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Increased risk of depression in patients with rheumatoid arthritis: a seven-year population-based cohort study
CONCLUSION: This population-based cohort study showed a strong relationship between RA and a subsequent risk of depression. The findings could be beneficial to healthcare providers for identifying individuals with a higher predisposition for depression, thereby possibly facilitating the provision of an appropriate rehabilitation intervention after RA onset to support the patient's adaptation.
Source: Clinics - March 17, 2015 Category: Journals (General) Source Type: research

Can the ankle brachial pressure index (ABPI) and carotis intima media thickness (CIMT) be new early stage markers of subclinical atherosclerosis in patients with rheumatoid arthritis?
CONCLUSION: Based on the present findings, patients with RA need to be evaluated in the early stage of the disease for subclinical peripheral artery disease using the ABPI, as well as CIMT, which is also a non-invasive technique, in terms of cerebrovascular events. Inflammatory markers exhibited no statistically significant difference. We think that the atherosclerotic process stems not only from the inflammatory effects of RA, but also perhaps from its immunological nature. PMID: 25777147 [PubMed - as supplied by publisher]
Source: Wiener Klinische Wochenschrift - March 17, 2015 Category: Journals (General) Authors: Kurt T, Temiz A, Gokmen F, Adam G, Ozcan S, Ozbudak E, Sacar M Tags: Wien Klin Wochenschr Source Type: research

Closing the loop on inflammation and atherothrombosis: why perform the CIRT and CANTOS trials?
Authors: Ridker PM Abstract Inflammation contributes to all phases of the atherothrombotic process, patients with elevated inflammatory biomarkers such as high-sensitivity C-reactive protein (hsCRP) have increased cardiovascular risk, and recent work directly implicates the interleukin-1 (IL-1) and interleukin-6 (IL-6) pathways in atherogenesis. Yet, it remains unknown whether targeted inhibition of inflammation will reduce cardiovascular event rates. To address directly this fundamental hypothesis, our research group has initiated two large-scale, randomized, placebo-controlled trials using targeted anti-inflammat...
Source: Transactions of the American Clinical and Climatological Association - June 4, 2015 Category: Journals (General) Tags: Trans Am Clin Climatol Assoc Source Type: research

Does happiness itself directly affect mortality? The prospective UK Million Women Study
Publication date: Available online 10 December 2015 Source:The Lancet Author(s): Bette Liu, Sarah Floud, Kirstin Pirie, Jane Green, Richard Peto, Valerie Beral Background Poor health can cause unhappiness and poor health increases mortality. Previous reports of reduced mortality associated with happiness could be due to the increased mortality of people who are unhappy because of their poor health. Also, unhappiness might be associated with lifestyle factors that can affect mortality. We aimed to establish whether, after allowing for the poor health and lifestyle of people who are unhappy, any robust evidence remai...
Source: The Lancet - December 12, 2015 Category: Journals (General) Source Type: research

Self-management support interventions for persons with chronic disease: an evidence-based analysis.
CONCLUSIONS: The Stanford CDSMP led to statistically significant, albeit clinically minimal, short-term improvements across a number of health status measures (including some measures of health-related quality of life), healthy behaviours, and self-efficacy compared to usual care. However, there was no evidence to suggest that the CDSMP improved health care utilization. More research is needed to explore longer-term outcomes, the impact of self-management on clinical outcomes, and to better identify responders and non-responders. PLAIN LANGUAGE SUMMARY: Self-management support interventions are becoming more common as ...
Source: Ontario Health Technology Assessment Series - December 20, 2015 Category: Journals (General) Tags: Ont Health Technol Assess Ser Source Type: research

Psoriasis and comorbidities. Epidemiological studies.
In conclusion, psoriasis was significantly associated with certain CNS diseases, and the risk of CVD was strongly associated with acute depression in these patients. These novel findings suggest an important link between psoriasis and CNS diseases, and high-light the necessity for a holistic approach to the diagnosis and treatment of patients with psoriasis. PMID: 26836804 [PubMed - as supplied by publisher]
Source: Danish Medical Journal - February 3, 2016 Category: Journals (General) Tags: Dan Med J Source Type: research

Relationship Between Chronic Conditions and Disability in African American Men and Women.
CONCLUSIONS: These findings demonstrate the importance of chronic conditions in understanding disability in African Americans and how it varies by gender. Also, these findings underscore the importance of developing health promoting strategies focused on chronic disease prevention and management to delay or postpone disability in African Americans. PUBLICATION INDICES: Pubmed, Pubmed Central, Web of Science database. PMID: 26928493 [PubMed - as supplied by publisher]
Source: Journal of the National Medical Association - March 2, 2016 Category: Journals (General) Tags: J Natl Med Assoc Source Type: research

Multifactorial intervention to prevent cardiovascular disease in patients with early rheumatoid arthritis: protocol for a multicentre randomised controlled trial
In this study, we compare the effect of a targeted, intensified, multifactorial intervention with that of conventional treatment of modifiable risk factors for cardiovascular disease (CVD) in patients with early RA fulfilling the 2010 American College of Rheumatology European League Against Rheumatism (ACR/EULAR) criteria. Methods and analysis The study is a prospective, randomised, open label trial with blinded end point assessment and balanced randomisation (1:1) conducted in 10 outpatient clinics in Denmark. The primary end point after 5 years of follow-up is a composite of death from cardiovascular causes, non-fa...
Source: BMJ Open - April 19, 2016 Category: Journals (General) Authors: Svensson, A. L., Christensen, R., Persson, F., Logstrup, B. B., Giraldi, A., Graugaard, C., Fredberg, U., Blegvad, J., Thygesen, T., Hansen, I. M. J., Colic, A., Bagdat, D., Ahlquist, P., Jensen, H. S., Horslev-Petersen, K., Sheetal, E., Christensen, T. G Tags: Open access, Cardiovascular medicine, Rheumatology Protocol Source Type: research

Having Rheumatoid Arthritis May Increase Heart Risk
TUESDAY, Nov. 15, 2016 -- People with rheumatoid arthritis may have an increased risk for a heart attack, stroke and other heart disease-related problems, a new study suggests. Researchers examined data from 353 rheumatoid arthritis patients in the...
Source: Drugs.com - Daily MedNews - November 15, 2016 Category: Journals (General) Source Type: news

Celecoxib for rheumatoid arthritis.
CONCLUSIONS: Celecoxib may improve clinical symptoms, alleviate pain and contribute to little or no difference in physical function compared with placebo. Celecoxib was associated with fewer numbers of participant withdrawals. Results for incidence of gastroduodenal ulcers (≥ 3 mm) and short-term serious adverse events were uncertain; however, there were few reported events for either.Celecoxib may slightly improve clinical symptoms compared with tNSAIDs. Results for reduced pain and improved physical function were uncertain. Particpants taking celecoxib had lower incidence of gastroduodenal ulcers (≥ 3 mm) and there w...
Source: Cochrane Database of Systematic Reviews - June 9, 2017 Category: General Medicine Authors: Fidahic M, Jelicic Kadic A, Radic M, Puljak L Tags: Cochrane Database Syst Rev Source Type: research

The effect of rheumatoid arthritis on the risk of cerebrovascular disease and coronary artery disease in young adults
Conclusion RA is an independent risk factor for CVD/CAD in young adults. The government should develop policies for preventing early onset hypertension to reduce the incidence of CVD/CAD among young patients with RA.
Source: Journal of the Chinese Medical Association - June 2, 2018 Category: General Medicine Source Type: research

Chronic diseases and socioeconomic inequalities in quality of life among Brazilian adults: findings from a population-based study in Southern Brazil
ConclusionsThe occurrence of long-lasting chronic diseases is associated with inequalities in QoL (physical and psychological domains), with stronger adverse effects among older adults, blacks and individuals with lower income or educational levels.
Source: The European Journal of Public Health - December 25, 2017 Category: General Medicine Source Type: research

Upadacitinib as monotherapy in patients with active rheumatoid arthritis and inadequate response to methotrexate (SELECT-MONOTHERAPY): a randomised, placebo-controlled, double-blind phase 3 study
This study is active but not recruiting and is registered with ClinicalTrials.gov, number NCT02706951.FindingsPatients were screened between Feb 23, 2016, and May 19, 2017 and 648 were randomly assigned to treatment. 598 (92%) completed week 14. At week 14, an ACR20 response was achieved by 89 (41%) of 216 patients (95% CI 35–48) in the continued methotrexate group, 147 (68%) of 217 patients (62–74) receiving upadacitinib 15 mg, and 153 (71%) of 215 patients (65–77) receiving upadacitinib 30 mg (p<0·0001 for both doses vs continued methotrexate). DAS28(CRP) 3·2 or lower was met by 42 (19%) of 216 (95% CI 14–2...
Source: The Lancet - May 24, 2019 Category: General Medicine Source Type: research

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