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Total 135484 results found since Jan 2013.
Circ_0006251 mediates the proliferation and apoptosis of vascular smooth muscle cells in CAD via enhancing TET3 and PPM1B expression
In conclusion, Circ_0006251 could be identified as a biomarker for CAD which might shed light on the diagnosis and therapy of CAD.PMID:37715433 | DOI:10.14715/cmb/2023.69.8.5
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Weibing Zhong Lin Wang Lingbing Xiong Source Type: research
LOXL1-AS1 promotes cell proliferation in hepatocellular carcinomathrough miR-1224-5p/ITPRIPL2/AKT axis
In this study, LOXL1-AS1 was overexpressed in HCC cell lines, and LOXL1-AS1 knockdown repressed cell proliferation and stimulated apoptosis in HCC. Besides, the activating role of LOXL1-AS1 in the AKT pathway was also confirmed. Further, miR-1224-5p was sponged by LOXL1-AS1, and overexpression exerted inhibitory function in HCC. Moreover, ITPRIPL2 as amiR-1224-5ptarget gene. Meanwhile, ITPRIPL2 deficiency suppressed HCC cell proliferation. Finally, miR-1224-5p inhibitor reversed the hindering role of LOXL1-AS1 depletion in HCC cell proliferation and AKT pathway, and this rescuing effect was offset by ITPRIPL2 silencing. In...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Tangen Chen Shuyun Zeng Quanyuan Liu Yufeng Chen Junjiang Lu Source Type: research
Application Value of Next-Generation Sequencing of Bronchial Alveolar Lavage Fluid in Emergency Patients with Infection
This study was performed to explore the application value of next-generation sequencing (NGS) of bronchial alveolar lavage fluid (BALF) in emergency patients with infection. In this regard, a total of 52 patients with infection who were diagnosed and treated in the emergency department of our hospital from September 2019 to September 2021 were selected as the research objects. The BALF of the patients was analyzed by NGS, and the results were compared with the pathogen detection results of traditional microbial culture of the patients to analyze the diagnostic value of NGS in patients with infection. The results showed tha...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Weiqin Wu Xiang Han Hongmei Zhao Hong Sun Qingsong Sun Source Type: research
DUSP1 regulates the JAK2/STAT3 signaling pathway through targeting miR-21 in cervical cancer cells
In conclusion, overexpression of DUSP1 can target and reduce the expression of miR-21, block the JAK2/STAT3 signaling pathway, reduce the viability of CC cells, inhibit the proliferation and migration and invasion ability of CC cells, and induce apoptosis of CC cells, thus providing a theoretical basis for the targeted treatment of clinical CC.PMID:37715430 | DOI:10.14715/cmb/2023.69.8.6
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Hailin Chen Songsen Ren Hui Wan Wengong Wei Yi Luo Meiling Cai Source Type: research
Expression and Function of VEGFRs in Normal Epidermis and Psoriatic Lesional Keratinocytes
In this study, the expression and role of VEGFRs in keratinocytes were examined using examples from psoriatic and healthy individuals. The experiment was completed by immunofluorescence analysis, reverse transcription polymerase chain reaction, Western blot, and real-time quantitative RT-PCR after the skin of nonlesional, adjacent, and lesional skin was excised. Observations indicated that in non-lesional psoriatic areas and adjacent lesional areas of the skin of psoriasis patients, the fluorescent signals of VEGFR-1 and VEGFR-2 were strongly labelled with keratinocytes, and in psoriatic lesions, keratinocytes were present...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Yong Wang Yong Yan Huiwen Yu Guangrong Jiang Shiying Zhao Meng Yi Source Type: research
Bioinformatics-based analysis of core genes and pathway enrichment in early diabetic nephropathy
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):51-56. doi: 10.14715/cmb/2023.69.7.9.ABSTRACTDiabetic nephropathy (DN) is the main cause of end-stage renal disease (ESRD). Bioinformatics technology was adopted to screen and analyze the core genes of early DN to explore its pathogenesis. GSE30528, GSE96804, and GSE30122 chip data were obtained from Gene Expression Omnibus (GEO) database to screen DN and healthy controls for differentially expressed genes. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) for functional annotation and signaling pathway enrichment; String and Cytoscape were used for protein...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Yangwenxuan Han Xiaoyan Liu Jing Shang Na Li Chunjian Zhang Ying Li Jiaxin Zheng Source Type: research
The discovery of the natural compound Boeravinone-C as a potential antiobesity drug candidate targeting pancreatic lipase using chemo-informatics-based approaches
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):57-65. doi: 10.14715/cmb/2023.69.7.10.ABSTRACTObesity is a metabolic disorder distinguished by excess fat deposition in fatty tissues. Pancreatic lipase is one of the promising drug targets for treating obesity due to its critical role in the hydrolysis of triglycerides into mono-glycerides and free fatty acids. Due to unsatisfactory results and severe side effects of the current drugs available for treating obesity, there is an urgent need to identify novel therapeutic options. Boerhaavia diffusa is one of the widely known species of flowering plant commonly known as Punam...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Aziz Unnisa Sirajuddin Anwar Chettupalli Ananda K Nasrin E Khalifa Weam M A Khojali Mhdia E Osman Kareem M Younes Amr S Abouzied Suresh B Jandrajupalli Swarnalatha Chandolu Source Type: research
Effects of celecoxib on AQP-1, NF- κB and apoptosis in lung tissue of neonatal rats with hyperoxia-induced lung injury
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):73-77. doi: 10.14715/cmb/2023.69.8.11.ABSTRACTTo analyze the effects of AQP-1, NF-κB and apoptosis in lung tissue of neonatal rats with hyperoxia-induced lung injury (HILI).162 neonatal SD rats were divided into control group (COG), model group (MOG) and celecoxib group (CEG), 54 rats in each group. Each group was subdivided into 1st, 5th and 10th-day groups with 18 rats in each group. The neonatal rat model of HILI was established. Nine rats in each group were randomly selected on the 3rd, 6th and 12th day respectively. The level of oxidative stress (OS) in bronchoalveola...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Zhengfei Fan Yuan Shen Source Type: research
Secretion of related factors and AMPK/PGC-1 α signal pathway by alveolar macrophages in viral acute lung injury
This study was to investigate the secretion of related factors by alveolar macrophages and AMPK/PGC-1 α signal pathway in viral acute lung injury (VALI) patients. 30 SD rats were randomly divided into blank control group (BCG) and VALI group (VALIG) with 15 rats in each group. The model of VALIG was induced by polyI: C and the BCG was given the same amount of normal saline. The IL-6, IL-8 and TNF-α levels in bronchoalveolar lavage fluid (BALF) were detected by ELISA. The protein, surface markers of alveolar macrophages, and related mRNA expression were detected by Western blot, ELISA, and qRT-PCR. IL-8, IL-6, TNF-α, MUC...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Zhengfei Fan Jiawei Zhu Source Type: research
Effect of 4-AP on MPP+/ MPTP-induced Parkinson's disease model
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):68-72. doi: 10.14715/cmb/2023.69.8.10.ABSTRACTTo study the effect of 4-AP on Parkinson's disease (PD) cells and animal model. PD cells were pretreated with different concentrations of 4-AP for 24 hours, then PD cells were prepared by MPP+, and the cell activity was detected by CCK8 kit. PD mice were prepared by MPTP and then given 4-AP for 10 days. Finally, the behavioral changes of mice were detected by pole climbing test and open field test, and the expression of TH in the midbrain was detected by IHC and WB. 4-AP could increase the activity of PD cells induced by MPP+. I...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Qiongwen Rong Chang Zhou Yuanyuan Ma Source Type: research
Low Expression of A3C and PLP2 Indicating a Favorable Prognosis in Human Gliomas
In conclusion, our results not only confirmed A3C played an important role in glioma development, but the A3C IHC test could successfully predict the therapeutic effects and disease prognosis.PMID:37715423 | DOI:10.14715/cmb/2023.69.7.12
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Jong-Shiaw Jin Yu-Ling Tsai Yu-Chan Chang Wen-Chiuan Tsai Source Type: research
The expression and clinical value of LRP11, FUBP1 and TET1 in cervical cancer
In this study, we examined three genes LRP11, FUBP1, and TET1 related to cervical cancer. The results of this study showed that the level of expression of these genes is high in lymph nodes and the thyroid and is less in the pancreas and liver. Also, the expression level of the FUBP1 gene is higher than that of LRP11, and the expression level of the LRP11 gene is higher than that of TET1. Regarding the structure and proteomics of the studied genes, it can be seen that due to the presence of more domains in the LRP11 and FUBP1 genes, these genes probably independently participate in various functions and have a wider range ...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Xiaojie Zhao Suhua Li Jiexin Wen Yawei Li Source Type: research
The repair and regeneration mechanism of platelet-rich fibrin-promoting tissue after alveolar bone defect through the notch pathway
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):85-90. doi: 10.14715/cmb/2023.69.7.14.ABSTRACTThis work investigated the effects of platelet-rich fibrin (PRF) combined with bone mesenchymal stem cells (BMSCs) on the repair of alveolar bone defect (ABD) and the related mechanism of the Notch1/Wnt3a signaling pathway. 28 healthy male New Zealand white rabbits were selected to prepare the BMSCs and PRF. Rabbits were rolled into a combination group (implanted with PRF + BMSCs for treatment), a PRF group (treated with PRF) a BMSC group (BMSCs for treatment), and a control group (Ctrl group, no material implantation), with 7 r...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Tao Li Hui Long Wei Niu Bo Feng Source Type: research
Hsa-miR-497-3p impedes the proliferation and invasion of triple-negative breast cancer cells by controlling epithelial-mesenchymal transition through ZEB1 targeting
This study aimed to examine the hsa-miR-497-3p effect and mechanism on the behavior of triple-negative breast cancer (TNBC) cells. We evaluated the expression of Hsa-miR-497-3p in tissue samples obtained from patients diagnosed with TNBC or luminal breast cancer (BrCa), utilizing the quantitative fluorescence polymerase chain reaction (PCR) method. We transfected hsa-miR-497-3p mimics and NC into MDA-MB-231 cells, whilehsa-miR-497-3p inhibitor and NC into TNBC cells, respectively. To examine the impact of hsa-miR-497-3p expression level on TNBC cell proliferation, invasion, and migration, we employed MTT, clone formation, ...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Qian Dong Hu Chen Ying Li Yan Kong Cuizhi Geng Yibing Liu Source Type: research
Adoption of nanoparticle micro-infusion valve in venous port access for tumor patients and self-care analysis
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):91-97. doi: 10.14715/cmb/2023.69.7.15.ABSTRACTIt aimed to discuss the adoption of nanoparticle micro-infusion valves in the totally implantable venous access port (TIVAP) of tumor patients and analyze the self-care of patients after surgery. A total of 189 tumor patients who received TIVAP chemotherapy were selected from the day chemotherapy outpatient department of the Second People's Hospital of Lianyungang City from June to October 2021. The questionnaire survey was conducted to collect and analyze the general information about the patients and the patient's self-care ab...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Lijuan Sun Hui Xu Qing Wang Source Type: research
