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Microbiome-targeted interventions for the control of oral-gut dysbiosis and chronic systemic inflammation
Trends Mol Med. 2023 Sep 18:S1471-4914(23)00191-0. doi: 10.1016/j.molmed.2023.08.006. Online ahead of print.ABSTRACTRecent research has confirmed the strong connection between imbalances in the oral and gut microbiome (oral-gut dysbiosis), periodontitis, and inflammatory conditions such as diabetes, Alzheimer's disease, and cardiovascular diseases. Microbiome modulation is crucial for preventing and treating several autoimmune and inflammatory diseases, including periodontitis. However, the causal relationships between the microbiome and its derived metabolites that mediate periodontitis and chronic inflammation constitute...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Juan Pacheco-Yanes Eric Reynolds Jian Li Eliana Mari ño Source Type: research
Current understanding of genetics and epigenetics in pseudoexfoliation syndrome and glaucoma
Mol Aspects Med. 2023 Sep 18;94:101214. doi: 10.1016/j.mam.2023.101214. Online ahead of print.ABSTRACTPseudoexfoliation is a complex, progressive, and systemic age-related disorder. The early stage of deposition of extracellular fibrillar material on ocular and extraocular tissues is termed as pseudoexfoliation syndrome (PEXS). The severe advanced stage is known as pseudoexfoliation glaucoma (PEXG), which involves increased intraocular pressure and optic nerve damage. Through genome-wide association and candidate gene studies, PEX has been associated with numerous genetic risk variants in various gene loci. However, the ge...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Ramani Shyam Kapuganti Debasmita Pankaj Alone Source Type: research
Analysis of image data from the EuroNet PHL-C2 trial indicates a potential reduction in injected F-18 FDG activities in children: a proposal to update the EANM Paediatric Dosage Card
CONCLUSION: The results of this work allow for a conservative update of the EANM Paediatric Dosage Card for [18F]FDG-PET/CT scans performed with conventional PET/CT systems.PMID:37728668 | DOI:10.1007/s00259-023-06396-w
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Johannes Tran-Gia Uta Eberlein Michael Lassmann Christine Mauz-K örholz Dieter K örholz Pietro Zuccetta Zvi Bar-Sever Ute Rosner Thomas Walter Georgi Osama Sabri Regine Kluge Arnoldo Piccardo Lars Kurch Source Type: research
< sup > 68 < /sup > GaGa ‑LNC1007 PET/CT in the evaluation of renal cell carcinoma: comparison with 2- < sup > 18 < /sup > FFDG/ < sup > 68 < /sup > GaGa-PSMA PET/CT
CONCLUSION: [68Ga]Ga-LNC1007 is a promising tracer for RCC imaging and can effectively identify aggressive pathological characteristics of RCC.PMID:37728667 | DOI:10.1007/s00259-023-06436-5
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Rong Lin Chao Wang Shaohao Chen Tingting Lin Hai Cai Shaoming Chen Yun Yang Jiaying Zhang Fuqi Xu Jingjing Zhang Xiaoyuan Chen Jie Zang Weibing Miao Source Type: research
Peroxiredoxins in erythrocytes: far beyond the antioxidant role
J Mol Med (Berl). 2023 Sep 20. doi: 10.1007/s00109-023-02368-7. Online ahead of print.ABSTRACTThe red blood cells (RBCs) are essential to transport oxygen (O2) and nutrients throughout the human body. Changes in the structure or functioning of the erythrocytes can lead to several deficiencies, such as hemolytic anemias, in which an increase in reactive oxidative species generation is involved in the pathophysiological process, playing a significant role in the severity of several clinical manifestations. There are important lines of defense against the damage caused by oxidizing molecules. Among the antioxidant molecules, ...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Carla Peres de Paula Jo ão Pedro Maia de Oliveira da Silva Karen Simone Romanello Victoria Sim ões Bernardo Flaviene Felix Torres Danilo Gr ünig Humberto da Silva Anderson Ferreira da Cunha Source Type: research
Correction: Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion
Cell Mol Life Sci. 2023 Sep 20;80(10):296. doi: 10.1007/s00018-023-04942-1.NO ABSTRACTPMID:37728633 | PMC:PMC10511356 | DOI:10.1007/s00018-023-04942-1
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Sunil Yeruva Konstanze Stangner Anna Jungwirth Matthias Hiermaier Maria Shoykhet Daniela Kugelmann Michael Hertl Shohei Egami Norito Ishii Hiroshi Koga Takashi Hashimoto Michael Weis Britt-Maria Beckmann Ruth Biller Dominik Sch üttler Stefan K ääb Jens Source Type: research
Upregulation of FAM134B inhibits endoplasmic reticulum stress-related degradation protein expression and promotes hepatocellular carcinogenesis
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17964. Online ahead of print.ABSTRACTEndoplasmic reticulum (ER) stress can stimulate the proliferation and metastasis of hepatocellular carcinoma (HCC) cells while hindering apoptosis and immune system function, but the molecular mechanism of ER stress in HCC has yet to be fully studied. We aim to investigate the molecular mechanism by which FAM134B inhibits autophagy of HCC cells by reducing the expression of ER stress-related degradation proteins. Clinical samples were collected for this study. Normal liver cell lines HL7702 and Hep3B and Huh7 HCC cell lines were cultured. C...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Houhong Wang Lu Liu Huihui Gong Heng Li Source Type: research
Microbiome-targeted interventions for the control of oral-gut dysbiosis and chronic systemic inflammation
Trends Mol Med. 2023 Sep 18:S1471-4914(23)00191-0. doi: 10.1016/j.molmed.2023.08.006. Online ahead of print.ABSTRACTRecent research has confirmed the strong connection between imbalances in the oral and gut microbiome (oral-gut dysbiosis), periodontitis, and inflammatory conditions such as diabetes, Alzheimer's disease, and cardiovascular diseases. Microbiome modulation is crucial for preventing and treating several autoimmune and inflammatory diseases, including periodontitis. However, the causal relationships between the microbiome and its derived metabolites that mediate periodontitis and chronic inflammation constitute...
Source: Trends in Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Juan Pacheco-Yanes Eric Reynolds Jian Li Eliana Mari ño Source Type: research
Selenium in combination with a tomato lipid extract as a therapy for benign prostatic hyperplasia and its alterations in rats with induced BPH
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17903. Online ahead of print.ABSTRACTBenign prostatic hyperplasia (BPH) is the most common adenoma in old men. Tomatoes are a rich source of bioactive compounds that, as well as selenium (Se), possess antioxidant and antiproliferative activity. The aim was to evaluate the therapeutic effect of Se in combination with a tomato extract in aged rats with BPH. Aged male Wistar rats were divided in the following groups (n = 10 rats/group): Control (C), BPH, BPH + Finasteride (BPH + F), BPH + Tomato Lipidic Extract (BPH + E), BPH + Selenium (BPH + S) and BPH plus E plus S (BPH + E + ...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: David Julian Arias-Ch ávez Patrick Mailloux-Salinas Jessica Ledesma Aparicio Elihu Campos-P érez Omar Noel Medina-Campos Jos é Pedraza-Chaverri Guadalupe Bravo Source Type: research
Macrophage-associated markers of metaflammation are linked to metabolic dysfunction in pediatric obesity
CONCLUSION: MAFLD and other metabolic disorders in pediatric patients with obesity are associated with an elevation of adipose tissue macrophage-related inflammation markers.PMID:37729736 | DOI:10.1016/j.cyto.2023.156372
Source: Cytokine - September 20, 2023 Category: Molecular Biology Authors: Julia Lischka Andrea Schanzer Charlotte de Gier Susanne Greber-Platzer Maximilian Zeyda Source Type: research
Green synthesis of (S)-1-(furan-2-yl)propan-1-ol from asymmetric bioreduction of 1-(furan-2-yl)propan-1-one using whole-cell of Lactobacillus paracasei BD101
In this study, the synthesis of (S)-2 was carried out by performing the asymmetric bioreduction of 1-(furan-2-yl)propan-1-one (1) using the Lactobacillus paracasei BD101 biocatalyst obtained from boza, a grain-based fermented beverage. (S)-2 was obtained with >99% conversion, >99% ee, and 96% yield under the optimized conditions. Furthermore, in 50 h, 8.37 g of 1 was entirely transformed into (S)-2 on gram scale (96% isolated yield, 8.11 g). This is the first report on the high-gram scale biocatalyzed synthesis of enantiopure (S)-2. These data suggest that L. paracasei BD101 can be used to bioreduction of 1 in gram s...
Source: Chirality - September 20, 2023 Category: Molecular Biology Authors: Ali Sava ş Bülbül Engin Şahin Source Type: research
Macrocyclization strategies for the total synthesis of cyclic depsipeptides
Org. Biomol. Chem., 2023, Accepted Manuscript DOI: 10.1039/D3OB01229H, Review ArticleAndre Paquette, Christopher Noyce Boddy Cyclic depsipeptides are an important class of peptide natural products that are defined by the presence of ester and amide bonds within the macrocycle. The structural diversity of depsipeptides has... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 19, 2023 Category: Molecular Biology Authors: Andre Paquette Source Type: research
Metal and Catalyst-free Strategy to Access 1,3-Thio-heteroaryl BCP Derivatives
Org. Biomol. Chem., 2023, Accepted Manuscript DOI: 10.1039/D3OB01377D, PaperSurbhi Gupta, Vinjamuri Srinivasu, Sureshkumar Devarajulu The widespread presence of bicyclo[1.1.1]pentane (BCP) and sulfur motifs in pharmaceutical compounds underscores the significance of synthesizing suitably functionalized BCP thioethers. In response, we have developed a metal-free and photocatalyst-free... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 19, 2023 Category: Molecular Biology Authors: Surbhi Gupta Source Type: research
A General Synthesis of Aromatic and Heteroaromatic Lipoxin B4 Analogues
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Patrick J Guiry, Benjamin Owen Lipoxins are an important class of pro-resolving mediators that play a crucial role in the resolution of inflammation. Thus, the synthesis of more chemically and metabolically stable synthetic lipoxin analogues... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 19, 2023 Category: Molecular Biology Authors: Patrick J Guiry Source Type: research
Recent advances in computational studies on Cu-catalyzed aerobic reactions: cooperation of copper catalysts and dioxygen
Org. Biomol. Chem., 2023, Advance Article DOI: 10.1039/D3OB00976A, Review ArticleYuan-Ye Jiang, Chao Chen This review summarizes the advances in computational studies on Cu-catalyzed aerobic reactions and focuses on the cooperation mechanisms of copper complexes and dioxygen. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 19, 2023 Category: Molecular Biology Authors: Yuan-Ye Jiang Source Type: research
