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Infectious Disease: Human Papillomavirus (HPV)
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Total 6718 results found since Jan 2013.
Maximising the cost-effectiveness of human papillomavirus testing for cervical screening in the context of routine HPV vaccination in Hong Kong: abridged secondary publication
Hong Kong Med J. 2023 Aug;29 Suppl 4(4):11-15.NO ABSTRACTPMID:37690800
Source: Hong Kong Med J - September 10, 2023 Category: General Medicine Authors: S M K Leung J Wu K K L Chan M Jit Source Type: research
First international proficiency study on human papillomavirus testing in cervical cancer screening
CONCLUSION: Internationally recognized proficiency studies of HPV screening, traceable to international standards, provided an overview of current testing performance. There was a high level of proficiency in terms of sensitivity and few false positives, but specificity was not optimal and further research on optimal specificity of HPV screening tests may be warranted.PMID:37688950 | DOI:10.1016/j.jcv.2023.105581
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Emel Yilmaz Carina Eklund Camilla Lagheden Karin Dahlin Robertsson Marina Lilja Miriam Elfstr öm Laila Sara Arroyo M ühr Joakim Dillner Source Type: research
Micro-interdigitated electrodes genosensor based on Au-deposited nanoparticles for early detection of cervical cancer
This study represents surface charge transduction of micro-interdigitated electrodes (micro-IDE) alumina insulated with silica, independent and mini genosensor modified with colloidal gold NPs (AuNPs), and determination of gene hybridization for early detection of cervical cancer. The surface of AuNPs deposited micro-IDE functionalized with optimized 3-aminopropyl-triethoxysilane (APTES) followed by hybridization with deoxyribonucleic acid (DNA) virus to develop DNA genosensor. The results of ssDNA hybridization with the ssDNA target of human papillomavirus (HPV) 18 have affirmed that micro-IDE functionalized with colloida...
Source: International Journal of Biological Macromolecules - September 9, 2023 Category: Biochemistry Authors: F Nadhirah Jaapar N A Parmin N Hamidah A Halim Uda Hashim Subash C B Gopinath F Syakirah Halim M N A Uda Amilia Afzan N Mohamad Nor Khairunisak Abdul Razak Source Type: research
EBCOG position statement on Inequalities in screening for cervical and breast cancer
Eur J Obstet Gynecol Reprod Biol. 2023 Aug 30:S0301-2115(23)00692-9. doi: 10.1016/j.ejogrb.2023.08.386. Online ahead of print.ABSTRACTGynaecological cancers, namely breast and cervical cancer represent a high burden in women's health. It is well established that cervical and breast cancer screening programmes are effective in reducing morbidity and mortality. It is of the most importance to define strategies to provide a universal access to screening. In European countries, significant progress has been made over the past years concerning screening strategies, namely the choice of screening test, its frequency as well as t...
Source: Reproductive Biology - September 9, 2023 Category: Reproduction Medicine Authors: M árcia Vieira-Coimbra Nuno Nogueira-Martins Rafal Zadykowicz Hugo Rodrigues Gaspar Jean Calleja-Agius Maja Pakiz Sambit Mukhopadhyay Tahir Mahmood Source Type: research
Micro-interdigitated electrodes genosensor based on Au-deposited nanoparticles for early detection of cervical cancer
This study represents surface charge transduction of micro-interdigitated electrodes (micro-IDE) alumina insulated with silica, independent and mini genosensor modified with colloidal gold NPs (AuNPs), and determination of gene hybridization for early detection of cervical cancer. The surface of AuNPs deposited micro-IDE functionalized with optimized 3-aminopropyl-triethoxysilane (APTES) followed by hybridization with deoxyribonucleic acid (DNA) virus to develop DNA genosensor. The results of ssDNA hybridization with the ssDNA target of human papillomavirus (HPV) 18 have affirmed that micro-IDE functionalized with colloida...
Source: International Journal of Biological Macromolecules - September 9, 2023 Category: Biochemistry Authors: F Nadhirah Jaapar N A Parmin N Hamidah A Halim Uda Hashim Subash C B Gopinath F Syakirah Halim M N A Uda Amilia Afzan N Mohamad Nor Khairunisak Abdul Razak Source Type: research
The ubiquitin specific protease 7 stabilizes HPV16E7 to promote HPV-mediated carcinogenesis
In this study, we uncovered that HPV interacts with the host ubiquitin specific protease 7 (USP7), a universal de-ubiquitinating enzyme, leading to the stabilization of E7 oncoprotein. We observed that HPV16E7 complexes with USP7 via the E7-CR3 domain, and this E7-USP7 complex exists predominantly in the nucleus. Our results showed that USP7 stabilizes and prolongs the half-life of HPV16E7 by antagonizing ubiquitination and proteasomal degradation. Consistently, when we inhibited USP7 activity using HBX 19818, HPV16E7 protein level was reduced and its turnover was increased. We also provide evidence that HBX 19818-induced ...
Source: Cellular and Molecular Life Sciences : CMLS - September 8, 2023 Category: Cytology Authors: Chichao Xia Chuanyun Xiao Ho Yin Luk Paul K S Chan Siaw Shi Boon Source Type: research
Risk stratification of invasive cervical cancer diagnosed after cervical conization
CONCLUSION: HPV16 positivity and nulliparity were identified as risk factors for undetected ICC. Careful treatment selection and preoperative scrupulous examination are especially important in these cases.PMID:37681246 | DOI:10.1093/jjco/hyad121
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Tomoka Shiga Ayumi Taguchi Mayuyo Mori Shogo Yamaguchi Harunori Honjoh Akira Nishijima Satoko Eguchi Yuichiro Miyamoto Kenbun Sone Kei Kawana Yutaka Osuga Source Type: research
Prevalence of human papillomavirus infection in abnormal pap smears
CONCLUSION: Our study shows that the percentage of HR-HPV-positive case increases with the severity of cytologic morphology. HPV had 4 times higher positivity in squamous intraepithelial lesion as compared to ASCUS.PMID:37681080 | PMC:PMC10481853 | DOI:10.25259/Cytojournal_8_2021
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Jaya Mishra Sweety Kalantri Vandana Raphael Biswajit Dey Yookarin Khonglah Ananya Das Source Type: research
The ubiquitin specific protease 7 stabilizes HPV16E7 to promote HPV-mediated carcinogenesis
In this study, we uncovered that HPV interacts with the host ubiquitin specific protease 7 (USP7), a universal de-ubiquitinating enzyme, leading to the stabilization of E7 oncoprotein. We observed that HPV16E7 complexes with USP7 via the E7-CR3 domain, and this E7-USP7 complex exists predominantly in the nucleus. Our results showed that USP7 stabilizes and prolongs the half-life of HPV16E7 by antagonizing ubiquitination and proteasomal degradation. Consistently, when we inhibited USP7 activity using HBX 19818, HPV16E7 protein level was reduced and its turnover was increased. We also provide evidence that HBX 19818-induced ...
Source: Cellular and Molecular Life Sciences : CMLS - September 8, 2023 Category: Cytology Authors: Chichao Xia Chuanyun Xiao Ho Yin Luk Paul K S Chan Siaw Shi Boon Source Type: research
Assessment of Disease Burden and Immunization Rates for Vaccine-Preventable Diseases in People Living with HIV: The Korea HIV/AIDS Cohort Study
CONCLUSION: The burden of vaccine-preventable diseases was quite high in HIV-infected patients. Nadir CD4 T-cell counts, peak HIV viral loads, and the number of ART regimen change are significant factors related to vaccination. Considering the low vaccination rates for VPDs, there was a discordance between experts' opinions and real clinical practice in the medical field.PMID:37674339 | DOI:10.3947/ic.2023.0045
Source: Herpes - September 7, 2023 Category: Infectious Diseases Authors: Hye Seong Yunsu Choi Kyoung Hwan Ahn Jun Yong Choi Shin-Woo Kim Sang Il Kim Mee-Kyung Kee Bo Youl Choi Boyoung Park Hak Jun Hyun Jin Gu Yoon Ji Yun Noh Hee Jin Cheong Woo Joo Kim Joon Young Song Source Type: research
Provision of screening services for cervical and breast cancer - A scientific study commissioned by the European Board & amp; College of Obstetrics and Gynaecology (EBCOG)
CONCLUSIONS: There are discrepancies around gynaecological cancer screenings provision among EBCOG member countries. It is important to establish European recommendations about screening for gynaecological cancers, in order to standardize the access to equitable better health care in gynaecological cancers within Europe.PMID:37679212 | DOI:10.1016/j.ejogrb.2023.08.385
Source: Reproductive Biology - September 7, 2023 Category: Reproduction Medicine Authors: M árcia Vieira-Coimbra Nuno Nogueira-Martins Rafal Zadykowicz Hugo Rodrigues Gaspar Jean Calleja-Agius Maja Pakiz Sambit Mukhopadhyay Tahir Mahmood Source Type: research
Relation between naked eye Swede score and the outcomes of atypias of undetermined significance
CONCLUSION: The correlation between the colposcopic and naked-eye Swede scores was statistically significant (0.82). Further studies with larger samples are important to establish the actual applicability of the naked eye method; however, in the absence of colposcopy, this appears to be an effective and very helpful method to make diagnostic decisions regarding HPV-induced lesions.PMID:37678129 | DOI:10.1016/j.ejogrb.2023.08.387
Source: Reproductive Biology - September 7, 2023 Category: Reproduction Medicine Authors: Fernanda Ghelman Nathalia Cristina Cruz Silva Leila Cristina Brollo Soares Source Type: research
Comparison of awareness, attitudes and knowledge on human papilloma virus vaccination in Singapore: 2019 versus 2013
CONCLUSION: The Singapore government's efforts to improve cervical cancer awareness through national campaigns and policy changes have led to an improvement in knowledge of HPV infection. However, this has not translated into improvements in the vaccine acceptance rates. The decision for vaccine uptake is complex, and there are multiple factors to be addressed to ensure cost-effective implementation of the strategies. Our study highlights the need for effective dissemination of vaccine information, additional subsidies and consideration of a mandatory school-based vaccination programme.PMID:37675669 | DOI:10.4103/singaporemedj.SMJ-2020-437
Source: Singapore Medical Journal - September 7, 2023 Category: General Medicine Authors: Michelle E-Jyn Kwek Joella Xiaohong Ang Manisha Mathur Lily Chye Lee Kho Source Type: research
