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Total 289 results found since Jan 2013.
Prevalent Multimorbidity Combinations Among Middle-Aged and Older Adults Seen in Community Health Centers
ConclusionsCHCs are increasingly seeing more complex multimorbidity patterns over time; these most often involve mental health morbidity and advanced cardiometabolic-renal morbidity.
Source: Journal of General Internal Medicine - January 28, 2022 Category: Internal Medicine Source Type: research
Mechanism of Dihydromyricetin on Inflammatory Diseases
Inflammation plays a crucial role in a variety of diseases, including diabetes, arthritis, asthma, Alzheimer’s disease (AD), acute cerebral stroke, cancer, hypertension, and myocardial ischemia. Therefore, we need to solve the problem urgently for the study of inflammation-related diseases. Dihydromyricetin (DHM) is a flavonoid mainly derived from Nekemias grossedentata (Hand.-Mazz.) J.Wen and Z.L.Nie (N.grossedentata). DHM possesses many pharmacological effects, including anti-inflammatory (NLRP-3, NF-κB, cytokines, and neuroinflammation), antioxidant, improving mitochondrial dysfunction, and regulating autophagy and s...
Source: Frontiers in Pharmacology - January 18, 2022 Category: Drugs & Pharmacology Source Type: research
Basis for diurnal exacerbation of neuropathic pain hypersensitivity and its application for drug development
J Biochem. 2021 Dec 30:mvab143. doi: 10.1093/jb/mvab143. Online ahead of print.ABSTRACTIn addition to diurnal rhythms in physiology and behavior, a variety of pathological conditions also exhibit marked day-night changes in symptom intensity, exemplified by allergic rhinitis, arthritis, asthma, myocardial infarction, congestive heart failure, stroke, and chronic pain disorders. Currently, novel therapeutic approaches are facilitated by the development of chemical compounds targeted to key proteins that cause diurnal exacerbation of pathological events. Neuropathic pain is a chronic condition that occurs by tumor-induced ne...
Source: Herpes - December 30, 2021 Category: Infectious Diseases Authors: Satoru Koyanagi Naoki Kusunose Sai Yasukochi Shigehiro Ohdo Source Type: research
Migraine and Medical Ramifications: A Comprehensive Overview Based on Observational Study Meta-Analyses
Conclusion: The results showed that migraine increased the risk of 29 health outcomes, though lowered the risk of breast cancer. However, evidence quality was graded as high only for angina. The evidence quality of ischaemic stroke, stroke, MACCE, WMAs, and asthma was graded as moderate. All remaining 24 outcomes had an evidence grade of “weak.”
Source: Frontiers in Neurology - December 24, 2021 Category: Neurology Source Type: research
Association of chronic kidney disease with exposure to polycyclic aromatic hydrocarbons in the US population
This study aims to investigate the association between seven urinary PAH concentrations (1-hydroxynaphthalene, 2-hydroxynaphthalene, 3-hydroxyfluorene 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene, and 2 & 3-hydroxyphenanthrene) and CKD in the US adult population. A cross-sectional analysis using the 2015-2016 National Health and Nutrition Examination Survey (NHANES) dataset was conducted. CKD was defined with estimated glomerular filtration rate (eGFR) and albumin to creatinine ratio (ACR). Participants with an eGFR < 60 ml/min/1.73m2 or ACR > 30 mg/gm were considered to have CKD. A specialized compl...
Source: Environmental Science and Pollution Research International - November 25, 2021 Category: Environmental Health Authors: Humairat H Rahman Danielle Niemann Stuart H Munson-McGee Source Type: research
Local incidence and outcomes of patients with pneumothorax and pneumomediastinum in COVID-19
Conclusions: Inpatient incidence of PTX and PM is 0.98%. Survival is lower (54.5%) but difficult to compare in the presence of frailty and co-morbidities.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Jackson, K., Aujayeb, A., Aujayeb, A. Tags: Clinical problems Source Type: research
Real-world impact of disease on functioning and activity: what is missed when using general instruments to estimate quality-adjusted life year
CONCLUSION: Differences in rankings of disease severity by metric indicate that the results of cost-utility analyses might be biased against treatments for certain diseases. As patient preferences for clinical outcomes vary, the full burden of disease should be considered in evaluations. Restricting access to treatments based on an incomplete estimate of burden could lead to misallocation of resources and a withholding of therapies that patients find valuable.PMID:34775901 | DOI:10.1080/03007995.2021.2006535
Source: Current Medical Research and Opinion - November 15, 2021 Category: Research Authors: Tingjian Yan Jesse D Ortendahl Eunice Chang Zac Wessler Amanda L Harmon Michael S Broder Source Type: research
Socioeconomic disparities in the prevalence of comorbid chronic conditions among Canadian adults with cancer
CONCLUSION: History of cancer is associated with a higher probability of many comorbid conditions. This excess comorbidity burden seems to be unequally shouldered by individuals in the lower socioeconomic stratum as well as minority populations.PMID:34726566 | DOI:10.1080/0284186X.2021.1995892
Source: Acta Oncologica - November 2, 2021 Category: Cancer & Oncology Authors: Omar Abdel-Rahman Scott North Source Type: research
