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Specialty: Biomedical Science
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Total 883 results found since Jan 2013.
Ferumoxytol- β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype
Conclusion: The nanocomposite FMT-β-glucan suppressed melanoma growth by inducing the M1 macrophage-activated tumor microenvironment.PMID:34400883 | PMC:PMC8364471 | DOI:10.7150/ijms.61525
Source: International Journal of Medical Sciences - August 17, 2021 Category: Biomedical Science Authors: Xinghan Liu Yujun Xu Yi Li Yuchen Pan Shuli Zhao Yayi Hou Source Type: research
A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation
Sci Signal. 2021 Aug 3;14(694):eabe0387. doi: 10.1126/scisignal.abe0387.ABSTRACTNoncanonical inflammasome activation by cytosolic lipopolysaccharide (LPS) is a critical component of the host response to Gram-negative bacteria. Cytosolic LPS recognition in macrophages is preceded by a Toll-like receptor (TLR) priming signal required to induce transcription of inflammasome components and facilitate the metabolic reprograming that fuels the inflammatory response. Using a genome-scale arrayed siRNA screen to find inflammasome regulators in mouse macrophages, we identified the mitochondrial enzyme nucleoside diphosphate kinase ...
Source: Science Signaling - August 4, 2021 Category: Biomedical Science Authors: Orna Ernst Jing Sun Bin Lin Balaji Banoth Michael G Dorrington Jonathan Liang Benjamin Schwarz Kaitlin A Stromberg Samuel Katz Sharat J Vayttaden Clinton J Bradfield Nadia Slepushkina Christopher M Rice Eugen Buehler Jaspal S Khillan Daniel W McVicar Cath Source Type: research
