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Cancer: Squamous Cell Carcinoma
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Total 19645 results found since Jan 2013.
GSE242834 Gene expression profiling and the effect of HDAC9 in cisplatin resistance of esophageal squamous cell carcinoma
Series Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensEsophageal cancer is one of the most serious health problems globally because of its high incidence and mortality rate. Cisplatin(CDDP) is the primary treatment but limited by the drug resistance. However, the mechanism of cisplatin resistance remains unclear. Herein, the CDDP-resistant cell line TE-1/CDDP was established to compared with TE-1, the expression profiles of circRNAs were compared between TE-1/CDDP and TE-1 using microarray analysis, Histone deacetylase 9(HDAC9) was identified significantly up-regulated. Using siRNA and conducting cell funct...
Source: GEO: Gene Expression Omnibus - September 14, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research
Risk factors for metachronous esophageal squamous cell carcinoma after endoscopic or surgical resection of esophageal carcinoma: a systematic review and meta-analysis
Conclusiontimely investigating the age of patients, previous history of cancer and monitoring the number of LVLs in the first 5 years after operation are of great significance to identify high-risk populations of MESCC for timely medical care. Education and behavior correction about smoking are advocated. Tumor markers should be regularly detected in the head and neck, esophagus, and stomach. Endoscopic resection was associated with a higher incidence of MESCC, which provided a reference for doctors to choose the removal method.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022377030.
Source: Frontiers in Oncology - September 14, 2023 Category: Cancer & Oncology Source Type: research
Diagnostic accuracy of sentinel lymph node frozen section analysis in patients with early-stage cervical cancer: A systematic review and meta-analysis
CONCLUSION: SLN frozen section detects 65% of lymph node metastases compared with SLN ultrastaging and may prevent unnecessary radical surgery in some patients with early-stage cervical cancer.PMID:37703622 | DOI:10.1016/j.ygyno.2023.08.019
Source: Gynecologic Oncology - September 13, 2023 Category: Cancer & Oncology Authors: Nuria Agust í David Viveros-Carre ño Nathalia Mora-Soto Pedro T Ram írez Alejandro Rauh-Hain Chi-Fang Wu Juliana Rodr íguez Carlos Fernando Grillo-Ardila Catherin Salazar Kirsten Jorgensen Blanca Segarra-Vidal Enrique Chac ón Alexander Melamed Ren é Source Type: research
OCT4's role and mechanism underlying oral squamous cell carcinoma
J Zhejiang Univ Sci B. 2023 Sept 15;24(9):796-806. doi: 10.1631/jzus.B2200602.ABSTRACTOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem c...
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Yuwei Dai Ziqiong Wu Yitong Chen Xinjian Ye Chaowei Wang Huiyong Zhu Source Type: research
Head and neck cancer treatment in the era of molecular medicine
Adv Cancer Res. 2023;160:205-252. doi: 10.1016/bs.acr.2023.03.004. Epub 2023 Apr 12.ABSTRACTHead and neck cancers are a heterogeneous group of highly aggressive tumors and collectively represent the sixth most common cancer worldwide. Most head and neck cancers are squamous cell carcinomas (HNSCCs). Current multimodal treatment concepts combine surgery, chemotherapy, irradiation, immunotherapy, and targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of HNSCC and revealed novel therapeutic targets and prognostic/predictive biomarkers. Notably, HNSCC is characterized b...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Subramanya Pandruvada Remi Kessler Ann Thai Source Type: research
OCT4's role and mechanism underlying oral squamous cell carcinoma
J Zhejiang Univ Sci B. 2023 Sept 15;24(9):796-806. doi: 10.1631/jzus.B2200602.ABSTRACTOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem c...
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Yuwei Dai Ziqiong Wu Yitong Chen Xinjian Ye Chaowei Wang Huiyong Zhu Source Type: research
Head and neck cancer treatment in the era of molecular medicine
Adv Cancer Res. 2023;160:205-252. doi: 10.1016/bs.acr.2023.03.004. Epub 2023 Apr 12.ABSTRACTHead and neck cancers are a heterogeneous group of highly aggressive tumors and collectively represent the sixth most common cancer worldwide. Most head and neck cancers are squamous cell carcinomas (HNSCCs). Current multimodal treatment concepts combine surgery, chemotherapy, irradiation, immunotherapy, and targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of HNSCC and revealed novel therapeutic targets and prognostic/predictive biomarkers. Notably, HNSCC is characterized b...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Subramanya Pandruvada Remi Kessler Ann Thai Source Type: research
Diagnostic accuracy of sentinel lymph node frozen section analysis in patients with early-stage cervical cancer: A systematic review and meta-analysis
CONCLUSION: SLN frozen section detects 65% of lymph node metastases compared with SLN ultrastaging and may prevent unnecessary radical surgery in some patients with early-stage cervical cancer.PMID:37703622 | DOI:10.1016/j.ygyno.2023.08.019
Source: Gynecologic Oncology - September 13, 2023 Category: Cancer & Oncology Authors: Nuria Agust í David Viveros-Carre ño Nathalia Mora-Soto Pedro T Ram írez Alejandro Rauh-Hain Chi-Fang Wu Juliana Rodr íguez Carlos Fernando Grillo-Ardila Catherin Salazar Kirsten Jorgensen Blanca Segarra-Vidal Enrique Chac ón Alexander Melamed Ren é Source Type: research
Head and neck cancer treatment in the era of molecular medicine
Adv Cancer Res. 2023;160:205-252. doi: 10.1016/bs.acr.2023.03.004. Epub 2023 Apr 12.ABSTRACTHead and neck cancers are a heterogeneous group of highly aggressive tumors and collectively represent the sixth most common cancer worldwide. Most head and neck cancers are squamous cell carcinomas (HNSCCs). Current multimodal treatment concepts combine surgery, chemotherapy, irradiation, immunotherapy, and targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of HNSCC and revealed novel therapeutic targets and prognostic/predictive biomarkers. Notably, HNSCC is characterized b...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Subramanya Pandruvada Remi Kessler Ann Thai Source Type: research
Machine learning analysis of lung squamous cell carcinoma gene expression datasets reveals novel prognostic signatures
CONCLUSION: This study demonstrates that an integrated approach involving machine learning and system biology may effectively identify novel biomarkers for LUSC.PMID:37703712 | DOI:10.1016/j.compbiomed.2023.107430
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Hemant Kumar Joon Anamika Thalor Dinesh Gupta Source Type: research
Risk factors for the occurrence of infection in patients with oral squamous cell carcinoma after restorative reconstruction and its impact on recurrence and quality of life: a retrospective cohort study
CONCLUSIONS: The incidence of postoperative infection after restorative and reconstructive surgery for OSCC deserves the attention of clinicians. For high-risk infected persons, relevant anti-infection measures should be taken early against the infectious source, and the possibility of nosocomial infection should be attached great importance in clinical work. After discharge, patients should also actively do follow-up, education and other related work to reduce the incidence of postoperative infection.PMID:37701120 | PMC:PMC10493792 | DOI:10.21037/tcr-23-1150
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Miaomiao Shen Weilan Shan Siyi Lv Kuan Cai Xuan Chen Zhengyun Xu Mingjin Gao Guodong Wang Source Type: research
OCT4's role and mechanism underlying oral squamous cell carcinoma
J Zhejiang Univ Sci B. 2023 Sept 15;24(9):796-806. doi: 10.1631/jzus.B2200602.ABSTRACTOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem c...
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Yuwei Dai Ziqiong Wu Yitong Chen Xinjian Ye Chaowei Wang Huiyong Zhu Source Type: research
Fibroblast growth factor 5 expression predicts the progression of oral squamous cell carcinoma
CONCLUSION: FGF5 can be induced by cellular stress and risk factors of OSCC, where high expression levels of FGF5 is potentially a useful parameter for predicting OSCC progression and patient survival.PMID:37704482 | DOI:10.1016/j.jfma.2023.08.020
Source: J Formos Med Assoc - September 13, 2023 Category: General Medicine Authors: Wan-Yi Shie Shih-Jung Cheng Kuan-Chi Chen Ching-Chun Tang Hsin-Hui Peng Hui-Hsin Ko Hsin-Han Hou Han-Yi Elizabeth Chou Source Type: research
Head and neck cancer treatment in the era of molecular medicine
Adv Cancer Res. 2023;160:205-252. doi: 10.1016/bs.acr.2023.03.004. Epub 2023 Apr 12.ABSTRACTHead and neck cancers are a heterogeneous group of highly aggressive tumors and collectively represent the sixth most common cancer worldwide. Most head and neck cancers are squamous cell carcinomas (HNSCCs). Current multimodal treatment concepts combine surgery, chemotherapy, irradiation, immunotherapy, and targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of HNSCC and revealed novel therapeutic targets and prognostic/predictive biomarkers. Notably, HNSCC is characterized b...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Subramanya Pandruvada Remi Kessler Ann Thai Source Type: research
