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Total 135484 results found since Jan 2013.
Enantiomerization and enantioselective bioaccumulation of diclofop-methyl in tubifex worms
In this study, the hydrolysis of diclofop-methyl (DM) in aqueous system and the bioaccumulation of its main metabolite, Diclofop (DA), in the tubifex worms were investigated using enantioselective high-performance liquid chromatography. With the addition of tubifex, rapid hydrolysis was observed for DM. It is revealed that the hydrolysis of DM in the water and the accumulation of DA in the worms were both enantioselective. Meanwhile, either the hydrolysis amount or the levels of enantioselectivity were influenced by the tubifex. After incubated for 24 h, about 94.6% of the DM was hydrolyzed and the enantiomer fraction of m...
Source: Chirality - September 18, 2023 Category: Molecular Biology Authors: Tiantian Liu Xinhong Duan Source Type: research
Rottlerin impairs early and late steps of Toxoplasma gondii infection in human trophoblast cells and villous explants
Chem Biol Interact. 2023 Sep 16:110716. doi: 10.1016/j.cbi.2023.110716. Online ahead of print.ABSTRACTCongenital toxoplasmosis, caused by the opportunistic protozoan parasite T. gondii, can cause stillbirths, miscarriages and fetal abnormalities, as well as encephalitis and chorioretinitis in newborns. Available treatment options rely on antiparasitic drugs that have been linked to serious side effects, high toxicity and the development of drug-resistant parasites. The search for alternative therapeutics to treat this disease without acute toxicity for the mother and child is essential for the advancement of current therap...
Source: Chemico-Biological Interactions - September 18, 2023 Category: Molecular Biology Authors: Samuel Cota Teixeira Marina Paschoalino Guilherme de Souza Alessandra Monteiro Rosini Joed Pires de Lima Junior Luana Carvalho Luz Aryani Felixa Fajardo Mart ínez Rosiane Nascimento Alves Marcos Paulo Oliveira Almeida Jaqueline Lopes Damasceno Marcelo Jo Source Type: research
Inhibition of C5aR1 as a promising approach to treat taxane-induced neuropathy
In conclusion, C5aR1 inhibition is proposed as a therapeutic option with the potential to exert long-term protective effect on PIPN-associated neuropathic pain and inflammation.PMID:37722320 | DOI:10.1016/j.cyto.2023.156370
Source: Cytokine - September 18, 2023 Category: Molecular Biology Authors: C Cristiano C Giorgio P Cocchiaro S Boccella M C Cesta V Castelli F M Liguori M R Cuozzo L Brandolini R Russo M Allegretti Source Type: research
Dual RNase activity of IRE1 as a target for anticancer therapies
J Cell Commun Signal. 2023 Sep 18. doi: 10.1007/s12079-023-00784-5. Online ahead of print.ABSTRACTThe unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate surviv...
Source: Journal of Cell Communication and Signaling - September 18, 2023 Category: Molecular Biology Authors: Sylwia Bartoszewska Jakub S ławski James F Collawn Rafa ł Bartoszewski Source Type: research
Monoamines' role in islet cell function and type 2 diabetes risk
Trends Mol Med. 2023 Sep 16:S1471-4914(23)00194-6. doi: 10.1016/j.molmed.2023.08.009. Online ahead of print.ABSTRACTThe two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets...
Source: Trends in Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Fiona Louise Roberts Luis Rodrigo Cataldo Malin Fex Source Type: research
Correction to: Sleep and Neuroimaging
Nucl Med Mol Imaging. 2023 Oct;57(5):256. doi: 10.1007/s13139-023-00807-4. Epub 2023 May 4.ABSTRACT[This corrects the article DOI: 10.1007/s13139-020-00636-9.].PMID:37720885 | PMC:PMC10504171 | DOI:10.1007/s13139-023-00807-4
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Kyoungjune Pak Jiyoung Kim Keunyoung Kim Seong Jang Kim In Joo Kim Source Type: research
Exploring the Opportunities and Challenges of ChatGPT in Academic Writing: Reply to Bom et al
Nucl Med Mol Imaging. 2023 Oct;57(5):213-214. doi: 10.1007/s13139-023-00816-3. Epub 2023 Aug 12.NO ABSTRACTPMID:37720884 | PMC:PMC10504185 | DOI:10.1007/s13139-023-00816-3
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Arosh S Perera Molligoda Arachchige Niccol ò Stomeo Source Type: research
Bilateral Ovarian Metastases of Hepatocellular Carcinoma Diagnosed with < sup > 18 < /sup > F-Fluorocholine PET/CT in a Patient with Endometriosis
Nucl Med Mol Imaging. 2023 Oct;57(5):251-253. doi: 10.1007/s13139-023-00796-4. Epub 2023 Apr 14.ABSTRACTA 47-year-old woman with history of hepatocellular carcinoma was referred for 18F-fluorocholine PET/CT evaluation due to elevated alpha-fetoprotein. The examination showed several peritoneal uptakes and two nodular pelvic foci. Coelioscopic exploration allowed confirmation and resection of multiple peritoneal metastases from hepatocellular carcinoma while pelvic biopsies revealed endometriosis and endosalpingiosis. However, alpha-fetoprotein kept rising: subsequent 18F-fluorodesoxyglucose PET/CT exploration found no pelv...
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Adrien Latg é Gerlinde Averous Anne Gressel Fran çois Faitot Benjamin Leroy-Freschini Source Type: research
Perirenal Fascia - an Uncommon Site of Metastases in Prostate Cancer Detected on < sup > 68 < /sup > Ga-PSMA-11 PET/CT
We report a case of a 50-year-old man with biopsy-proven high-risk PCa in which multiple tracer avid perirenal fascia deposits were identified on 68Ga-PSMA-11 PET/CT, in addition to multi-focal prostatic primary, extensive nodal, and skeletal metastases. This case highlights that perirenal fascia is an uncommon metastatic site in PCa.PMID:37720882 | PMC:PMC10504131 | DOI:10.1007/s13139-023-00801-w
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Kunal Ramesh Chandekar Swayamjeet Satapathy Sridhar Panaiyadiyan Rakesh Kumar Source Type: research
The Value of < sup > 18 < /sup > F-FDG PET/MRI in Detecting Lumbar Radiculopathy for Selective Percutaneous Endoscopic Discectomy: a Case Report
Nucl Med Mol Imaging. 2023 Oct;57(5):247-250. doi: 10.1007/s13139-023-00797-3. Epub 2023 Mar 29.ABSTRACTMagnetic resonance imaging (MRI) is the most popular imaging modality for investigating intervertebral disc herniation. However, it has a high chance for identifying incidental findings that are morphologically or structurally abnormal but not responsible for patients' symptoms. Although a previous study suggested that 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) may help identify neuroinflammation in lumbar radiculopathy, there is currently no direct evidence obtaine...
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Chih-Ying Su Guo-Shu Huang Wei-Chou Chang Chih-Chien Wang Chun-Wen Chen Yi-Chih Hsu Source Type: research
Response to the Letter to the Editor: Ethical Concerns of ChatGPT
Nucl Med Mol Imaging. 2023 Oct;57(5):215. doi: 10.1007/s13139-023-00819-0. Epub 2023 Aug 15.NO ABSTRACTPMID:37720880 | PMC:PMC10504132 | DOI:10.1007/s13139-023-00819-0
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Hee-Seung Henry Bom Source Type: research
Interesting Presentation of Mycosis Fungoides in Staging on F-18 FDG PET/CT
We report an interesting case of mycosis fungoides with bilateral upper limb edema and share its findings on F-18 FDG PET/CT.PMID:37720879 | PMC:PMC10504174 | DOI:10.1007/s13139-023-00794-6
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Deepanksha Datta Tanvi Sarwal Rajesh Kumar Sandeep Bairwa Vinay N Gowda Aasma Nalwa Source Type: research
Contribution of Metabolic Parameters and Pericolic Fat Stranding on Preoperative 18F-FDG PET/CT in Predicting Post-operative Histopathology and Outcome in Colorectal Cancer
CONCLUSION: Preoperative PET/CT contributes to CRC management by detecting additional metastases as well as predicting prognosis and postoperative findings such as T stage, N stage and tumor differentiation. The SUVmax may differentiate between T3 and T4 tumor. Reporting of pericolic fat stranding may contribute to the estimation of lymphatic invasion and positive surgical margin.PMID:37720878 | PMC:PMC10504194 | DOI:10.1007/s13139-023-00808-3
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Selin Soyluoglu Busra Ozdemir Gunay Source Type: research
< sup > 68 < /sup > Ga-DOTANOC PET/CT for Screening and Surveillance of Von Hippel-Lindau (VHL) disease
CONCLUSION: Our results show that 68 Ga-DOTANOC PET/CT may be a useful modality for screening and follow-up of associated tumors in patients with germline gene mutation for VHL. It can be used as a one-stop imaging modality for VHL patients and may substitute for separate radiological investigations, making it more convenient for patients in terms of time and cost.PMID:37720877 | PMC:PMC10504222 | DOI:10.1007/s13139-023-00810-9
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Shamim Ahmed Shamim Geetanjali Arora Naresh Kumar Jhangir Hussain Shreya Datta Gupta Arun Raj St Kritin Shankar Alpesh Goyal Rajesh Khadgawat Sambit Sagar Chandrasekhar Bal Source Type: research
Inhibition of C5aR1 as a promising approach to treat taxane-induced neuropathy
In conclusion, C5aR1 inhibition is proposed as a therapeutic option with the potential to exert long-term protective effect on PIPN-associated neuropathic pain and inflammation.PMID:37722320 | DOI:10.1016/j.cyto.2023.156370
Source: Cytokine - September 18, 2023 Category: Molecular Biology Authors: C Cristiano C Giorgio P Cocchiaro S Boccella M C Cesta V Castelli F M Liguori M R Cuozzo L Brandolini R Russo M Allegretti Source Type: research
