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Correlation of apolipoprotein AI, apolipoprotein B and their ratio with the severity of cerebral white matter lesions.
CONCLUSIONS: An increased ApoB/AI ratio is an independent risk factor and an increased ApoAI level is an independent protective factor for moderate to severe WML. PMID: 30187870 [PubMed - in process]
Source: Journal of Southern Medical University - July 30, 2018 Category: Universities & Medical Training Authors: Huang W, Lv T, Li H, Du S, Yang C, Yuan S Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

Exercise Cardiac Magnetic Resonance Imaging: A feasibility study and Meta-Analysis.
Abstract Cardiac stress testing improves detection and risk assessment of heart disease. Magnetic resonance imaging (MRI) is the clinical gold-standard for assessing cardiac morphology and function at rest; however, exercise MRI has not been widely adapted for cardiac assessment due to imaging and device limitations. Commercially available MR ergometers, together with improved imaging sequences, have overcome many previous limitations, making cardiac stress MRI more feasible. Here, we aimed to demonstrate clinical feasibility, and establish the normative, healthy response to supine exercise MRI. Eight young, healt...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - June 27, 2018 Category: Physiology Authors: Beaudry RI, Samuel TJ, Wang J, Tucker WJ, Haykowsky MJ, Nelson MD Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Hemodynamic Characteristics in Significant Symptomatic and Asymptomatic Primary Mitral Valve Regurgitation at Rest and During Exercise Valvular Heart Disease
Conclusions— Symptoms in patients with severe mitral valve regurgitation relate to congestion (pulmonary capillary wedge pressure and PAP), but not to peak oxygen consumption, which is determined by forward left ventricular stroke volume. Exercise testing reveals a higher mitral valve regurgitation burden in apparently asymptomatic patients. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT02961647.
Source: Circulation: Cardiovascular Imaging - February 15, 2018 Category: Radiology Authors: Bakkestrom, R., Banke, A., Christensen, N. L., Pecini, R., Irmukhamedov, A., Andersen, M., Borlaug, B. A., Moller, J. E. Tags: Valvular Heart Disease, Echocardiography, Exercise Testing, Magnetic Resonance Imaging (MRI) Source Type: research

Postoperative Reverse Remodeling and Symptomatic Improvement in Normal-Flow Low-Gradient Aortic Stenosis After Aortic Valve Replacement Valvular Heart Disease
Conclusions— Patients with NFLG had less severe AS and LV remodeling than patients with normal-flow high-gradient. Furthermore, NFLG patients experienced less reverse remodeling but the same symptomatic benefit. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT02316587.
Source: Circulation: Cardiovascular Imaging - December 8, 2017 Category: Radiology Authors: Carter-Storch, R., Moller, J. E., Christensen, N. L., Irmukhadenov, A., Rasmussen, L. M., Pecini, R., Ovrehus, K. A., Sondergard, E. V., Marcussen, N., Dahl, J. S. Tags: Valvular Heart Disease, Aortic Valve Replacement/Transcatheter Aortic Valve Implantation Source Type: research

Left ventricular diastolic dysfunction in women with nonobstructive ischemic heart disease: insights from magnetic resonance imaging and spectroscopy
Ischemic heart disease, in the absence of obstructive coronary artery disease, is prevalent in women and constitutes a major risk factor for developing major adverse cardiovascular events, including myocardial infarction, stroke, and heart failure. For decades, diagnosis was considered benign and often minimized; however, it is now known that this etiology carries much risk and is a significant burden to the health care system. This review summarizes the current state of knowledge on nonobstructive ischemic heart disease (NOIHD), the association between NOIHD and left ventricular diastolic dysfunction, potential links betw...
Source: AJP: Regulatory, Integrative and Comparative Physiology - October 1, 2017 Category: Physiology Authors: Nelson, M. D. Tags: Review Source Type: research

Pericardial, But Not Hepatic, Fat by CT Is Associated With CV Outcomes and Structure: The Multi-Ethnic Study of Atherosclerosis
Conclusions Pericardial fat is associated with poorer CVD prognosis and LV remodeling, independent of insulin resistance, inflammation, and CT measures of hepatic fat.
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - September 4, 2017 Category: Radiology Authors: Shah, R. V., Anderson, A., Ding, J., Budoff, M., Rider, O., Petersen, S. E., Jensen, M. K., Koch, M., Allison, M., Kawel-Boehm, N., Wisocky, J., Jerosch-Herold, M., Mukamal, K., Lima, J. A. C., Murthy, V. L. Tags: Original Research Source Type: research

Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular EventsNovelty and Significance Arterial Stiffness
The predictive value of aortic arch pulse wave velocity (PWV) assessed by magnetic resonance imaging for cardiovascular disease (CVD) events has not been fully established. The aim of the present study was to evaluate the association of arch PWV with incident CVD events in MESA (Multi-Ethnic Study of Atherosclerosis). Aortic arch PWV was measured using magnetic resonance imaging at baseline in 3527 MESA participants (mean age, 62±10 years at baseline; 47% men) free of overt CVD. Cox regression was used to evaluate the risk of incident CVD (coronary heart disease, stroke, transient ischemic attack, or heart failure) in rel...
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: Yoshiaki Ohyama, Bharath Ambale-Venkatesh, Chikara Noda, Jang-Young Kim, Yutaka Tanami, Gisela Teixido-Tura, Atul R. Chugh, Alban Redheuil, Chia-Ying Liu, Colin O. Wu, W. Gregory Hundley, David A. Bluemke, Eliseo Guallar, Joao A.C. Lima Tags: Epidemiology, Magnetic Resonance Imaging (MRI) Original Articles Source Type: research

Left ventricular diastolic dysfunction in women with non-obstructive ischemic heart disease: Insights from magnetic resonance imaging and spectroscopy.
Abstract Ischemic Heart Disease, in the absence of obstructive coronary artery disease, is prevalent in women, and constitutes a major risk factor for developing major adverse cardiovascular events, including myocardial infarction, stroke, and heart failure. For decades, diagnosis was considered benign and often minimized; however, it is now known that this etiology caries much risk and is a significant burden to the health care system. This review summarizes the current state-of-knowledge on non-obstructive ischemic heart disease (NOIHD), the association between NOIHD and left ventricular diastolic dysfunction, p...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 9, 2017 Category: Physiology Authors: Nelson MD Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Turbulent Kinetic Energy Assessed by Multipoint 4-Dimensional Flow Magnetic Resonance Imaging Provides Additional Information Relative to Echocardiography for the Determination of Aortic Stenosis Severity Valvular Heart Disease
Conclusions— Elevated TKE levels imply higher energy losses associated with bicuspid aortic valves and dilated ascending aortic geometries that are not assessable by current echocardiographic measures. These findings indicate that TKE may provide complementary information to echocardiography, helping to distinguish within the heterogeneous population of patients with moderate to severe AS.
Source: Circulation: Cardiovascular Imaging - June 13, 2017 Category: Radiology Authors: Binter, C., Gotschy, A., Sundermann, S. H., Frank, M., Tanner, F. C., Luscher, T. F., Manka, R., Kozerke, S. Tags: Hemodynamics, Pathophysiology, Valvular Heart Disease, Magnetic Resonance Imaging (MRI) Source Type: research

Knowledge ‐based reconstruction for measurement of right ventricular volumes on cardiovascular magnetic resonance images in a mixed population
ConclusionA systematic difference (overestimation) was noted for right ventricular size as assessed with knowledge‐based reconstruction compared with conventional methods for analysis. Observer variability for the new method was comparable to what has been reported for the right ventricle in children and congenital heart disease with conventional analysis.
Source: Congenital Heart Disease - June 5, 2017 Category: Cardiology Authors: Elise D. Pieterman, Ricardo P. J. Budde, Dani ëlle Robbers‐Visser, Ron T. van Domburg, Willem A. Helbing Tags: ORIGINAL ARTICLE Source Type: research

Association between leukoaraiosis and hemorrhagic transformation after cardioembolic stroke due to atrial fibrillation and/or rheumatic heart disease
Cardioembolic stroke due to atrial fibrillation (AF) and/or rheumatic heart disease (RHD) often involves hemorrhagic transformation (HT), and we examined whether leukoaraiosis (LA) was associated with HT in these cases. We prospectively enrolled 251 patients who were admitted to two hospitals within one month of experiencing cardioembolic stroke due to AF/RHD. LA severity was assessed using three visual rating scales. HT was identified in 99 patients (39.4%) based on baseline computed tomography (CT) and post-admission magnetic resonance imaging or second CT.
Source: Journal of the Neurological Sciences - May 2, 2017 Category: Neurology Authors: Chen-Chen Wei, Shu-Ting Zhang, Yun-Han Wang, Jun-Feng Liu, Jie Li, Ruo-Zhen Yuan, Ge Tan, Shi-Hong Zhang, Ming Liu Source Type: research

Cerebral Microbleeds Do Not Predict Hemorrhagic Transformation in Acute Ischemic Stroke Patients with Atrial Fibrillation and/or Rheumatic Heart Disease.
Conclusion The present study suggests that CMBs do not predict the presence of hemorrhagic transformation in acute ischemic stroke patients with AF and/or RHD. The results were not affected by anticoagulant or antiplatelet agents used in acute stage of ischemic stroke. PMID: 28294063 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - March 12, 2017 Category: Neurology Authors: Liu J, Wang D, Li J, Lin J, Xiong Y, Liu B, Wei C, Wu B, Ma Z, Zhang S, Liu M Tags: Curr Neurovasc Res Source Type: research

Impaired atrioventricular transport in patients with transposition of the great arteries palliated by atrial switch and preserved systolic right ventricular function: A magnetic resonance imaging study
ConclusionsSystemic right ventricle pre‐load and stroke volume depend mainly on intraatrial pathway function. Moreover, systemic right ventricle remodeling and right atrial dysfunction impair systemic right ventricle filling, leading to BNP increase and exercise limitation. Cardiac magnetic resonance imaging should assess systemic right ventricle filling abnormalities in D‐TGA patients.
Source: Congenital Heart Disease - March 1, 2017 Category: Cardiology Authors: Magalie Ladouceur, Nadjia Kachenoura, Gilles Soulat, Emilie Bollache, Alban Redheuil, Michel Azizi, Christophe Delclaux, Gilles Chatellier, Pierre Boutouyrie, Laurence Iserin, Damien Bonnet, Elie Mousseaux Tags: ORIGINAL ARTICLE Source Type: research

Idiopathic and Systemic Sclerosis associated Pulmonary Arterial Hypertension: A Comparison of Demographic, Haemodynamic and Magnetic Resonance Imaging Characteristics and Outcomes.
CONCLUSION: The reasons for poorer outcomes in SSc-PAH are likely to be multifactorial including, but not limited to, older age and reduced gas transfer. PMID: 28223154 [PubMed - as supplied by publisher]
Source: Chest - February 17, 2017 Category: Respiratory Medicine Authors: Ramjug S, Hussain N, Hurdman J, Billings C, Charampopoulos A, Elliot CA, Kiely DG, Sabroe I, Rajaram S, Swift AJ, Condliffe R Tags: Chest Source Type: research

Comparison of Carotid Plaque Score and Coronary Artery Calcium Score for Predicting Cardiovascular Disease Events: The Multi-Ethnic Study of Atherosclerosis Epidemiology
BackgroundCoronary artery calcium (CAC) predicts coronary heart disease (CHD) events better than carotid wall plaque presence; however, differences in the utility of CAC burden and carotid plaque burden across the spectrum of cardiovascular disease (CVD) events is unknown.Methods and ResultsCVD, CHD and stroke/transient ischemic attack (TIA) events were evaluated prospectively in a multiethnic cohort without CVD at baseline. Carotid plaque score was determined by the number of ultrasound‐detected plaques in the common, bifurcation, and internal carotid artery segments. CAC was detected by computed tomography. Predictive ...
Source: JAHA:Journal of the American Heart Association - February 14, 2017 Category: Cardiology Authors: Gepner, A. D., Young, R., Delaney, J. A., Budoff, M. J., Polak, J. F., Blaha, M. J., Post, W. S., Michos, E. D., Kaufman, J., Stein, J. H. Tags: Epidemiology, Primary Prevention, Risk Factors, Computerized Tomography (CT), Magnetic Resonance Imaging (MRI) Original Research Source Type: research

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