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Cancer: Adenocarcinoma
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Validity of Endoscopic Submucosal Dissection for Gastric Cancer Diagnosed as Differentiated Adenocarcinoma Before Treatment Regardless of Lesion Size
CONCLUSION: Even with a tumor diameter ≥31 mm, curative resection was achieved in about 60% of cases in which intramucosal lesions were considered possible preoperatively, but the rate was low at 8.3% for tumor diameter ≥101 mm. Long-term outcomes appear favorable, with only 0.4% of the patients dying of disease but delayed gastric emptying observed in 1.7% of cases.PMID:37681270 | DOI:10.5152/tjg.2023.22611
Source: The Turkish Journal of Gastroenterology - September 8, 2023 Category: Gastroenterology Authors: Kosuke Nomura Shu Hoteya Yorinari Ochiai Takayuki Okamura Yugo Suzuki Junnosuke Hayasaka Yutaka Mitsunaga Masami Tanaka Kazuhiro Fuchinoue Hiroyuki Odagiri Satoshi Yamashita Akira Matsui Daisuke Kikuchi Source Type: research
Clinicopathologic study of stage I adenosquamous carcinoma of the lung
CONCLUSIONS: Early-stage adenosquamous carcinoma of the lung is a histological type associated with severe prognosis and postoperative recurrence, often in distant sites, in approximately one-third of cases. High serum carcinoembryonic antigen levels and vascular invasion might be risk factors of recurrence.PMID:37681230 | DOI:10.1093/jjco/hyad122
Source: Clinical Lung Cancer - September 8, 2023 Category: Cancer & Oncology Authors: Yoshinori Handa Takuhiro Ikeda Hideaki Hanaki Yoshihiro Miyata Hidenori Mukaida Morihito Okada Source Type: research
Construction of RNA Methylation Modification-immune-related lncRNA Molecular Subtypes and Prognostic Scoring System in Lung Adenocarcinoma
CONCLUSION: The RMM-I molecular subtype constituted the novel molecular characteristic subtype of LUAD, which complemented the existing pathological typing. More refined and accurate molecular subtypes provide help to reveal the mechanism of LUAD development. In addition, the RMM-I score offers a reliable tool for accurate prognosis of LUAD.PMID:37680151 | DOI:10.2174/0929867331666230901110629
Source: Current Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: Jiajing Wang Jianfeng Shu Source Type: research
Spinal metastases from non-small cell lung cancer - Is surgical extent enough by following suggestions of the Tomita and Tokuhashi scores?
CONCLUSION: Patients with spinal metastases from lung cancer had better prognosis than that predicted by the Tomita and Tokuhashi scores. Spine surgeons should acknowledge this discrepancy and treat these patients with at least the aggressiveness suggested. Patients with adenocarcinoma, amenable to target therapy, denosumab, good general condition, systemic treatment-naïve are better candidates for surgery. Those with cachexic status and unresectable visceral metastases are worse candidates.PMID:37684123 | DOI:10.1016/j.asjsur.2023.08.179
Source: Asian Journal of Surgery - September 8, 2023 Category: Surgery Authors: An-Ping Huang Ching-Yao Yang Furen Xiao Shih-Hung Yang Chang-Mu Chen Dar-Ming Lai Fon-Yih Tsuang Source Type: research
Validity of Endoscopic Submucosal Dissection for Gastric Cancer Diagnosed as Differentiated Adenocarcinoma Before Treatment Regardless of Lesion Size
CONCLUSION: Even with a tumor diameter ≥31 mm, curative resection was achieved in about 60% of cases in which intramucosal lesions were considered possible preoperatively, but the rate was low at 8.3% for tumor diameter ≥101 mm. Long-term outcomes appear favorable, with only 0.4% of the patients dying of disease but delayed gastric emptying observed in 1.7% of cases.PMID:37681270 | DOI:10.5152/tjg.2023.22611
Source: The Turkish Journal of Gastroenterology - September 8, 2023 Category: Gastroenterology Authors: Kosuke Nomura Shu Hoteya Yorinari Ochiai Takayuki Okamura Yugo Suzuki Junnosuke Hayasaka Yutaka Mitsunaga Masami Tanaka Kazuhiro Fuchinoue Hiroyuki Odagiri Satoshi Yamashita Akira Matsui Daisuke Kikuchi Source Type: research
Cancer Stem Cells of Esophageal Adenocarcinoma are Suppressed by Inhibitors of TRPV2 and SLC12A2
CONCLUSIONS: Based on the present results, TRPV2 and SLC12A2 are involved in the maintenance of CSCs, and their specific inhibitors, tranilast and furosemide, respectively, have potential as targeted therapeutic agents for EAC.PMID:37684371 | DOI:10.1245/s10434-023-14247-z
Source: Ann Oncol - September 8, 2023 Category: Cancer & Oncology Authors: Atsushi Shiozaki Hiroyuki Inoue Hiroki Shimizu Toshiyuki Kosuga Kenichi Takemoto Michihiro Kudou Takuma Ohashi Tomohiro Arita Hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Eigo Otsuji Source Type: research
Disfunction of communication among immune cells in minimal-deviation adenocarcinoma of the cervix as an immunotherapeutic opportunity
In this study, we conducted single-cell transcriptomic analyses of MDA samples (Ca) and adjacent normal tissues (PCa). The present study reveals the prevalence of dendritic cells (DCs) and T cells in the carcinoma (Ca) of mammary ductal adenocarcinoma (MDA), with DCs undergoing significant metabolic reprogramming and immune stress. Additionally, our findings demonstrate the crucial involvement of DCs and T cells in the pathogenesis and metastatic progression of MDA, as evidenced by single-cell transcriptomic profiling of MDA and HPV samples. This resource provides a more profound understanding of the indolent nature of MDA...
Source: International Immunopharmacology - September 8, 2023 Category: Allergy & Immunology Authors: Hui Zhang Chunhua Liu Xiaoqian Zhai Qianqian Zhang Yao Zhou Hu Huang Mingde Ding Qiang Shi Yan Liu Ying Tang Guanghai Liu Hongmei Wang Source Type: research
Novel ALK immunohistochemistry assay (clone OTI1A4, Dako) is a sensitive, reliable marker for identifying ALK rearrangements in lung adenocarcinomas : A validation study
CONCLUSIONS: Immunohistochemistry-based assays provide a valid and reasonably priced alternative, especially in settings where molecular confirmatory tests are neither offered nor accessible. Given high interassay and molecular concordance, we propose that the novel Dako OTI1A4 assay can be reliably used to identify cases with ALK rearrangement.PMID:37681660 | DOI:10.1093/ajcp/aqad111
Source: American Journal of Clinical Pathology - September 8, 2023 Category: Pathology Authors: Ozgur Can Eren Cisel Aydin Mericoz Emine Bozkurtlar Pinar Bulutay Arzu Baygul Ibrahim Kulac Source Type: research
Validity of Endoscopic Submucosal Dissection for Gastric Cancer Diagnosed as Differentiated Adenocarcinoma Before Treatment Regardless of Lesion Size
CONCLUSION: Even with a tumor diameter ≥31 mm, curative resection was achieved in about 60% of cases in which intramucosal lesions were considered possible preoperatively, but the rate was low at 8.3% for tumor diameter ≥101 mm. Long-term outcomes appear favorable, with only 0.4% of the patients dying of disease but delayed gastric emptying observed in 1.7% of cases.PMID:37681270 | DOI:10.5152/tjg.2023.22611
Source: The Turkish Journal of Gastroenterology - September 8, 2023 Category: Gastroenterology Authors: Kosuke Nomura Shu Hoteya Yorinari Ochiai Takayuki Okamura Yugo Suzuki Junnosuke Hayasaka Yutaka Mitsunaga Masami Tanaka Kazuhiro Fuchinoue Hiroyuki Odagiri Satoshi Yamashita Akira Matsui Daisuke Kikuchi Source Type: research
Novel ALK immunohistochemistry assay (clone OTI1A4, Dako) is a sensitive, reliable marker for identifying ALK rearrangements in lung adenocarcinomas : A validation study
CONCLUSIONS: Immunohistochemistry-based assays provide a valid and reasonably priced alternative, especially in settings where molecular confirmatory tests are neither offered nor accessible. Given high interassay and molecular concordance, we propose that the novel Dako OTI1A4 assay can be reliably used to identify cases with ALK rearrangement.PMID:37681660 | DOI:10.1093/ajcp/aqad111
Source: American Journal of Clinical Pathology - September 8, 2023 Category: Pathology Authors: Ozgur Can Eren Cisel Aydin Mericoz Emine Bozkurtlar Pinar Bulutay Arzu Baygul Ibrahim Kulac Source Type: research
68Ga-PSMA-11 PET/CT in a Case of Isolated Parietal Peritoneal Metastasis From Prostate Adenocarcinoma
We present 68Ga-PSMA-11 PET/CT findings in a case of isolated parietal peritoneal metastasis from prostate adenocarcinoma 35 months after radical prostatectomy. The peritoneal metastases showed multifocal intense PSMA uptake, but subtle structural abnormalities on 68Ga-PSMA-11 PET/CT. The patient was subsequently treated with androgen deprivation therapy. The peritoneal metastases progressed 25 months after the initiation of androgen deprivation therapy and were removed surgically. Histologic and immunohistochemical evaluation revealed metastatic prostate adenocarcinoma with treatment-related neuroendocrine differentiation...
Source: Clinical Prostate Cancer - September 8, 2023 Category: Cancer & Oncology Authors: Qian Zhao Aisheng Dong Changjing Zuo Source Type: research
Novel ALK immunohistochemistry assay (clone OTI1A4, Dako) is a sensitive, reliable marker for identifying ALK rearrangements in lung adenocarcinomas : A validation study
CONCLUSIONS: Immunohistochemistry-based assays provide a valid and reasonably priced alternative, especially in settings where molecular confirmatory tests are neither offered nor accessible. Given high interassay and molecular concordance, we propose that the novel Dako OTI1A4 assay can be reliably used to identify cases with ALK rearrangement.PMID:37681660 | DOI:10.1093/ajcp/aqad111
Source: American Journal of Clinical Pathology - September 8, 2023 Category: Pathology Authors: Ozgur Can Eren Cisel Aydin Mericoz Emine Bozkurtlar Pinar Bulutay Arzu Baygul Ibrahim Kulac Source Type: research
Validity of Endoscopic Submucosal Dissection for Gastric Cancer Diagnosed as Differentiated Adenocarcinoma Before Treatment Regardless of Lesion Size
CONCLUSION: Even with a tumor diameter ≥31 mm, curative resection was achieved in about 60% of cases in which intramucosal lesions were considered possible preoperatively, but the rate was low at 8.3% for tumor diameter ≥101 mm. Long-term outcomes appear favorable, with only 0.4% of the patients dying of disease but delayed gastric emptying observed in 1.7% of cases.PMID:37681270 | DOI:10.5152/tjg.2023.22611
Source: The Turkish Journal of Gastroenterology - September 8, 2023 Category: Gastroenterology Authors: Kosuke Nomura Shu Hoteya Yorinari Ochiai Takayuki Okamura Yugo Suzuki Junnosuke Hayasaka Yutaka Mitsunaga Masami Tanaka Kazuhiro Fuchinoue Hiroyuki Odagiri Satoshi Yamashita Akira Matsui Daisuke Kikuchi Source Type: research
Construction of RNA Methylation Modification-immune-related lncRNA Molecular Subtypes and Prognostic Scoring System in Lung Adenocarcinoma
CONCLUSION: The RMM-I molecular subtype constituted the novel molecular characteristic subtype of LUAD, which complemented the existing pathological typing. More refined and accurate molecular subtypes provide help to reveal the mechanism of LUAD development. In addition, the RMM-I score offers a reliable tool for accurate prognosis of LUAD.PMID:37680151 | DOI:10.2174/0929867331666230901110629
Source: Current Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: Jiajing Wang Jianfeng Shu Source Type: research
