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Total 289 results found since Jan 2013.

Socioeconomic disparities in the prevalence of comorbid chronic conditions among Canadian adults with cancer
CONCLUSION: History of cancer is associated with a higher probability of many comorbid conditions. This excess comorbidity burden seems to be unequally shouldered by individuals in the lower socioeconomic stratum as well as minority populations.PMID:34726566 | DOI:10.1080/0284186X.2021.1995892
Source: Acta Oncologica - November 2, 2021 Category: Cancer & Oncology Authors: Omar Abdel-Rahman Scott North Source Type: research

Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects
Biomed Pharmacother. 2021 Nov;143:112175. doi: 10.1016/j.biopha.2021.112175. Epub 2021 Sep 27.ABSTRACTWithania somnifera (L.) Dunal (Solanaceae) has been used as a traditional Rasayana herb for a long time. Traditional uses of this plant indicate its ameliorative properties against a plethora of human medical conditions, viz. hypertension, stress, diabetes, asthma, cancer etc. This review presents a comprehensive summary of the geographical distribution, traditional use, phytochemistry, and pharmacological activities of W. somnifera and its active constituents. In addition, it presents a detailed account of its presence as...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 15, 2021 Category: Drugs & Pharmacology Authors: Subhabrata Paul Shreya Chakraborty Uttpal Anand Swarnali Dey Samapika Nandy Mimosa Ghorai Suchismita Chatterjee Saha Manoj Tukaram Patil Ramesh Kandimalla Jaros ław Proćków Abhijit Dey Source Type: research

Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR
Eur J Med Chem. 2021 Aug 27;225:113804. doi: 10.1016/j.ejmech.2021.113804. Online ahead of print.ABSTRACTInflammation is a most complex pathological process that gives birth to different diseases. Different inflammatory mediators are released during an inflammation responsible for acute pain and chronic inflammatory diseases like cancer, asthma, rheumatoid arthritis, osteoarthritis, neurodegenerative diseases, metabolic and cardiovascular disorders. The arachidonic acid pathway, which results in the production of inflammatory mediators, provides several targets for anti-inflammatory intervention. The most popularly used me...
Source: European Journal of Medicinal Chemistry - September 3, 2021 Category: Chemistry Authors: Minakshi A Meshram Utkarsha O Bhise Priyanka N Makhal Venkata Rao Kaki Source Type: research

Cancers, Vol. 13, Pages 3368: Physical Comorbidities and Depression in Recent and Long-Term Adult Cancer Survivors: NHANES 2007 –2018
Cancers, Vol. 13, Pages 3368: Physical Comorbidities and Depression in Recent and Long-Term Adult Cancer Survivors: NHANES 2007–2018 Cancers doi: 10.3390/cancers13133368 Authors: Dafina Petrova Andrés Catena Miguel Rodríguez-Barranco Daniel Redondo-Sánchez Eloísa Bayo-Lozano Rocio Garcia-Retamero José-Juan Jiménez-Moleón María-José Sánchez Many adult cancer patients present one or more physical comorbidities. Besides interfering with treatment and prognosis, physical comorbidities could also increase the already heightened psychological risk of cancer patients. To test this possibility, we...
Source: Cancers - July 5, 2021 Category: Cancer & Oncology Authors: Dafina Petrova Andr és Catena Miguel Rodr íguez-Barranco Daniel Redondo-S ánchez Elo ísa Bayo-Lozano Rocio Garcia-Retamero Jos é-Juan Jiménez-Moleón Mar ía-José Sánchez Tags: Article Source Type: research

The impact of seven major noncommunicable diseases on direct medical costs, absenteeism, and presenteeism in Gulf Cooperation Council countries
CONCLUSION: The economic burden of noncommunicable diseases in Gulf Cooperation Council countries is substantial, suggesting that successful preventive interventions have the potential to improve both population health and reduce costs. Further research is needed to capture a broader array of noncommunicable diseases and to develop more precise estimates.PMID:34138664 | DOI:10.1080/13696998.2021.1945242
Source: Journal of Medical Economics - June 17, 2021 Category: Health Management Authors: Eric Andrew Finkelstein Jesse D Malkin Drishti Baid Ada Alqunaibet Khaled Mahdi Mohammed Bin Hamad Al-Thani Buthaina Abdulla Bin Belaila Ebrahim Al Nawakhtha Saleh Alqahtani Sameh El-Saharty Christopher H Herbst Source Type: research

Paving the Way for Diversity in Clinical Trials
Racial disparities in clinical trials have long been an issue that’s just another part of the implicit bias in health care. Compared to white people, Black people are largely at higher risk for heart disease, cancer, stroke, diabetes, asthma, and even mental health problems.
Source: WebMD Health - March 23, 2021 Category: Consumer Health News Source Type: news

Sexual Orientation Disparities in Risk Factors for Adverse COVID-19-Related Outcomes, by Race/Ethnicity - Behavioral Risk Factor Surveillance System, United States, 2017-2019.
Abstract Sexual minority persons experience health disparities associated with sexual stigma and discrimination and have a high prevalence of several health conditions that have been associated with severe coronavirus disease 2019 (COVID-19) (1,2). Current COVID-19 surveillance systems do not capture information about sexual orientation. To begin bridging the gap in knowledge about COVID-19 risk among sexual minority adults, CDC examined disparities between sexual minority and heterosexual adults in the prevalence of underlying conditions with strong or mixed evidence of associations with severe COVID-19-related i...
Source: MMWR Morb Mortal Wkl... - February 5, 2021 Category: Epidemiology Authors: Heslin KC, Hall JE Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Medicinal plants against ischemic stroke.
Abstract Ischemic stroke is one of the major causes of global deaths. Prominent changes in the Central Nervous System (CNS) are observable including emotional, cognitive and behavioural changes during the recovery phase of a stroke. Brain ischemia affects a large portion of patients across the world with permanent disability or death. During the ischemic stroke onset, apart from inducing brain damage, existing microglial cells, immune cells, inflammatory factors such as chemokines and cytokines affect the process of brain repair. For the reduction of this damage, there is a need of understanding the basic mechanis...
Source: Current Pharmaceutical Biotechnology - December 9, 2020 Category: Biotechnology Authors: Roy A, Datta S Tags: Curr Pharm Biotechnol Source Type: research

Rural U.S. Hospitals Are On Life Support As a Third Wave of COVID-19 Strikes
When COVID-19 hit the Southwest Georgia Regional Medical Center in Cuthbert, a small rural town in Randolph County, in late March, the facility—which includes a 25-bed hospital, an adjacent nursing home and a family-medicine clinic, was quickly overwhelmed. In just a matter of days, 45 of the 62 nursing home residents tested positive. Negative residents were isolated in the hospital while the severely ill patients from both the nursing home and the local community were transferred to other better-equipped facilities. “We were trying to get the patients out as fast as possible,” says Steve Whatley, Southwe...
Source: TIME: Health - October 20, 2020 Category: Consumer Health News Authors: Emily Barone Tags: Uncategorized COVID-19 Source Type: news

Relationships between Chronic Diseases and Depression among Middle-aged and Elderly People in China: A Prospective Study from CHARLS
SummaryGiven the rapid increase in the prevalence of chronic diseases in aging populations, this prospective study including 17 707 adults aged ≥45 years from China Health and Retirement Longitudinal Study was used to estimate the associations between chronic disease, multimorbidity, and depression among middle-aged and elderly adults in China, and explore the mediating factors. Depressive symptoms were assessed using the 10-item Centre f or Epidemiological Studies Depression Scale (CES-D-10) questionnaire. Twelve chronic physical conditions, including hypertension, diabetes, dyslipidemia, cancer, chronic lung disease, l...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 1, 2020 Category: Research Source Type: research

Inflammatory effects of particulate matter air pollution.
Abstract Air pollution is an important cause of non-communicable diseases globally with particulate matter (PM) as one of the main air pollutants. PM is composed of microscopic particles that contain a mixture of chemicals and biological elements that can be harmful to human health. The aerodynamic diameter of PM facilitates their deposition when inhaled. For instance, coarse PM having a diameter of < 10 μm is deposited mainly in the large conducting airways, but PM of < 2.5 μm can cross the alveolar-capillary barrier, traveling to other organs within the body. Epidemiological studies have shown the ...
Source: Environmental Science and Pollution Research International - August 31, 2020 Category: Environmental Health Authors: Arias-Pérez RD, Taborda NA, Gómez DM, Narvaez JF, Porras J, Hernandez JC Tags: Environ Sci Pollut Res Int Source Type: research

African Americans Struggle With the Current COVID-19
Objectives: Our study aims to explore the differential impact of this pandemic on clinical presentations and outcomes in African Americans (AAs) compared to white patients. Background: AAs have worse outcomes compared to whites while facing heart diseases, stroke, cancer, asthma, influenza and pneumonia, diabetes, and HIV/AIDS. However, there is no current study to show the impact of COVID-19 pandemic on the AA communities. Methods: This is a retrospective study that included patients with laboratory-confirmed COVID-19 from 2 tertiary centers in New Orleans, LA. Clinical and laboratory data were collected. Multivar...
Source: Annals of Surgery - August 22, 2020 Category: Surgery Tags: COVID PAPERS Source Type: research