Filtered By:
Specialty: Science
This page shows you your search results in order of date. This is page number 9.
Order by Relevance | Date
Total 125 results found since Jan 2013.
Effect of siRNA-mediated knockdown of eIF3c gene on survival of colon cancer cells.
This study was focused on investigating the effect of small interfering RNA (siRNA)-mediated eIF3c gene knockdown on colon cancer cell survival. The eIF3c gene was observed to be highly expressed in colon cancer cell models. The expression levels of the gene in eIF3c siRNA infected and control siRNA infected cells were compared via real-time polymerase chain reaction (PCR) and western blotting analysis. Cell proliferation levels were analyzed employing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and colony formation assays. Furthermore, the effects of eIF3c gene knockdown on the cell cycle and apopto...
Source: J Zhejiang Univ Sci ... - June 1, 2013 Category: Science Authors: Song N, Wang Y, Gu XD, Chen ZY, Shi LB Tags: J Zhejiang Univ Sci B Source Type: research
MTMR9/7 regulate CD4 T-cell differentiation Immunology
Screening a complete mouse phosphatase lentiviral shRNA library using high-throughput sequencing revealed several phosphatases that regulate CD4 T-cell differentiation. We concentrated on two lipid phosphatases, the myotubularin-related protein (MTMR)9 and -7. Silencing MTMR9 by shRNA or siRNA resulted in enhanced T-helper (Th)1 differentiation and increased Th1 protein kinase B (PKB)/AKT...
Source: Proceedings of the National Academy of Sciences - May 14, 2013 Category: Science Authors: Guo, L., Martens, C., Bruno, D., Porcella, S. F., Yamane, H., Caucheteux, S. M., Zhu, J., Paul, W. E. Tags: PNAS Plus Source Type: research
Delivery of siRNA to adipose macrophages in mice Physiology
Adipose tissue (AT) inflammation and infiltration by macrophages is associated with insulin resistance and type 2 diabetes in obese humans, offering a potential target for therapeutics. However, whether AT macrophages (ATMs) directly contribute to systemic glucose intolerance has not been determined. The reason is the lack of methods to ablate...
Source: Proceedings of the National Academy of Sciences - May 14, 2013 Category: Science Authors: Aouadi, M., Tencerova, M., Vangala, P., Yawe, J. C., Nicoloro, S. M., Amano, S. U., Cohen, J. L., Czech, M. P. Tags: Biological Sciences Source Type: research
DTF1 in RNA-directed DNA methylation Plant Biology
DNA methylation is an important epigenetic mark in many eukaryotic organisms. De novo DNA methylation in plants can be achieved by the RNA-directed DNA methylation (RdDM) pathway, where the plant-specific DNA-dependent RNA polymerase IV (Pol IV) transcribes target sequences to initiate 24-nt siRNA production and action. The putative DNA binding...
Source: Proceedings of the National Academy of Sciences - May 14, 2013 Category: Science Authors: Zhang, H., Ma, Z.-Y., Zeng, L., Tanaka, K., Zhang, C.-J., Ma, J., Bai, G., Wang, P., Zhang, S.-W., Liu, Z.-W., Cai, T., Tang, K., Liu, R., Shi, X., He, X.-J., Zhu, J.-K. Tags: Biological Sciences Source Type: research
Research Resource A Genome-Wide siRNA Screen Reveals Positive and Negative Regulators of the NOD2 and NF-{kappa}B Signaling Pathways
A small interfering RNA screen provides insight into the mechanisms of Crohn's disease pathogenesis.
Source: Signal Transduction Knowledge Environment - January 16, 2013 Category: Science Authors: Neil Warner, Aaron Burberry, Luigi Franchi, Yun-Gi Kim, Christine McDonald, Maureen A. Sartor, Gabriel Nunez Source Type: news
