Filtered By:
Condition: Thrombosis

This page shows you your search results in order of relevance. This is page number 6.

Order by Relevance | Date

Total 15499 results found since Jan 2013.

Vessel Wall Magnetic Resonance Imaging in Acute Ischemic Stroke: Effects of Embolism and Mechanical Thrombectomy on the Arterial Wall Clinical Sciences
Conclusions— Mechanical thrombectomy results in intracranial arterial wall thickening and enhancement, potentially mimicking the VW-MRI appearance of primary arteritis. This arterial wall abnormality is less common in patients with arterial occlusion who have been treated with medical therapy alone.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Power, S., Matouk, C., Casaubon, L. K., Silver, F. L., Krings, T., Mikulis, D. J., Mandell, D. M. Tags: Embolic stroke, Computerized tomography and Magnetic Resonance Imaging, Pathology of Stroke, Primary and Secondary Stroke Prevention Clinical Sciences Source Type: research

Different Doses of Recombinant Tissue-Type Plasminogen Activator for Acute Stroke in Chinese Patients Clinical Sciences
Conclusions— These results did not support the dose of 0.9 mg/kg of r-tPA being optimal for all patients in the East Asian population. In elderly patients (71–80 years), a lower dose of 0.6 mg/kg is associated with a better outcome. Confirmation of the results through randomized trial is required.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Chao, A.-C., Liu, C.-K., Chen, C.-H., Lin, H.-J., Liu, C.-H., Jeng, J.-S., Hu, C.-J., Chung, C.-P., Hsu, H.-Y., Sheng, W.-Y., Hu, H.-H., on behalf of the Taiwan Thrombolytic Therapy for Acute Ischemic Stroke (TTT-AIS) Study Group Tags: Thrombolysis Clinical Sciences Source Type: research

Role of Imaging in Current Acute Ischemic Stroke Workflow for Endovascular Therapy Understanding and Applying the Endovascular Trials
Ischemic stroke is caused by a thrombus that blocks an intracranial artery. Brain tissue beyond the blocked artery survives for a variable period of time because of blood and nutrients received through tiny vessels called collaterals. Imaging the brain and the vasculature that supplies it is therefore a vital first step in treating patients with acute ischemic stroke. In this review, we focus on current evidence for imaging selection of patients for endovascular therapy in the context of the recently positive clinical trials, such as Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke ...
Source: Stroke - May 22, 2015 Category: Neurology Authors: Menon, B. K., Campbell, B. C. V., Levi, C., Goyal, M. Tags: CT and MRI, Emergency treatment of Stroke Understanding and Applying the Endovascular Trials Source Type: research

Coagulation and Fibrinolytic Activity of Tenecteplase and Alteplase in Acute Ischemic Stroke Brief Reports
Conclusions— In patients with acute ischemic stroke, alteplase 0.9 mg/kg caused significant disruption of the fibrinolytic system, whereas tenecteplase 0.25 mg/kg did not, consistent with the trend toward lower intracerebral hemorrhage incidence with tenecteplase in the ATTEST study. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01472926.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Huang, X., Moreton, F. C., Kalladka, D., Cheripelli, B. K., MacIsaac, R., Tait, R. C., Muir, K. W. Tags: Treatment, Ischemic Stroke, Thrombosis Brief Reports Source Type: research

Permeable Thrombi Are Associated With Higher Intravenous Recombinant Tissue-Type Plasminogen Activator Treatment Success in Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions— Thrombus perviousness, as measured on computed tomography in the acute stage of ischemic stroke, is strongly associated with recanalization after intravenous r-tPA treatment and with favorable functional outcome.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Santos, E. M. M., Dankbaar, J. W., Treurniet, K. M., Horsch, A. D., Roos, Y. B., Kappelle, L. J., Niessen, W. J., Majoie, C. B., Velthuis, B., Marquering, H. A., on behalf of the DUST Investigators, Duijm, Keizer, van der Lugt, Dippel, Droogh - de Greeve, Tags: Computerized Tomography (CT), Prognosis, Revascularization, Treatment, Ischemic Stroke Clinical Sciences Source Type: research

Neurologic Examination at 24 to 48 Hours Predicts Functional Outcomes in Basilar Artery Occlusion Stroke Clinical Sciences
Conclusions— Twenty-four- to 48-hour NIHSS accurately predicts 1-month poor outcome and mortality and represents a clinically valuable prognostic tool for the care of basilar artery occlusion patients.
Source: Stroke - September 25, 2016 Category: Neurology Authors: Rangaraju, S., Jovin, T. G., Frankel, M., Schonewille, W. J., Algra, A., Kappelle, L. J., Nogueira, R. G., on behalf of the BASICS Study Group Tags: Mortality/Survival, Cerebrovascular Disease/Stroke, Ischemic Stroke, Thrombosis Clinical Sciences Source Type: research

Erythrocyte Fraction Within Retrieved Thrombi Contributes to Thrombolytic Response in Acute Ischemic Stroke Clinical Sciences
Conclusions—In EVT-attempted patients with acute ischemic stroke, IVT responsiveness would be closely associated with RBC fraction.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Mun Hee Choi, Geun Hwa Park, Jin Soo Lee, Sung Eun Lee, Seong-Joon Lee, Jang-Hee Kim, Ji Man Hong Tags: Ischemic Stroke Original Contributions Source Type: research

Comparison of Clinical Risk Stratification for Predicting Stroke and Thromboembolism in Atrial Fibrillation Clinical Sciences
Conclusions— A direct comparison of 9 risk schemes reveals no profound differences in risk stratification accuracy for high-risk patients. Accurate prediction of low-risk patients is perhaps more valuable in determining those unlikely to benefit from oral anticoagulation therapy. Among our cohort, CHA2DS2-VASc performed best in this purpose.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Aakre, C. A., McLeod, C. J., Cha, S. S., Tsang, T. S. M., Lip, G. Y. H., Gersh, B. J. Tags: Cerebrovascular disease/stroke, Arrhythmias, clinical electrophysiology, drugs, Embolic stroke, Anticoagulants Clinical Sciences Source Type: research

Thrombus Permeability Is Associated With Improved Functional Outcome and Recanalization in Patients With Ischemic Stroke Clinical Sciences
Conclusions— This study shows that simultaneous measurement of thrombus attenuation in noncontrast computed tomography and computed tomographic angiography allows for quantification of thrombus perviousness. Thrombus perviousness is strongly associated with improved functional outcome, smaller final infarct volume, and higher recanalization rate.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Santos, E. M. M., Marquering, H. A., den Blanken, M. D., Berkhemer, O. A., Boers, A. M. M., Yoo, A. J., Beenen, L. F., Treurniet, K. M., Wismans, C., van Noort, K., Lingsma, H. F., Dippel, D. W. J., van der Lugt, A., van Zwam, W. H., Roos, Y. B. W. E. M., Tags: Angiography, Computerized Tomography (CT), Quality and Outcomes, Ischemic Stroke, Thrombosis Clinical Sciences Source Type: research

Intravenous Thrombolysis With Recombinant Tissue-Type Plasminogen Activator in a Stroke Patient Receiving Dabigatran Anticoagulant After Antagonization With Idarucizumab Brief Reports
Conclusions— This case represents a new therapeutic paradigm. It is further supported by in vitro data showing no nonspecific interactions of idarucizumab with recombinant tissue-type plasminogen activator–induced thrombolysis. Thus, patients effectively anticoagulated with dabigatran who were previously contraindicated for thrombolytic therapy in this situation may now receive treatment because of the ability to rapidly reverse the anticoagulant activity of dabigatran with idarucizumab.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Berrouschot, J., Stoll, A., Hogh, T., Eschenfelder, C. C. Tags: Cerebrovascular Procedures, Ischemic Stroke Brief Reports Source Type: research

Randomized, Multicenter Trial of ARTSS-2 (Argatroban With Recombinant Tissue Plasminogen Activator for Acute Stroke) Clinical Sciences
Conclusions—In patients treated with r-tPA, adjunctive argatroban was not associated with increased risk of symptomatic intracerebral hemorrhage and provides evidence that a definitive effectiveness trial is indicated.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique Identifier: NCT01464788.
Source: Stroke - May 22, 2017 Category: Neurology Authors: Andrew D. Barreto, Gary A. Ford, Loren Shen, Claudia Pedroza, Jon Tyson, Chunyan Cai, Mohammad H. Rahbar, James C. Grotta, on behalf of the ARTSS-2 Investigators Tags: Clinical Studies, Cerebrovascular Disease/Stroke, Ischemic Stroke, Thrombosis Original Contributions Source Type: research

Fibrin Clot Permeability as a Predictor of Stroke and Bleeding in Anticoagulated Patients With Atrial Fibrillation Clinical Sciences
Background and Purpose—Formation of denser fiber networks has been reported in atrial fibrillation and ischemic stroke. In this longitudinal cohort study, we evaluated whether fibrin clot density may predict thromboembolic and bleeding risk in patients with atrial fibrillation on vitamin K antagonists.Methods—In 236 patients with atrial fibrillation receiving vitamin K antagonists treatment, we measured ex vivo plasma clot permeability (Ks), a measure of the pore size in fibrin networks.Results—During a median follow-up of 4.3 (interquartile range, 3.7–4.8) years, annual rates of ischemic stroke or transient ischem...
Source: Stroke - September 25, 2017 Category: Neurology Authors: Leszek Drabik, Paweł Wołkow, Anetta Undas Tags: Atrial Fibrillation, Ischemic Stroke, Thrombosis Original Contributions Source Type: research

Associations Between Collateral Status and Thrombus Characteristics and Their Impact in Anterior Circulation Stroke Clinical Sciences
Conclusions—Patients with lower thrombus burden and higher thrombus perviousness scores had higher collateral score. The positive effect of thrombus perviousness on clinical outcome was only present in patients with moderate and high collateral scores.Clinical Trial Registration—URL: http://www.trialregister.nl. Unique identifier: NTR1804 and URL: http://www.controlled-trials.com Unique identifier: ISRCTN10888758.
Source: Stroke - January 22, 2018 Category: Neurology Authors: Heitor C. Alves, Kilian M. Treurniet, Bruna G. Dutra, Ivo G. H. Jansen, Anna M.M. Boers, Emilie M.M. Santos, Olvert A. Berkhemer, Diederik W.J. Dippel, Aad van der Lugt, Wim H. van Zwam, Robert J. van Oostenbrugge, Hester F. Lingsma, Yvo B.W.E.M. Roos, Al Tags: Computerized Tomography (CT), Ischemic Stroke Original Contributions Source Type: research

Low Levels of Caveolin-1 Predict Symptomatic Bleeding After Thrombolytic Therapy in Patients With Acute Ischemic Stroke Brief Report
Background and Purpose—Experimental models of cerebral ischemia demonstrate that the decrease in the caveolin-1 membrane protein results in an increase in endothelial permeability. Because this phenomenon is responsible for hemorrhagic transformation (HT) after cerebral ischemia, we aimed to determine whether caveolin-1 levels may predict bleeding after recombinant tissue-type plasminogen activator (r-tPA) administration in patients with acute stroke.Methods—We studied 133 patients with a first hemispheric stroke treated with r-tPA within 4.5 hours of symptom onset. HT was evaluated and classified on cranial computed t...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Mar Castellanos, Cecile van Eendenburg, Carme Gubern, Elisabet Kadar, Gemma Huguet, Josep Puig, Tomas Sobrino, Gerard Blasco, Joaquin Serena, Juan Manuel Sanchez Tags: Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Blood-Brain Barrier, Ischemic Stroke Brief Reports Source Type: research

Younger Stroke Patients With Large Pretreatment Diffusion-Weighted Imaging Lesions May Benefit From Endovascular Treatment Clinical Sciences
Conclusions— There was a growing risk for poor outcome and symptomatic intracerebral hemorrhage with increasing pretreatment DWI lesion volumes. Nevertheless, favorable outcome was achieved in every third patient with DWI lesions >70 mL after successful endovascular reperfusion, whereas after poor or failed reperfusion, outcome was favorable in only every 12th patient. Therefore, endovascular treatment might be considered in patients with large DWI lesions, especially in younger patients.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Gilgen, M. D., Klimek, D., Liesirova, K. T., Meisterernst, J., Klinger-Gratz, P. P., Schroth, G., Mordasini, P., Hsieh, K., Slotboom, J., Heldner, M. R., Broeg-Morvay, A., Mono, M.-L., Fischer, U., Mattle, H. P., Arnold, M., Gralla, J., El-Koussy, M., Jun Tags: Acute Cerebral Infarction, Thrombolysis, Other Stroke Treatment - Medical Clinical Sciences Source Type: research