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Cancer: Squamous Cell Carcinoma
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Total 19645 results found since Jan 2013.
Gelatin-based 3D biomimetic scaffolds platform potentiates culture of cancer stem cells in esophageal squamous cell carcinoma
Biomaterials. 2023 Sep 11;302:122323. doi: 10.1016/j.biomaterials.2023.122323. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are crucial for tumorigenesis, metastasis, and therapy resistance in esophageal squamous cell carcinoma (ESCC). To further elucidate the mechanism underlying characteristics of CSCs and develop CSCs-targeted therapy, an efficient culture system that could expand and maintain CSCs is needed. CSCs reside in a complex tumor microenvironment, and three-dimensional (3D) culture systems of biomimetic scaffolds are expected to better support the growth of CSCs by recapitulating the biophysical prop...
Source: Biomaterials - September 17, 2023 Category: Materials Science Authors: Yenan Wu Haiwei Liang Aiping Luo Yong Li Zhiqiang Liu Xin Li Wenxin Li Kaini Liang Junyang Li Zhihua Liu Yanan Du Source Type: research
Emerging cell cycle related non-coding RNA biomarkers from saliva and blood for oral squamous cell carcinoma
Mol Biol Rep. 2023 Sep 17. doi: 10.1007/s11033-023-08791-w. Online ahead of print.ABSTRACTThe unnotified or undifferentiable early stages of oral squamous cell carcinoma (OSCC) progression are the prime reasons for late-stage detection and poor survival outcomes of oral cancer. This review summarizes the prior research and recent advancements on the influence of dysregulated non-coding RNA (ncRNA) on cell cycle and their employability as diagnostic and prognostic biomarkers of oral cancer. The literature search was performed using the following keywords: 'serum/saliva non-coding RNAs' and 'serum/saliva non-coding RNAs and ...
Source: Molecular Biology Reports - September 17, 2023 Category: Molecular Biology Authors: Asrarunissa Kalmatte Punchappady Devasya Rekha Chandrahas Koumar Ratnacaram Source Type: research
Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress
Biomed Pharmacother. 2023 Sep 15;167:115518. doi: 10.1016/j.biopha.2023.115518. Online ahead of print.ABSTRACTHead and neck squamous cell carcinoma present a high mortality rate. Melatonin has been shown to have oncostatic effects in different types of cancers. However, inconsistent results have been reported for in vivo applications. Consequently, an alternative administration route is needed to improve bioavailability and establish the optimal dosage of melatonin for cancer treatment. On the other hand, the use of patient-derived tumor models has transformed the field of drug research because they reflect the heterogenei...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 17, 2023 Category: Drugs & Pharmacology Authors: Laura Martinez-Ruiz Javier Florido C ésar Rodriguez-Santana Alba L ópez-Rodríguez Ana Guerra-Librero Beatriz I Fern ández-Gil Patricia Garc ía-Tárraga Jos é Manuel Garcia-Verdugo Felix Oppel Holger Sudhoff David S ánchez-Porras Amadeo Ten-Steve Jo Source Type: research
Emerging cell cycle related non-coding RNA biomarkers from saliva and blood for oral squamous cell carcinoma
Mol Biol Rep. 2023 Sep 17. doi: 10.1007/s11033-023-08791-w. Online ahead of print.ABSTRACTThe unnotified or undifferentiable early stages of oral squamous cell carcinoma (OSCC) progression are the prime reasons for late-stage detection and poor survival outcomes of oral cancer. This review summarizes the prior research and recent advancements on the influence of dysregulated non-coding RNA (ncRNA) on cell cycle and their employability as diagnostic and prognostic biomarkers of oral cancer. The literature search was performed using the following keywords: 'serum/saliva non-coding RNAs' and 'serum/saliva non-coding RNAs and ...
Source: Mol Biol Cell - September 17, 2023 Category: Molecular Biology Authors: Asrarunissa Kalmatte Punchappady Devasya Rekha Chandrahas Koumar Ratnacaram Source Type: research
Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress
Biomed Pharmacother. 2023 Sep 15;167:115518. doi: 10.1016/j.biopha.2023.115518. Online ahead of print.ABSTRACTHead and neck squamous cell carcinoma present a high mortality rate. Melatonin has been shown to have oncostatic effects in different types of cancers. However, inconsistent results have been reported for in vivo applications. Consequently, an alternative administration route is needed to improve bioavailability and establish the optimal dosage of melatonin for cancer treatment. On the other hand, the use of patient-derived tumor models has transformed the field of drug research because they reflect the heterogenei...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 17, 2023 Category: Drugs & Pharmacology Authors: Laura Martinez-Ruiz Javier Florido C ésar Rodriguez-Santana Alba L ópez-Rodríguez Ana Guerra-Librero Beatriz I Fern ández-Gil Patricia Garc ía-Tárraga Jos é Manuel Garcia-Verdugo Felix Oppel Holger Sudhoff David S ánchez-Porras Amadeo Ten-Steve Jo Source Type: research
Emerging cell cycle related non-coding RNA biomarkers from saliva and blood for oral squamous cell carcinoma
Mol Biol Rep. 2023 Sep 17. doi: 10.1007/s11033-023-08791-w. Online ahead of print.ABSTRACTThe unnotified or undifferentiable early stages of oral squamous cell carcinoma (OSCC) progression are the prime reasons for late-stage detection and poor survival outcomes of oral cancer. This review summarizes the prior research and recent advancements on the influence of dysregulated non-coding RNA (ncRNA) on cell cycle and their employability as diagnostic and prognostic biomarkers of oral cancer. The literature search was performed using the following keywords: 'serum/saliva non-coding RNAs' and 'serum/saliva non-coding RNAs and ...
Source: Molecular Biology Reports - September 17, 2023 Category: Molecular Biology Authors: Asrarunissa Kalmatte Punchappady Devasya Rekha Chandrahas Koumar Ratnacaram Source Type: research
Differentiating Keratoacanthoma From Squamous Cell Carcinoma: Are We Losing the Battle or Our Bearings? - Comment on "Intralesional Methotrexate for Keratoacanthomas: A Case Series"
Actas Dermosifiliogr. 2023 Sep 14:S0001-7310(23)00734-2. doi: 10.1016/j.ad.2023.08.010. Online ahead of print.NO ABSTRACTPMID:37716500 | DOI:10.1016/j.ad.2023.08.010
Source: Actas Dermo-Sifiliograficas - September 16, 2023 Category: Dermatology Authors: P L ópez Sanz Miriam Fern ández-Parrado Eduardo Escario Travesedo Source Type: research
Nobiletin regulates invasion, migration and metastasis in hypopharyngeal squamous cell carcinoma
This study examined the effects of NOB on the proliferation, migration, and invasiveness of the FaDu cell line derived from hypopharyngeal squamous cell carcinoma. We determined protein kinase phosphorylation by western blot analysis, migration by Transwell assay, and metastatic potential by enzyme-linked immunosorbent assay of vascular endothelial growth factor. NOB inhibited cell proliferation by 40% at concentrations of 15 µM and 40 µM, and reduced migration and induced apoptosis at 50 µM by downregulating extracellular signal-regulated kinase, protein kinase B, and phosphoinositide 3-kinase. Our results suggest that...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Marisol Rosas-Mart ínez Jos é Antonio González Rosales Gloria Guti érrez-Venegas Source Type: research
Inhibitory Effect of Fingolimod on Head and Neck Squamous Cell Carcinoma and Its Mechanism: Gene Set Enrichment Analysis
This study aimed to clarify the therapeutic effect of Fingolimod on head and neck squamous cell carcinoma (HNSC) and initially explore its mechanism through data mining, clinical sample analysis and basic experiments. The normalized Enrichment Score (NES) of Fingolimod in tumor tissues was obtained by SwissTargetPrediction and The Cancer Genome Atlas (TCGA) database. IC50 (50% inhibitory concentration) of Fingolimod for HNSC was verified based on the Genomics of Drug Sensitivity in Cancer (GDSC) database. SCC9 cells were cultured in vitro for the application of Fingolimod. Cell proliferation was determined by the Cell Coun...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Lemeng Chang Chunhua Xie Kaiping Chou Qingnan Meng Lihui Zhao Source Type: research
Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC
Mol Cell Proteomics. 2023 Sep 14:100647. doi: 10.1016/j.mcpro.2023.100647. Online ahead of print.ABSTRACTThe NFE2L2(NRF2) oncogene and transcription factor drives a gene expression program that promotes cancer progression, metabolic reprogramming, immune evasion and chemoradiation resistance. Patient stratification by NRF2 activity may guide treatment decisions to improve outcome. Here, we developed a mass spectrometry (MS)-based targeted proteomics assay based on internal standard triggered parallel reaction monitoring (IS-PRM) to quantify 69 NRF2 pathway components and targets, as well as 21 proteins of broad clinical si...
Source: Molecular and Cellular Proteomics : MCP - September 16, 2023 Category: Molecular Biology Authors: Nathan T Wamsley Emily M Wilkerson Li Guan Kyle M LaPak Travis P Schrank Brittany J Holmes Robert W Sprung Petra Erdmann Gilmore Sophie P Gerndt Ryan S Jackson Randal C Paniello Patrik Pipkorn Sidharth V Puram Jason T Rich Reid R Townsend Jos é P Zevallo Source Type: research
Differentiating Keratoacanthoma From Squamous Cell Carcinoma: Are We Losing the Battle or Our Bearings? - Comment on "Intralesional Methotrexate for Keratoacanthomas: A Case Series"
Actas Dermosifiliogr. 2023 Sep 14:S0001-7310(23)00734-2. doi: 10.1016/j.ad.2023.08.010. Online ahead of print.NO ABSTRACTPMID:37716500 | DOI:10.1016/j.ad.2023.08.010
Source: Actas Dermo-Sifiliograficas - September 16, 2023 Category: Dermatology Authors: P L ópez Sanz Miriam Fern ández-Parrado Eduardo Escario Travesedo Source Type: research
Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC
Mol Cell Proteomics. 2023 Sep 14:100647. doi: 10.1016/j.mcpro.2023.100647. Online ahead of print.ABSTRACTThe NFE2L2(NRF2) oncogene and transcription factor drives a gene expression program that promotes cancer progression, metabolic reprogramming, immune evasion and chemoradiation resistance. Patient stratification by NRF2 activity may guide treatment decisions to improve outcome. Here, we developed a mass spectrometry (MS)-based targeted proteomics assay based on internal standard triggered parallel reaction monitoring (IS-PRM) to quantify 69 NRF2 pathway components and targets, as well as 21 proteins of broad clinical si...
Source: Molecular and Cellular Proteomics : MCP - September 16, 2023 Category: Molecular Biology Authors: Nathan T Wamsley Emily M Wilkerson Li Guan Kyle M LaPak Travis P Schrank Brittany J Holmes Robert W Sprung Petra Erdmann Gilmore Sophie P Gerndt Ryan S Jackson Randal C Paniello Patrik Pipkorn Sidharth V Puram Jason T Rich Reid R Townsend Jos é P Zevallo Source Type: research
Candida species as potential risk factors for oral squamous cell carcinoma: Systematic review and meta-analysis
Cancer Epidemiol. 2023 Sep 14;86:102451. doi: 10.1016/j.canep.2023.102451. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is considered a multifactorial disease and has been associated with microbial infections, although the association with Candida spp. is still controversial. This systematic review focused on clinical trials which evaluated the relation between oral Candida spp colonization and OSCC. PubMed; Scopus; Embase; Web of Science and Scientific Direct were assessed. Independent reviewers conducted the diagram steps. For data extraction the PRISMA protocol was followed. The quality analysis of ...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Camilla Olga Tasso T úlio Morandin Ferrisse Anal ú Barros de Oliveira Beatriz Ribeiro Ribas Janaina Habib Jorge Source Type: research
Porocarcinoma of the Left Foot: A Case Review
We present the case of a 62-year-old man with a lesion on the left foot. The diagnosis of the initial biopsy was squamous cell carcinoma. Six months later, the lesion reoccurred, and a second biopsy confirmed it to be eccrine porocarcinoma.PMID:37715975 | DOI:10.7547/17-069
Source: Journal of the American Podiatric Medical Association - September 16, 2023 Category: Podiatry Authors: Amy Wong Teviah Sachs Carmen D Sarita-Reyes Anthony Tomich Daniel J Callaghan Jonathan Ho Ali Al-Haseni Vitaliy Volansky Hau Pham Source Type: research
Nobiletin regulates invasion, migration and metastasis in hypopharyngeal squamous cell carcinoma
This study examined the effects of NOB on the proliferation, migration, and invasiveness of the FaDu cell line derived from hypopharyngeal squamous cell carcinoma. We determined protein kinase phosphorylation by western blot analysis, migration by Transwell assay, and metastatic potential by enzyme-linked immunosorbent assay of vascular endothelial growth factor. NOB inhibited cell proliferation by 40% at concentrations of 15 µM and 40 µM, and reduced migration and induced apoptosis at 50 µM by downregulating extracellular signal-regulated kinase, protein kinase B, and phosphoinositide 3-kinase. Our results suggest that...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Marisol Rosas-Mart ínez Jos é Antonio González Rosales Gloria Guti érrez-Venegas Source Type: research
