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Infectious Disease: Influenza
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Total 16445 results found since Jan 2013.
The role of pneumococcal vaccination in reducing the cardiovascular risk of cardiac patients: opinion of experts of the Prevention Committee of the Polish Cardiac Society supported by the Polish Vaccinology Society
Kardiol Pol. 2023 Sep 3. doi: 10.33963/v.kp.96718. Online ahead of print.ABSTRACTRespiratory diseases have been the fourth most common cause of death in Poland in recent years. Respiratory infection, especially pneumonia, can lead to exacerbation of chronic cardiovascular disease. Streptococcus pneumoniae is the most common bacterial pathogen causing community-acquired pneumonia. Pneumococci are also the most common pathogen complicating the course of influenza virus infection. Pneumonia, especially invasive pneumococcal disease, is associated with the risk of death in the course of respiratory failure or sepsis and also w...
Source: Kardiologia Polska - September 3, 2023 Category: Cardiology Authors: Artur Mamcarz Marcin We łnicki Jaros ław Drożdż Marcin Grabowski Piotr Jankowski Ernest Kuchar Przemys ław Leszek Przemys ław Mitkowski Jacek Wysocki Source Type: research
Developmental and reproductive safety of Advax-CpG55.2 ™ adjuvanted COVID-19 and influenza vaccines in mice
Vaccine. 2023 Aug 31:S0264-410X(23)01007-1. doi: 10.1016/j.vaccine.2023.08.053. Online ahead of print.ABSTRACTSpikoGen® is a recombinant spike protein vaccine against COVID-19 that obtained marketing authorization in the Middle East on October 6th, 2021, becoming the first adjuvanted protein-based COVID-19 vaccine of its type to achieve approval. SpikoGen® vaccine utilizes a unique adjuvant Advax-CpG55.2, which comprises delta inulin and CpG55.2 oligonucleotide, a synthetic human toll-like receptor (TLR)-9 agonist. As part of a safety assessment, developmental and reproductive toxicity (DART) studies were undertaken in m...
Source: Vaccine - September 2, 2023 Category: Allergy & Immunology Authors: Isaac G Sakala Yoshikazu Honda-Okubo Nikolai Petrovsky Source Type: research
Immunogenicity and protective efficacy of human metapneumovirus virus-like particles produced by a recombinant baculovirus in mice
CONCLUSIONS: This is the first study to demonstrate that HMPV VLP was successfully prepared in the baculovirus expression system. HMPV VLP could induce specific humoral and cellular immune responses as well as protective efficacy, and aluminum hydroxide may be an effective adjuvant in mice.PMID:37657510 | DOI:10.1016/j.virusres.2023.199215
Source: Virus Research - September 1, 2023 Category: Virology Authors: Fenlian Ma Aijun Chen Lihong Yao Hanchun Gao Qian Zhang Wenzhe Hou Lishu Zheng Source Type: research
Characterization of novel, severely immunodeficient Prkdc < sup > Δex57/Δex57 < /sup > mice
Biochem Biophys Res Commun. 2023 Aug 26;678:193-199. doi: 10.1016/j.bbrc.2023.08.055. Online ahead of print.ABSTRACTSeverely immunodeficient mice are useful for understanding the pathogenesis of certain tumors and for developing therapeutic agents for such tumors. In addition, engraftment of these mice with human hematopoietic cells can yield information that helps us understand the in vivo molecular mechanisms underlying actual human viral infections. In our present research, we discovered a novel, severely immunodeficient strain of mice having a mutation in exon 57 of the Prkdc gene (PrkdcΔex57/Δex57) in an inbred colo...
Source: Biochemical and Biophysical Research communications - August 31, 2023 Category: Biochemistry Authors: Yumie Takagi Katsuko Sudo Sachiko Yamaguchi Shuzo Urata Tatsukuni Ohno Sachiko Hirose Kiyoshi Matsumoto Takashi Kuramoto Tadao Serikawa Jiro Yasuda Masashi Ikutani Susumu Nakae Source Type: research
Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection
Cell Host Microbe. 2023 Aug 21:S1931-3128(23)00326-8. doi: 10.1016/j.chom.2023.08.001. Online ahead of print.ABSTRACTHost:pathogen interactions dictate the outcome of infection, yet the limitations of current approaches leave large regions of this interface unexplored. Here, we develop a novel fitness-based screen that queries factors important during the middle to late stages of infection. This is achieved by engineering influenza virus to direct the screen by programming dCas9 to modulate host gene expression. Our genome-wide screen for pro-viral factors identifies the cytoplasmic DNA exonuclease TREX1. TREX1 degrades cy...
Source: Cell Host and Microbe - August 31, 2023 Category: Microbiology Authors: Cason R King Yiping Liu Katherine A Amato Grace A Schaack Clayton Mickelson Autumn E Sanders Tony Hu Srishti Gupta Ryan A Langlois Judith A Smith Andrew Mehle Source Type: research
Molecular characterization and phylogenetic analysis of avian influenza H3N8 virus isolated from imported waterfowl in Malaysia
Trop Biomed. 2023 Jun 1;40(2):220-235. doi: 10.47665/tb.40.2.014.ABSTRACTWild aquatic birds are natural reservoirs of influenza A viruses and H3 subtype is one of the most prevalent subtypes in waterfowl. Two H3N8 viruses of low pathogenic avian influenza (LPAI) were isolated via egg inoculation technique from the fecal swab specimens from imported barnacle goose and paradise shelduck in Veterinary Research Institute Ipoh, Malaysia. The full length of eight gene segments of the two viruses were amplified and sequenced with specific primers. The sequences were molecularly characterized, and the sequence identity were assess...
Source: Tropical Biomedicine - August 31, 2023 Category: Tropical Medicine Authors: B L Leow S A Shohaimi F F Mohd Yusop M R Sidik F H Mohd Saeid Source Type: research
Characterization of novel, severely immunodeficient Prkdc < sup > Δex57/Δex57 < /sup > mice
Biochem Biophys Res Commun. 2023 Aug 26;678:193-199. doi: 10.1016/j.bbrc.2023.08.055. Online ahead of print.ABSTRACTSeverely immunodeficient mice are useful for understanding the pathogenesis of certain tumors and for developing therapeutic agents for such tumors. In addition, engraftment of these mice with human hematopoietic cells can yield information that helps us understand the in vivo molecular mechanisms underlying actual human viral infections. In our present research, we discovered a novel, severely immunodeficient strain of mice having a mutation in exon 57 of the Prkdc gene (PrkdcΔex57/Δex57) in an inbred colo...
Source: Biochemical and Biophysical Research communications - August 31, 2023 Category: Biochemistry Authors: Yumie Takagi Katsuko Sudo Sachiko Yamaguchi Shuzo Urata Tatsukuni Ohno Sachiko Hirose Kiyoshi Matsumoto Takashi Kuramoto Tadao Serikawa Jiro Yasuda Masashi Ikutani Susumu Nakae Source Type: research
Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection
Cell Host Microbe. 2023 Aug 21:S1931-3128(23)00326-8. doi: 10.1016/j.chom.2023.08.001. Online ahead of print.ABSTRACTHost:pathogen interactions dictate the outcome of infection, yet the limitations of current approaches leave large regions of this interface unexplored. Here, we develop a novel fitness-based screen that queries factors important during the middle to late stages of infection. This is achieved by engineering influenza virus to direct the screen by programming dCas9 to modulate host gene expression. Our genome-wide screen for pro-viral factors identifies the cytoplasmic DNA exonuclease TREX1. TREX1 degrades cy...
Source: Cell Host and Microbe - August 31, 2023 Category: Microbiology Authors: Cason R King Yiping Liu Katherine A Amato Grace A Schaack Clayton Mickelson Autumn E Sanders Tony Hu Srishti Gupta Ryan A Langlois Judith A Smith Andrew Mehle Source Type: research
Asymptomatic infection with clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) in carnivore pets, Italy, April 2023
Euro Surveill. 2023 Aug;28(35). doi: 10.2807/1560-7917.ES.2023.28.35.2300441.ABSTRACTIn April 2023, an outbreak of clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses carrying the T271A mammalian adaptive mutation in the PB2 protein was detected in a backyard poultry farm in Italy. Five domestic dogs and one cat living on the premises had seroconverted in the absence of clinical signs. Virological and serological monitoring of individuals exposed to the virus proved the absence of human transmission, however, asymptomatic influenza A(H5N1) infections in mammalian pets may have important public health implicati...
Source: Euro Surveill - August 31, 2023 Category: Infectious Diseases Authors: Ana Moreno Francesco Bonfante Alessio Bortolami Irene Cassaniti Anna Caruana Vincenzo Cottini Danilo Cereda Marco Farioli Alice Fusaro Antonio Lavazza Pierdavide Lecchini Davide Lelli Andrea Maroni Ponti Claudia Nassuato Ambra Pastori Francesca Rovida Lui Source Type: research
Molecular characterization and phylogenetic analysis of avian influenza H3N8 virus isolated from imported waterfowl in Malaysia
Trop Biomed. 2023 Jun 1;40(2):220-235. doi: 10.47665/tb.40.2.014.ABSTRACTWild aquatic birds are natural reservoirs of influenza A viruses and H3 subtype is one of the most prevalent subtypes in waterfowl. Two H3N8 viruses of low pathogenic avian influenza (LPAI) were isolated via egg inoculation technique from the fecal swab specimens from imported barnacle goose and paradise shelduck in Veterinary Research Institute Ipoh, Malaysia. The full length of eight gene segments of the two viruses were amplified and sequenced with specific primers. The sequences were molecularly characterized, and the sequence identity were assess...
Source: Tropical Biomedicine - August 31, 2023 Category: Tropical Medicine Authors: B L Leow S A Shohaimi F F Mohd Yusop M R Sidik F H Mohd Saeid Source Type: research
Enhancing Prognostic Assessment for Influenza-Associated Pneumonia: An Examination of Contributing Risk Factors
CONCLUSIONS: The prognosis of influenza-associated pneumonia can be effectively predicted by assessing peripheral blood parameters, including lymphocyte count, albumin level, urinary markers, and the oxygenation index upon admission. Notably, the Composite Index LOAU, as a comprehensive amalgamation of these factors, holds promising potential to enhance prognostic precision and management outcomes in cases of influenza-associated pneumonia.PMID:37652408
Source: Alternative Therapies in Health and Medicine - August 31, 2023 Category: Complementary Medicine Authors: Yi Lin Yuping Li Xiang Lian Zhenping Qian Weijie Wang Pingguang Zhu Source Type: research
