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Specialty: Biomedical Science
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Total 883 results found since Jan 2013.
NAP1L5 targeting combined with MYH9 Inhibit HCC progression through PI3K/AKT/mTOR signaling pathway
In this study, low expression of NAP1L5 was found in hepatocellular carcinoma, and the downregulation of NAP1L5 was related to shorter survival and disease-free survival. In addition, its expression is also related to the tumor size and recurrence of hepatocellular carcinoma. The overexpression and knockdown of NAP1L5 by plasmid and siRNA showed that NAP1L5 inhibited the proliferation, migration and invasion and induced apoptosis of hepatoma cells. In vivo experiments confirmed that NAP1L5 can inhibit the growth and metastasis of hepatocellular carcinoma cells. In the mechanistic study, we found that NAP1L5 affects the occ...
Source: Aging - November 14, 2022 Category: Biomedical Science Authors: Rui Zhao Yuzhen Ge Yongjun Gong Bo Li Benli Xiao Shi Zuo Source Type: research
Retraction: siRNA-mediated knockdown against NUF2 suppresses pancreatic cancer proliferation in vitro and in vivo
Biosci Rep. 2022 Nov 30;42(11):BSR-2014-0124_RET. doi: 10.1042/BSR-2014-0124_RET.NO ABSTRACTPMID:36354013 | DOI:10.1042/BSR-2014-0124_RET
Source: Bioscience Reports - November 10, 2022 Category: Biomedical Science Source Type: research
DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathway
In conclusion, we establish DAZAP1 as a tumor-promoting gene with therapeutic potential and provide mechanistic insights into targeting DAZAP1 as a new strategy for the diagnosis and treatment of MM.PMID:36242590 | DOI:10.18632/aging.204326
Source: Aging - October 15, 2022 Category: Biomedical Science Authors: Yanyan Zhou Shaohua Huangfu Muxi Li Chao Tang Jinjun Qian Mengjie Guo Zuojian Zhou Ye Yang Chunyan Gu Source Type: research
circRERE regulates the expression of GBX2 through miR-1299 and ZC3H13/N < sup > 6 < /sup > -methyladenosine (m < sup > 6 < /sup > A) to promote growth and invasion of hepatocellular carcinoma cells
J Biosci. 2022;47:52.ABSTRACTHepatocellular carcinoma (HCC) is one of the most common malignant tumours in the world. Current studies have shown that circular RNAs (circRNAs) and N6-methyladenosine (m6A) methylation play important roles in the progression of HCC, but further studies are needed to confirm the underlying mechanisms. The expression of circRERE was significantly upregulated in HCC cells, and its downregulation reduced HCC cell viability and invasion while increasing apoptosis. Further study showed that circRERE bound directly to miR- 1299. After downregulating the expression of circRERE, miR-1299 expression wa...
Source: Journal of Biosciences - October 12, 2022 Category: Biomedical Science Authors: Yong-Hua Lin Bao-Yan Zhang Zhi-Chao Singh Chen Source Type: research
Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging
Aging (Albany NY). 2022 Sep 7;14(undefined). doi: 10.18632/aging.204273. Online ahead of print.ABSTRACTThere is growing evidence that the appearance and texture of the skin that is altered during the aging process are considerably enhanced by the accumulation of senescent dermal fibroblasts. These senescent cells magnify aging via an inflammatory, histolytic, and senescence-associated secretory phenotype (SASP). Secreted frizzled-related protein 4 (SFRP4) was previously determined to be expressed in dermal fibroblasts of aging skin, and its increased expression has been shown to promote cellular senescence. However, its ro...
Source: Aging - September 9, 2022 Category: Biomedical Science Authors: Kento Takaya Toru Asou Kazuo Kishi Source Type: research
Overexpression of Protein Phosphatase 2 Regulatory Subunit B"Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma
CONCLUSION: Our findings showed the correlation of PPP2R3A and HK1 in the glycolysis of HCC, which reveals a new mechanism for the oncogenic roles of PPP2R3A in cancer.PMID:35945177 | DOI:10.3967/bes2022.082
Source: Biomedical and Environmental Sciences : BES - August 9, 2022 Category: Biomedical Science Authors: Ning Jiao Wan Sheng Ji Biao Zhang Yu Kui Shang Yu Chen Zhang Wei Qun Yu Hai Long Jin Chao Li Cheng Ying Zhang Cheng Yan Wen Yue Qing Zhang Source Type: research
