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Condition: Thrombosis

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Total 15499 results found since Jan 2013.

Effect of Alteplase Within 6 Hours of Acute Ischemic Stroke on All-Cause Mortality (Third International Stroke Trial) Clinical Sciences
Conclusions— These exploratory analyses of the third International Stroke Trial (IST-3) trial support improving acute stroke patients’ access to earlier alteplase treatment, treatment of patients with poor prognosis, and further randomized controlled trials in minor stroke to replicate these findings. Clinical Trial Registration— URL: http://www.controlled-trials.com. Unique identifier: ISRCTN25765518.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Whiteley, W. N., Thompson, D., Murray, G., Cohen, G., Lindley, R. I., Wardlaw, J., Sandercock, P., on behalf of the IST-3 Collaborative Group Tags: Acute Cerebral Infarction, Thrombolysis Clinical Sciences Source Type: research

Mechanisms and Outcomes of Ischemic Stroke in Pregnancy and Postpartum: A Retrospective Cross-Sectional Study (P3.070)
CONCLUSIONS: Women with pregnancy-associated ischemic strokes were younger and had fewer vascular risk factors when compared with other young women with ischemic strokes. Outcomes were similar in the two groups, with a substantial proportion of poor outcomes in both groups. Our results are limited by the small sample size and retrospective nature of the study. Larger studies are needed to better characterize the pathophysiology of pregnancy-associated stroke.Disclosure: Dr. Miller has nothing to disclose. Dr. Yaghi has nothing to disclose. Dr. Boehme has nothing to disclose. Dr. Willey has nothing to disclose. Dr. Elkind h...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Miller, E., Yaghi, S., Boehme, A., Willey, J., Elkind, M., Marshall, R. Tags: Cerebrovascular Disease and Interventional Neurology: Ischemic Stroke Outcome Source Type: research

Cross-National Key Performance Measures of the Quality of Acute Stroke Care in Western Europe Clinical Sciences
Conclusions— On the basis of experience of quality registers in Europe, we have proposed a common set of performance measures that will facilitate the international comparison of acute stroke care quality.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Norrving, B., Bray, B. D., Asplund, K., Heuschmann, P., Langhorne, P., Rudd, A. G., Wagner, M., Wiedmann, S., Wolfe, C. D. A., for the European Implementation Score Collaboration Tags: Health policy and outcome research Clinical Sciences Source Type: research

Neurogenesis in Stroke Recovery
Abstract Stroke, resulting from limited blood flow to the brain, is one of the most important causes of morbidity and mortality worldwide. Stroke is classified as ischemic, due to lack of blood flow, or hemorrhagic, due to bleeding. Because 87 % of strokes are classified as ischemic, this type will be the predominant focus of this review. Except for thrombolytic therapy, there is no established treatment to reduce the neurological deficits caused by ischemic stroke. Therefore, it is necessary to develop new therapeutic strategies designed to improve neurological functions after ischemic stroke. Recently, therapie...
Source: Translational Stroke Research - March 17, 2016 Category: Neurology Source Type: research

Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review
Conclusions The hyperdense artery sign is associated with RBC-rich thrombi and improved recanalization rates. However, there was no association between the histopathological characteristics of thrombi and stroke etiology and angiographic outcomes.
Source: Journal of NeuroInterventional Surgery - May 30, 2017 Category: Neurosurgery Authors: Brinjikji, W., Duffy, S., Burrows, A., Hacke, W., Liebeskind, D., Majoie, C. B. L. M., Dippel, D. W. J., Siddiqui, A. H., Khatri, P., Baxter, B., Nogeuira, R., Gounis, M., Jovin, T., Kallmes, D. F. Tags: Editor''s choice, Ischemic stroke Source Type: research

Outcomes of Thrombolytic Treatment for Acute Ischemic Stroke in Dialysis Dependant Patients in the United States (S02.003)
CONCLUSIONS: The three fold higher odds of in-hospital mortality associated with administration of IV thrombolytics in dialysis dependant patients who present with acute ischemic stroke warrants a careful assessment of risk benefit ratio in this population.Disclosure: Dr. Adil has nothing to disclose. Dr. Adil has nothing to disclose. Dr. Irfan has nothing to disclose. Dr. Chaudhry has nothing to disclose. Dr. ATACH Investigators has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Tariq, N., Adil, M., Irfan, M., Chaudhry, S., Qureshi, A. Tags: S02 Acute Stroke Therapy Source Type: research

Paradoxical Association of Smoking With In-Hospital Mortality Among Patients Admitted With Acute Ischemic Stroke Stroke
Conclusions Similar to myocardial ischemia, smoking was independently associated with lower inpatient mortality in acute ischemic stroke. This effect may be due to tobacco-induced changes in cerebrovascular vasoreactivity, or may be due in part to residual confounding. Larger, multicenter studies are needed to confirm the finding and the effect on 30-day and 1-year mortality.
Source: JAHA:Journal of the American Heart Association - June 19, 2013 Category: Cardiology Authors: Ali, S. F., Smith, E. E., Bhatt, D. L., Fonarow, G. C., Schwamm, L. H. Tags: Stroke Source Type: research

Prehospital stroke care: New prospects for treatment and clinical research
Brain cells die rapidly after stroke and any effective treatment must start as early as possible. In clinical routine, the tight time–outcome relationship continues to be the major limitation of therapeutic approaches: thrombolysis rates remain low across many countries, with most patients being treated at the late end of the therapeutic window. In addition, there is no neuroprotective therapy available, but some maintain that this concept may be valid if administered very early after stroke. Recent innovations have opened new perspectives for stroke diagnosis and treatment before the patient arrives at the hospital....
Source: Neurology - July 29, 2013 Category: Neurology Authors: Audebert, H. J., Saver, J. L., Starkman, S., Lees, K. R., Endres, M. Tags: All Clinical trials, All Cerebrovascular disease/Stroke VIEWS & amp;amp; REVIEWS Source Type: research

The Totaled Health Risks in Vascular Events (THRIVE) Score Predicts Ischemic Stroke Outcomes Independent of Thrombolytic Therapy in the NINDS tPA Trial
Conclusions: The THRIVE score provides accurate prediction of long-term neurologic outcomes in patients with acute ischemic stroke regardless of treatment modality. Both the THRIVE score and tPA administration predict outcome, but the THRIVE score does not influence the impact of tPA on outcome, and tPA administration does not influence the impact of THRIVE score on outcome.
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2012 Category: Neurology Authors: Hooman Kamel, Nihar Patel, Vivek A. Rao, Sean P. Cullen, Bonnie S. Faigeles, Wade S. Smith, Alexander C. Flint Tags: Original Articles Source Type: research

The CHA(2)DS(2)-VASc Score Reflects Clinical Outcomes in Nonvalvular Atrial Fibrillation Patients with an Initial Cardioembolic Stroke
Conclusions: The severity of NVAF-induced initial cardioembolic stroke increased with higher CHA(2)DS(2)-VASc scores, and the outcomes were poor. The present study suggests that the CHA(2)DS(2)-VASc score may be useful not only for the evaluation of stroke risk but also for the prediction of clinical outcomes after stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - March 25, 2013 Category: Neurology Authors: Ichiro Deguchi, Takeshi Hayashi, Yasuko Ohe, Yuji Kato, Harumitsu Nagoya, Takuya Fukuoka, Hajime Maruyama, Yohsuke Horiuchi, Norio Tanahashi Tags: Original Articles Source Type: research

Within-Day and Weekly Variations of Thrombolysis in Acute Ischemic Stroke: Results From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register Clinical Sciences
Conclusions— Frequency of thrombolytic treatment seems to follow the same circadian pattern of stroke incidence, whereas its correspondence to a weekly pattern is less clear. Time of treatment is an independent predictor of outcome.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Lorenzano, S., Ahmed, N., Tatlisumak, T., Gomis, M., Davalos, A., Mikulik, R., Sevcik, P., Ollikainen, J., Wahlgren, N., Toni, D., for the SITS Investigators Tags: Acute Cerebral Infarction, Thrombolysis Clinical Sciences Source Type: research

Initial Experience with Upfront Arterial and Perfusion Imaging among Ischemic Stroke Patients Presenting within the 4.5-hour Time Window
Conclusions: An upfront CTA/CTP protocol aided stroke team decision-making in nearly half of cases. Implementation of a CTA/CTP protocol was associated with a learning curve of 6 months before door to needle time ≤60 minutes returned to similar rates as the pre-CTA/CTP protocol.
Source: Journal of Stroke and Cerebrovascular Diseases - January 24, 2013 Category: Neurology Authors: Ali Reza Noorian, Katja Bryant, Ashley Aiken, Andrew D. Nicholson, Adam B. Edwards, Mason P. Markowski, Seena Dehkharghani, Jemisha C. Bouloute, Jacquelyn Abney, Fadi Nahab Tags: Original Articles Source Type: research

Perception Of Stroke Symptoms And Utilization Of Emergency Medical Systems In Argentina (P7.132)
CONCLUSIONS:These results suggest a low level of stroke symptoms awareness in our country even in a population of middle/high socioeconomic level. The role and procedures of EMS in Argentina should be revised as early arrival and treatment appear to be associated with no utilization of them.Study Supported by:Disclosure: Dr. Hawkes has nothing to disclose. Dr. Calandri has nothing to disclose. Dr. Farez has received personal compensation for activities with Merck Serono. Dr. Farez has received research support from Novartis. Dr. Arena has nothing to disclose. Dr. Pujol Lereis has nothing to disclose. Dr. Ameriso has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Hawkes, M., Calandri, I., Farez, M., Arena, J., Pujol Lereis, V., Ameriso, S. Tags: Cerebrovascular Disease and Interventional Neurology: Barriers and Opportunities in Acute Stroke Treatment Source Type: research

Initial Body Temperature in Ischemic Stroke: Nonpotentiation of Tissue-Type Plasminogen Activator Benefit and Inverse Association With Severity Clinical Sciences
Conclusions— In patients with hyperacute stroke, higher presenting temperatures are associated with less severe neurological deficits and reduced final infarct volumes. Presenting temperature does not modify the benefit of tPA on 3-month favorable outcome.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Kim, S. H., Saver, J. L. Tags: Thrombolysis Clinical Sciences Source Type: research

Balancing access and quality in comprehensive stroke care
The establishment of stroke units and stroke centers has transformed the inpatient care of cerebrovascular disease and resulted in improved outcomes for patients hospitalized with stroke. Studies show that organized care as part of a stroke unit results in reduced mortality and disability after stroke,1 and that patients hospitalized at primary stroke centers have lower mortality and are more likely to receive thrombolytic therapy.2
Source: Neurology - March 23, 2015 Category: Neurology Authors: Kelly, A. G., Attia, J. Tags: All Health Services Research, Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, All epidemiology EDITORIALS Source Type: research