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We are preventing some dementias now-But how? The Potamkin lecture
Alzheimers Dement. 2022 Sep 22. doi: 10.1002/alz.12770. Online ahead of print.ABSTRACTMost dementias are untreatable and their prevalence is increasing around the world. However, the incidence of dementia is declining in some countries. We need to find out urgently why and how and apply the lessons promptly and widely. Given the multiplicity and variability of environmental, socioeconomic, and individual risk and protective factors, the approach needs to be comprehensive, customized to work in a particular setting, and cost effective, to justify the needed funding. Stroke, heart disease, and dementia share the same major p...
Source: The Journal of Alzheimers Association - September 22, 2022 Category: Psychiatry Authors: Vladimir Hachinski Dementia Prevention/Brain Health Initiative Source Type: research

PNR Weekly Digest: April 6, 2021
Items regarding COVID-19 information are indicated with an * In the Dragonfly: Understanding End-of-Life Matters Whether your focus of concern is on a family member or yourself, this April the NNLM Reading Club suggests three books that may help with your understanding of end-of-life matters and those conversations you probably have been putting off…read the post to see the book selections Professional Development: NNLM CE Opportunities: NNLM offers training on a variety of topics related to health information. A complete listing of NNLM educational opportunities is available. Please note you need to create an NNLM accou...
Source: Dragonfly - April 6, 2021 Category: Databases & Libraries Authors: Carolyn Martin Tags: PNR Weekly Digest Source Type: news

Multiple cerebral microbleeds and atypical β-amyloid deposits: A case report
Rationale: Cerebral microbleeds are increasingly recognized in various neurological disorders such as cerebral amyloid angiopathy (CAA), Alzheimer disease, and stroke. The presence and number of cerebral microbleeds are known to be independent predictors of cognitive impairment. Patient concerns: A 73-year-old woman visited our memory disorder clinic complaining of progressive memory impairment, which started 2 years ago. Diagnoses: The patient had innumerable cortical/subcortical cerebral microbleeds in the entire brain. We diagnosed the patient with amnestic mild cognitive impairment due to CAA. Interestingly, on...
Source: Medicine - December 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Light-Induced Pupillary Responses in Alzheimer's Disease
Light-Induced Pupillary Responses in Alzheimer's Disease Pratik S. Chougule1, Raymond P. Najjar1,2, Maxwell T. Finkelstein1, Nagaendran Kandiah3,4 and Dan Milea1,2,5* 1Department of Visual Neurosciences, Singapore Eye Research Institute, Singapore, Singapore 2The Ophthalmology & Visual Sciences ACP, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore 3Department of Neurology, National Neuroscience Institute, Singapore, Singapore 4Duke-National University of Singapore (NUS), Singapore, Singapore 5Singapore National Eye Centre, Singapore, Singapore The impact of Alzhe...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Blood-Brain Barrier: From Physiology to Disease and Back.
Abstract The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and pathogens from entering the brain. At the same time, the BBB regulates transport of molecules into and out of the central nervous system (CNS), which maintains tightly controlled chemical composition of the neuronal milieu that is required for proper neuronal functioning. In this review, we first examine molecular and cellular mechanisms underlying the establishment of the BBB. Then, we focus on BBB transport physiology, endothelial and pericyte transporters, and perivascular and paravascular transport. Next, we discuss ...
Source: Physiological Reviews - October 4, 2018 Category: Physiology Authors: Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV Tags: Physiol Rev Source Type: research

Response to “Comment on ‘Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research’”
Research and Toxicology Department, Humane Society International, London, United Kingdom About This Article open Citation: Langley G. 2016. Response to “Comment on ‘Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research.’” Environ Health Perspect 124:A85; http://dx.doi.org/10.1289/ehp.1611305 Address correspondence to G. Langley, 8 Crow Furlong, Hitchin, Hertfordshire, SG5 2HW, United Kingdom. E-mail: sciencesources@btinternet.com The author works for Humane Society International, one of whose goals is the phasing out of animal use in testing and research. Final Publication: 1...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Correspondence May 2016 Source Type: research

Two Tests to Predict How Long You Might Live
In this study of over 6,500 adults (at least 52 years of age), participants were asked that question. Over 8 years of follow-up, people who felt at least 3 years younger than their actual age were less likely to die than those who felt their actual age or older. There are lots of reasons why this might make sense. If you feel older than your age, you probably already have some underlying health conditions. Or you might be depressed which we know leads to increased mortality. If you don't feel "right," you need to listen to your body, and realize it is telling you that you need to get it checked. And the lesson here would b...
Source: Healthy Living - The Huffington Post - July 16, 2015 Category: Consumer Health News Source Type: news

Quick magnesium treatment fails to improve stroke outcomes, but study has silver lining
In the first study of its kind, a consortium led by UCLA physicians found that giving stroke patients intravenous magnesium within an hour of the onset of symptoms does not improve stroke outcomes.   However, the 8-year trial did find that with the help of paramedics in the field, intravenous medications can frequently be administered to stroke victims within that so-called "golden hour," during which they have the best chance to survive and avoid debilitating, long-term neurological damage.   The latter finding is a "game-changer," said Dr. Jeffrey Saver, director of the UCLA Stroke Center and a professor of ...
Source: UCLA Newsroom: Health Sciences - February 13, 2014 Category: Universities & Medical Training Source Type: news