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Total 170 results found since Jan 2013.

CLEC4A and CLEC12B C-type lectin receptors mediate interactions with < em > Pneumocystis < /em > cell wall components
Conclusion. The data presented here provide new members of the CLRs family recognizing Pneumocystis. Future studies using CLEC4A and/or CLEC12B deficient mice in the PCP mouse model should provide further insights into the host immunological response to Pneumocystis.PMID:37294293 | DOI:10.1099/jmm.0.001714
Source: Journal of Medical Microbiology - June 9, 2023 Category: Microbiology Authors: Theodore J Kottom Eva M Carmona Kyle Schaefbauer Andrew H Limper Source Type: research

Endocytic SNAREs are involved in optimal Coxiella burnetii vacuole development
Summary Coxiella burnetii is a Gram‐negative intracellular bacterium. As previously described, both the endocytic and the autophagic pathways contribute to the maturation of Coxiella replicative vacuoles (CRVs). The large CRVs share the properties of both phagolysosomal and autophagolysosomal compartments. Vamp3, Vamp7 and Vamp8 are v‐SNAREs involved in the endocytic pathway which participate mainly in the fusion between endosomes and lysosomes. In the present study we observed that Vamp7 interacts with C. burnetii at different infection times (1 h–48 h p.i.). We have determined that a truncated mutant of Vamp7...
Source: Cellular Microbiology - January 7, 2013 Category: Microbiology Authors: Emanuel Martín Campoy, María Eugenia Mansilla, María Isabel Colombo Tags: Research Article Source Type: research

Tousled-like Kinases Modulate Reactivation of Gammaherpesviruses from Latency.
Abstract Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to human malignancies. The majority of tumor cells harbor latent virus, and a small percentage undergo spontaneous lytic replication. Both latency and lytic replication are important for viral pathogenesis and spread, but the cellular players involved in the switch between the two viral life-cycle phases are not clearly understood. We conducted a small interfering RNA (siRNA) screen targeting the cellular kinome and identified Tousled-like kinases (TLKs) as cellular kinases that control KSHV reactivation from latency. Upon treatment of latent KSHV-...
Source: Cell Host and Microbe - February 13, 2013 Category: Microbiology Authors: Dillon PJ, Gregory SM, Tamburro K, Sanders MK, Johnson GL, Raab-Traub N, Dittmer DP, Damania B Tags: Cell Host Microbe Source Type: research

Host metabolism promotes growth of Chlamydia pneumoniae in a low oxygen environment.
Abstract Chlamydia pneumoniae infections of the respiratory tract are common and are associated with acute and chronic diseases such as community-acquired pneumonia (CAP) and chronic obstructive pulmonary disease (COPD). Recent studies have shown that reduced environmental oxygen availability promotes chlamydial growth in infected host cells. The underlying mechanisms remain unclear. We performed a targeted siRNA screen coupled with an automated high-throughput microscopic analysis to identify key host cell genes that play a role in promoting the hypoxic growth of C. pneumoniae. A total of 294 siRNAs - targeting 9...
Source: International Journal of Medical Microbiology - April 6, 2013 Category: Microbiology Authors: Szaszák M, Shima K, Käding N, Hannus M, Solbach W, Rupp J Tags: Int J Med Microbiol Source Type: research

Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells
Conclusions: The accumulation of the RhoA and Rac1 on the PVM and the requisite of their normal GTPase activity for efficient invasion implied their involvement and function in T. gondii invasion.
Source: BMC Microbiology - Latest articles - May 30, 2013 Category: Microbiology Authors: Ren-Hua NaGuo-Hui ZhuJi-Xuan LuoXiao-Jing MengLiwang CuiHong-Juan PengXiao-guang ChenJulian Gomez-Cambronero Source Type: research

Helicobacter pylori down‐regulates expression of human β‐defensin 1 in the gastric mucosa in a type IV secretion dependent fashion
Summary Helicobacter pylori establishes a chronic lifelong infection in the human gastric mucosa, which may lead to peptic ulcer disease or gastric adenocarcinoma. The human beta‐defensins (hβDs) are antimicrobial peptides, hβD1 being constitutively expressed in the human stomach. We hypothesised that H. pylori may persist, in part, by downregulating gastric hβD1 expression. We measured hβD1 and hβD2 expression in vivo in relation to the presence, density and severity of H. pylori infection, investigated differential effects of H. pylori virulence factors, and studied underlying signalling mechanisms in vitro. Signi...
Source: Cellular Microbiology - July 29, 2013 Category: Microbiology Authors: S.R. Patel, K. Smith, D.P. Letley, K.W. Cook, A.A. Memon, R.J.M. Ingram, E. Staples, S. Backert, A.M. Zaitoun, J.C. Atherton, K. Robinson Tags: Research Article Source Type: research

Helicobacter pylori downregulates expression of human β‐defensin 1 in the gastric mucosa in a type IV secretion‐dependent fashion
Summary Helicobacter pylori establishes a chronic lifelong infection in the human gastric mucosa, which may lead to peptic ulcer disease or gastric adenocarcinoma. The human beta‐defensins (hβDs) are antimicrobial peptides, hβD1 being constitutively expressed in the human stomach. We hypothesized that H. pylori may persist, in part, by downregulating gastric hβD1 expression. We measured hβD1 and hβD2 expression in vivo in relation to the presence, density and severity of H. pylori infection, investigated differential effects of H. pylori virulence factors, and studied underlying signalling mechanisms in vitro....
Source: Cellular Microbiology - August 6, 2013 Category: Microbiology Authors: S. R. Patel, K. Smith, D. P. Letley, K. W. Cook, A. A. Memon, R. J. M. Ingram, E. Staples, S. Backert, A. M. Zaitoun, J. C. Atherton, K. Robinson Tags: Research Article Source Type: research

Effect of the silencing of the Ehcp112 gene on the in vitro virulence of Entamoeba histolytica
This study described that the silencing of the cysteine proteinase EhCP112 in Entamoeba histolytica produces a significant reduction in cytolysis and phagocytosis, indicating the participation of this proteinase in the in vitro virulence of the parasite. Image: A) Internalization of a fluorescein-labeled siRNA. B) EhCP112 silencing.
Source: Parasites and Vectors - August 28, 2013 Category: Microbiology Authors: Ramón Ocádiz-RuizWendy FonsecaMáximo MartínezRamón Ocádiz-QuintanarEsther OrozcoMario Rodríguez Source Type: research

Identification of conserved motifs in the Westnile virus envelope essential for particle secretion
Conclusions: The conserved 461PXAP464 and 349YCYL352 motifs in the WNV envelope are indispensable for WNV particle production. Although these motifs bear sequence similarity to retroviral late domains and are essential for WNV assembly, they are functionally distinct suggesting that they are not the typical late domain like motifs of retroviruses and may play a role other than Alix/Tsg101 utilization/dependence.
Source: BMC Microbiology - Latest articles - September 4, 2013 Category: Microbiology Authors: Himanshu GargRaphael LeeNg TekSebastian Maurer-StrohAnjali Joshi Source Type: research

Rothia dentocariosa induces TNF‐alpha production in a TLR2‐dependent manner
This article is protected by copyright. All rights reserved.
Source: FEMS Immunology and Medical Microbiology - November 25, 2013 Category: Microbiology Authors: Hideo Kataoka, Makoto Taniguchi, Haruka Fukamachi, Takafumi Arimoto, Hirobumi Morisaki, Hirotaka Kuwata Tags: Short Communication Source Type: research

Evaluation of Acanthamoeba myosin-IC as a potential therapeutic target.
Abstract Members of the genus Acanthamoeba are facultative pathogens of humans, causing a sight threatening keratitis and a fatal encephalitis. We have targeted myosin-IC by siRNA silencing as a therapeutic approach, since it is known that the function of this protein is vital for the amoeba. In this work, specific siRNAs were developed against the Acanthamoeba myosin-IC gene. Treated and control amoebae were cultured in growth and encystment medium in order to evaluate the induced effects after myosin-IC gene knock-down as we have anticipated that cyst formation may be impaired. The effective of silencing the myo...
Source: Antimicrobial Agents and Chemotherapy - January 27, 2014 Category: Microbiology Authors: Martín-Navarro CM, Lorenzo-Morales J, López-Arencibia A, Reyes-Batlle M, Piñero JE, Valladares B, Maciver SK Tags: Antimicrob Agents Chemother Source Type: research

Inhibition of HSP70 reduces porcine reproductive and respiratory syndrome virus replication in vitro
Conclusions: Our study revealed that HSP70 is an essential host factor required for the replication of PRRSV. The inhibition of HSP70 significantly reduced PRRSV replication, which may be applied as an effective antiviral strategy.
Source: BMC Microbiology - Latest articles - March 13, 2014 Category: Microbiology Authors: Jintao GaoShuqi XiaoXiaohong LiuLiangliang WangQianqian JiDelin MoYaosheng Chen Source Type: research