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Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt
Conclusion We have shown that SCD subjects are much more likely than non-SCD subjects to have impaired cardiac, but intact peripheral responses to orthostatic stress induced by HUT. These abnormal responses are associated with low baseline cardiac parasympathetic activity, independent of hemoglobin level. The classification of autonomic phenotypes based on HUT response may have potential use for predicting disease severity, guiding and targeting treatments/interventions to alleviate the risk of adverse outcomes in SCD. Ethics Statement All experiments were conducted at Children’s Hospital Los Angeles (CHLA). The ...
Source: Frontiers in Physiology - April 10, 2019 Category: Physiology Source Type: research

Impact of sleep onset on hemodynamic parameters in obese patients with or without obstructive sleep apnea
Discussion: SO was not associated with a significant decrease in any investigated HP. Perhaps obesity alone attenuates the physiological reduction of the sympathetic activity at SO. The higher variation of hemodynamic parameters in OSA indicates its impact on the cardiovascular stability.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Staats, R., Barros, I., Maroco, J., Grencho, D., Moreira, S., Valenca, J., Pinto, P., Barbara, C., Matos, A. F. Tags: Sleep and Control of Breathing Source Type: research

What Your Tongue And Tonsils Could Tell You About Your Sleeping Habits
Your dentist might be able to tell if you're having trouble sleeping.  Yes. A new study published in the Saudi Medical Journal found that the size of a person's tonsils may indicate their risk for obstructive sleep apnea, a condition in which blocked upper airways cause breathing to stop and restart repeatedly during sleep. Tongue indentations, or teeth imprints on the tongue that suggest it's too big for the mouth, may also be a sign.  More than 18 million adults in the United States are affected by OSA. Since people with the condition are often suffering from interrupted and reduced sleep, it can lead to ...
Source: Science - The Huffington Post - March 9, 2016 Category: Science Source Type: news

Probable Nootropic-induced Psychiatric Adverse Effects: A Series of Four Cases
Conclusion Healthcare providers in general, and specifically those in the mental health and substance abuse fields, should keep in mind that nootropic use is an under recognized and evolving problem. Nootropic use should be considered in cases where there are sudden or unexplained exacerbations of psychiatric symptoms in patients who have been stable and medication adherent. It is also important to remember that most nootropics are not detected on standard drug toxicology screening tests. We have very little clinical information on how nootropics may interact with psychotropics (or other medications) and potentially cause ...
Source: Innovations in Clinical Neuroscience - December 1, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Case Series and Literature Review Current Issue Mental Disorders Psychiatry Psychopharmacology Substance Use Disorders Ampakines Armodafinil brain enhancer Cerebrolysin Citicoline cognitive enhancer homeopathic medicine natural r Source Type: research

Lessons Learned From Trends in Insufficient Sleep Across the United States
This article originally appeared on the Amerisleep blog. Rosie Osmun is the Creative Content Manager at Amerisleep, a progressive memory foam mattress brand focused on eco-friendly sleep solutions. Rosie writes more posts on the Amerisleep blog about the science of sleep, eco-friendly living, leading a healthy lifestyle and more. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Healthy Living - The Huffington Post - October 16, 2015 Category: Consumer Health News Source Type: news