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Condition: Thrombosis

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Total 15499 results found since Jan 2013.

Intravenous Thrombolysis in Unknown-Onset Stroke Clinical Sciences
Conclusions—Our data suggest no excess risk of symptomatic intracerebral hemorrhage but increased mortality and reduced favorable outcome in patients with UKO stroke compared with patients treated within the approved time window.
Source: Stroke - February 26, 2017 Category: Neurology Authors: Laura Dorado, Niaz Ahmed, Gotz Thomalla, Manuel Lozano, Branko Maloȷcic, Mushtaq Wani, Monica Millan, Ales Tomek, Antoni Davalos Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Early Insulin Glycemic Control Combined With tPA Thrombolysis Reduces Acute Brain Tissue Damages in a Focal Embolic Stroke Model of Diabetic Rats Brief Reports
Conclusions— Early insulin glycemic control may be beneficial in combination with tPA thrombolysis for ischemic stroke with diabetes mellitus or poststroke hyperglycemia.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Fan, X., Ning, M., Lo, E. H., Wang, X. Tags: Animal models of human disease, Type 1 diabetes, Acute Cerebral Infarction, Embolic stroke, Emergency treatment of Stroke, Thrombolysis Brief Reports Source Type: research

Pulmonary Embolism in Ischemic Stroke: Clinical Presentation, Risk Factors, and Outcome Stroke
Conclusions In this large cohort study, PE occurred in nearly 1% of AIS patients. PE was more common in patients with severe stroke, history of cancer, previous DVT/PE or acute DVT and associated with lower short- and long-term survival, greater disability, and longer length of stay.
Source: JAHA:Journal of the American Heart Association - November 25, 2013 Category: Cardiology Authors: Pongmoragot, J., Rabinstein, A. A., Nilanont, Y., Swartz, R. H., Zhou, L., Saposnik, G., The Investigators of the Registry of the Canadian Stroke Network (RCSN) and University of Toronto Stroke Program for the Stroke Outcomes Research Canada (SORCan [www. Tags: Stroke Source Type: research

Efficacy and Safety of Platelet Glycoprotein Receptor Blockade in Aged and Comorbid Mice With Acute Experimental Stroke Basic Sciences
Conclusions— Inhibition of early steps of thrombus formation protects adult and comorbid mice from ischemic stroke. The use of clinically meaningful mouse strains might improve the translation of preclinical stroke research to the clinic.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Kraft, P., Schuhmann, M. K., Fluri, F., Lorenz, K., Zernecke, A., Stoll, G., Nieswandt, B., Kleinschnitz, C. Tags: Animal Models of Human Disease, Hypertension, Treatment, Ischemic Stroke, Atherosclerosis Basic Sciences Source Type: research

Atrial Fibrillation Is Associated With a Worse 90-Day Outcome Than Other Cardioembolic Stroke Subtypes Clinical Sciences
Conclusions— AF is associated with an unfavorable 90-day outcome among patients with a CES independent of established risk factors and initial stroke severity. This suggests that AF-specific mechanisms affect CES severity and functional status after CES. If confirmed in future studies, further investigation into the underlying pathophysiological mechanisms may provide novel avenues to AF detection and treatment.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Henninger, N., Goddeau, R. P., Karmarkar, A., Helenius, J., McManus, D. D. Tags: Atrial Fibrillation, Etiology, Ischemic Stroke Clinical Sciences Source Type: research

Effects of Alteplase for Acute Stroke on the Distribution of Functional Outcomes: A Pooled Analysis of 9 Trials Clinical Sciences
Conclusions— Treatment with intravenous alteplase initiated within 4.5 hours of stroke onset increases the chance of achieving an improved level of function for all patients across the age spectrum, including the over 80s and across all severities of stroke studied (top versus bottom fifth means: 22 versus 4); the earlier that treatment is initiated, the greater the benefit.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Lees, K. R., Emberson, J., Blackwell, L., Bluhmki, E., Davis, S. M., Donnan, G. A., Grotta, J. C., Kaste, M., von Kummer, R., Lansberg, M. G., Lindley, R. I., Lyden, P., Murray, G. D., Sandercock, P. A. G., Toni, D., Toyoda, K., Wardlaw, J. M., Whiteley, Tags: Treatment, Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Clinical Sciences Source Type: research

Coexistent Sickle Cell Disease Has No Impact on the Safety or Outcome of Lytic Therapy in Acute Ischemic Stroke Clinical Sciences
Conclusions—Coexistent SCD had no significant impact on the safety or outcome of thrombolytic therapy in acute ischemic stroke. Although the sample size is relatively small, these data suggest that adults with SCD and acute ischemic stroke should be treated with thrombolysis, if they otherwise qualify. Addition studies, however, should track the intracranial hemorrhage rate and provide information on other SCD-related care such as transfusion.
Source: Stroke - February 26, 2017 Category: Neurology Authors: Robert J. Adams, Margueritte Cox, Shelly D. Ozark, Julie Kanter, Phillip J. Schulte, Ying Xian, Gregg C. Fonarow, Eric E. Smith, Lee H. Schwamm Tags: Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

CHA2DS2-VASc Score (Congestive Heart Failure, Hypertension, Age >=75 Doubled, Diabetes Mellitus, Prior Stroke or Transient Ischemic Attack Doubled, Vascular Disease, Age 65-74, Female) for Stroke in Asian Patients With Atrial Fibrillation Clinical Sciences
Background and Purpose—The CHA2DS2-VASc stroke score (congestive heart failure, hypertension, age ≥75 (doubled), diabetes mellitus, prior stroke or transient ischemic attack (doubled), vascular disease, age 65–74, female) is used in most guidelines for risk stratification in atrial fibrillation (AF), but most data for this score have been derived in Western populations. Ethnic differences in stroke risk may be present. Our objective was to investigate risk factors for stroke in AF and application of the CHA2DS2-VASc score in an Asian AF population from Korea.Methods—A total of 5855 oral anticoagulant–naive nonval...
Source: Stroke - May 22, 2017 Category: Neurology Authors: Tae-Hoon Kim, Pil-Sung Yang, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y.H. Lip Tags: Arrhythmias, Risk Factors, Ischemic Stroke Original Contributions Source Type: research

Stroke Incidence and Usage Rate of Thrombolysis in A Japanese Urban City: The Kurashiki Stroke Registry
Conclusion: In this urban Japanese city, the age-adjusted incidence of first-ever stroke between March 2009 and February 2010 was 60.7 per 100,000 residents, which was relatively low compared with findings for other countries. Thrombolysis was given to approximately 5% of patients with acute ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - November 3, 2011 Category: Neurology Authors: Yasuyuki Iguchi, Kazumi Kimura, Keiichi Sone, Hiroshi Miura, Hiroshi Endo, Sen Yamagata, Hisashi Koide, Kenji Suzuki, Tomoichiro Kimura, Masaru Sakurai, Nobuya Mishima, Kenji Yoshii, Hiroyuki Fujisawa, Sunao Ebisutani, Kurashiki Stroke Registry investigat Tags: Original Articles Source Type: research

Prothrombin G20210A Mutation Is Associated With Young-Onset Stroke: The Genetics of Early-Onset Stroke Study and Meta-Analysis Clinical Sciences
Conclusions— The prothrombin G20210A mutation is associated with ischemic stroke in young adults and may have an even stronger association among those with earlier onset strokes. Our finding of a stronger association in the younger young adult population requires replication.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Jiang, B., Ryan, K. A., Hamedani, A., Cheng, Y., Sparks, M. J., Koontz, D., Bean, C. J., Gallagher, M., Hooper, W. C., McArdle, P. F., O'Connell, J. R., Stine, O. C., Wozniak, M. A., Stern, B. J., Mitchell, B. D., Kittner, S. J., Cole, J. W. Tags: Coagulation, Acute Cerebral Infarction, Genetics of Stroke, Epidemiology Clinical Sciences Source Type: research

Establishment of Government-Initiated Comprehensive Stroke Centers for Acute Ischemic Stroke Management in South Korea Clinical Sciences
Conclusions— The Regional CSC program has improved the performance of acute stroke management in South Korea and can be used as a model for rapidly improving stroke management.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Kim, J., Hwang, Y.-H., Kim, J.-T., Choi, N.-C., Kang, S.-Y., Cha, J.-K., Ha, Y. S., Shin, D.-I., Kim, S., Lim, B.-H. Tags: Emergency treatment of Stroke Clinical Sciences Source Type: research

Population-Based Study of Blood Biomarkers in Prediction of Subacute Recurrent Stroke Clinical Sciences
Conclusions— In the largest study to date, we found limited predictive use for early recurrent stroke for a panel of inflammatory, thrombotic, and cell damage biomarkers.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Segal, H. C., Burgess, A. I., Poole, D. L., Mehta, Z., Silver, L. E., Rothwell, P. M. Tags: Other diagnostic testing, Risk Factors for Stroke, Coagulation and fibronolysis Clinical Sciences Source Type: research

Acute Reperfusion Therapy and Stroke Care in Asia After Successful Endovascular Trials Understanding and Applying the Endovascular Trials
The current status of and prospects for acute stroke care in Asia in the situation where both intravenous thrombolysis and endovascular therapies have been recognized as established strategies for acute stroke are reviewed. Of 15 million people annually having stroke worldwide, 9 million are Asians. The burdens of both ischemic and hemorrhagic strokes are severe in Asia. The unique features of stroke in Asia include susceptibility to intracranial atherosclerosis, high prevalence of intracerebral hemorrhage, effects of dietary and lifestyle habits, and several disorders with genetic causes. These features affect acute strok...
Source: Stroke - May 22, 2015 Category: Neurology Authors: Toyoda, K., Koga, M., Hayakawa, M., Yamagami, H. Tags: Emergency treatment of Stroke, Anticoagulants, Thrombolysis, Angioplasty and Stenting Understanding and Applying the Endovascular Trials Source Type: research

Effects of Blood Pressure and Blood Pressure-Lowering Treatment During the First 24 Hours Among Patients in the Third International Stroke Trial of Thrombolytic Treatment for Acute Ischemic Stroke Clinical Sciences
Conclusions— Among patients with ischemic stroke who are candidates for thrombolytic treatment, high baseline blood pressure and a large pressure variability during the first 24 hours may be associated with a poor prognosis, whereas a large reduction in blood pressure and the use of blood pressure–lowering treatment during the first 24 hours may be associated with a favorable prognosis. These data support the rationale for further trials of agents that lower blood pressure or reduce blood pressure variability in the acute phase of ischemic stroke. Clinical Trial Registration— URL: http://www.clinicaltria...
Source: Stroke - November 23, 2015 Category: Neurology Authors: Berge, E., Cohen, G., Lindley, R. I., Sandercock, P., Wardlaw, J. M., Sandset, E. C., Whiteley, W. Tags: Treatment, Cerebrovascular Disease/Stroke, Ischemic Stroke Clinical Sciences Source Type: research

Sex Disparities in Ischemic Stroke Care: FL-PR CReSD Study (Florida-Puerto Rico Collaboration to Reduce Stroke Disparities) Clinical Sciences
Conclusions— Women received comparable stroke care to men in this registry as measured by prespecified Get With The Guidelines metrics. However, women less likely received thrombolysis and had door-to-needle time <1 hour, an observation that calls for the implementation of interventions to reduce sex disparity in these measures.
Source: Stroke - September 25, 2016 Category: Neurology Authors: Asdaghi, N., Romano, J. G., Wang, K., Ciliberti-Vargas, M. A., Koch, S., Gardener, H., Dong, C., Rose, D. Z., Waddy, S. P., Robichaux, M., Garcia, E. J., Gonzalez-Sanchez, J. A., Burgin, W. S., Sacco, R. L., Rundek, T. Tags: Secondary Prevention, Women, Quality and Outcomes, Ischemic Stroke Clinical Sciences Source Type: research