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Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways
This study aimed to update and summarize progress in understanding how natural medicines treat AS via inflammatory and oxidative stress-related signaling pathways. We also planned to create an information base for the development of novel drugs for future AS treatment.PMID:36249778 | PMC:PMC9563010 | DOI:10.3389/fphar.2022.997598
Source: Atherosclerosis - October 17, 2022 Category: Cardiology Authors: Tianwei Meng Xinghua Li Chengjia Li Jiawen Liu Hong Chang Nan Jiang Jiarui Li Yabin Zhou Zhiping Liu Source Type: research

Association of polygenic risk scores with incident atherosclerotic cardiovascular disease events among individuals with coronary artery calcium score of zero: The multi-ethnic study of atherosclerosis
CONCLUSIONS: Among individuals with CAC = 0, the ASCVD PRS was associated with incident ASCVD events. This appears to be driven by genetic variants related to stroke but not CHD, and particularly among women and non-Whites. ASCVD event rates remained below the threshold recommended for consideration for initiation of statin therapy even in the high PRS groups.PMID:35952728 | DOI:10.1016/j.pcad.2022.08.003
Source: Atherosclerosis - August 11, 2022 Category: Cardiology Authors: Mahmoud Al Rifai Jie Yao Xiuqing Guo Wendy S Post Shaista Malik Roger S Blumenthal Christie M Ballantyne Matthew Budoff Kent D Taylor Henry J Lin Stephen S Rich Catherine Hajek Philip Greenland Jerome I Rotter Salim S Virani Source Type: research

Exposure to phthalates and cardiovascular diseases in Chinese with type 2 diabetes
In conclusion, phthalate exposure was positively associated with CVD in Chinese with type 2 diabetes. Type 2 diabetic men who are currently smoking, have an uncontrolled lipid profile, and are not using statins might be more susceptible to CVD when exposed to phthalates.PMID:34109519 | DOI:10.1007/s11356-021-14807-4
Source: Environmental Science and Pollution Research International - June 10, 2021 Category: Environmental Health Authors: Haojie Zhang Jingsi Chen Chi Chen Heng Wan Yi Chen Yuying Wang Wen Zhang Bo Chen Ningjian Wang Yingli Lu Source Type: research

Impacts of Clinical Pharmacist Intervention on the Secondary Prevention of Coronary Heart Disease: A Randomized Controlled Clinical Study
This study aimed to investigate the impact of clinical pharmacist intervention on the prognosis of acute coronary syndrome (ACS) in Chinese patients with CHD. Two hundred and forty patients who had ACS were recruited. Participants were randomly assigned to the intervention group (n = 120) or the control group (n = 120). The intervention group received a medication assessment and education by the clinical pharmacist at discharge and telephone follow-ups at 1 week and 1 and 3 months after discharge. The control group received usual care. The primary outcomes of this study were the proportion of patients who had major adverse...
Source: Frontiers in Pharmacology - October 7, 2019 Category: Drugs & Pharmacology Source Type: research

How to continue lipid-lowering therapy in patients with coronary heart disease and severe liver dysfunction?: A case report of plaque regression by a combination of Chinese and Western Medicine
Rationale: Atherosclerotic cardiovascular disease (ASCVD), including coronary heart disease (CHD), atherosclerotic stroke and peripheral vascular disease, has become the most deadly chronic noncommunicable disease throughout the world in recent decades, while plaque regression could reduce the occurrence of ASCVD. Traditional Chinese Medicine (TCM) has been widely used for prevention and treatment of these diseases. In the perspective of TCM, phlegm and blood stasis are considered to be leading pathogenesis for CHD. Hence, activating blood circulation and dissipating phlegm, which is of great benefit to regress plaque, h...
Source: Medicine - October 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Ability to Suppress TGF- β-Activated Myofibroblast Differentiation Distinguishes the Anti-pulmonary Fibrosis Efficacy of Two Danshen-Containing Chinese Herbal Medicine Prescriptions
Conclusion: This study suggests that a clinically efficacious cardiovascular Chinese herbal medicine (DLP) can be successfully repurposed to treat a lung disease in pulmonary fibrosis guided by TCM theory. Our comparative study between DLP and DHP demonstrated a critical requirement of suppressing both pro-inflammatory and pro-fibrotic pathways for the treatment of pulmonary fibrosis, supporting that a multi-component prescription capable of “removing both phlegm and blood stasis” will better achieve co-protection of heart and lung in PHD. Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic ...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Low LDL-C and risk of hemorrhagic stroke in Chinese adults
It is well-established that higher LDL and total cholesterol are associated with increased risk of atherosclerotic cardiovascular disease (ASCVD), that is, coronary heart disease (CHD) and ischemic stroke events, and that cholesterol-lowering by statins and other therapies reduce ASCVD risk. However, the picture is less clear for the 10% to 20% of strokes that are hemorrhagic rather than ischemic. A meta-analysis of observational studies shows that lower levels of LDL-C and total cholesterol are associated with higher risk of hemorrhagic strokes (HS), and with intracranial hemorrhage (ICH), a subset of HS.
Source: Journal of Clinical Lipidology - September 1, 2018 Category: Lipidology Authors: Rachel H. Mackey Tags: Editorial Source Type: research

Association between the   TIMD4-HAVCR1 variants and serum lipid levels, coronary heart disease and ischemic stroke risk and atorvastatin lipid-lowering efficacy.
This study aimed to determine the TIMD4-HAVCR1 variants, their haplotypes and gene-environment interactions on serum lipid levels, the risk of CHD and IS, and the lipid-lowering efficacy of atorvastatin in a southern Chinese Han population. Genotypes of 3 variants in 622 controls, 579 CHD and 546 IS patients were determined by the Snapshot technology. Atorvastatin calcium tablet (20 mg/d) was given in 724 hyperlipidemic patients for 8 weeks after genotyping. The rs12522248 genotypic and allelic frequencies were different between controls and patients, and were associated with the risk of CHD and IS. The rs1501908G-rs125222...
Source: Bioscience Reports - December 5, 2017 Category: Biomedical Science Authors: Zhang QH, Yin RX, Chen WX, Cao XL, Chen YM Tags: Biosci Rep Source Type: research

Use of drug treatment for secondary prevention of cardiovascular disease in urban and rural communities of China: China Kadoorie Biobank Study of 0.5million people
Conclusions: Despite recent improvements in hospital care in China, only one in three individuals with prior CVD was routinely treated with any proven secondary preventive drugs. The treatment rates were correlated with the existence of other risk factors, in particular evidence of hypertension.
Source: International Journal of Cardiology - January 23, 2014 Category: Cardiology Authors: Yiping Chen, Liming Li, Qiuli Zhang, Robert Clarke, Junshi Chen, Yu Guo, Zheng Bian, Xianhai Pan, Richard Peto, Ran Tao, Kunxiang Shi, Rory Collins, Liangcai Ma, Huarong Sun, Zhengming Chen, on behalf of China Kadoorie Biobank Study Tags: Original Articles Source Type: research