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Total 135484 results found since Jan 2013.
Evaluation of enhanced permeability effect and different linear energy transfer of radionuclides in a prostate cancer xenograft model
In conclusion, we found that specific targeting might negatively influence normal organ uptake when targeting secreted antigens. Furthermore, different energy deposition i.e. linear energy transfer of a radionuclide might have diverse effects on receptor expression and cell proliferation in tumors.PMID:37736493 | PMC:PMC10509292
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Oskar Vilhelmsson Timmermand Marcella Safi Bo Holmqvist Joanna Strand Source Type: research
The role of 18F-fluorodeoxyglucose PET/computed tomography in the diagnosis and monitoring of large vessel vasculitides - a review article
Am J Nucl Med Mol Imaging. 2023 Aug 15;13(4):127-135. eCollection 2023.ABSTRACTIn the last two decades, advancements in positron emission tomography (PET) technology have increased the diagnostic accuracy of patients with large-vessel vasculitis (LVV). Numerous systematic reviews and meta-analyses have been conducted, and patients suspected of having LVV can be diagnosed earlier with 18F-FDG PET. Two subtypes, giant cell arteritis (GCA) and Takayasu arteritis (TA), will progress when their response to corticosteroids and enhanced immunosuppression is inadequate. In the majority of patients, disease activity cannot be monit...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Mahshid Bahrami Hossein Mohammadi Hannaneh Mirgaloyebayat Zahra Mohajeri Pooya Fazeli Azad Mojahedi Ali Afsharirad Reza Tavakoli Amirhossein Sadeghian Sayed Mohammad Amin Nourian Source Type: research
Novel technique of detecting inflammatory and osseous changes in the glenohumeral joint associated with patient age and weight using FDG- and NaF-PET imaging
CONCLUSION: Our study demonstrates the varying effect of limb laterality and BMI on FDG and NaF uptake at the GH joint. Adoption of molecular imaging will require future studies that correlate tracer uptake with relevant medical and illness history as well as degenerative change evident on traditional imaging.PMID:37736491 | PMC:PMC10509288
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Peter Sang Uk Park Lori Jia William Y Raynor Om H Gandhi Mia Mijung Park Thomas J Werner Poul Flemming H øilund-Carlsen Abass Alavi Source Type: research
Associated Factors of Tophaceous Gout: A Study Involving 20 Primary Care Clinics in an Urbanized State in Malaysia
CONCLUSIONS: Tophaceous gout is associated with longer disease duration, higher baseline serum uric acid level, and younger age at symptoms onset. Hence, early initiation of urate-lowering therapy with a treat-to-target approach is crucial to prevent tophi formation.PMID:37736055 | PMC:PMC10509634 | DOI:10.5001/omj.2023.87
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Syang Pyng Gan Mollyza Mohd Zain Shereen Suyin Ch'ng Hasliza Hassan Wan Farzihan Wan Adib Anizah Muzaid Ing Soo Lau Habibah Yusoof Azmillah Rosman Hazlyna Baharuddin Source Type: research
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)
Nat Struct Mol Biol. 2023 Sep 21. doi: 10.1038/s41594-023-01105-5. Online ahead of print.ABSTRACTSubstrate polyubiquitination drives a myriad of cellular processes, including the cell cycle, apoptosis and immune responses. Polyubiquitination is highly dynamic, and obtaining mechanistic insight has thus far required artificially trapped structures to stabilize specific steps along the enzymatic process. So far, how any ubiquitin ligase builds a proteasomal degradation signal, which is canonically regarded as four or more ubiquitins, remains unclear. Here we present time-resolved cryogenic electron microscopy studies of the ...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Tatyana Bodrug Kaeli A Welsh Derek L Bolhuis Ethan Paul аkonis Raquel C Martinez-Chacin Bei Liu Nicholas Pinkin Thomas Bonacci Liying Cui Pengning Xu Olivia Roscow Sascha Josef Amann Irina Grishkovskaya Michael J Emanuele Joseph S Harrison Joshua P Steim Source Type: research
Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils
Cell Mol Immunol. 2023 Sep 22. doi: 10.1038/s41423-023-01084-z. Online ahead of print.ABSTRACTInhibitory immune receptors set thresholds for immune cell activation, and their deficiency predisposes a person to autoimmune responses. However, the agonists of inhibitory immune receptors remain largely unknown, representing untapped sources of treatments for autoimmune diseases. Here, we show that V-set and transmembrane domain-containing 1 (VSTM1) is an inhibitory receptor and that its binding by the competent ligand soluble galectin-1 (Gal1) is essential for maintaining neutrophil viability mediated by downregulated reactive...
Source: Cellular and Molecular Immunology - September 22, 2023 Category: Molecular Biology Authors: Xu Jiang Xinyue Xiao Hao Li Yiyi Gong Min Wang Huaxia Yang Lidan Zhao Ying Jiang Yanping Wei Chongchong Zhao Jin Li Yuling Chen Shan Feng Haiteng Deng Shiliang Ma Yue Xu Yudong Liu George C Tsokos Minghong Jiang Xuan Zhang Source Type: research
Cancer-associated fibroblasts express CD1d and activate invariant natural killer T cells under cellular stress
Cell Mol Immunol. 2023 Sep 21. doi: 10.1038/s41423-023-01082-1. Online ahead of print.NO ABSTRACTPMID:37735500 | DOI:10.1038/s41423-023-01082-1
Source: Cellular and Molecular Immunology - September 22, 2023 Category: Molecular Biology Authors: Shengduo Pei Jonas Sj ölund Yueyun Pan Kristian Pietras Mikael C I Karlsson Source Type: research
Analytical and preparative chiral supercritical fluid chromatography resolutions using crown ether-derived column
In this study, crown ether-derived column Crownpak® CR-I (+) was evaluated under SFC conditions using 12 primary amines, and the chromatographic results were compared against eight immobilized polysaccharide-based columns. Crownpak® CR-I (+) achieved a significantly higher success rate. It was found that the addition of 5% water to the modifier dramatically improved the peak shape for chiral separation of primary amines on Crownpak® CR-I (+). The first reported preparative SFC separations on Crownpak® CR-I (+) are shown, offering a new approach for the preparative resolution of primary amines. The case studies demonstr...
Source: Chirality - September 22, 2023 Category: Molecular Biology Authors: Lei Yue Larry Miller John Reilly Source Type: research
Toward Tryptathionine-stapled OBOC Libraries: Solid Phase Synthesis of a Bioactive Stapled Octretoate Analog
Org. Biomol. Chem., 2023, Accepted Manuscript DOI: 10.1039/D3OB01378B, PaperAntoine Blanc, Mihajlo Todorovic, Iulia Dude, Helen Merkens, Francois Benard, David Perrin New somatostatin analogs are highly desirable for diagnosing and treating neuroendocrine tumors (NETs). Here we describe the solid-phase synthesis of a new octreotate analog where the disulfide bond is replaced... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 21, 2023 Category: Molecular Biology Authors: Antoine Blanc Source Type: research
P/N-Heteroleptic Cu(I)-photosensitizer-catalyzed domino radical relay annulation of 1,6-enynes with aryldiazonium salts
Org. Biomol. Chem., 2023, Accepted Manuscript DOI: 10.1039/D3OB01177A, PaperQian Liu, Qibo Ni, Yan Zhou, Lang Chen, Siwei Xiang, Limeng Zheng, Yunkui Liu A visible-light driven photocatalytic construction of benzo[b]fluorenones from 1,6-enynes and aryldiazonium salts has been achieved via a P/N-heteroleptic Cu(I)-photosensitizer-catalyzed domino radical relay annulation process. Preliminary mechanistic studies revealed that the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 21, 2023 Category: Molecular Biology Authors: Qian Liu Source Type: research
Supramolecular Assembly of Pyrene-DNA Conjugates: Influence of Pyrene Substitution Pattern and Implications for Artificial LHCs
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Robert Haener, Jan Thiede, Simon Rothenb ühler, Ioan Iacovache, Simon Matthias Langenegger, Benoît Zuber The supramolecular self-assembly of pyrene-DNA conjugates into nanostructures is presented. DNA functionalized with different types of pyrene isomers at the 3'-end self-assemble into nano-objects. The shape of the nanostructures is... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 21, 2023 Category: Molecular Biology Authors: Robert Haener Source Type: research
Synthesis of Pyrimidine-Fused Skeletons through Copper-Catalyzed Consecutive Sonogashira Coupling and Aminocyclization
Org. Biomol. Chem., 2023, Accepted Manuscript DOI: 10.1039/D3OB01248D, CommunicationHeng He, Jian-Quan Liu, Xiangshan Wang A copper-catalyzed sequence involving Sonogashira coupling reaction and 5-exo-dig aminocyclization between a terminal alkyne and 2-(2-bromophenyl)pyrimidine analog based on six-membered rings was presented. This protocol provides a controlled and modular... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 21, 2023 Category: Molecular Biology Authors: Heng He Source Type: research
Tunable full-color emission of stilbazoles containing a 2-halo-3,4-dicyanopyridine acceptor
Org. Biomol. Chem., 2023, Advance Article DOI: 10.1039/D3OB01326J, PaperAnastasia I. Ershova, Sergey V. Fedoseev, Sergey A. Blinov, Mikhail Yu. Ievlev, Konstantin V. Lipin, Oleg V. Ershov Synthesis of a series of novel push –pull stilbazole-based chromophores with tunable multicolor emission ranging from 442 nm to 710 nm and covering the whole visible spectrum is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 21, 2023 Category: Molecular Biology Authors: Anastasia I. Ershova Source Type: research
Synthesis of functionalized alkenes via Cu(I)-catalysed allylation of acetanilides using Morita-Baylis-Hillman bromides
Org. Biomol. Chem., 2023, Accepted Manuscript DOI: 10.1039/D3OB01480K, PaperRamesh Kumar Vishwakarma, Krishna Nand Singh An easy access to functionalized alkenes has been developed by the C-H functionalization of anilides with Morita-Baylis-Hillman (MBH) bromides in the presence of copper chloride, TBHP and acetic acid. Unsubstituted... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 21, 2023 Category: Molecular Biology Authors: Ramesh Kumar Vishwakarma Source Type: research
Rod-like nanostructures through amphiphilic OPE-Porphyrin self-organization
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Chiara Gangemi, Maria Angela Castriciano, Ester D'Agostino, Andrea Romeo, Paola M Bonaccorsi, Anna Barattucci, Luigi Monsu Scolaro A new amphiphilic monosubstituted porphyrin functionalized by a β-D-glucoside terminated oligophenylenethylene (OPE) able to self-arrange into nano-aggregates in polar solvents has been synthesized and fully characterized in its monomeric and... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 21, 2023 Category: Molecular Biology Authors: Chiara Gangemi Source Type: research
