, they found a significant decrease in major neurological complications and significant increases in the rates of GTR rate and discharge to home. Although there was a large decrease in the rate of postoperative CSF leak over time, this was largely attributable to the inclusion of very early cases prior to the routine use of vascularized nasoseptal flaps. There was a significant increase in new panhy...
Source: Neurosurgical Focus - November 30, 2016 Category: Neurosurgery Authors: Kshettry VR, Do H, Elshazly K, Farrell CJ, Nyquist G, Rosen M, Evans JJ Tags: Neurosurg Focus Source Type: research

Acute Posterior Cranial Fossa Hemorrhage —Is Surgical Decompression Better than Expectant Medical Management?
ConclusionsSDC following PCFH was associated with a reduction in mortality compared to expectant MT with or without EVD insertion. A high-quality multicenter randomized control trial is required to evaluate the superiority of SDC for PCFH.
Source: Neurocritical Care - November 30, 2016 Category: Neurology Source Type: research

Evaluating the effect of hydrocephalus cause on the manner of changes in the effective parameters and clinical symptoms of the disease
Publication date: January 2017 Source:Journal of Clinical Neuroscience, Volume 35 Author(s): Seifollah Gholampour, Nasser Fatouraee, Amir Saeed Seddighi, Afsoun Seddighi In the present study, the heads of 11 normal subjects and 21 patients affected by hydrocephalus due to three different causes were simulated using fluid–structure interaction (FSI). To validate the results, the calculated diagram of CSF velocity in aqueduct of Sylvius (AS) was compared with the similar velocity diagram measured using Cine PC-MRI for the same subject. After ensuring the agreement of results, other outputs such as CSF pressure were calcul...
Source: Journal of Clinical Neuroscience - December 14, 2016 Category: Neuroscience Source Type: research

Simvastatin Promotes Hematoma Absorption and Reduces Hydrocephalus Following Intraventricular Hemorrhage in Part by Upregulating CD36
AbstractWe previously found that hematoma worsens hydrocephalus after intraventricular hemorrhage (IVH) via increasing iron deposition and aggravating ependymal cilia injury; therefore, promoting hematoma absorption may be a promising strategy for IVH. Recently, some investigations imply that simvastatin has the ability of accelerating hematoma absorption. Thus, this study was designed to examine the efficacy of simvastatin for IVH in rats. Intracerebral hemorrhage with ventricular extension was induced in adult male Sprague –Dawley rats after autologous blood injection. Simvastatin or vehicle was administered orally at ...
Source: Translational Stroke Research - January 18, 2017 Category: Neurology Source Type: research