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Factors contributing to poor COVID-19 outcomes in diabetic patients: Findings from a single-center cohort study
This article is a retrospective cohort study that include diabetic patients hospitalized with COVID-19 infection. A definition of diabetes was based on th e past history of diabetes or if the HbA1c was 6.5% or higher. Demographics, clinical characteristics, comorbidities, laboratory results, and complications were extracted from the electronic medical records. The mortality rate increased with increasing age (from 5.56% in younger patients to 46% in t he elderly) and with severity (from 25.71% in moderate cases to 43.77% in critical cases). We found that a critical severity on admission (OR: 5.26, 95% CI: 1.28–21.66,p = ...
Source: PLoS One - August 31, 2023 Category: Biomedical Science Authors: Nosayba Al-Azzam Source Type: research

Clinical characteristics and predictors for in-hospital mortality in adult COVID-19 patients: A retrospective single center cohort study in Vilnius, Lithuania
ConclusionsAge, congestive heart failure, obesity, COPD, prior stroke, and increased concentration of urea, LDH, CRP, IL-6, troponin I, ALT to AST ratio were identified to be the predictors for in-hospital mortality of COVID-19 patients.
Source: PLoS One - August 25, 2023 Category: Biomedical Science Authors: Ieva Kubiliute Source Type: research

Relation of Hemoglobin A1C Levels to Risk of Ischemic Stroke and Mortality in Patients With Diabetes Mellitus and Atrial Fibrillation
This study aimed to assess the incidence and risks of ischemic stroke and mortality according to baseline HbA1c levels in patients with DM and AF. We conducted a cohort study using Clalit Health Services electronic medical records. The study population included all Clalit Health Services members aged ≥25 years, with the first diagnosis of AF between January 1, 2010, and December 31, 2016, who had a diagnosis of DM.
Source: The American Journal of Cardiology - March 29, 2022 Category: Cardiology Authors: Louise Kezerle, Moti Haim, Amichay Akriv, Adi Berliner Senderey, Asaf Bachrach, Maya Leventer-Roberts, Meytal Avgil Tsadok Source Type: research

Impacts of type 2 diabetes mellitus and hypertension on the incidence of cardiovascular diseases and stroke in China real-world setting: a retrospective cohort study
Conclusion T2DM and HTN were strongly associated with combined VE and stroke risk; however, the HTN-only group had a higher combined VE and stroke risk than the T2DM-only group.
Source: BMJ Open - November 29, 2021 Category: General Medicine Authors: Liu, Y., Li, J., Dou, Y., Ma, H. Tags: Open access, Diabetes and Endocrinology Source Type: research

Higher Mortality of Ischaemic Stroke Patients Hospitalized with COVID-19 Compared to Historical Controls
Conclusions: Ischaemic stroke patients with COVID-19 had significantly higher 60-day all-cause mortality compared to propensity score-matched historical controls (ischaemic stroke patients without COVID-19).Cerebrovasc Dis
Source: Cerebrovascular Diseases - March 26, 2021 Category: Neurology Source Type: research

Early prognostic value of nocturnal blood pressure: a single-centre experience
Ambulatory blood pressure monitoring (ABPM) is now considered by current guidelines to be a reliable method of measurement for the diagnosis and assessment of hypertension. The aim of this study was to relate the short-term outcomes, comorbidity and ABPM findings determined from evaluating an everyday clinical cohort of hypertensive patients. A prospective study was carried out that included hypertensive patients who had undergone 24-h ABPM from January 2016 to November 2017. The following parameters were recorded in the database: age, sex, current antihypertensive treatment and documented history of comorbidities. New epi...
Source: Blood Pressure Monitoring - April 26, 2019 Category: Cardiology Tags: Clinical Studies Source Type: research

Combination of Dexmedetomidine and Ketamine for Magnetic Resonance Imaging Sedation
Conclusions: The efficacy of DEX–KET sedation was comparable to that of midazolam for MRI examination. DEX–KET was related to shorter scan time and lower occurrence of complications compared to midazolam. Introduction Neurocritically ill patients often require brain magnetic resonance imaging (MRI) in addition to conventional neurological evaluations. Brain MRI can reveal structural lesions with a high sensitivity due to its excellent spatial resolution and enhanced soft tissue contrast (1–3). To acquire MRI images, patients' cooperation is imperative. However, keeping patients with ...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Cardiovascular Risk in Mild to Moderately Decreased Glomerular Filtration Rate, Diabetes and Coronary Heart Disease in a Southern European Region
ConclusionsIn 60- to 84-year-olds with eGFR = 30-59, similarly to DM, the likelihood of being admitted to hospital for CHD and CVD was about half that of individuals with established CHD. Thus, eGFR = 30-59 does not appear to be a coronary-risk equivalent. Individuals with CHD and DM, or eGFR = 30-59 plus DM, should be prioritized for more intensive risk management.ResumenIntroducción y objetivosSe considera que los individuos con disminución leve-moderada de la tasa de filtrado glomerular estimada (TFGe, 30-59 ml/min/1,73 m2) están en alto riesgo de enfermedad cardiovascular (ECV). ...
Source: Revista Espanola de Cardiologia - January 30, 2019 Category: Cardiology Source Type: research

Mortality and Stroke Recurrence in a Rehabilitation Cohort of Patients with Cerebral Infarcts and Chagas Disease
Conclusions: Cardiac conditions did not correlate with mortality or recurrence. Age was a protective factor against recurrence, probably due to cumulative risk of IS over time, while initial mRS was associated with both outcomes. Treating diseases such as DM and bladder dysfunction, and early treatment to reduce the initial mRS could potentially prevent both outcomes; also, establishing a correct etiological diagnosis is important.Eur Neurol 2018;79:177 –184
Source: European Neurology - March 14, 2018 Category: Neurology Source Type: research

Serum 1,5-Anhydroglucitol: Risk Factor of Acute Ischemic Stroke and Transient Ischemic Attack in Well-Controlled Diabetes
Conclusions: Low serum 1,5-AG levels could be a possible marker for AIS/TIA risk in patients with well-controlled DM.Cerebrovasc Dis 2017;44:325 –329
Source: Cerebrovascular Diseases - October 26, 2017 Category: Neurology Source Type: research

Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity
Conclusions: In the present study, we observed that early life exposure to PM2.5 may play an important role in the early life origins of COWO and may increase the risk of COWO in children of mothers who were overweight or obese before pregnancy beyond the risk that can be attributed to MPBMI alone. Our findings emphasize the clinical and public health policy relevance of early life PM2.5 exposure. https://doi.org/10.1289/EHP261 Received: 29 March 2016 Revised: 08 August 2016 Accepted: 23 August 2016 Published: 14 June 2017 Address correspondence to X. Wang, Center on the Early Life Origins of Disease, Department of P...
Source: EHP Research - June 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Hypoglycaemia seriousness and weight gain as determinants of cardiovascular disease outcomes among sulfonylurea users
ConclusionsThis study provides evidence of increased CVD risk associated with hypoglycaemia, especially serious hypoglycaemia events. While associations were attenuated with non‐serious hypoglycaemia, the results were suggestive of a potential increased risk.
Source: Diabetes, Obesity and Metabolism - May 1, 2017 Category: Endocrinology Authors: Anthony P. Nunes, Kristy Iglay, Larry Radican, Samuel S. Engel, Jing Yang, Michael C. Doherty, David D. Dore Tags: ORIGINAL ARTICLE Source Type: research

CHA2DS2-VASc Scores and Major Bleeding in Patients With Nonvalvular Atrial Fibrillation Who Are Receiving Rivaroxaban
Conclusion Higher CHA2DS2-VASc scores are associated with increased incidence of major bleeding in nonvalvular atrial fibrillation patients receiving rivaroxaban.
Source: Annals of Emergency Medicine - April 23, 2017 Category: Emergency Medicine Source Type: research