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Specialty: Gastroenterology
Condition: Bleeding

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Total 54 results found since Jan 2013.

Gastrointestinal bleeding in patients on novel oral anticoagulants: Risk, prevention and management.
Abstract Novel oral anticoagulants (NOACs), which include direct thrombin inhibitor (dabigatran) and direct factor Xa inhibitors (rivaroxaban, apixaban and edoxaban), are gaining popularity in the prevention of embolic stroke in non-valvular atrial fibrillation as well as in the prevention and treatment of venous thromboembolism. However, similar to traditional anticoagulants, NOACs have the side effects of bleeding, including gastrointestinal bleeding (GIB). Results from both randomized clinical trials and observations studies suggest that high-dose dabigatran (150 mg b.i.d), rivaroxaban and high-dose edoxaban (6...
Source: World Journal of Gastroenterology : WJG - March 21, 2017 Category: Gastroenterology Authors: Cheung KS, Leung WK Tags: World J Gastroenterol Source Type: research

The impact of minor blood transfusion on the outcome after coronary artery bypass grafting
Conclusion Minor perioperative bleeding and subsequent transfusion of 1–2 RBC units did not affect the risk of early death, but increased the risk of other major adverse events. Minimizing perioperative bleeding and prevention of even low-volume RBC transfusion may improve the outcome after CABG.
Source: Journal of Critical Care - April 23, 2017 Category: Gastroenterology Source Type: research

Risk of Gastrointestinal Bleeding in Patients Taking Non-vitamin K Antagonist Oral Anticoagulants: a Systematic Review and Meta-analysis
Non-vitamin K antagonist oral anticoagulants (NOACs) are convenient and effective in prevention and treatment of venous thromboembolism and prevention of stroke in patients with atrial fibrillation. However, these drugs have been associated with increased risk of gastrointestinal (GI) bleeding. We conducted a systematic review and meta-analysis to determine the risk of GI bleeding in patients receiving these drugs.
Source: Clinical Gastroenterology and Hepatology - April 27, 2017 Category: Gastroenterology Authors: Corey S. Miller, Alastair Dorreen, Myriam Martel, Thao Huynh, Alan N. Barkun Source Type: research

Mo1086 Severity of Gastrointestinal Bleeding in Patients Treated With Direct-Acting Oral Anticoagulants (Doacs)
Direct-acting oral anticoagulants (DOACs), which have recently been approved for stroke prevention in non-valvular atrial fibrillation and treatment of venous thromboembolism, have become increasingly preferred over warfarin given their predictable pharmacodynamics and lack of required monitoring. DOACs have been shown to be associated with an increased frequency of gastrointestinal bleeding (GIB) compared to warfarin, but the severity of GIB in these patients is poorly understood.
Source: Gastrointestinal Endoscopy - April 28, 2017 Category: Gastroenterology Authors: Mark M. Brodie, Tyler Smith, Jill Newman, Don C. Rockey Tags: Monday – ASGE poster Source Type: research

Mo1074 Outcomes of Gastrointestinal Hemorrhage in the Setting of Novel Versus Traditional Antithrombotic Agents
The objective of our study was to compare outcomes among patients presenting with GI bleed that were prescribed novel versus traditional antithrombotic agents.
Source: Gastrointestinal Endoscopy - April 28, 2017 Category: Gastroenterology Authors: Jonathan I. Chang, Elizabeth Dong, Karl Kwok, Bechien U. Wu Tags: Monday – ASGE poster Source Type: research

Safety and feasibility of liver resection with continued antiplatelet therapy using aspirin
ConclusionsLiver resection can be safely performed while continuing aspirin therapy without increasing hemorrhagic morbidity. Our results suggest that interruption of aspirin therapy is unnecessary for patients undergoing liver resection.This article is protected by copyright. All rights reserved.
Source: Journal of Hepato-Biliary-Pancreatic Sciences - April 1, 2017 Category: Gastroenterology Authors: Kazuteru Monden, Hiroshi Sadamori, Masayoshi Hioki, Satoshi Ohno, Hiromi Saneto, Toru Ueki, Kazuhisa Yabushita, Kazumi Ono, Kousaku Sakaguchi, Norihisa Takakura Tags: Original Article Source Type: research

Risk of Gastrointestinal Bleeding in Patients Taking Non –Vitamin K Antagonist Oral Anticoagulants: A Systematic Review and Meta-Analysis
Non –vitamin K antagonist oral anticoagulants (novel oral anticoagulants [NOACs]) are convenient and effective in the prevention and treatment of venous thromboembolism and the prevention of stroke in patients with atrial fibrillation. However, these drugs have been associated with an increased risk o f gastrointestinal (GI) bleeding. We conducted a systematic review and meta-analysis to determine the risk of GI bleeding in patients receiving these drugs.
Source: Clinical Gastroenterology and Hepatology - April 27, 2017 Category: Gastroenterology Authors: Corey S. Miller, Alastair Dorreen, Myriam Martel, Thao Huynh, Alan N. Barkun Source Type: research

New predictive model for acute gastrointestinal bleeding in patients taking oral anticoagulants: A cohort study
ConclusionsGastrointestinal bleeding increased the risk of subsequent mortality during follow‐up of anticoagulated patients, highlighting the importance of prevention. The study developed a new scoring model for acute GI bleeding risk based on five factors (no‐proton pump inhibitor use, chronic kidney disease, chronic obstructive pulmonary disease, history of peptic ulcer disease, and liver cirrhosis), which was superior to the HAS‐BLED score.
Source: Journal of Gastroenterology and Hepatology - December 28, 2017 Category: Gastroenterology Authors: Akira Shimomura, Naoyoshi Nagata, Takuro Shimbo, Toshiyuki Sakurai, Shiori Moriyasu, Hidetaka Okubo, Kazuhiro Watanabe, Chizu Yokoi, Junichi Akiyama, Naomi Uemura Tags: Gastroenterology Source Type: research

Mo1133 PROSPECTIVE EVALUATION OF 30-DAY BLEEDING AND THROMBOEMBOLIC RISKS IN PATIENTS UNDERGOING COLONOSCOPY WHILE TAKING WARFARIN OR NOVEL ANTICOAGULANTS
With the rising prevalence of ischemic heart disease and atrial fibrillation as well as the expanding indications on the use of anticoagulants, there are increasing number of patients undergoing colonoscopies while on these agents. International societies issued guidelines on the peri-endoscopic management of the anticoagulants but little is known on the actual outcome of these patients, particularly those taking novel anti-coagulants (NOACs). We aim to prospectively evaluate the 30-day morbidities (gastrointestinal bleeding, stroke and cardiovascular complications) and mortalities of patients taking warfarin, NOACs and/or...
Source: Gastrointestinal Endoscopy - May 30, 2018 Category: Gastroenterology Authors: Sze Hang Kevin Liu, Lijia Chen, Sze Kan Leung, Wai K. Leung Tags: Monday abstract Source Type: research

Mo1090 DIRECT-ACTING ORAL ANTICOAGULANT (DOAC) USE IS NOT ASSOCIATED WITH INCREASED RISK OF COMPLICATIONS AFTER POLYPECTOMY
Direct-acting oral anticoagulants (DOACs) such as rivaroxaban, apixaban, dabigatran, and edoxaban represent 62% of new anticoagulation prescriptions. Compared to warfarin, DOACs increase the risk of gastrointestinal bleeding but reduce the risk of stroke. Little is known about the risk of complications after polypectomy in patients with active DOAC use. We aimed to determine the risk of complications after polypectomy in this population.
Source: Gastrointestinal Endoscopy - May 30, 2018 Category: Gastroenterology Authors: Jessica X. Yu, Melissa Oliver, Jody Lin, Matthew S. Chang, Allison J. Kwong, Berkeley Limketkai, Roy M. Soetikno, Jayanta Bhattacharya, Tonya R. Kaltenbach Tags: Monday abstract Source Type: research

Chemoprevention of Barrett ’s Esophagus and Esophageal Adenocarcinoma
AbstractBarrett ’s esophagus is common in Western countries, but progression to esophageal adenocarcinoma is uncommon. Chemoprevention therefore needs to consider whether benefits outweigh risks given an otherwise healthy population. This will depend on the particular population at risk and the relative safety of a potential preventive agent. Most evidence regarding the potential benefit of chemoprevention of Barrett’s esophagus and prevention of progression to esophageal adenocarcinoma is based on observational studies such as case–control and cohort studies. Given the potential benefits and relatively low risks, pa...
Source: Digestive Diseases and Sciences - June 12, 2018 Category: Gastroenterology Source Type: research

Adverse effects of proton pump inhibitors: fact or fake news?
Purpose of review The present review summarizes the past year's literature, both clinical and basic science, regarding potential adverse effects of proton pump inhibitors. Recent findings Proton pump inhibitors are amongst the most widely prescribed and overprescribed medications worldwide. Although generally considered well tolerated, epidemiologic studies mining large databases have reported a panoply of purported serious adverse effects associated with proton pump inhibitors, including chronic kidney disease, cognitive decline, myocardial infarction, stroke, bone fracture and even death. It should be noted that the...
Source: Current Opinion in Gastroenterology - October 16, 2018 Category: Gastroenterology Tags: STOMACH AND DUODENUM: Edited by Mitchell L. Schubert Source Type: research

Increased susceptibility of aging gastric mucosa to injury and delayed healing: Clinical implications.
Abstract In this editorial we comment on the article by Fukushi K et al published in the recent issue of the World Journal of Gastroenterology 2018; 24(34): 3908-3918. We focus specifically on the mechanisms of the anti-thrombotic action of aspirin, gastric mucosal injury and aging-related increased susceptibility of gastric mucosa to injury. Aspirin is widely used not only for the management of acute and chronic pain and arthritis, but also importantly for the primary and secondary prevention of cardiovascular events such as myocardial infarcts and strokes. Clinical trials have consistently shown that antiplatele...
Source: World Journal of Gastroenterology : WJG - November 14, 2018 Category: Gastroenterology Authors: Tarnawski AS, Ahluwalia A Tags: World J Gastroenterol Source Type: research

Efficacy and Safety of Anticoagulation for Atrial Fibrillation in Patients with Cirrhosis: A Systematic Review and Meta-analysis
The atrial fibrillation-related stroke is clearly prevented by anticoagulation treatment, however, management of anticoagulation for AF in patients with cirrhosis represents a challenge due to bleeding concerns. To address this issue, a systematic review and meta-analysis of the literature was performed.
Source: Digestive and Liver Disease - December 13, 2018 Category: Gastroenterology Authors: Ronpichai Chokesuwattanaskul, Charat Thongprayoon, Tarun Bathini, Aldo Torres-Ortiz, Oisin A. O ’Corragain, Kanramon Watthanasuntorn, Ploypin Lertjitbanjong, Konika Sharma, Somchai Preechawat, Patompong Ungprasert, Paul T. Kröner, Karn Wijarnpreecha, W Tags: Meta-Analysis Source Type: research

Acute Esophageal Necrosis: A View in the Dark
Acute esophageal necrosis (AEN), also known as Gurvits syndrome, black esophagus, or acute necrotizing esophagitis, is a rare clinical entity and an unusual reason for upper gastrointestinal bleeding. It is typically described in critically ill patients with multiple medical conditions, arising from a combination of ischemic insult to the esophageal mucosa due to low-flow vascular states, corrosive injury caused by reflux of acid and pepsin, and decreased function of the mucosal barrier systems and reparative mechanisms as occurs in malnourished and debilitated physical states. Patients with AEN tend to be older men, as me...
Source: Case Reports in Gastroenterology - January 16, 2019 Category: Gastroenterology Source Type: research