Evaluating the effect of hydrocephalus cause on the manner of changes in the effective parameters and clinical symptoms of the disease

Publication date: January 2017 Source:Journal of Clinical Neuroscience, Volume 35 Author(s): Seifollah Gholampour, Nasser Fatouraee, Amir Saeed Seddighi, Afsoun Seddighi In the present study, the heads of 11 normal subjects and 21 patients affected by hydrocephalus due to three different causes were simulated using fluid–structure interaction (FSI). To validate the results, the calculated diagram of CSF velocity in aqueduct of Sylvius (AS) was compared with the similar velocity diagram measured using Cine PC-MRI for the same subject. After ensuring the agreement of results, other outputs such as CSF pressure were calculated non-invasively using FSI. The intracranial pressure and CSF pressure in AS and behind the optic nerve sheath were in patients 5–5.3 times the value in normal subjects and the ventricular system volume in patients was 10.2–11.1 times the value in normal subjects. However, the difference between the coefficient of variation and the maximum value of pressure and volume in different types of hydrocephalus was small. Furthermore, the difference between CSF stroke volumes in various types of hydrocephalus patients was less than 4.4%. Results showed that the intensity of clinical symptoms was similar in patients with similar CSF pressure and the cause of the hydrocephalus disease didn’t have any significant effect on the intensity of patients’ clinical symptoms and the manner of changes in effective parameters on disease. It was also found that th...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research