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Specialty: Biomedical Science
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Total 883 results found since Jan 2013.
ACE2 inhibits proliferation of smooth muscle cell through AT1R and its downstream signaling pathway
J Biosci. 2023;48:25.ABSTRACTTo investigate the effect of the angiotensin converting enzyme 2 (ACE2) on AT1R expression, ERK1/2 and STAT3 protein phosphorylation in rat vascular smooth muscle cells (VSMCs) was studied. VSMCs were transfected with a lentiviral vector including the ACE2 gene and with siRNA to regulate the level of ACE2 in VSMCs. The levels of mRNA and proteins of ACE2, AT1R, ERK1/2, p-ERK1/2, STAT3, and p-STAT3 in VSMCs were examined using real-time PCR and western blot. The proliferation of VSMCs was observed by CCK-8 assay and BrdU measurement. Upregulation of ACE2 inhibited the growth of cells elicited by...
Source: Journal of Biosciences - August 4, 2023 Category: Biomedical Science Authors: Jingjing Gong Zhuoqiang Lu Rongtong Li Changsheng Xu Xueqing Jin Source Type: research
SCCA1/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production
Patients with cancer who have high serum levels of squamous cell carcinoma antigen 1 (SCCA1, now referred to as SERPINB3) commonly experience treatment resistance and have a poor prognosis. Despite being a clinical biomarker, the modulation of SERPINB3 in tumor immunity is poorly understood. We found positive correlations of SERPINB3 with CXCL1, CXCL8 (CXCL8/9), S100A8, and S100A9 (S100A8/A9) myeloid cell infiltration through RNA-Seq analysis of human primary cervical tumors. Induction of SERPINB3 resulted in increased CXCL1/8 and S100A8/A9 expression, which promoted monocyte and myeloid-derived suppressor cell (MDSC) migr...
Source: Journal of Clinical Investigation - August 1, 2023 Category: Biomedical Science Authors: Liyun Chen, Victoria Shi, Songyan Wang, Lulu Sun, Rebecca Freeman, Jasmine Yang, Matthew J. Inkman, Subhajit Ghosh, Fiona Ruiz, Kay Jayachandran, Yi Huang, Jingqin Luo, Jin Zhang, Pippa Cosper, Clifford J. Luke, Catherine S. Spina, Perry W. Grigsby, Julie Source Type: research
Exosomal lnc-CDHR derived from human umbilical cord mesenchymal stem cells attenuates peritoneal epithelial-mesenchymal transition through AKT/FOXO pathway
CONCLUSIONS: Exosomal lnc-CDHR derived from hUMSCs may competitively bind to miR-3149 to regulate suppression on target PTEN genes and alleviate EMT of HMrSV5 through AKT/FOXO pathway.PMID:37466443 | DOI:10.18632/aging.204883
Source: Aging - July 19, 2023 Category: Biomedical Science Authors: Taiwei Jiao Yuling Huang Haiyan Sun Lina Yang Source Type: research
MIR34A modulates lens epithelial cell apoptosis and cataract development via the HK1/caspase 3 signaling pathway
Aging (Albany NY). 2023 Jul 6;15. doi: 10.18632/aging.204854. Online ahead of print.ABSTRACTCataracts are the leading cause of blindness in the world. Age is a major risk factor for cataracts, and with increasing aging, the burden of cataracts will grow, but the exact details of cataractogenesis remain unclear. A recent study showed that microRNA-34a (MIR34A) is involved in the development of cataracts, but the underlying pathogenesis remains obscure. Here, our results of microRNA target prediction showed that hexokinase 1 (HK1) is one of the genes targeted by MIR34A. Based on this finding, we focused on the function of MI...
Source: Aging - July 6, 2023 Category: Biomedical Science Authors: Lujia Feng Yantao Wei Yimeng Sun Linbin Zhou Shaowei Bi Weirong Chen Wu Xiang Source Type: research
Budding uninhibited by benzimidazoles-1 (BUB1) regulates EGFR signaling by reducing EGFR internalization
Aging (Albany NY). 2023 Jul 3;15. doi: 10.18632/aging.204820. Online ahead of print.ABSTRACTEGFR signaling initiates upon ligand binding which leads to activation and internalization of the receptor-ligand complex. Here, we evaluated if BUB1 impacted EGFR signaling by regulating EGFR receptor internalization and activation. BUB1 was ablated genomically (siRNA) or biochemically (2OH-BNPP1) in cells. EGF ligand was used to initiate EGFR signaling while disuccinimidyl suberate (DSS) was used for cross linking cellular proteins. EGFR signaling was measured by western immunoblotting and receptor internalization was evaluated by...
Source: Aging - July 3, 2023 Category: Biomedical Science Authors: Shyam Nyati Grant Young Corey Speers Mukesh K Nyati Alnawaz Rehemtulla Source Type: research
LINC01117 inhibits invasion and migration of lung adenocarcinoma through influencing EMT process
ConclusionsLINC01117 was highly expressed in LUAD, and knockdown of LINC01117 significantly inhibited the migration and invasion of LUAD cells, while overexpression of LINC01117 significantly promoted the migration and invasion of LUAD cells, and affected the EMT process, and was able to alter the distribution of YAP1 in the nucleus and cytoplasm. This suggests that LINC01117 may regulate the activity of the Hippo pathway by altering the nuclear and cytoplasmic distribution of YAP1, which in turn induces the EMT process in lung adenocarcinoma cells and thus exerts a pro-cancer effect. It suggests that LINC01117 may play a ...
Source: PLoS One - June 29, 2023 Category: Biomedical Science Authors: Linjun Liu Source Type: research
MIC26 and MIC27 are bona fide subunits of the MICOS complex in mitochondria and do not exist as glycosylated apolipoproteins
by Melissa Lubeck, Nick H. Derkum, Ritam Naha, Rebecca Strohm, Marc D. Driessen, Bengt-Frederik Belgardt, Michael Roden, Kai St ühler, Ruchika Anand, Andreas S. Reichert, Arun Kumar Kondadi
Impairments of mitochondrial functions are linked to human ageing and pathologies such as cancer, cardiomyopathy, neurodegeneration and diabetes. Specifically, aberrations in ultrastructure of mitochondrial inner membrane (IM) and factors regulating them are linked to diabetes. The development of diabetes is connected to the ‘Mitochondrial Contact Site and Cristae Organising System’ (MICOS) complex which is a large membrane protei...
Source: PLoS One - June 6, 2023 Category: Biomedical Science Authors: Melissa Lubeck Source Type: research
Mechanisms of human umbilical cord mesenchymal stem cells-derived exosomal lncRNA GAS5 in alleviating EMT of HPMCs via Wnt/ β-catenin signaling pathway
CONCLUSIONS: Exosomes from the hUC-MSCs-CM could alleviate the EMT of HPMCs induced by HG via regulating lncRNA GAS5/miR-21/PTEN through the Wnt/β-catenin signaling pathway.PMID:37229651 | DOI:10.18632/aging.204719
Source: Aging - May 25, 2023 Category: Biomedical Science Authors: Yuling Huang Jianfei Ma Yi Fan Lina Yang Source Type: research
Induction of pro-inflammatory genes by fibronectin DAMPs in three fibroblast cell lines: Role of TAK1 and MAP kinases
by Pranav Maddali, Anthony Ambesi, Paula J. McKeown-Longo
Changes in the organization and structure of the fibronectin matrix are believed to contribute to dysregulated wound healing and subsequent tissue inflammation and tissue fibrosis. These changes include an increase in the EDA isoform of fibronectin as well as the mechanical unfolding of fibronecti n type III domains. In previous studies using embryonic foreskin fibroblasts, we have shown that fibronectin’s EDA domain (FnEDA) and the partially unfolded first Type III domain (FnIII-1c) function as Damage Associated Molecular Pattern (DAMP) molecules to stimulate th...
Source: PLoS One - May 25, 2023 Category: Biomedical Science Authors: Pranav Maddali Source Type: research
Activating SIRT1 deacetylates NF- κB p65 to alleviate liver inflammation and fibrosis via inhibiting NLRP3 pathway in macrophages
Conclusions: Activating SIRT1 inhibits the inflammation in macrophages by down-regulating NLRP3 pathway through deacetylating NF-κB p65, which in turn inhibits the activation of HSCs to alleviate hepatic inflammation and fibrosis.PMID:37057212 | PMC:PMC10087625 | DOI:10.7150/ijms.77955
Source: International Journal of Medical Sciences - April 14, 2023 Category: Biomedical Science Authors: Shuli He Yaru Wang Jinying Liu Pengju Li Xiaoying Luo Bingyong Zhang Source Type: research
