• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Associations of Serum 25(OH)D with Risk of Recurrent Cardiovascular Events in Individuals with Coronary Heart Disease
This study aimed to investigate the associations of serum 25-hydroxyvitamin D [25(OH)D] concentration and the vitamin D receptor (VDR) polymorphisms with the risk of recurrent cardiovascular events in individuals with established CHD.METHODS: A total of 22,571 participants with CHD were included from the UK Biobank. Recurrent cardiovascular events, including myocardial infarction (MI), heart failure (HF), stroke, and CVD mortality, were identified from electronic health records. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).RESULTS: The median (interquartile ra...
Source: The Journal of Clinical Endocrinology and Metabolism - June 6, 2023 Category: Endocrinology Authors: Xiaoyu Lin Xue Chen Sen Liu Yulei Deng Yuexuan Wang Qi Lu Rui Li Yunjing Ou Qingying Tian Yunfei Liao Guanglin Cui Kun Yang An Pan Gang Liu Source Type: research

Effectiveness of Simvastatin Versus Gemfibrozil for Primary Prevention of Cardiovascular Events: A Retrospective Cohort Study of 223,699 Primary Care Patients
ConclusionThe results of this study showed better population-level effectiveness of simvastatin compared with gemfibrozil for the primary prevention of MACE; however, a definitive randomized controlled trial is required to compare simvastatin with gemfibrozil among patients with low HDL cholesterol, as they appear to obtain benefit with gemfibrozil.
Source: Clinical Drug Investigation - October 14, 2022 Category: Drugs & Pharmacology Source Type: research

Comparative Risks of Nonsteroidal Antiinflammatory Drugs on Cardiovascular Diseases: A Population-Based Cohort Study
This article is protected by copyright. All rights reserved.PMID:36063443 | DOI:10.1002/jcph.2142
Source: The Journal of Clinical Pharmacology - September 5, 2022 Category: Drugs & Pharmacology Authors: Eric Yuk Fai Wan Esther Yee Tak Yu Linda Chan Anna Hoi Ying Mok Yuan Wang Esther Wai Yin Chan Ian Chi Kei Wong Cindy Lo Kuen Lam Source Type: research

Cut-off values for anthropometric indices in predicting morbidity and mortality in Turkey: a cohort
ConclusionsThis cohort study in Turkey showed that having higher anthropometric measurements is mostly associated with higher CHD incidence and mostly lower mortality among older men. This association deserves further studies.Key messagesIn Turkey, higher anthropometric measurements are associated with higher coronary heart disease incidence in among participants.In Turkey, higher anthropometric measurements are mostly associated with lower all-cause mortality in older age-groups.
Source: The European Journal of Public Health - October 20, 2021 Category: General Medicine Source Type: research

Noncommunicable disease incidences in 2012-2017, Turkey
ConclusionsRegardless of the difficulties in comparing incidence of NCD with other countries, we think our results show that hypertension, diabetes, stroke and CHD have higher incidence than Western European countries. We also showed that these metrics can be obtained through data linkage of National Health Records for the first time in Turkey.Key messagesThe NCDs needs to be monitored by surveillance using the current data sources for health services.This data can provide very useful information regularly to monitor and control NCDs if necessary actions are taken to adjust data management.
Source: The European Journal of Public Health - October 20, 2021 Category: General Medicine Source Type: research

Weight Change and the Onset of Cardiovascular Diseases: Emulating Trials Using Electronic Health Records
Conclusion: Among individuals with obesity, the weight-loss group had a lower risk of coronary heart disease but not of stroke. Weight gain was associated with increased risk of CVD across BMI groups. See video abstract at, http://links.lww.com/EDE/B838.
Source: Epidemiology - August 3, 2021 Category: Epidemiology Tags: Chronic Diseases Source Type: research

Electronic Medical Record Risk Modeling of Cardiovascular Outcomes Among Patients with Type 2 Diabetes
ConclusionsThe Ochsner model overestimated 5-year CHD risk, but had relatively higher calibration than the other models in CHD. Risk equations fitted for local populations improved cardiovascular risk stratification for patients with T2DM. Application of machine learning simplified the models compared to “generalized” risk equations.
Source: Diabetes Therapy - June 18, 2021 Category: Endocrinology Source Type: research

Validity of Cardiovascular Disease Event Ascertainment Using Linkage to UK Hospital Records
Conclusion: Our analyses support the validity of cardiovascular disease ascertainment using linkage to the UK Hospital Episode Statistics database records by showing agreement with high resolution disease data collected in the Whitehall II cohort.
Source: Epidemiology - August 2, 2017 Category: Epidemiology Tags: Validation Studies Source Type: research

'Fat but fit' still at higher risk of heart disease
Conclusion The question of whether someone can be "fat but fit" has been much debated. If you're obese but exercise, eat well and don't have metabolic risk factors, the theory goes, you could be just as healthy as someone of recommended weight. This study suggests that may not be true. It is definitely worth adopting a healthy lifestyle, whatever your weight. The study found that, the more metabolic risk factors people had, the more likely they were to develop heart disease, cardiovascular disease and so on. Metabolic risk factors do make a difference. But in this large study, on average, people who were obese ...
Source: NHS News Feed - May 17, 2017 Category: Consumer Health News Tags: Food/diet Obesity Source Type: news

Are healthcare costs from obesity associated with body mass index, comorbidity or depression? Cohort study using electronic health records
The objective of this study was to evaluate the association between body mass index (BMI) and healthcare costs in relation to obesity‐related comorbidity and depression. A population‐based cohort study was undertaken in the UK Clinical Practice Research Datalink (CPRD). A stratified random sample was taken of participants registered with general practices in England in 2008 and 2013. Person time was classified by BMI category and morbidity status using first diagnosis of diabetes (T2DM), coronary heart disease (CHD), stroke or malignant neoplasms. Participants were classified annually as depressed or not depressed. Cos...
Source: Clinical Obesity - March 31, 2016 Category: Eating Disorders and Weight Management Authors: C. Rudisill, J. Charlton, H. P. Booth, M. C. Gulliford Tags: Original Article Source Type: research

Understanding Population Cardiovascular Health: Harnessing the Power of Electronic Health Records.
Abstract In 2004 the American Heart Association (AHA) set forth an ambitious strategic goal for 2010 to 1) reduce death from coronary heart disease and stroke by 25%, 2) reduce the prevalence of smoking, high cholesterol, uncontrolled hypertension, and physical inactivity by 25%, and 3) to stop increases in obesity and diabetes relative to rates in 1999. Having achieved or exceeded goals 1 and 2 by 2008 through a number of collaborative efforts, including public education, practice guidelines and quality improvement initiatives, in 2009, the AHA reframed its focus more broadly to one of achieving increased levels ...
Source: Circulation - September 1, 2015 Category: Cardiology Authors: Newby LK Tags: Circulation Source Type: research

Abstract 146: Clinical and Economic Consequences of Statin Intolerance in the U.S.: Results from an Integrated Health System Session Title: Poster Session I
Conclusion: While the majority of SI patients were on a statin, SI patients demonstrate a higher risk of some cardiovascular events; incur higher healthcare costs; and difficulty reaching LDL-C goals compared to patients without SI. Alternative treatment strategies are needed to better serve this at-risk patient population.
Source: Circulation: Cardiovascular Quality and Outcomes - April 29, 2015 Category: Cardiology Authors: Sanchez, R. J., Graham, J. H., Evans, M. A., Mallya, U. G., Panaccio, M. P., Steinhubl, S. R. Tags: Session Title: Poster Session I Source Type: research