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Total 125 results found since Jan 2013.

CircRNA.0007127 triggers apoptosis through the miR-513a-5p/CASP8 axis in K-562 cells
CONCLUSIONS: CircRNA.0007127 regulates K-562 cell apoptosis through the miR-513a-5p/CASP8 axis, which can serve as a novel powerful molecular target for K-562 cells.PMID:36111570 | DOI:10.1631/jzus.B2200048
Source: J Zhejiang Univ Sci ... - September 16, 2022 Category: Science Authors: Xiajing Li Yiyu Zhang Ning Wang Zhaohu Yuan Xiaojie Chen Qicong Chen Hui Deng Xinxin Tong Honglin Chen Yuyou Duan Yaming Wei Source Type: research

UV ‐induced DNA Damage in Skin is Reduced by CaSR Inhibition
In this study we investigated whether the CaSR is involved more directly in protection from UV damage in studies of human keratinocytes in primary culture and in mouse skin studiedin vivo. siRNA-directed reductions in CaSR protein levels in human keratinocytes significantly reduced UV-induced direct cyclobutane pyrimidine dimers (CPD) by around 80% and oxidative DNA damage (8-OHdG) by around 65% compared to control transfected cells. Similarly, in untransfected cells, the CaSR negative modulator, NPS-2143 (500 nM), reduced UV-induced CPD and 8-OHdG by around 70%. NPS-2143 also enhanced DNA repair and reduced reactive oxyge...
Source: Photochemistry and Photobiology - March 15, 2022 Category: Science Authors: Chen Yang, Mark Stephen Rybchyn, Warusavithana Gunawardena Manori De Silva, Jim Matthews, Andrew J.A. Holland, Arthur David Conigrave, Rebecca Sara Mason Tags: RESEARCH ARTICLE Source Type: research

Erratum to: Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment
J Zhejiang Univ Sci B. 2022 Feb 15;23(2):171-172. doi: 10.1631/jzus.B19e0468.ABSTRACTThe online version of the original article can be found at https://doi.org/10.1631/jzus.B1900468 The original version of this article (Liu et al., 2020) unfortunately contained some mistakes. 1. Figs. 7c and 7d in p.229 were incorrect. The upper left and bottom left pictures in Fig. 7c were accidentally duplicated with the pictures at the same position of Fig. 1a. The upper right and bottom right pictures were mistakenly placed in Fig. 7c. Therefore, the calculation results in Fig. 7d were also mistaken. The correct versions should be as f...
Source: J Zhejiang Univ Sci ... - February 21, 2022 Category: Science Authors: Xuan Liu Xueqing Zhou Xuwei Shang Li Wang Yi Li Hong Yuan Fuqiang Hu Source Type: research